Works matching AU Flatt, Peter R.

Results: 122

The Beneficial Impact of a Novel Pancreatic Polypeptide Analogue on Islet Cell Lineage.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 9, p. 4215, doi. 10.3390/ijms26094215

By:

Zhu, Wuyun;
Tanday, Neil;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Insulinotropic and antidiabetic properties of Eucalyptus citriodora leaves and isolation of bioactive phytomolecules.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 8, p. 1049, doi. 10.1093/jpp/rgab030

By:

Ansari, Prawej;
Flatt, Peter R.;
Harriott, Patrick;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Identification of Multiple Pancreatic and Extra-Pancreatic Pathways Underlying the Glucose-Lowering Actions of Acacia arabica Bark in Type-2 Diabetes and Isolation of Active Phytoconstituents.

Published in:

Plants (2223-7747), 2021, v. 10, n. 6, p. 1190, doi. 10.3390/plants10061190

By:

Ansari, Prawej;
Flatt, Peter R.;
Harriott, Patrick;
Hannan, J. M. A.;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals.

Published in:

Plants (2223-7747), 2020, v. 9, n. 10, p. 1348, doi. 10.3390/plants9101348

By:

Ansari, Prawej;
Flatt, Peter R.;
Harriott, Patrick;
Abdel-Wahab, Yasser H.A.

Publication type:

Article

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0286062

By:

Sridhar, Ananyaa;
Khan, Dawood;
Elliott, Jessie A.;
Naughton, Violetta;
Flatt, Peter R.;
Irwin, Nigel;
Moffett, Charlotte R.

Publication type:

Article

Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?

Published in:

Diabetes & Vascular Disease Research, 2007, v. 4, n. 2, p. 150, doi. 10.3132/dvdr.2007.034

By:

Flatt, Peter R

Publication type:

Article

Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes.

Published in:

Diabetes & Vascular Disease Research, 2006, v. 3, n. 3, p. 159, doi. 10.3132/dvdr.2006.024

By:

Green, Brian D;
Flatt, Peter R;
Bailey, Clifford J

Publication type:

Article

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice.

Published in:

Journal of Bone & Mineral Research, 2020, v. 35, n. 7, p. 1363, doi. 10.1002/jbmr.4004

By:

Gobron, Benoît;
Bouvard, Béatrice;
Vyavahare, Sagar;
Blom, Liv VV;
Pedersen, Kristian K;
Windeløv, Johanne A;
Boer, Geke A;
Harada, Norio;
Zhang, Sheng;
Shimazu‐Kuwahara, Satoko;
Wice, Burton;
Inagaki, Nobuya;
Legrand, Erick;
Flatt, Peter R;
Chappard, Daniel;
Hartmann, Bolette;
Holst, Jens J;
Rosenkilde, Mette M;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes.

Published in:

Biological Chemistry, 2020, v. 401, n. 11, p. 1293, doi. 10.1515/hsz-2020-0195

By:

English, Andrew;
Craig, Sarah L.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Zinc-induced activation of GPR39 regulates glucose homeostasis through glucose-dependent insulinotropic polypeptide secretion from enteroendocrine K-cells.

Published in:

Biological Chemistry, 2019, v. 400, n. 8, p. 1023, doi. 10.1515/hsz-2018-0393

By:

Moran, Brian M.;
Miskelly, Michael G.;
Abdel-Wahab, Yasser H.A.;
Flatt, Peter R.;
McKillop, Aine M.

Publication type:

Article

Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.

Published in:

Biological Chemistry, 2018, v. 399, n. 1, p. 79, doi. 10.1515/hsz-2017-0136

By:

Khan, Dawood;
Vasu, Srividya;
Moffett, R. Charlotte;
Gault, Victor A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4] tigerinin-1R in mice with diet-induced obesity and insulin resistance.

Published in:

Biological Chemistry, 2016, v. 397, n. 8, p. 753, doi. 10.1515/hsz-2016-0120

By:

Ojo, Opeolu O.;
Srinivasan, Dinesh K.;
Owolabi, Bosede O.;
McGahon, Mary K.;
Moffett, R. Charlotte;
Curtis, Tim M.;
Conlon, J. Michael;
Flatt, Peter R.;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Activation of GPR119 by fatty acid agonists augments insulin release from clonal ß-cells and isolated pancreatic islets and improves glucose tolerance in mice.

