Works by Feigenbaum, Lionel

Results: 36

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

Published in:

Nature Immunology, 2012, v. 13, n. 6, p. 569, doi. 10.1038/ni.2292

By:

Pobezinsky, Leonid A;
Angelov, Georgi S;
Tai, Xuguang;
Jeurling, Susanna;
Van Laethem, François;
Feigenbaum, Lionel;
Park, Jung-Hyun;
Singer, Alfred

Publication type:

Article

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Published in:

Nature Immunology, 2010, v. 11, n. 3, p. 257, doi. 10.1038/ni.1840

By:

Jung-Hyun Park;
Adoro, Stanley;
Guinter, Terry;
Erman, Batu;
Alag, Amala S.;
Catalfamo, Marta;
Kimura, Motoko Y.;
Yongzhi Cui;
Lucas, Philip J.;
Gress, Ronald E.;
Kubo, Masato;
Hennighausen, Lothar;
Feigenbaum, Lionel;
Singer, Alfred

Publication type:

Article

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells.

Published in:

Nature Immunology, 2008, v. 9, n. 10, p. 1122, doi. 10.1038/ni.1647

By:

Wang, Lie;
Wildt, Kathryn F;
Zhu, Jinfang;
Zhang, Xianyu;
Feigenbaum, Lionel;
Tessarollo, Lino;
Paul, William E;
Fowlkes, B J;
Bosselut, Rémy

Publication type:

Article

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Published in:

Nature Immunology, 2007, v. 8, n. 10, p. 1049, doi. 10.1038/ni1512

By:

Park, Jung-Hyun;
Adoro, Stanley;
Lucas, Philip J;
Sarafova, Sophia D;
Alag, Amala S;
Doan, Loretta L;
Erman, Batu;
Liu, Xiaolong;
Ellmeier, Wilfried;
Bosselut, Remy;
Feigenbaum, Lionel;
Singer, Alfred

Publication type:

Article

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.

Published in:

Nature Immunology, 2005, v. 6, n. 4, p. 373, doi. 10.1038/ni1183

By:

Sun, Guangping;
Liu, Xiaolong;
Mercado, Peter;
Jenkinson, Rhiannon S.;
Kypriotou, Magdalini;
Feigenbaum, Lionel;
Galéra, Philippe;
Bosselut, Rémy

Publication type:

Article

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

Published in:

Nature Immunology, 2005, v. 6, n. 2, p. 152, doi. 10.1038/ni1160

By:

Tai, Xuguang;
Cowan, Michelle;
Feigenbaum, Lionel;
Singer, Alfred

Publication type:

Article

Early TCRa expression generates TCRa? complexes that signal the DN-to-DP transition and impair development.

Published in:

Nature Immunology, 2002, v. 3, n. 6, p. 564, doi. 10.1038/ni800

By:

Erman, Batu;
Feigenbaum, Lionel;
Coligan, John E.;
Singer, Alfred

Publication type:

Article

Loss of ATM kinase activity leads to embryonic lethality in mice.

Published in:

Journal of Cell Biology, 2012, v. 198, n. 3, p. 295, doi. 10.1083/jcb.201204035

By:

Daniel, Jeremy A.;
Pellegrini, Manuela;
Lee, Baeck-Seung;
Guo, Zhi;
Filsuf, Darius;
Belkina, Natalya V.;
You, Zhongsheng;
Paull, Tanya T.;
Sleckman, Barry P.;
Feigenbaum, Lionel;
Nussenzweig, André

Publication type:

Article

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.

Published in:

Journal of Cell Biology, 2010, v. 188, n. 4, p. 515, doi. 10.1083/jcb.200911115

By:

Rane, Neena S.;
Chakrabarti, Oishee;
Feigenbaum, Lionel;
Hegde, Ramanujan S.

Publication type:

Article

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

Published in:

Journal of Cell Biology, 2008, v. 183, n. 5, p. 777, doi. 10.1083/jcb.200805154

By:

Daniel, Jeremy A.;
Pellegrini, Manuela;
Lee, Ji-Hoon;
Paull, Tanya T.;
Feigenbaum, Lionel;
Nussenzweig, André

Publication type:

Article

Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells.

