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Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.
Published in:
EMBO Molecular Medicine, 2015, v. 7, n. 3, p. 288, doi. 10.15252/emmm.201404508
By:
- Clemmensen, Christoffer;
- Finan, Brian;
- Fischer, Katrin;
- Tom, Robby Zachariah;
- Legutko, Beata;
- Sehrer, Laura;
- Heine, Daniela;
- Grassl, Niklas;
- Meyer, Carola W;
- Henderson, Bart;
- Hofmann, Susanna M;
- Tschöp, Matthias H;
- Van der Ploeg, Lex HT;
- Müller, Timo D
Publication type:
Article
p62 Links ß-adrenergic input to mitochondrial function and thermogenesis.
Published in:
Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 469, doi. 10.1172/JCI64209
By:
- Müller, Timo D.;
- Sang Jun Lee;
- Jastroch, Martin;
- Kabra, Dhiraj;
- Stemmer, Kerstin;
- Aichler, Michaela;
- Abplanalp, Bill;
- Ananthakrishnan, Gayathri;
- Bhardwaj, Nakul;
- Collins, Sheila;
- Divanovic, Senad;
- Endele, Max;
- Finan, Brian;
- Gao, Yuanqing;
- Habegger, Kirk M.;
- Hembree, Jazzmin;
- Heppner, Kristy M.;
- Hofmann, Susanna;
- Holland, Jenna;
- Küchler, Daniela
Publication type:
Article
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Published in:
Nature Medicine, 2015, v. 21, n. 1, p. 27, doi. 10.1038/nm.3761
By:
- Finan, Brian;
- Yang, Bin;
- Ottaway, Nickki;
- Smiley, David L;
- Ma, Tao;
- Clemmensen, Christoffer;
- Chabenne, Joe;
- Zhang, Lianshan;
- Habegger, Kirk M;
- Fischer, Katrin;
- Campbell, Jonathan E;
- Sandoval, Darleen;
- Seeley, Randy J;
- Bleicher, Konrad;
- Uhles, Sabine;
- Riboulet, William;
- Funk, Jürgen;
- Hertel, Cornelia;
- Belli, Sara;
- Sebokova, Elena
Publication type:
Article
Targeted estrogen delivery reverses the metabolic syndrome.
Published in:
Nature Medicine, 2012, v. 18, n. 12, p. 1847, doi. 10.1038/nm.3009
By:
- Finan, Brian;
- Yang, Bin;
- Ottaway, Nickki;
- Stemmer, Kerstin;
- Müller, Timo D;
- Yi, Chun-Xia;
- Habegger, Kirk;
- Schriever, Sonja C;
- García-Cáceres, Cristina;
- Kabra, Dhiraj G;
- Hembree, Jazzminn;
- Holland, Jenna;
- Raver, Christine;
- Seeley, Randy J;
- Hans, Wolfgang;
- Irmler, Martin;
- Beckers, Johannes;
- de Angelis, Martin Hrab?;
- Tiano, Joseph P;
- Mauvais-Jarvis, Franck
Publication type:
Article
Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Published in:
2024
By:
- Sachs, Stephan;
- Götz, Anna;
- Finan, Brian;
- Feuchtinger, Annette;
- DiMarchi, Richard D.;
- Döring, Yvonne;
- Weber, Christian;
- Tschöp, Matthias H.;
- Müller, Timo D.;
- Hofmann, Susanna M.
Publication type:
Correction Notice
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Published in:
Cardiovascular Diabetology, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12933-023-01940-2
By:
- Sachs, Stephan;
- Götz, Anna;
- Finan, Brian;
- Feuchtinger, Annette;
- DiMarchi, Richard D.;
- Döring, Yvonne;
- Weber, Christian;
- Tschöp, Matthias H.;
- Müller, Timo D.;
- Hofmann, Susanna M.
Publication type:
Article
100 years of glucagon and 100 more.