Published in:

Biological Chemistry, 2014, v. 395, n. 4, p. 453, doi. 10.1515/hsz-2013-0255

By:

Moran, Brian M.;
Abdel-Wahab, Yasser H. A.;
Flatt, Peter R.;
McKillop, Aine M.

Publication type:

Article

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4.

Published in:

Biological Chemistry, 2013, v. 394, n. 7, p. 909, doi. 10.1515/hsz-2013-0115

By:

Vasu, Srividya;
McClenaghan, Neville H.;
McCluskey, Jane T.;
Flatt, Peter R.

Publication type:

Article

Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats.

Published in:

Biological Chemistry, 2011, v. 392, n. 10, p. 909, doi. 10.1515/BC.2011.176

By:

Irwin, Nigel;
Francis, Jacqueline M.E.;
Flatt, Peter R.

Publication type:

Article

Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.

Published in:

Biological Chemistry, 2009, v. 390, n. 1, p. 75, doi. 10.1515/BC.2009.002

By:

Irwin, Nigel;
McClean, Paula L.;
Patterson, Steven;
Hunter, Kerry;
Flatt, Peter R.

Publication type:

Article

Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.

Published in:

Biological Chemistry, 2008, v. 389, n. 4, p. 441, doi. 10.1515/BC.2008.049

By:

Taylor, Ashley;
Irwin, Nigel;
McKillop, Aine M.;
Flatt, Peter R.;
Gault, Victor A.

Publication type:

Article

Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue.

Published in:

Biological Chemistry, 2008, v. 389, n. 2, p. 143, doi. 10.1515/BC.2008.018

By:

Abdel-Wahab, Yasser H. A.;
Power, Gavin J.;
Ng, Ming T.;
Flatt, Peter R.;
Conlon, J. Michael

Publication type:

Article

Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets.

Published in:

Biological Chemistry, 2008, v. 389, n. 2, p. 189, doi. 10.1515/BC.2008.019

By:

Cassidy, Roslyn S.;
Irwin, Nigel;
R. Flatt, Peter

Publication type:

Article

Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders.

Published in:

Biomedicines, 2025, v. 13, n. 2, p. 454, doi. 10.3390/biomedicines13020454

By:

Ansari, Prawej;
Reberio, Alexa D.;
Ansari, Nushrat J.;
Kumar, Sandeep;
Khan, Joyeeta T.;
Chowdhury, Suraiya;
Abd El-Mordy, Fatma Mohamed;
Hannan, J. M. A.;
Flatt, Peter R.;
Abdel-Wahab, Yasser H. A.;
Seidel, Veronique

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Effects of 2 Novel PYY(1-36) Analogues, (P 3 L 31 P 34)PYY(1-36) and PYY(1-36)(Lys 12 PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Published in:

Clinical Medicine Insights: Endocrinology & Diabetes, 2019, v. 12, p. N.PAG, doi. 10.1177/1179551419855626

By:

Lafferty, Ryan A;
Gault, Victor A;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Abnormalities of GIP in spontaneous syndromes of obesity and diabetes in mice.

Published in:

1983

By:

Flatt, Peter R.;
Bailey, Clifford J.;
Kwasowski, Peter;
Swanston-Flatt, Sara K.;
Marks, Vincent;
Flatt, P R;
Bailey, C J;
Kwasowski, P;
Swanston-Flatt, S K;
Marks, V

Publication type:

journal article

Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus.

Published in:

Journal of Cellular Physiology, 2015, v. 230, n. 12, p. 3009, doi. 10.1002/jcp.25033

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Bouvard, Béatrice;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Effects of Long-Term Exposure to Nicotinamide and Sodium Butyrate on Growth, Viability, and the Function of Clonal Insulin Secreting Cells.

Published in:

Endocrine Research, 2004, v. 30, n. 1, p. 61, doi. 10.1081/ERC-120028485

By:

Liu, Hui‐Kang;
Green, Brian D.;
Flatt, Peter R.;
McClenaghan, Neville H.;
McCluskey, Jane T.

Publication type:

Article

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.

