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Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
- Published in:
- 2009
- By:
- Publication type:
- journal article
Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.
- Published in:
- NPJ Parkinson's Disease, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41531-020-00143-w
- By:
- Publication type:
- Article
α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin.
- Published in:
- Journal of Neuroscience, 2023, v. 43, n. 9, p. 1614, doi. 10.1523/JNEUROSCI.1922-22.2022
- By:
- Publication type:
- Article
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
- Published in:
- 2007
- By:
- Publication type:
- journal article
Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.
- Published in:
- Glia, 2019, v. 67, n. 10, p. 1933, doi. 10.1002/glia.23671
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- Publication type:
- Article
OPINION: Modelling neurodegenerative diseases in Drosophila: a fruitful approach?
- Published in:
- Nature Reviews Neuroscience, 2002, v. 3, n. 3, p. 237, doi. 10.1038/nrn751
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- Publication type:
- Article
Toward More Accessible Fully Automated 3D Volumetric MRI Decision Trees for the Differential Diagnosis of Multiple System Atrophy, Related Disorders, and Age-Matched Healthy Subjects.
- Published in:
- Cerebellum, 2023, v. 22, n. 6, p. 1098, doi. 10.1007/s12311-022-01472-7
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- Publication type:
- Article
Genetic Modifiers of Tauopathy in Drosophila.
- Published in:
- Genetics, 2003, v. 165, n. 3, p. 1233, doi. 10.1093/genetics/165.3.1233
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- Publication type:
- Article
Cell cycle and neurodegeneration in fly
- Published in:
- 2009
- By:
- Publication type:
- Abstract
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
- Published in:
- PLoS Biology, 2018, v. 16, n. 12, p. 1, doi. 10.1371/journal.pbio.2006265
- By:
- Publication type:
- Article
The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts.
- Published in:
- Nature, 1993, v. 364, n. 6437, p. 537, doi. 10.1038/364537a0
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- Publication type:
- Article
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42822-1
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- Publication type:
- Article
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40348-0
- By:
- Publication type:
- Article
The Homozygote VCPR<sup>155H/R155H</sup> Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology.
- Published in:
- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0046308
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- Publication type:
- Article
Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0044214
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- Publication type:
- Article
The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo.
- Published in:
- PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0013084
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- Publication type:
- Article
α-synuclein impairs autophagosome maturation through abnormal actin stabilization.
- Published in:
- PLoS Genetics, 2021, v. 17, n. 2, p. 1, doi. 10.1371/journal.pgen.1009359
- By:
- Publication type:
- Article
In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 4, p. 862, doi. 10.1523/JNEUROSCI.3072-08.2008
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- Publication type:
- Article
Aggregated α-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 12, p. 3338, doi. 10.1523/JNEUROSCI.0285-07.2007
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- Publication type:
- Article
Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann--Sträussler--Scheinker Syndrome.
- Published in:
- Journal of Neuroscience, 2006, v. 26, n. 48, p. 12408, doi. 10.1523/JNEUROSCI.3372-06.2006
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- Publication type:
- Article
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
- Published in:
- Nature Cell Biology, 2007, v. 9, n. 2, p. 139, doi. 10.1038/ncb1528
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- Publication type:
- Article
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.
- Published in:
- Human Molecular Genetics, 2024, v. 33, n. 10, p. 860, doi. 10.1093/hmg/ddae018
- By:
- Publication type:
- Article
Nitric oxide mediates glial-induced neurodegeneration in Alexander disease.
- Published in:
- Nature Communications, 2015, v. 6, n. 11, p. 8966, doi. 10.1038/ncomms9966
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- Publication type:
- Article
Glia are critical for the neuropathology of complex I deficiency in Drosophila.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 17, p. 4686, doi. 10.1093/hmg/ddu188
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- Publication type:
- Article
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 4, p. 870, doi. 10.1093/hmg/ddt478
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- Publication type:
- Article
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
- Published in:
- Molecular Brain, 2009, v. 2, p. 1, doi. 10.1186/1756-6606-2-5
- By:
- Publication type:
- Article
Nicotine‐Mediated Rescue of α‐Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila.
- Published in:
- Movement Disorders, 2023, v. 38, n. 2, p. 244, doi. 10.1002/mds.29283
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- Publication type:
- Article
STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 7, p. 978, doi. 10.3390/cells12070978
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- Publication type:
- Article
Tau promotes neurodegeneration through global chromatin relaxation.