Published in:
Diabetologia, 2023, v. 66, n. 8, p. 1378, doi. 10.1007/s00125-023-05947-y
By:
- Wewer Albrechtsen, Nicolai J.;
- Holst, Jens J.;
- Cherrington, Alan D.;
- Finan, Brian;
- Gluud, Lise Lotte;
- Dean, E. Danielle;
- Campbell, Jonathan E.;
- Bloom, Stephen R.;
- Tan, Tricia M.-M.;
- Knop, Filip K.;
- Müller, Timo D.
Publication type:
Article
GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice.
Published in:
Diabetologia, 2015, v. 58, n. 3, p. 604, doi. 10.1007/s00125-014-3478-3
By:
- Schwenk, Robert;
- Baumeier, Christian;
- Finan, Brian;
- Kluth, Oliver;
- Brauer, Christine;
- Joost, Hans-Georg;
- DiMarchi, Richard;
- Tschöp, Matthias;
- Schürmann, Annette
Publication type:
Article
Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice.
Published in:
Diabetes, Obesity & Metabolism, 2021, v. 23, n. 1, p. 195, doi. 10.1111/dom.14215
By:
- Sachs, Stephan;
- Niu, Lili;
- Geyer, Philipp;
- Jall, Sigrid;
- Kleinert, Maximilian;
- Feuchtinger, Annette;
- Stemmer, Kerstin;
- Brielmeier, Markus;
- Finan, Brian;
- DiMarchi, Richard D.;
- Tschöp, Matthias H.;
- Wewer Albrechtsen, Nicolai;
- Mann, Matthias;
- Müller, Timo D.;
- Hofmann, Susanna M.
Publication type:
Article
G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053347
By:
- Müller, Anne;
- Kleinau, Gunnar;
- Piechowski, Carolin L.;
- Müller, Timo D.;
- Finan, Brian;
- Pratzka, Juliane;
- Grüters, Annette;
- Krude, Heiko;
- Tschöp, Matthias;
- Biebermann, Heike
Publication type:
Article
Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.
Published in:
Endocrinology, 2020, v. 161, n. 1, p. 1, doi. 10.1210/endocr/bqz013
By:
- Nason, Shelly R;
- Kim, Teayoun;
- Antipenko, Jessica P;
- Finan, Brian;
- DiMarchi, Richard;
- Hunter, Chad S;
- Habegger, Kirk M
Publication type:
Article
A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs.
Published in:
Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.693958
By:
- He, Rongjun;
- Mowery, Stephanie A.;
- Chabenne, Joseph;
- Finan, Brian;
- Mayer, John P.;
- DiMarchi, Richard D.
Publication type:
Article
Hypothalamic leptin action is mediated by histone deacetylase 5.
Published in:
Nature Communications, 2016, v. 7, n. 2, p. 10782, doi. 10.1038/ncomms10782
By:
- Kabra, Dhiraj G.;
- Pfuhlmann, Katrin;
- García-Cáceres, Cristina;
- Schriever, Sonja C.;
- Casquero García, Veronica;
- Kebede, Adam Fiseha;
- Fuente-Martin, Esther;
- Trivedi, Chitrang;
- Heppner, Kristy;
- Uhlenhaut, N. Henriette;
- Legutko, Beata;
- Kabra, Uma D.;
- Gao, Yuanqing;
- Yi, Chun-Xia;
- Quarta, Carmelo;
- Clemmensen, Christoffer;
- Finan, Brian;
- Müller, Timo D.;
- Meyer, Carola W.;
- Paez-Pereda, Marcelo
Publication type:
Article
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
Published in:
Nature Communications, 2013, v. 4, n. 6, p. 1968, doi. 10.1038/ncomms2968
By:
- Müller, Timo D.;
- Müller, Anne;
- Yi, Chun-Xia;
- M Habegger, Kirk;
- Meyer, Carola W.;
- Gaylinn, Bruce D.;
- Finan, Brian;
- Heppner, Kristy;
- Trivedi, Chitrang;
- Bielohuby, Maximilian;
- Abplanalp, William;
- Meyer, Franziska;
- Piechowski, Carolin L.;
- Pratzka, Juliane;
- Stemmer, Kerstin;
- Holland, Jenna;
- Hembree, Jazzmin;
- Bhardwaj, Nakul;
- Raver, Christine;
- Ottaway, Nickki
Publication type:
Article
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans.