Published in:

Frontiers in Endocrinology, 2019, p. N.PAG, doi. 10.3389/fendo.2019.00051

By:

Mansur, Sity Aishah;
Mieczkowska, Aleksandra;
Flatt, Peter R.;
Chappard, Daniel;
Irwin, Nigel;
Mabilleau, Guillaume

Publication type:

Article

Novel enzyme‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice.

Published in:

Biofactors, 2024, v. 50, n. 6, p. 1101, doi. 10.1002/biof.2059

By:

Zhu, Wuyun;
Tanday, Neil;
Lafferty, Ryan A.;
Flatt, Peter R.;
Irwin, Nigel

Publication type:

Article

Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation.

Published in:

Biofactors, 2023, v. 49, n. 3, p. 646, doi. 10.1002/biof.1938

By:

Sarnobat, Dipak;
Moffett, R. Charlotte;
Ma, Jinfang;
Flatt, Peter R.;
McClenaghan, Neville H.;
Tarasov, Andrei I.

Publication type:

Article

Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152818

By:

Martin, Christine M.;
Parthsarathy, Vadivel;
Hasib, Annie;
Ng, Ming T.;
McClean, Stephen;
Flatt, Peter R.;
Gault, Victor A.;
Irwin, Nigel

Publication type:

Article

Molecular determinants and intracellular targets of taurine signalling in pancreatic islet β‐cells.

Published in:

Acta Physiologica, 2024, v. 240, n. 3, p. 1, doi. 10.1111/apha.14101

By:

Turbitt, Julie;
Moffett, R. Charlotte;
Brennan, Lorraine;
Johnson, Paul R. V.;
Flatt, Peter R.;
McClenaghan, Neville H.;
Tarasov, Andrei I.

Publication type:

Article

Insulinotropic Actions of the Frog Skin Host-Defense Peptide Alyteserin-2a: A Structure-Activity Study.

Published in:

Chemical Biology & Drug Design, 2013, v. 82, n. 2, p. 196, doi. 10.1111/cbdd.12151

By:

Ojo, Opeolu O.;
Abdel ‐ Wahab, Yasser H. A.;
Flatt, Peter R.;
Conlon, J. Michael

Publication type:

Article

Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine.

Published in:

2011

By:

McKillop AM;
Flatt PR;
McKillop, Aine M;
Flatt, Peter R

Publication type:

journal article

Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine.

Published in:

Diabetes Care, 2011, v. 34, n. 12, p. 2624, doi. 10.2337/dc11-0837

By:

MCKILLOP, AINE M.;
FLATT, PETER R.

Publication type:

Article

N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic β-cell-associated gene expression

Published in:

Cell Biology International, 2004, v. 28, n. 1, p. 69, doi. 10.1016/j.cellbi.2003.10.004

By:

Liu, Hui-Kang;
Green, Brian D.;
Gault, Victor A.;
McCluskey, Jane T.;
McClenaghan, Neville H.;
P.M. O'Harte, Finbarr;
Flatt, Peter R.

Publication type:

Article

Molecular mechanisms of insulin secretion and insulin action.

Published in:

Journal of Biological Education (Society of Biology), 1991, v. 25, n. 1, p. 9, doi. 10.1080/00219266.1991.9655167

By:

Flatt, Peter R.;
Bailey, Clifford J.

Publication type:

Article

Antidiabetic actions of aqueous bark extract of Swertia chirayita on insulin secretion, cellular glucose uptake and protein glycation.

Published in:

Journal of Experimental & Integrative Medicine, 2014, v. 4, n. 4, p. 268, doi. 10.5455/jeim.160814.or.110

By:

Thomson, Heather-Anne J.;
Ojo, Opeolu O.;
Flatt, Peter R.;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

In vitro modulation of pancreatic insulin secretion, extrapancreatic insulin action and peptide glycation by Curcuma longa aqueous extracts.

Published in:

Journal of Experimental & Integrative Medicine, 2014, v. 4, n. 3, p. 187, doi. 10.5455/jeim.170414.or.101

By:

Kasabri, Violet;
Flatt, Peter R.;
Abdel-Wahab, Yasser H. A.

Publication type:

Article

Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.

