Works by Federoff, Howard J.

Results: 76

Disclosure of Clinical Trial Results When Product Development Is Abandoned.

Published in:

Science Translational Medicine, 2011, v. 3, n. 102, p. 1, doi. 10.1126/scitranslmed.3002939

By:

Rogawski, Michael A.;
Federoff, Howard J.

Publication type:

Article

PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease.

Published in:

Science Translational Medicine, 2010, v. 2, n. 52, p. 1, doi. 10.1126/scitranslmed.3001059

By:

Zheng, Bin;
Liao, Zhixiang;
Locascio, Joseph J.;
Lesniak, Kristen A.;
Roderick, Sarah S.;
Watt, Marla L.;
Eklund, Aron C.;
Zhang-James, Yanli;
Kim, Peter D.;
Hauser, Michael A.;
Grünblatt, Edna;
Moran, Linda B.;
Mandel, Silvia A.;
Riederer, Peter;
Miller, Renee M.;
Federoff, Howard J.;
Wüllner, Ullrich;
Papapetropoulos, Spyridon;
Youdim, Moussa B.;
Cantuti-Castelvetri, Ippolita

Publication type:

Article

Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease.

Published in:

2019

By:

Heiss, John D.;
Lungu, Codrin;
Hammoud, Dima A.;
Herscovitch, Peter;
Ehrlich, Debra J.;
Argersinger, Davis P.;
Sinharay, Sanhita;
Scott, Gretchen;
Wu, Tianxia;
Federoff, Howard J.;
Zaghloul, Kareem A.;
Hallett, Mark;
Lonser, Russell R.;
Bankiewicz, Krystof S.

Publication type:

journal article

The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1αin Neurons and Astrocytes.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 8, p. 1988, doi. 10.1523/JNEUROSCI.5323-07.2008

By:

Vangeison, Grace;
Carr, Dan;
Federoff, Howard J.;
Rempe, David A.

Publication type:

Article

Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 48, p. 10963, doi. 10.1523/JNEUROSCI.3461-04.2004

By:

Hongmin Wang;
Seong-Woon Yu;
Koh, David W.;
Lew, Jasmine;
Coombs, Carmen;
Bowers, William;
Federoff, Howard J.;
Poirier, Guy G.;
Dawson, Ted M.;
Dawson, Valina L.

Publication type:

Article

Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 34, p. 7445, doi. 10.1523/JNEUROSCI.4204-03.2004

By:

Miller, Renee M.;
Callahan, Linda M.;
Casaceli, Cindy;
Chen, Linlin;
Kiser, Gretchen L.;
Chui, Buena;
Kaysser-Kranich, Tamma M.;
Sendera, Timothy J.;
Palaniappan, Chockalingam;
Federoff, Howard J.

Publication type:

Article

p75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid β Peptide Cytotoxicity.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 19, p. 7385, doi. 10.1523/JNEUROSCI.23-19-07385.2003

By:

Yan Zhang;
Yanguo Hong;
Bounhar, Younes;
Blacker, Megan;
Roucou, Xavier;
Tounekti, Omar;
Vereker, Emily;
Bowers, William J.;
Federoff, Howard J.;
Goodyer, Cynthia G.;
LeBlanc, Andrea

Publication type:

Article

Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease.

Published in:

Expert Review of Neurotherapeutics, 2013, v. 13, n. 6, p. 685, doi. 10.1586/ERN.13.59

By:

MacArthur, Linda;
Ressom, Habtom;
Shah, Salim;
Federoff, Howard J.

Publication type:

Article

Nur(R1)turing a Notion on the Etiopathogenesis of Parkinson’s Disease.

Published in:

Neurotoxicity Research, 2009, v. 16, n. 3, p. 261, doi. 10.1007/s12640-009-9056-7

By:

Federoff, Howard J.

Publication type:

Article

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity.

Published in:

Neurotoxicity Research, 2009, v. 16, n. 3, p. 238, doi. 10.1007/s12640-009-9053-x

By:

Xiaomin Su;
Federoff, Howard J.;
Maguire-Zeiss, Kathleen A.

Publication type:

Article

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.

Published in:

Metabolites (2218-1989), 2018, v. 8, n. 3, p. 50, doi. 10.3390/metabo8030050

By:

Fiandaca, Massimo S.;
Gross, Thomas J.;
Johnson, Thomas M.;
Hu, Michele T.;
Evetts, Samuel;
Wade-Martins, Richard;
Merchant-Borna, Kian;
Bazarian, Jeffrey;
Cheema, Amrita K.;
Mapstone, Mark;
Federoff, Howard J.

Publication type:

Article

Evolving From Reductionism to Holism.