Published in:
Science Translational Medicine, 2013, v. 5, n. 209, p. 1, doi. 10.1126/scitranslmed.3007218
By:
- Finan, Brian;
- Tao Ma;
- Ottaway, Nickki;
- Müller, Timo D.;
- Habegger, Kirk M.;
- Heppner, Kristy M.;
- Kirchner, Henriette;
- Holland, Jenna;
- Hembree, Jazzminn;
- Raver, Christine;
- Lockie, Sarah H.;
- Smiley, David L.;
- Gelfanov, Vasily;
- Bin Yang;
- Hofmann, Susanna;
- Bruemmer, Dennis;
- Drucker, Daniel J.;
- Pfluger, Paul T.;
- Perez-Tilve, Diego;
- Gidda, Jaswant
Publication type:
Article
Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety.
Published in:
Molecules, 2019, v. 24, n. 10, p. 1855, doi. 10.3390/molecules24101855
By:
- He, Rongjun;
- Finan, Brian;
- Mayer, John P.;
- DiMarchi, Richard D.;
- Mosberg, Henry;
- Sawyer, Tomi;
- Haskell-Luevano, Carrie
Publication type:
Article
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21309-x
By:
- Klein, Anders B.;
- Nicolaisen, Trine S.;
- Ørtenblad, Niels;
- Gejl, Kasper D.;
- Jensen, Rasmus;
- Fritzen, Andreas M.;
- Larsen, Emil L.;
- Karstoft, Kristian;
- Poulsen, Henrik E.;
- Morville, Thomas;
- Sahl, Ronni E.;
- Helge, Jørn W.;
- Lund, Jens;
- Falk, Sarah;
- Lyngbæk, Mark;
- Ellingsgaard, Helga;
- Pedersen, Bente K.;
- Lu, Wei;
- Finan, Brian;
- Jørgensen, Sebastian B.
Publication type:
Article
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16230-8
By:
- Fischer, Katrin;
- Fenzl, Anna;
- Liu, Dianxin;
- Dyar, Kenneth A.;
- Kleinert, Maximilian;
- Brielmeier, Markus;
- Clemmensen, Christoffer;
- Fedl, Anna;
- Finan, Brian;
- Gessner, Andre;
- Jastroch, Martin;
- Huang, Jianfeng;
- Keipert, Susanne;
- Klingenspor, Martin;
- Brüning, Jens C.;
- Kneilling, Manfred;
- Maier, Florian C.;
- Othman, Ahmed E.;
- Pichler, Bernd J.;
- Pramme-Steinwachs, Ines
Publication type:
Article
Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.
Published in:
2022
By:
- Kim, Teayoun;
- Nason, Shelly;
- Antipenko, Jessica;
- Finan, Brian;
- Shalev, Anath;
- DiMarchi, Richard;
- Habegger, Kirk M.
Publication type:
journal article
CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity.
Published in:
2021
By:
- Zizzari, Philippe;
- He, Rongjun;
- Falk, Sarah;
- Bellocchio, Luigi;
- Allard, Camille;
- Clark, Samantha;
- Lesté-Lasserre, Thierry;
- Marsicano, Giovanni;
- Clemmensen, Christoffer;
- Perez-Tilve, Diego;
- Finan, Brian;
- Cota, Daniela;
- Quarta, Carmelo
Publication type:
journal article
936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-936-P
By:
- HOFMANN, SUSANNA M.;
- WEWER ALBRECHTSEN, NICOLAI J.;
- TSCHÖP, MATTHIAS H.;
- FEUCHTINGER, ANNETTE;
- BRIELMEIER, MARKUS;
- FINAN, BRIAN;
- DIMARCHI, RICHARD;
- KLEINERT, MAXIMILIAN;
- SACHS, STEPHAN;
- MÜLLER, TIMO D.;
- STEMMER, KERSTIN;
- MANN, MATTHIAS
Publication type:
Article
The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.