Published in:

BioMed Research International, 2013, v. 2013, p. 1, doi. 10.1155/2013/913179

By:

Jianjun Zhou;
Feigenbaum, Lionel;
Yee, Carole;
Song, Hongbin;
Yates, Clayton

Publication type:

Article

Expression of the SNARE Protein SNAP-23 Is Essential for Cell Survival.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118311

By:

Kaul, Sunil;
Mittal, Sharad K.;
Feigenbaum, Lionel;
Kruhlak, Michael J.;
Roche, Paul A.

Publication type:

Article

“Glowing Head” Mice: A Genetic Tool Enabling Reliable Preclinical Image-Based Evaluation of Cancers in Immunocompetent Allografts.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0109956

By:

Day, Chi-Ping;
Carter, John;
Ohler, Zoe Weaver;
Bonomi, Carrie;
El Meskini, Rajaa;
Martin, Philip;
Graff-Cherry, Cari;
Feigenbaum, Lionel;
Tüting, Thomas;
Van Dyke, Terry;
Hollingshead, Melinda;
Merlino, Glenn

Publication type:

Article

Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.

Published in:

FASEB Journal, 2008, v. 22, p. 349, doi. 10.1096/fasebj.22.2_supplement.349

By:

Williams, Joy Ann;
Lumsden, Joanne;
Yu, Xiang;
Feigenbaum, Lionel;
Zhang, Jingjing;
Steinberg, Seth;
Hodes, Richard

Publication type:

Article

H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 2, p. 354, doi. 10.1093/hmg/ddw392

By:

Hisashi Hasumi;
Yukiko Hasumi;
Baba, Masaya;
Hafumi Nishi;
Mitsuko Furuya;
Vocke, Cathy D.;
Lang, Martin;
Irie, Nobuko;
Chiharu Esumi;
Merino, Maria J.;
Takashi Kawahara;
Yasuhiro Isono;
Kazuhide Makiyama;
Warner, Andrew C.;
Haines, Diana C.;
Ming-Hui Wei;
Zbar, Berton;
Hagenau, Herbert;
Feigenbaum, Lionel;
Keiichi Kondo

Publication type:

Article

Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.

Published in:

European Journal of Immunology, 2013, v. 43, n. 4, p. 918, doi. 10.1002/eji.201242944

By:

Xiong, Yumei;
Castro, Ehydel;
Yagi, Ryoji;
Zhu, Jinfang;
Lesourne, Renaud;
Love, Paul E.;
Feigenbaum, Lionel;
Bosselut, Rémy

Publication type:

Article

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4.

Published in:

European Journal of Immunology, 2010, v. 40, n. 9, p. 2385, doi. 10.1002/eji.201040534

By:

Wang, Lie;
Carr, Tiffany;
Xiong, Yumei;
Wildt, Kathryn F.;
Zhu, Jinfang;
Feigenbaum, Lionel;
Bendelac, Albert;
Bosselut, Rémy

Publication type:

Article

Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus.

Published in:

European Journal of Immunology, 2009, v. 39, n. 10, p. 2906, doi. 10.1002/eji.200839191

By:

Liepinsh, Dmitry J.;
Kruglov, Andrei A.;
Galimov, Arthur R.;
Shakhov, Alexander N.;
Shebzukhov, Yuriy V.;
Kuchmiy, Anna A.;
Grivennikov, Sergei I.;
Tumanov, Alexei V.;
Drutskaya, Marina S.;
Feigenbaum, Lionel;
Kuprash, Dmitry V.;
Nedospasov, Sergei A.

Publication type:

Article

Poor immunogenicity of a self/tumor antigen derives from peptide--MHC-I instability and is independent of tolerance.

Published in:

Journal of Clinical Investigation, 2004, v. 114, n. 4, p. 551, doi. 10.1172/JCI200421695

By:

Zhiya Yu;
Theoret, Marc R.;
Touloukian, Christopher E.;
Surman, Deborah R.;
Garman, Scott C.;
Feigenbaum, Lionel;
Baxter, Tiffany K.;
Baker, Brian M.;
Restifo, Nicholas P.

Publication type:

Article

Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance.

Published in:

2004

By:

Yu, Zhiya;
Theoret, Marc R;
Touloukian, Christopher E;
Surman, Deborah R;
Garman, Scott C;
Feigenbaum, Lionel;
Baxter, Tiffany K;
Baker, Brian M;
Restifo, Nicholas P

Publication type:

journal article

Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain.

