Found: 71

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  • Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 10, p. 6709, doi. 10.1002/alz.14095
    By:
    • Povala, Guilherme;
    • De Bastiani, Marco Antônio;
    • Bellaver, Bruna;
    • Ferreira, Pamela C. L.;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z.;
    • Souza, Diogo O.;
    • Rosa‐Neto, Pedro;
    • Pascoal, Tharick A.;
    • Zatt, Bruno;
    • Zimmer, Eduardo R.
    Publication type:
    Article

  • Employing transfer learning to optimize deep learning models for Alzheimer's disease classification using two tau PET tracers.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082824
    By:
    • Bauer‐Negrini, Guilherme;
    • Povala, Guilherme;
    • Lucchese, Luisa Vieira;
    • Lussier, Firoza Z;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Aguzzoli, Cristiano Schaffer;
    • Soares, Carolina;
    • Zalzale, Hussein;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Lemaire, Peter Charles;
    • Cabrera, Arlec;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Stevenson, Jenna
    Publication type:
    Article

  • Increased Genetic Risk for ADHD Potentiates Cognitive Impairment and Brain Hypometabolism in Alzheimer's Disease Patients.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080519
    By:
    • Leffa, Douglas Teixeira;
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Lussier, Firoza Z;
    • Ferrari‐Souza, João Pedro;
    • Ferreira, Pamela C.L.;
    • Zalzale, Hussein;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Soares, Carolina;
    • Abbas, Sarah;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Lopez, Oscar L.;
    • Villemagne, Victor L;
    • Klunk, William E;
    • Cohen, Annie;
    • Zimmer, Eduardo R.;
    • Karikari, Thomas K;
    • Rosa‐Neto, Pedro
    Publication type:
    Article

  • Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080138
    By:
    • Aguzzoli, Cristiano Schaffer;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Soares, Carolina;
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.
    Publication type:
    Article

  • Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer's Disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079969
    By:
    • Aguzzoli, Cristiano Schaffer;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Soares, Carolina;
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb
    Publication type:
    Article

  • Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079188
    By:
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Lussier, Firoza Z;
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Aguzzoli, Cristiano Schaffer;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Abbas, Sarah;
    • Rohden, Francieli;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Benedet, Andrea Lessa;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Cohen, Annie;
    • Lopez, Oscar L.
    Publication type:
    Article

  • Increased regional brain inflammation predicts longitudinal brain atrophy in individuals in the Alzheimer's disease continuum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079000
    By:
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Lussier, Firoza Z;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Benedet, Andrea Lessa;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Cohen, Ann D.;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Klunk, William E;
    • Villemagne, Victor L;
    • Karikari, Thomas K;
    • Zimmer, Eduardo R
    Publication type:
    Article

  • Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078423
    By:
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Benedet, Andrea Lessa;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Zalzale, Hussein;
    • Rohden, Francieli;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su
    Publication type:
    Article

  • Astrocyte reactivity potentiates longitudinal tau tangle accumulation in cognitively unimpaired individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078421
    By:
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Ashton, Nicholas J.;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Villemagne, Victor L
    Publication type:
    Article

  • Amyloid and Tau Predominance Subtyping Identifies CI Patients With Different Clinical Phenotypes.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078343
    By:
    • Zalzale, Hussein;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Ferrari‐Souza, João Pedro;
    • Soares, Carolina;
    • Lussier, Firoza Z;
    • Aguzzoli, Cristiano Schaffer;
    • Lemaire, Peter Charles;
    • Abbas, Sarah;
    • Rohden, Francieli;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Stevenson, Alyssa;
    • Pallen, Vanessa;
    • Ashton, Nicholas J.;
    • Benedet, Andrea Lessa;
    • Blennow, Kaj;
    • Zetterberg, Henrik
    Publication type:
    Article

  • The relationship between [<sup>18</sup>F]FDG‐PET signal and key‐players of brain glucose metabolism.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080440
    By:
    • Limberger, Christian;
    • Machado, Luiza Santos;
    • Ferrari‐Souza, João Pedro;
    • Povala, Guilherme;
    • Carello‐Collar, Giovanna;
    • Pascoal, Tharick A.;
    • Bouzier‐Sore, Anne‐Karine;
    • Pellerin, Luc;
    • de Souza, Débora Guerini;
    • Zimmer, Eduardo R.
    Publication type:
    Article

  • Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079764
    By:
    • Ferrari‐Souza, João Pedro;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Soares, Carolina;
    • Benedet, Andrea Lessa;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa
    Publication type:
    Article

  • APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079681
    By:
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Benedet, Andrea Lessa;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Soares, Carolina;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa
    Publication type:
    Article

  • Fluid and imaging amyloid‐beta biomarkers discordant individuals present different blood transcriptomic phenotypes.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080776
    By:
    • Schlickmann, Thomas Hugentobler;
    • de Bastiani, Marco Antônio;
    • Bellaver, Bruna;
    • Zalzale, Hussein;
    • Souza, Lara Angi;
    • Machado, Luiza Santos;
    • da Rocha, Andreia Silva;
    • Da Ros, Lucas Uglione;
    • Ferrari‐Souza, João Pedro;
    • Carello‐Collar, Giovanna;
    • Lazzarotto, Gabriela;
    • Limberger, Christian;
    • de Carvalho, Lavínia Perquim;
    • Vidor, Pedro;
    • Borelli, Wyllians Vendramini;
    • Rohden, Francieli;
    • Pascoal, Tharick A.;
    • Zimmer, Eduardo R.
    Publication type:
    Article

  • Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer's disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080143
    By:
    • Rohden, Francieli;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Aguzzoli, Cristiano Schaffer;
    • Soares, Carolina;
    • Povala, Guilherme;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Benedet, Andrea Lessa;
    • Cohen, Annie
    Publication type:
    Article

  • CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079855
    By:
    • Soares, Carolina;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Aguzzoli, Cristiano Schaffer;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb
    Publication type:
    Article

  • Late‐life hypertension acts together with amyloid‐β pathology to promote early cognitive decline.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079952
    By:
    • Da Ros, Lucas Uglione;
    • Ferrari‐Souza, João Pedro;
    • Bastiani, Marco Antônio De;
    • Hauschild, Lucas Augusto;
    • Lussier, Firoza Z;
    • Chamoun, Mira;
    • Bezgin, Gleb;
    • Benedet, Andrea Lessa;
    • Pascoal, Tharick A.;
    • Rosa‐Neto, Pedro
    Publication type:
    Article

  • Synapse dysfunction and astrocyte reactivity are associated independently of amyloid‐β and tau pathologies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079816
    By:
    • Rohden, Francieli;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Aguzzoli, Cristiano Schaffer;
    • Lussier, Firoza Z;
    • Soares, Carolina;
    • Povala, Guilherme;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Leffa, Douglas Teixeira;
    • Abbas, Sarah;
    • Cabrera, Arlec;
    • Lemaire, Peter Charles;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Benedet, Andrea Lessa;
    • Cohen, Annie
    Publication type:
    Article

  • Sex impacts the association of plasma Glial Fibrillary Acidic Protein with neurodegeneration in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076402
    By:
    • Abbas, Sarah;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Lemaire, Peter Charles;
    • Soares, Carolina;
    • Rohden, Francieli;
    • Aguzzoli, Cristiano Schaffer;
    • Cabrera, Arlec;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Chamoun, Mira;
    • Bezgin, Gleb;
    • Stevenson, Jenna
    Publication type:
    Article

  • Astrocyte reactivity moderates the effect of education on cognitive reserve.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080034
    By:
    • Borelli, Wyllians Vendramini;
    • Antônio De Bastiani, Marco;
    • Bieger, Andrei;
    • Ferrari‐Souza, João Pedro;
    • Castilhos, Raphael Machado;
    • Rosa‐Neto, Pedro;
    • Zimmer, Eduardo R.
    Publication type:
    Article

  • Synaptic dysfunction, Tau pathology and Neurodegeneration.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080006
    By:
    • Soares, Carolina;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su
    Publication type:
    Article

  • Sex modulates the role of astrocyte reactivity in preclinical Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077995
    By:
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Leffa, Douglas Teixeira;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Lopez, Oscar L.;
    • Tudorascu, Dana
    Publication type:
    Article

  • Plasma p‐tau181 and nfl as surrogates biomarkers in clinical trials targeting preclinical stage of Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077906
    By:
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Tissot, Cécile;
    • Bellaver, Bruna;
    • Leffa, Douglas Teixeira;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Cohen, Ann D.;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Klunk, William E;
    • Soucy, Jean‐Paul;
    • Gauthier, Serge;
    • Villemagne, Victor L;
    • Zetterberg, Henrik;
    • Blennow, Kaj;
    • Rosa‐Neto, Pedro
    Publication type:
    Article

