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Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease.
- Published in:
- Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1417938
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- Article
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.
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- Biological Research, 2024, v. 57, n. 1, p. 1, doi. 10.1186/s40659-024-00504-2
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- Article
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1358323
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- Article
Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.
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- Liver International, 2024, v. 44, n. 2, p. 433, doi. 10.1111/liv.15782
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- Article
Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases.
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- Neural Regeneration Research, 2024, v. 19, n. 1, p. 55, doi. 10.4103/1673-5374.375301
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- Article
Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 24, p. 17251, doi. 10.3390/ijms242417251
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- Article
Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
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- European Journal of Neurology, 2023, v. 30, n. 10, p. 3032, doi. 10.1111/ene.15935
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- Article
Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 10407, doi. 10.3390/ijms241210407
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- Article
Sustained Hyperammonemia Activates NF-κB in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy.
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- Molecular Neurobiology, 2023, v. 60, n. 6, p. 3071, doi. 10.1007/s12035-023-03264-4
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- Article
Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats.
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- Cellular & Molecular Life Sciences, 2023, v. 80, n. 4, p. 1, doi. 10.1007/s00018-023-04750-7
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- Article
Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats.
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- Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-022-02688-4
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- Article
Golexanolone, a GABA<sub>A</sub> receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
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- CNS Neuroscience & Therapeutics, 2022, v. 28, n. 11, p. 1861, doi. 10.1111/cns.13926
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- Article
Plasma Extracellular Vesicles Play a Role in Immune System Modulation in Minimal Hepatic Encephalopathy.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12335, doi. 10.3390/ijms232012335
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- Article
Minimal hepatic encephalopathy is associated to alterations in eye movements.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21230-3
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- Article
Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11770, doi. 10.3390/ijms231911770
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- Article
Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content.
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- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.921947
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- Article
Hyperammonemia Alters the Function of AMPA and NMDA Receptors in Hippocampus: Extracellular cGMP Reverses Some of These Alterations.
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- Neurochemical Research, 2022, v. 47, n. 7, p. 2016, doi. 10.1007/s11064-022-03588-y
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- Article
Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation.
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- Biomedicines, 2022, v. 10, n. 6, p. 1263, doi. 10.3390/biomedicines10061263
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- Article
Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP.
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- Molecular Neurobiology, 2022, v. 59, n. 6, p. 3431, doi. 10.1007/s12035-022-02803-9
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- Article
The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia.
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- Neuropathology & Applied Neurobiology, 2022, v. 48, n. 4, p. 1, doi. 10.1111/nan.12799
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- Article
Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06416-z
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- Article
Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat.
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- Molecular Neurobiology, 2021, v. 58, n. 10, p. 4959, doi. 10.1007/s12035-021-02462-2
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- Article
Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage.
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- Biomedicines, 2021, v. 9, n. 8, p. 1002, doi. 10.3390/biomedicines9081002
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- Article
The Dual Role of the GABA A Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6772, doi. 10.3390/ijms22136772
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- Article
A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease.
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- Journal of Clinical Medicine, 2021, v. 10, n. 13, p. 2806, doi. 10.3390/jcm10132806
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- Article
A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats.
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- Cell Biology & Toxicology, 2021, v. 37, n. 1, p. 129, doi. 10.1007/s10565-020-09572-y
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- Article
Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-80941-7
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- Article
Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway.
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- 2020
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- Publication type:
- journal article
Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy.
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- Journal of Clinical Medicine, 2020, v. 9, n. 7, p. 2154, doi. 10.3390/jcm9072154
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- Article
Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission.
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- Journal of Neurochemistry, 2020, v. 154, n. 1, p. 56, doi. 10.1111/jnc.14941
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- Article
Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats.
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- Cells (2073-4409), 2020, v. 9, n. 3, p. 572, doi. 10.3390/cells9030572
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- Article
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway.
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- 2020
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- Publication type:
- journal article
Tadalafil Treatment Improves Inflammation, Cognitive Function, And Mismatch Negativity Of Patients With Low Urinary Tract Symptoms And Erectile Dysfunction.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-53136-y
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- Publication type:
- Article
Differential role of interleukin-1β in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats.
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- FASEB Journal, 2019, v. 33, n. 9, p. 9913, doi. 10.1096/fj.201900230RR
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- Article
Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy.
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- 2019
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- Publication type:
- journal article
Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.
- Published in:
- Acta Physiologica, 2019, v. 226, n. 2, p. N.PAG, doi. 10.1111/apha.13270
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- Publication type:
- Article
Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms.
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- Molecular Neurobiology, 2019, v. 56, n. 6, p. 4428, doi. 10.1007/s12035-018-1387-z
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- Article
The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis.
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- Liver International, 2019, v. 39, n. 5, p. 861, doi. 10.1111/liv.14046
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- Publication type:
- Article
Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors.
- Published in:
- Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00132
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- Publication type:
- Article
Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.
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- Molecular Neurobiology, 2018, v. 55, n. 6, p. 5047, doi. 10.1007/s12035-017-0705-1
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- Publication type:
- Article
Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms.
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- 2018
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- Publication type:
- journal article
Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy.
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- PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0186463
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- Article
Determination of selected neurotoxic insecticides in small amounts of animal tissue utilizing a newly constructed mini-extractor.
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- Analytical & Bioanalytical Chemistry, 2017, v. 409, n. 25, p. 6015, doi. 10.1007/s00216-017-0533-1
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- Article
Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits.
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- Liver International, 2017, v. 37, n. 7, p. 1013, doi. 10.1111/liv.13345
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- Publication type:
- Article
Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.
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- CNS Neuroscience & Therapeutics, 2017, v. 23, n. 5, p. 386, doi. 10.1111/cns.12688
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- Publication type:
- Article
Real-time cytometric assay of nitric oxide and superoxide interaction in peripheral blood monocytes: A no-wash, no-lyse kinetic method.
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- Cytometry. Part B, 2017, v. 92, n. 3, p. 211, doi. 10.1002/cyto.b.21237
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- Article
Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts.
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- Neurochemical Research, 2017, v. 42, n. 3, p. 788, doi. 10.1007/s11064-016-1980-3
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- Article
The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients.
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- PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171211
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- Article
Current state of knowledge of hepatic encephalopathy (part II): changes in brain white matter tracts integrity are associated with cognitive deficits in minimal hepatic encephalopathy.
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- Metabolic Brain Disease, 2016, v. 31, n. 6, p. 1359, doi. 10.1007/s11011-016-9909-8
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- Article
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.
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- Frontiers in Molecular Neuroscience, 2016, v. 9, p. 1, doi. 10.3389/fnmol.2016.00106
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- Article