Published in:

2009

By:

Federoff, Howard J.;
Gostin, Lawrence O.

Publication type:

Opinion

Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 11, p. 3538, doi. 10.3390/ijms19113538

By:

Lehrich, Brandon M.;
Liang, Yaxuan;
Khosravi, Pooya;
Federoff, Howard J.;
Fiandaca, Massimo S.

Publication type:

Article

Single-Chain Fragment Variable Passive Immunotherapies for Neurodegenerative Diseases.

Published in:

International Journal of Molecular Sciences, 2013, v. 14, n. 9, p. 19109, doi. 10.3390/ijms140919109

By:

Huang, Liang;
Su, Xiaomin;
Federoff, Howard J.

Publication type:

Article

Effect of early-stage Alzheimer's disease on household financial outcomes.

Published in:

2020

By:

Gresenz, Carole Roan;
Mitchell, Jean M.;
Marrone, James;
Federoff, Howard J.

Publication type:

journal article

HUMMR, a hypoxia-and HIF-1α--inducible protein, alters mitochondrial distribution and transport.

Published in:

Journal of Cell Biology, 2009, v. 185, n. 6, p. 1065, doi. 10.1083/jcb.200811033

By:

Yan Li;
Seung Lim;
Hoffman, David;
Aspenstrom, Pontus;
Federoff, Howard J.;
Rempe, David A.

Publication type:

Article

Cloning and Characterization of the Rat Gene Encoding GAP-43.

Published in:

European Journal of Neuroscience, 1990, v. 2, n. 10, p. 822, doi. 10.1111/j.1460-9568.1990.tb00393.x

By:

Grabczyk, Ed;
Zuber, Mauricio X.;
Federoff, Howard J.;
Ng, Shi-Chung;
Pack, Alison;
Fishman, Mark C.

Publication type:

Article

Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0195318

By:

Fiandaca, Massimo S.;
Mapstone, Mark;
Mahmoodi, Amin;
Gross, Thomas;
Macciardi, Fabio;
Cheema, Amrita K.;
Merchant-Borna, Kian;
Bazarian, Jeffrey;
Federoff, Howard J.

Publication type:

Article

Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 28, p. 9567, doi. 10.1523/JNEUROSCI.0942-10.2010

By:

Kells, Adrian P.;
Eberling, Jamie;
Xiaomin Su;
Pivirotto, Philip;
Bringas, John;
Hadaczek, Piotr;
Narrow, Wade C.;
Bowers, William J.;
Federoff, Howard J.;
Forsayeth, John;
Bankiewicz, Krystof S.

Publication type:

Article

Identification of a Novel Nurr1-Interacting Protein.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 37, p. 9277, doi. 10.1523/JNEUROSCI.3021-08.2008

By:

Yu Luo;
Feng Xing;
Guiliano, Rita;
Federoff, Howard J.

Publication type:

Article

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.

Published in:

Journal of Neuroinflammation, 2005, v. 2, p. 23, doi. 10.1186/1742-2094-2-23

By:

Janelsins, Michelle C.;
Mastrangelo, Michael A.;
Oddo, Salvatore;
LaFerla, Frank M.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

Sam Seifter Reflections.

Published in:

Einstein Journal of Biology & Medicine, 2008, v. 24, n. 1, p. 18

By:

Federoff, Howard J.

Publication type:

Article

Altered Gene Expression Profiles Reveal Similarities and Differences Between Parkinson Disease and Model Systems.

Published in:

Neuroscientist, 2005, v. 11, n. 6, p. 539, doi. 10.1177/1073858405278330

By:

Miller, Renee M.;
Federoff, Howard J.

Publication type:

Article

Author Correction: Plasma microRNA markers of upper limb recovery following human stroke.

Published in:

2020

By:

Edwardson, Matthew A.;
Zhong, Xiaogang;
Fiandaca, Massimo S.;
Federoff, Howard J.;
Cheema, Amrita K.;
Dromerick, Alexander W.

Publication type:

Correction Notice

Multidisciplinary Approaches to Biomedical Research.

Published in:

2010

By:

Perzynski, Adam T.;
Federoff, Howard J.;
Rubin, Elaine R.

Publication type:

Letter

A New Research and Development Policy Framework for the Biomedical Research Enterprise.

Published in:

2010

By:

Federoff, Howard J.;
Rubin, Elaine R.

Publication type:

Opinion

Systems healthcare: a holistic paradigm for tomorrow.

Published in:

BMC Systems Biology, 2017, v. 11, p. 1, doi. 10.1186/s12918-017-0521-2

By:

Fiandaca, Massimo S.;
Mapstone, Mark;
Connors, Elenora;
Jacobson, Mireille;
Monuki, Edwin S.;
Malik, Shaista;
Macciardi, Fabio;
Federoff, Howard J.