Published in:

Nutrients, 2024, v. 16, n. 21, p. 3709, doi. 10.3390/nu16213709

By:

Ansari, Prawej;
Khan, Joyeeta T.;
Chowdhury, Suraiya;
Reberio, Alexa D.;
Kumar, Sandeep;
Seidel, Veronique;
Abdel-Wahab, Yasser H. A.;
Flatt, Peter R.

Publication type:

Article

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice.

Published in:

PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0202350

By:

O’Harte, Finbarr P. M.;
Parthsarathy, Vadivel;
Hogg, Christopher;
Flatt, Peter R.

Publication type:

Article

Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.

Published in:

ChemMedChem, 2015, v. 10, n. 8, p. 1424, doi. 10.1002/cmdc.201500140

By:

Irwin, Nigel;
Patterson, Steven;
de Kort, Martin;
Moffett, R. Charlotte;
Wisse, Jeffry A. J.;
Dokter, Wim H. A.;
Bos, Ebo S.;
Miltenburg, André M. M.;
Flatt, Peter R.

Publication type:

Article

(Val8)GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

Published in:

ChemMedChem, 2013, v. 8, n. 4, p. 595, doi. 10.1002/cmdc.201200409

By:

Lennox, Rachael;
Porter, David W.;
Flatt, Peter R.;
Gault, Victor A.

Publication type:

Article

Erratum. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes 2015;64:2996-3009.

Published in:

2016

By:

Irwin, Nigel;
Pathak, Varun;
Flatt, Peter R

Publication type:

journal article

Acute and long-term effects of nateglinide on insulin secretory pathways.

Published in:

British Journal of Pharmacology, 2004, v. 142, n. 2, p. 367, doi. 10.1038/sj.bjp.0705766

By:

Ball, Andrew J.;
Flatt, Peter R.;
McClenaghan, Neville H.

Publication type:

Article

Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide.

Published in:

British Journal of Pharmacology, 2000, v. 130, n. 2, p. 478, doi. 10.1038/sj.bjp.0703306

By:

McClenaghan, Neville H;
Ball, Andrew J;
Flatt, Peter R

Publication type:

Article

Insulin-releasing action of the novel antidiabetic agent BTS 67 582.

Published in:

1998

By:

McClenaghan, Neville H.;
Flatt, Peter R.;
Bailey, Clifford J.;
McClenaghan, N H;
Flatt, P R;
Bailey, C J

Publication type:

journal article

Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic β-cell secretory responsiveness.

Published in:

British Journal of Pharmacology, 1997, v. 121, n. 3, p. 389, doi. 10.1038/sj.bjp.0701139

By:

Clarke, Jacqueline;
Flatt, Peter R.;
Barnett, Christopher R.

Publication type:

Article

Effects of anti-diabetic drugs on bone metabolism.

Published in:

Expert Review of Endocrinology & Metabolism, 2015, v. 10, n. 6, p. 663, doi. 10.1586/17446651.2015.1077697

By:

Mabilleau, Guillaume;
Chappard, Daniel;
Flatt, Peter R;
Irwin, Nigel

Publication type:

Article

Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9–39)amide in obese diabetic ( ob/ob) mice.

Published in:

Biological Chemistry, 2007, v. 388, n. 2, p. 221, doi. 10.1515/BC.2007.024

By:

Parker, Jeremy C.;
Irwin, Nigel;
Lavery, Kerry S.;
Green, Brian D.;
O'Harte, Finbarr P. M.;
Gault, Victor A.;
Flatt, Peter R.

Publication type:

Article

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.

Published in:

Biological Chemistry, 2007, v. 388, n. 2, p. 173, doi. 10.1515/BC.2007.019

By:

Gault, Victor A.;
Hunter, Kerry;
Irwin, Nigel;
Greer, Brett;
Green, Brian D.;
Harriott, Patrick;
O'Harte, Finbarr P. M.;
Flatt, Peter R.

Publication type:

Article

A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones.

Published in:

Biological Chemistry, 2006, v. 387, n. 7, p. 941, doi. 10.1515/BC.2006.118

By:

Marenah, Lamin;
McCluskey, Jane T.;
Abdel-Wahab, Yasser H. A.;
O'Harte, Finbarr P. M.;
McClenaghan, Neville H.;
Flatt, Peter R.

Publication type:

Article