- Published in:
- Nature Neuroscience, 2014, v. 17, n. 3, p. 357, doi. 10.1038/nn.3639
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- Publication type:
- Article
Senseless makes sense for spinocerebellar ataxia-1.
- Published in:
- Nature Neuroscience, 2005, v. 8, n. 11, p. 1422, doi. 10.1038/nn1105-1422
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- Publication type:
- Article
a-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.
- Published in:
- Nature Neuroscience, 2005, v. 8, n. 5, p. 657, doi. 10.1038/nn1443
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- Publication type:
- Article
Anastasis Drives Senescence and Non-Cell Autonomous Neurodegeneration in the Astrogliopathy Alexander Disease.
- Published in:
- Journal of Neuroscience, 2022, v. 42, n. 12, p. 2584, doi. 10.1523/JNEUROSCI.1659-21.2021
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- Publication type:
- Article
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
- Published in:
- Journal of Neuroscience, 2018, v. 38, n. 1, p. 108, doi. 10.1523/JNEUROSCI.1550-17.2017
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- Publication type:
- Article
Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo.
- Published in:
- PLoS Genetics, 2010, v. 6, n. 7, p. 1, doi. 10.1371/journal.pgen.1001026
- By:
- Publication type:
- Article
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.
- Published in:
- Human Molecular Genetics, 2006, v. 15, n. 20, p. 3012, doi. 10.1093/hmg/ddl243
- By:
- Publication type:
- Article
Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases.
- Published in:
- Human Molecular Genetics, 2004, v. 13, n. 18, p. 2011, doi. 10.1093/hmg/ddh214
- By:
- Publication type:
- Article
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.
- Published in:
- Human Molecular Genetics, 2003, v. 12, n. 19, p. 2457, doi. 10.1093/hmg/ddg265
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- Publication type:
- Article
Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 620, p. 1, doi. 10.1126/scitranslmed.abg4711
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- Publication type:
- Article
Neurodegenerative disorders with extensive tau pathology: A comparative study and review.
- Published in:
- Annals of Neurology, 1996, v. 40, n. 2, p. 139, doi. 10.1002/ana.410400204
- By:
- Publication type:
- Article
Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons.
- Published in:
- Journal of Neurochemistry, 2003, v. 85, n. 6, p. 1614, doi. 10.1046/j.1471-4159.2003.01819.x
- By:
- Publication type:
- Article
A Drosophila model of Parkinson's disease.
- Published in:
- Nature, 2000, v. 404, n. 6776, p. 394, doi. 10.1038/35006074
- By:
- Publication type:
- Article
Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.
- Published in:
- Toxicological Sciences, 2021, v. 182, n. 2, p. 159, doi. 10.1093/toxsci/kfab060
- By:
- Publication type:
- Article
A neuroprotective role for the DNA damage checkpoint in tauopathy.
- Published in:
- Aging Cell, 2012, v. 11, n. 2, p. 360, doi. 10.1111/j.1474-9726.2011.00778.x
- By:
- Publication type:
- Article
A Drosophila model relevant to chemotherapy-related cognitive impairment.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-46616-9
- By:
- Publication type:
- Article
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
- Published in:
- Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00454-3
- By:
- Publication type:
- Article
Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation.
- Published in:
- Journal of Neuroscience, 2016, v. 36, n. 11, p. 3170, doi. 10.1523/JNEUROSCI.1912-15.2016
- By:
- Publication type:
- Article
An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.
- Published in:
- Journal of Neuroscience, 2016, v. 36, n. 5, p. 1445, doi. 10.1523/JNEUROSCI.0256-15.2016
- By:
- Publication type:
- Article
Alexander Disease.
- Published in:
- Journal of Neuroscience, 2012, v. 32, n. 15, p. 5017, doi. 10.1523/JNEUROSCI.5384-11.2012
- By:
- Publication type:
- Article
Protein Misfolding and Oxidative Stress Promote Glial-Mediated Neurodegeneration in an Alexander Disease Model.
- Published in:
- Journal of Neuroscience, 2011, v. 31, n. 8, p. 2868, doi. 10.1523/JNEUROSCI.3410-10.2011
- By:
- Publication type:
- Article
Glial Fibrillary Tangles and JAK/STAT-Mediated Glial and Neuronal Cell Death in a Drosophila Model of Glial Tauopathy.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 48, p. 16102, doi. 10.1523/JNEUROSCI.2491-10.2010
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- Publication type:
- Article