  • Amyloid β‐dependent tau phosphorylation is triggered by reactive astrocytes in preclinical Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077861
    By:
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Lussier, Firoza Z;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Villemagne, Victor L;
    • Ikonomovic, Milos D;
    • Gauthier, Serge;
    • Zimmer, Eduardo R;
    • Zetterberg, Henrik
    Publication type:
    Article

  • Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer's disease individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076691
    By:
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Therriault, Joseph;
    • Ferrari‐Souza, João Pedro;
    • Tissot, Cécile;
    • Leffa, Douglas Teixeira;
    • Brum, Wagner S.;
    • Benedet, Andrea Lessa;
    • Lussier, Firoza Z;
    • Cabrera, Arlec;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Triana‐Baltzer, Gallen;
    • Kolb, Hartmuth C.;
    • Rahmouni, Nesrine
    Publication type:
    Article

  • GABA transporters gene expression associates with [<sup>18</sup>F]FDG‐PET signal in regions typically hypometabolic in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079619
    By:
    • Carello‐Collar, Giovanna;
    • Ferrari‐Souza, João Pedro;
    • Machado, Luiza Santos;
    • Povala, Guilherme;
    • Limberger, Christian;
    • Pascoal, Tharick A.;
    • Zimmer, Eduardo R
    Publication type:
    Article

  • Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.082041
    By:
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Benedet, Andrea Lessa;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Zalzale, Hussein;
    • Rohden, Francieli;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su
    Publication type:
    Article

  • Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081973
    By:
    • Aguzzoli, Cristiano Schaffer;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Soares, Carolina;
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.
    Publication type:
    Article

  • Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer's disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081975
    By:
    • Rohden, Francieli;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Aguzzoli, Cristiano Schaffer;
    • Soares, Carolina;
    • Povala, Guilherme;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Benedet, Andrea Lessa;
    • Cohen, Annie
    Publication type:
    Article

  • Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081954
    By:
    • Soares, Carolina;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su
    Publication type:
    Article

  • Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer's Disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081950
    By:
    • Aguzzoli, Cristiano Schaffer;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Soares, Carolina;
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb
    Publication type:
    Article

  • CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081943
    By:
    • Soares, Carolina;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Povala, Guilherme;
    • Aguzzoli, Cristiano Schaffer;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Lussier, Firoza Z;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Lemaire, Peter Charles;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Tissot, Cécile;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb
    Publication type:
    Article

  • Synapse dysfunction and astrocyte reactivity are associated independently of amyloid‐β and tau pathologies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081939
    By:
    • Rohden, Francieli;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Aguzzoli, Cristiano Schaffer;
    • Lussier, Firoza Z;
    • Soares, Carolina;
    • Povala, Guilherme;
    • Ferrari‐Souza, João Pedro;
    • Zalzale, Hussein;
    • Leffa, Douglas Teixeira;
    • Abbas, Sarah;
    • Cabrera, Arlec;
    • Lemaire, Peter Charles;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Benedet, Andrea Lessa;
    • Cohen, Annie
    Publication type:
    Article

  • Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081933
    By:
    • Ferrari‐Souza, João Pedro;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Soares, Carolina;
    • Benedet, Andrea Lessa;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa
    Publication type:
    Article

  • APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081925
    By:
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Benedet, Andrea Lessa;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Soares, Carolina;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Macedo, Arthur C.;
    • Vermeiren, Marie;
    • Bezgin, Gleb;
    • Kang, Min Su;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa
    Publication type:
    Article

  • GABA transporters gene expression associates with [18F]FDG‐PET signal in regions typically hypometabolic in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081920
    By:
    • Carello‐Collar, Giovanna;
    • Ferrari‐Souza, João Pedro;
    • Machado, Luiza Santos;
    • Povala, Guilherme;
    • Limberger, Christian;
    • Pascoal, Tharick A.;
    • Zimmer, Eduardo R
    Publication type:
    Article

  • Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081881
    By:
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Lussier, Firoza Z;
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Aguzzoli, Cristiano Schaffer;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Abbas, Sarah;
    • Rohden, Francieli;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Benedet, Andrea Lessa;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Cohen, Annie;
    • Lopez, Oscar L.
    Publication type:
    Article