Published in:

JNCI: Journal of the National Cancer Institute, 2008, v. 100, n. 15, p. 1092, doi. 10.1093/jnci/djn216

By:

Gril, Brunilde;
Palmieri, Diane;
Bronder, Julie L.;
Herring, Jeanne M.;
Vega-Valle, Eleazar;
Feigenbaum, Lionel;
Liewehr, David J.;
Steinberg, Seth M.;
Merino, Maria J.;
Rubin, Stephen D.;
Steeg, Patricia S.

Publication type:

Article

Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 16, p. 7024, doi. 10.1128/MCB.24.16.7024-7031.2004

By:

Chiang, Y. Jeffrey;
Hemann, Michael T.;
Hathcock, Karen S.;
Tessarollo, Lino;
Feigenbaum, Lionel;
Hahn, William C.;
Hodes, Richard J.

Publication type:

Article

Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.

Published in:

2017

By:

Johnson, Bryce G.;
Dang, Lan T.;
Marsh, Graham;
Roach, Allie M.;
Levine, Zebulon G.;
Monti, Anthony;
Reyon, Deepak;
Feigenbaum, Lionel;
Duffield, Jeremy S.

Publication type:

journal article

Thyrocyte‐specific expression of Cre recombinase in transgenic miceThis article is a US Government work and, as such, is in the public domain in the United States of America.

Published in:

Genesis: The Journal of Genetics & Development, 2004, v. 39, n. 3, p. 212, doi. 10.1002/gene.20043

By:

Takashi Kusakabe;
Akio Kawaguchi;
Rumi Kawaguchi;
Lionel Feigenbaum;
Shioko Kimura

Publication type:

Article

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Published in:

Nature Immunology, 2015, v. 16, n. 5, p. 517, doi. 10.1038/ni.3146

By:

Pobezinsky, Leonid A;
Etzensperger, Ruth;
Jeurling, Susanna;
Alag, Amala;
Kadakia, Tejas;
McCaughtry, Tom M;
Kimura, Motoko Y;
Sharrow, Susan O;
Guinter, Terry I;
Feigenbaum, Lionel;
Singer, Alfred

Publication type:

Article

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.

Published in:

Nature Immunology, 2015, v. 16, n. 2, p. 197, doi. 10.1038/ni.3053

By:

Yu, Fang;
Sharma, Suveena;
Edwards, Julie;
Feigenbaum, Lionel;
Zhu, Jinfang

Publication type:

Article

The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling.

Published in:

Nature Immunology, 2014, v. 15, n. 7, p. 638, doi. 10.1038/ni.2917

By:

Luckey, Megan A;
Kimura, Motoko Y;
Waickman, Adam T;
Feigenbaum, Lionel;
Singer, Alfred;
Park, Jung-Hyun

Publication type:

Article

CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain.

Published in:

European Journal of Immunology, 2002, v. 32, n. 6, p. 1811, doi. 10.1002/1521-4141(200206)32:6<1811::AID-IMMU1811>3.0.CO;2-G

By:

Bhandoola, Avinash;
Bosselut, Remy;
Yu, Qing;
Cowan, Michelle L.;
Feigenbaum, Lionel;
Love, Paul E.;
Singer, Alfred

Publication type:

Article

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.

Published in:

2006

By:

Pellegrini, Manuela;
Celeste, Arkady;
Difilippantonio, Simone;
Guo, Rong;
Wang, Weidong;
Feigenbaum, Lionel;
Nussenzweig, André

Publication type:

Letter

Epimorphic regeneration in mice is p53-independent.

Published in:

Cell Cycle, 2010, v. 9, n. 18, p. 3667, doi. 10.4161/cc.9.18.13119

By:

Arthur, L. Matthew;
Demarest, Renee M.;
Clark, Lise;
Gourevitch, Dmitri;
Bedelbaeva, Kamila;
Anderson, Rhonda;
Snyder, Andrew;
Capobianco, Anthony J.;
Lieberman, Paul;
Feigenbaum, Lionel;
Heber-Katz, E.

Publication type:

Article

Normal viability of Kai1/Cd82 deficient mice.

Published in:

Molecular Carcinogenesis, 2014, v. 53, n. 8, p. 610, doi. 10.1002/mc.22009

By:

Risinger, John I.;
Custer, Mary;
Feigenbaum, Lionel;
Simpson, R. Mark;
Hoover, Shelley B.;
Webster, Joshua D.;
Chandramouli, Gadisetti V. R.;
Tessarollo, Lino;
Barrett, J. Carl

Publication type:

Article

IFN-? gene expression is controlled by the architectural transcription factor HMGA1.