Published in:
Diabetes, 2020, v. 69, n. 5, p. 882, doi. 10.2337/db19-1216
By:
- Capozzi, Megan E.;
- Coch, Reilly W.;
- Koech, Jepchumba;
- Astapova, Inna I.;
- Wait, Jacob B.;
- Encisco, Sara E.;
- Douros, Jonathan D.;
- El, Kimberly;
- Finan, Brian;
- Sloop, Kyle W.;
- Herman, Mark A.;
- D'Alessio, David A.;
- Campbell, Jonathan E.
Publication type:
Article
Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.
Published in:
2020
By:
- Finan, Brian;
- Capozzi, Megan E.;
- Campbell, Jonathan E.
Publication type:
journal article
1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1965-P
By:
- KIM, TEAYOUN;
- ANTIPENKO, JESSICA P.;
- NASON, SHELLY;
- PRESEDO, NATALIE;
- VAN DER POL, WILLIAM J.;
- FINAN, BRIAN;
- DIMARCHI, RICHARD;
- MORROW, CASEY D.;
- HABEGGER, KIRK M.
Publication type:
Article
1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1870-P
By:
- NASON, SHELLY;
- KIM, TEAYOUN;
- ANTIPENKO, JESSICA P.;
- FINAN, BRIAN;
- DIMARCHI, RICHARD;
- HABEGGER, KIRK M.
Publication type:
Article
Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway.
Published in:
Diabetes, 2019, v. 68, n. 6, p. 1329, doi. 10.2337/db18-1009
By:
- Ratner, Cecilia;
- Zhenyan He;
- Grunddal, Kaare V.;
- Skov, Louise J.;
- Hartmann, Bolette;
- Fa Zhang;
- Feuchtinger, Annette;
- Bjerregaard, Anette;
- Christoffersen, Christina;
- Tschöp, Matthias H.;
- Finan, Brian;
- DiMarchi, Richard D.;
- Leinninger, Gina M.;
- Williams, Kevin W.;
- Clemmensen, Christoffer;
- Holst, Birgitte
Publication type:
Article
Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway.
Published in:
2019
By:
- Ratner, Cecilia;
- He, Zhenyan;
- Grunddal, Kaare V;
- Skov, Louise J;
- Hartmann, Bolette;
- Zhang, Fa;
- Feuchtinger, Annette;
- Bjerregaard, Anette;
- Christoffersen, Christina;
- Tschöp, Matthias H;
- Finan, Brian;
- DiMarchi, Richard D;
- Leinninger, Gina M;
- Williams, Kevin W;
- Clemmensen, Christoffer;
- Holst, Birgitte
Publication type:
journal article
Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.
Published in:
2018
By:
- Teayoun Kim;
- Nason, Shelly;
- Holleman, Cassie;
- Pepin, Mark;
- Wilson, Landon;
- Berryhill, Taylor F.;
- Wende, Adam R.;
- Steele, Chad;
- Young, Martin E.;
- Barnes, Stephen;
- Drucker, Daniel J.;
- Finan, Brian;
- DiMarchi, Richard;
- Perez-Tilve, Diego;
- Tschöp, Matthias;
- Habegger, Kirk M.;
- Kim, Teayoun;
- Tschoep, Matthias
Publication type:
journal article
GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet.
Published in:
Diabetes, 2014, v. 63, n. 4, p. 1422, doi. 10.2337/db13-1609
By:
- Clemmensen, Christoffer;
- Chabenne, Joseph;
- Finan, Brian;
- Sullivan, Lorraine;
- Fischer, Katrin;
- Küchler, Daniela;
- Sehrer, Laura;
- Ograjsek, Teja;
- Hofmann, Susanna M.;
- Schriever, Sonja C.;
- Pfluger, Paul T.;
- Pinkstaff, Jason;
- Tschöp, Matthias H.;
- DiMarchi, Richard;
- Müller, Timo D.
Publication type:
Article

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