Publication type:

Article

Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.

Published in:

Nature Medicine, 2003, v. 9, n. 2, p. 231, doi. 10.1038/nm821

By:

Snyder, Jennifer E.;
Bowers, William J.;
Livingstone, Alexandra M.;
Lee, F. Eun-Hyung;
Federoff, Howard J.;
Mosmann, Tim R.

Publication type:

Article

Topical Application of Viral Vectors for Epidermal Gene Transfer.

Published in:

Journal of Investigative Dermatology, 1997, v. 108, n. 5, p. 803, doi. 10.1111/1523-1747.ep12292254

By:

Lu, Bo;
Federoff, Howard J.;
Wang, Yibin;
Goldsmith, Lowell A.;
Scott, Glynis

Publication type:

Article

Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.

Published in:

Journal of Gene Medicine, 2008, v. 10, n. 2, p. 152, doi. 10.1002/jgm.1130

By:

Burris, Clark A.;
de Silva, Suresh;
Narrow, Wade C.;
Casey, Ann E.;
Lotta Jr, Louis T.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction.

Published in:

Cancer Immunology, Immunotherapy, 2008, v. 57, n. 5, p. 663, doi. 10.1007/s00262-007-0405-1

By:

Nechushtan, Hovav;
Pham, Dien;
Yu Zhang;
Morgensztern, Daniel;
Yi, Kyung H.;
Seung-Uon Shin;
Federoff, Howard J.;
Bowers, William J.;
Tolba, Khaled A.;
Rosenblatt, Joseph D.

Publication type:

Article

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease.

Published in:

GeroScience, 2022, v. 44, n. 3, p. 1525, doi. 10.1007/s11357-022-00580-w

By:

Macciardi, Fabio;
Giulia Bacalini, Maria;
Miramontes, Ricardo;
Boattini, Alessio;
Taccioli, Cristian;
Modenini, Giorgia;
Malhas, Rond;
Anderlucci, Laura;
Gusev, Yuriy;
Gross, Thomas J.;
Padilla, Robert M.;
Fiandaca, Massimo S.;
Head, Elizabeth;
Guffanti, Guia;
Federoff, Howard J.;
Mapstone, Mark

Publication type:

Article

The Evolution of Gene Transfer, Gene Therapy, and the RAC: IOM Recommendations to the NIH Director.

Published in:

Molecular Therapy, 2014, v. 22, n. 4, p. 685, doi. 10.1038/mt.2014.37

By:

Federoff, Howard J;
Wagner, John E

Publication type:

Article

Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease.

Published in:

Molecular Therapy, 2011, v. 19, n. 6, p. 1048, doi. 10.1038/mt.2011.11

By:

Richardson, R Mark;
Kells, Adrian P;
Rosenbluth, Kathryn H;
Salegio, Ernesto Aguilar;
Fiandaca, Massimo S;
Larson, Paul S;
Starr, Philip A;
Martin, Alastair J;
Lonser, Russell R;
Federoff, Howard J;
Forsayeth, John R;
Bankiewicz, Krystof S

Publication type:

Article

Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice.

Published in:

Molecular Therapy, 2010, v. 18, n. 8, p. 1471, doi. 10.1038/mt.2010.111

By:

Ryan, Deborah A.;
Mastrangelo, Michael A.;
Narrow, Wade C.;
Sullivan, Mark A.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease.

Published in:

Molecular Therapy, 2009, v. 17, n. 12, p. 2031, doi. 10.1038/mt.2009.174

By:

Sudol, Kelly L.;
Mastrangelo, Michael A.;
Narrow, Wade C.;
Frazer, Maria E.;
Levites, Yona R.;
Golde, Todd E.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease.

Published in:

Molecular Therapy, 2008, v. 16, n. 8, p. 1392, doi. 10.1038/mt.2008.113

By:

Johnston, Louisa C.;
Su, Xiaomin;
Maguire-Zeiss, Kathleen;
Horovitz, Karen;
Ankoudinova, Irina;
Guschin, Dmitry;
Hadaczek, Piotr;
Federoff, Howard J.;
Bankiewicz, Krystof;
Forsayeth, John

Publication type:

Article

Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4.

Published in:

Molecular Therapy, 2008, v. 16, n. 5, p. 845, doi. 10.1038/mt.2008.39

By:

Frazer, Maria E.;
Hughes, Jennifer E.;
Mastrangelo, Michael A.;
Tibbens, Jennifer L.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset.

Published in:

Molecular Therapy, 2008, v. 16, n. 3, p. 481, doi. 10.1038/sj.mt.6300387

By:

Wuertzer, Charles A.;
Sullivan, Mark A.;
Xing Qiu;
Federoff, Howard J.