Published in:

International Immunology, 2005, v. 17, n. 3, p. 297, doi. 10.1093/intimm/dxh209

By:

Kai-Yin Chau;
Andrea M. Keane-Myers;
Monica Fedele;
Yasuhiro Ikeda;
Remi J. Creusot;
Lisa Menozzi;
David J. Cousins;
Guidalberto Manfioletti;
Lionel Feigenbaum;
Alfredo Fusco;
Santa Jeremy Ono

Publication type:

Article

Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.

Published in:

Carcinogenesis, 2008, v. 29, n. 12, p. 2377, doi. 10.1093/carcin/bgn190

By:

EL Habib Dakir;
Lionel Feigenbaum;
R. Ilona Linnoila

Publication type:

Article

Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation.

Published in:

Science Translational Medicine, 2010, v. 2, n. 61, p. 1, doi. 10.1126/scitranslmed.3001108

By:

Wolf, Ronald;
Mascia, Francesca;
Dharamsi, Alif;
Zack Howard, O. M.;
Cataisson, Christophe;
Bliskovski, Val;
Winston, Jason;
Feigenbaum, Lionel;
Lichti, Ulrike;
Ruzicka, Thomas;
Chavakis, Triantafyllos;
Yuspa, Stuart H.

Publication type:

Article

Interferon-γ links ultraviolet radiation to melanomagenesis in mice.

Published in:

Nature, 2011, v. 469, n. 7331, p. 548, doi. 10.1038/nature09666

By:

Zaidi, M. Raza;
Davis, Sean;
Noonan, Frances P.;
Graff-Cherry, Cari;
Hawley, Teresa S.;
Walker, Robert L.;
Feigenbaum, Lionel;
Fuchs, Elaine;
Lyakh, Lyudmila;
Young, Howard A.;
Hornyak, Thomas J.;
Arnheiter, Heinz;
Trinchieri, Giorgio;
Meltzer, Paul S.;
De Fabo, Edward C.;
Merlino, Glenn

Publication type:

Article

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Published in:

Nature Cell Biology, 2005, v. 7, n. 7, p. 675, doi. 10.1038/ncb1270

By:

Difilippantonio, Simone;
Celeste, Arkady;
Fernandez-Capetillo, Oscar;
Hua-Tang Chen;
San Martin, Bernardo Reina;
Van Laethem, Francois;
Yong-Ping Yang;
Petukhova, Galina V.;
Eckhaus, Michael;
Feigenbaum, Lionel;
Manova, Katia;
Kruhlak, Michael;
Camerini-Otero, R. Daniel;
Sharan, Shyam;
Nussenzweig, Michel;
Nussenzweig, André

Publication type:

Article

Works by Feigenbaum, Lionel

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4<sup>+</sup> T cells.

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

Early TCRa expression generates TCRa? complexes that signal the DN-to-DP transition and impair development.

Loss of ATM kinase activity leads to embryonic lethality in mice.

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells.

Expression of the SNARE Protein SNAP-23 Is Essential for Cell Survival.

“Glowing Head” Mice: A Genetic Tool Enabling Reliable Preclinical Image-Based Evaluation of Cancers in Immunocompetent Allografts.

Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.

H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.

Thpok-independent repression of Runx3 by Gata3 during CD4<sup>+</sup> T-cell differentiation in the thymus.

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4.

Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus.

Poor immunogenicity of a self/tumor antigen derives from peptide--MHC-I instability and is independent of tolerance.

Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance.

Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain.

Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo.

Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.

Thyrocyte‐specific expression of Cre recombinase in transgenic miceThis article is a US Government work and, as such, is in the public domain in the United States of America.

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.

The transcription factor ThPOK suppresses Runx3 and imposes CD4<sup>+</sup> lineage fate by inducing the SOCS suppressors of cytokine signaling.

CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain.

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.

Epimorphic regeneration in mice is p53-independent.

Normal viability of Kai1/Cd82 deficient mice.

IFN-? gene expression is controlled by the architectural transcription factor HMGA1.

Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.

Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation.

Interferon-γ links ultraviolet radiation to melanomagenesis in mice.

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.