  • Increased regional brain inflammation predicts longitudinal brain atrophy in individuals in the Alzheimer's disease continuum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081863
    By:
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Ferreira, Pamela C.L.;
    • Lussier, Firoza Z;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Benedet, Andrea Lessa;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Cohen, Ann D.;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Klunk, William E;
    • Villemagne, Victor L;
    • Karikari, Thomas K;
    • Zimmer, Eduardo R
    Publication type:
    Article

  • Amyloid and Tau Predominance Subtyping Identifies CI Patients With Different Clinical Phenotypes.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081805
    By:
    • Zalzale, Hussein;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Ferrari‐Souza, João Pedro;
    • Soares, Carolina;
    • Lussier, Firoza Z;
    • Aguzzoli, Cristiano Schaffer;
    • Lemaire, Peter Charles;
    • Abbas, Sarah;
    • Rohden, Francieli;
    • Leffa, Douglas Teixeira;
    • Cabrera, Arlec;
    • Therriault, Joseph;
    • Stevenson, Alyssa;
    • Pallen, Vanessa;
    • Ashton, Nicholas J.;
    • Benedet, Andrea Lessa;
    • Blennow, Kaj;
    • Zetterberg, Henrik
    Publication type:
    Article

  • Sex modulates the role of astrocyte reactivity in preclinical Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081780
    By:
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Leffa, Douglas Teixeira;
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Rohden, Francieli;
    • Abbas, Sarah;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Lopez, Oscar L.;
    • Tudorascu, Dana
    Publication type:
    Article

  • Plasma p‐tau181 and nfl as surrogates biomarkers in clinical trials targeting preclinical stage of Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081774
    By:
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Tissot, Cécile;
    • Bellaver, Bruna;
    • Leffa, Douglas Teixeira;
    • Povala, Guilherme;
    • Lussier, Firoza Z;
    • Therriault, Joseph;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Cohen, Ann D.;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Klunk, William E;
    • Soucy, Jean‐Paul;
    • Gauthier, Serge;
    • Villemagne, Victor L;
    • Zetterberg, Henrik;
    • Blennow, Kaj;
    • Rosa‐Neto, Pedro
    Publication type:
    Article

  • Amyloid β‐dependent tau phosphorylation is triggered by reactive astrocytes in preclinical Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081771
    By:
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Ferreira, Pamela C.L.;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas Teixeira;
    • Lussier, Firoza Z;
    • Benedet, Andrea Lessa;
    • Ashton, Nicholas J.;
    • Tissot, Cécile;
    • Therriault, Joseph;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Lopez, Oscar L.;
    • Tudorascu, Dana;
    • Villemagne, Victor L;
    • Ikonomovic, Milos D;
    • Gauthier, Serge;
    • Zimmer, Eduardo R;
    • Zetterberg, Henrik
    Publication type:
    Article

  • Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer's disease individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081726
    By:
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Povala, Guilherme;
    • Therriault, Joseph;
    • Ferrari‐Souza, João Pedro;
    • Tissot, Cécile;
    • Leffa, Douglas Teixeira;
    • Brum, Wagner S.;
    • Benedet, Andrea Lessa;
    • Lussier, Firoza Z;
    • Cabrera, Arlec;
    • Zalzale, Hussein;
    • Soares, Carolina;
    • Aguzzoli, Cristiano Schaffer;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa;
    • Poltronetti, Nina Margherita
    Publication type:
    Article

  • GABA transporters gene expression associates with [<sup>18</sup>F]FDG‐PET signal in regions typically hypometabolic in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079619
    By:
    • Carello‐Collar, Giovanna;
    • Ferrari‐Souza, João Pedro;
    • Machado, Luiza Santos;
    • Povala, Guilherme;
    • Limberger, Christian;
    • Pascoal, Tharick A.;
    • Zimmer, Eduardo R
    Publication type:
    Article

  • Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 4463, doi. 10.1002/alz.13393
    By:
    • Ferreira, Pamela C. L.;
    • Therriault, Joseph;
    • Tissot, Cécile;
    • Ferrari‐Souza, João Pedro;
    • Benedet, Andréa L.;
    • Povala, Guilherme;
    • Bellaver, Bruna;
    • Leffa, Douglas T.;
    • Brum, Wagner S.;
    • Lussier, Firoza Z.;
    • Bezgin, Gleb;
    • Servaes, Stijn;
    • Vermeiren, Marie;
    • Macedo, Arthur C.;
    • Cabrera, Arlec;
    • Stevenson, Jenna;
    • Triana‐Baltzer, Gallen;
    • Kolb, Hartmuth;
    • Rahmouni, Nesrine;
    • Klunk, William E.
    Publication type:
    Article

  • Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 9, p. 3815, doi. 10.1002/alz.13014
    By:
    • Bellaver, Bruna;
    • Puig‐Pijoan, Albert;
    • Ferrari‐Souza, João Pedro;
    • Leffa, Douglas T.;
    • Lussier, Firoza Z.;
    • Ferreira, Pamela C. L.;
    • Tissot, Cécile;
    • Povala, Guilherme;
    • Therriault, Joseph;
    • Benedet, Andréa L.;
    • Ashton, Nicholas J.;
    • Servaes, Stijn;
    • Chamoun, Mira;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Vermeiren, Marie;
    • Macedo, Arthur C.;
    • Fernández‐Lebrero, Aida;
    • García‐Escobar, Greta;
    • Navalpotro‐Gómez, Irene
    Publication type:
    Article

  • The impact of hypertension on longitudinal cognitive decline in cognitively unimpaired individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.065702
    By:
    • Da Ros, Lucas Uglione;
    • Ferrari‐Souza, João Pedro;
    • Hauschild, Lucas Augusto;
    • Brum, Wagner Scheeren;
    • Bellaver, Bruna;
    • Leffa, Douglas Teixeira;
    • Ferreira, Pamela C.L.;
    • Bieger, Andrei;
    • De Bastiani, Marco Antônio;
    • Pascoal, Tharick A;
    • Zimmer, Eduardo R.
    Publication type:
    Article

  • Impact of meningeal and age‐related off‐target binding on longitudinal [<sup>18</sup>F]MK6240 quantification.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.066227
    By:
    • Tissot, Cécile;
    • Lussier, Firoza Z;
    • Ferrari‐Souza, João Pedro;
    • Servaes, Stijn;
    • Bezgin, Gleb;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Vermeiren, Marie;
    • Kunach, Peter;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Chamoun, Mira;
    • Benedet, Andréa Lessa;
    • Wang, Yi‐Ting;
    • Arias, Jaime Fernandez;
    • Kang, Min Su;
    • Villemagne, Victor L;
    • Tudorascu, Dana L
    Publication type:
    Article

  • Apolipoprotein E ε4 associates with microglial activation in early Braak regions independently of amyloid‐β and tau.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.065731
    By:
    • Ferrari‐Souza, João Pedro;
    • Lussier, Firoza Z;
    • Tissot, Cécile;
    • Leffa, Douglas Teixeira;
    • Ferreira, Pamela C.L.;
    • Bellaver, Bruna;
    • Brum, Wagner S.;
    • Benedet, Andréa Lessa;
    • Therriault, Joseph;
    • Wang, Yi‐Ting;
    • Chamoun, Mira;
    • Servaes, Stijn;
    • Bezgin, Gleb;
    • Kang, Min Su;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Pallen, Vanessa;
    • Poltronetti, Nina Margherita;
    • Souza, Diogo O.;
    • Gauthier, Serge
    Publication type:
    Article

  • Comparison of plasma amyloid, tau, and astrocyte biomarkers to identify AD pathophysiology.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.065854
    By:
    • Ferreira, Pamela C.L.;
    • Tissot, Cécile;
    • Ferrari‐Souza, João Pedro;
    • Bellaver, Bruna;
    • Brum, Wagner S.;
    • Leffa, Douglas Teixeira;
    • Therriault, Joseph;
    • Benedet, Andréa Lessa;
    • Servaes, Stijn;
    • Lussier, Firoza Z;
    • Chamoun, Mira;
    • Stevenson, Jenna;
    • Rahmouni, Nesrine;
    • Tudorascu, Dana L;
    • Klunk, William E;
    • Villemagne, Victor L;
    • Cohen, Ann D;
    • Zimmer, Eduardo R.;
    • Ashton, Nicholas J.;
    • Zetterberg, Henrik
    Publication type:
    Article