Publication type:

Article

Neuronal Specificity of HSV/Sleeping Beauty Amplicon Transduction In Utero Is Driven Primarily by Tropism and Cell Type Composition.

Published in:

Molecular Therapy, 2007, v. 15, n. 10, p. 1848, doi. 10.1038/sj.mt.6300267

By:

Peterson, Elise B.;
Mastrangelo, Michael A.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

247. Devising Aβ-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery.

Published in:

Molecular Therapy, 2006, v. 13, p. S94, doi. 10.1016/j.ymthe.2006.08.274

By:

Fowlkes, Kelly L.;
Mastrangelo, Michael A.;
Narrow, Wade C.;
Levites, Yona;
Golde, Todd E.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model<sup>*</sup>.

Published in:

Molecular Therapy, 2006, v. 13, p. S95, doi. 10.1016/j.ymthe.2006.08.275

By:

Janelsins, Michelle C.;
Mastrangelo, Michael A.;
Park, Keigan M.;
Fowlkes, Kelly L.;
Kinsky, Maria;
Narrow, Wade C.;
Oddo, Salvatore;
LaFerla, Frank M.;
Federoff, Howard J.;
Bowers, William J.

Publication type:

Article

Neuronal Precursor-Restricted Transduction via in Utero CNS Gene Delivery of a Novel Bipartite HSV Amplicon/Transposase Hybrid Vector.

Published in:

Molecular Therapy, 2006, v. 13, n. 3, p. 580, doi. 10.1016/j.ymthe.2005.11.011

By:

Bowers, William J.;
Mastrangelo, Michael A.;
Howard, Darlene F.;
Southerland, Hilary A.;
Maguire-Zeiss, Kathleen A.;
Federoff, Howard J.

Publication type:

Article

966. AAV Delivered Single-Chain Antibodies as Passive Immuno-Therapy for Prion Disease

Published in:

2005

By:

Wuertzer, Charles A.;
Sullivan, Mark A.;
Federoff, Howard J.

Publication type:

Abstract

431. In Utero CNS Delivery of an Integrating HSV-1 Amplicon Vector Leads to Prolonged, Neuron-Specific Gene Expression

Published in:

2005

By:

Bowers, William J.;
Mastrangelo, Michael A.;
Casey, Ann E.;
Southerland, Hilary A.;
Maguire-Zeiss, Kathleen A.;
Federoff, Howard J.

Publication type:

Abstract

Transcriptional and posttranslational regulation of cre recombinase by ru486 as the basis for an enhanced inducible expression system

Published in:

Molecular Therapy, 2003, v. 8, n. 5, p. 790, doi. 10.1016/j.ymthe.2003.07.005

By:

Kyrkanides, Stephanos;
Miller, Jen-nie H.;
Bowers, William J.;
Federoff, Howard J.

Publication type:

Article

Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS

Published in:

Molecular Therapy, 2003, v. 7, n. 2, p. 218, doi. 10.1016/S1525-0016(02)00036-9

By:

Olschowka, John A.;
Bowers, William J.;
Hurley, Sean D.;
Mastrangelo, Michael A.;
Federoff, Howard J.

Publication type:

Article

HSV Amplicon-Mediated Delivery of LIGHT Enhances the Antigen-Presenting Capacity of Chronic Lymphocytic Leukemia

Published in:

Molecular Therapy, 2002, v. 6, n. 4, p. 455, doi. 10.1006/mthe.2002.0693

By:

Tolba, Khaled A.;
Bowers, William J.;
Eling, David J.;
Casey, Ann E.;
Kipps, Thomas J.;
Federoff, Howard J.;
Rosenblatt, Joseph D.

Publication type:

Article

Neurotrophin-3 Transduction Attenuates Cisplatin Spiral Ganglion Neuron Ototoxicity in the Cochlea

Published in:

Molecular Therapy, 2002, v. 6, n. 1, p. 12, doi. 10.1006/mthe.2002.0627

By:

Bowers, William J.;
Chen, Xiaowei;
Guo, Huang;
Frisina, D. Robert;
Federoff, Howard J.;
Frisina, Robert D.

Publication type:

Article

Reporter Gene Transfer Induces Apoptosis in Primary Cortical Neurons

Published in:

Molecular Therapy, 2002, v. 5, n. 6, p. 723, doi. 10.1006/mthe.2002.0609

By:

Detrait, Eric R.;
Bowers, William J.;
Halterman, Marc W.;
Giuliano, Rita E.;
Bennice, Lisa;
Federoff, Howard J.;
Richfield, Eric K.

Publication type:

Article