Works matching AU Farrell, Nicholas P.

Results: 42

A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides.

Published in:

Angewandte Chemie, 2022, v. 134, n. 3, p. 1, doi. 10.1002/ange.202110455

By:

Hennessy, Joseph;
McGorman, Bríonna;
Molphy, Zara;
Farrell, Nicholas P.;
Singleton, Daniel;
Brown, Tom;
Kellett, Andrew

Publication type:

Article

On the Biology of Werner's Complex.

Published in:

Angewandte Chemie, 2021, v. 133, n. 31, p. 17260, doi. 10.1002/ange.202105019

By:

Paiva, Raphael E. F.;
Peterson, Erica J.;
Malina, Jaroslav;
Zoepfl, Mary;
Hampton, J. David;
Johnson, Wyatt E.;
Graminha, Angelica;
Ourahmane, Amine;
McVoy, Michael A.;
Brabec, Viktor;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Conformational Modulation of Iduronic Acid‐Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs.

Published in:

Angewandte Chemie, 2021, v. 133, n. 6, p. 3320, doi. 10.1002/ange.202013749

By:

Gorle, Anil K.;
Haselhorst, Thomas;
Katner, Samantha J.;
Everest‐Dass, Arun V.;
Hampton, James D.;
Peterson, Erica J.;
Koblinski, Jennifer E.;
Katsuta, Eriko;
Takabe, Kazuaki;
Itzstein, Mark;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Gold‐Catalyzed C–S Aryl‐Group Transfer in Zinc Finger Proteins.

Published in:

Angewandte Chemie, 2018, v. 130, n. 30, p. 9449, doi. 10.1002/ange.201803082

By:

de Paiva, Raphael E. F.;
Du, Zhifeng;
Nakahata, Douglas H.;
Lima, Frederico A.;
Corbi, Pedro P.;
Farrell, Nicholas P.

Publication type:

Article

Substitution‐Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex‐Forming Templates.

Published in:

Angewandte Chemie, 2018, v. 130, n. 28, p. 8671, doi. 10.1002/ange.201803448

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 2, p. 720, doi. 10.1093/nar/gkq803

By:

Malina, Jaroslav;
Kasparkova, Jana;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

The phosphate clamp: a small and independent motif for nucleic acid backbone recognition.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 1, p. 325, doi. 10.1093/nar/gkq723

By:

Komeda, Seiji;
Moulaei, Tinoush;
Chikuma, Masahiko;
Odani, Akira;
Kipping, Ralph;
Farrell, Nicholas P.;
Williams, Loren Dean

Publication type:

Article

Binding affinity studies of 1,2,3-triazole copper(II) complexes to human serum albumin.

Published in:

Journal of Coordination Chemistry, 2018, v. 71, n. 11-13, p. 1894, doi. 10.1080/00958972.2018.1495331

By:

de Paula, Queite A.;
Joly, Jean-Pierre;
Selmeczi, Katalin;
Fonseca, David E. P.;
Caramori, Giovanni F.;
Farrell, Nicholas P.;
Da Costa Ferreira, Ana M.

Publication type:

Article

Investigation of 1-Methylcytosine as a Ligand in Gold(III) Complexes: Synthesis and Protein Interactions.

Published in:

Inorganics, 2019, v. 7, n. 1, p. 1, doi. 10.3390/inorganics7010001

By:

Beaton, James;
Farrell, Nicholas P.

Publication type:

Article

A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 3, p. 1, doi. 10.1002/anie.202110455

By:

Hennessy, Joseph;
McGorman, Bríonna;
Molphy, Zara;
Farrell, Nicholas P.;
Singleton, Daniel;
Brown, Tom;
Kellett, Andrew

Publication type:

Article

On the Biology of Werner's Complex.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 31, p. 17123, doi. 10.1002/anie.202105019

By:

de Paiva, Raphael E. F.;
Peterson, Erica J.;
Malina, Jaroslav;
Zoepfl, Mary;
Hampton, J. David;
Johnson, Wyatt E.;
Graminha, Angelica;
Ourahmane, Amine;
McVoy, Michael A.;
Brabec, Viktor;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Conformational Modulation of Iduronic Acid‐Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 6, p. 3283, doi. 10.1002/anie.202013749

By:

Gorle, Anil K.;
Haselhorst, Thomas;
Katner, Samantha J.;
Everest‐Dass, Arun V.;
Hampton, James D.;
Peterson, Erica J.;
Koblinski, Jennifer E.;
Katsuta, Eriko;
Takabe, Kazuaki;
Itzstein, Mark;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells.

Published in:

2016

By:

Takashi Shingu;
Holmes, Lindsay;
Henry, Verlene;
Qianghu Wang;
Latha, Khatri;
Gururaj, Anupama E.;
Gibson, Laura A.;
Doucette, Tiffany;
Lang, Frederick F.;
Ganesh Rao;
Liang Yuan;
Sulman, Erik P.;
Farrell, Nicholas P.;
Priebe, Waldemar;
Hess, Kenneth R.;
Wang, Yaoqi A.;
Jian Hu;
Bögler, Oliver;
Shingu, Takashi;
Wang, Qianghu

Publication type:

journal article

Heme proteins and metalloporphyrins: Redox chemistry and oxygen binding.

Published in:

International Journal of Quantum Chemistry, 1979, v. 16, n. 2, p. 311, doi. 10.1002/qua.560160213

By:

Dolphin, David;
Addison, Anthony W.;
Cairns, Max;
Dinello, Robert K.;
Farrell, Nicholas P.;
James, Brian R.;
Paulson, Donald R.;
Welborn, Curtis

Publication type:

Article

Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared with cisplatin and oxaliplatin.

Published in:

Cell Cycle, 2012, v. 11, n. 5, p. 963, doi. 10.4161/cc.11.5.19447

By:

Murphy, Robert F.;
Komlodi-Pasztor, Edina;
Robey, Rob;
Balis, Frank M.;
Farrell, Nicholas P.;
Fojo, Tito

Publication type:

Article

Substitution‐Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single‐ and Double‐Stranded DNA and RNA Oligonucleotides.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 12, p. 2995, doi. 10.1002/chem.201806276

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

Substitution‐Inert Polynuclear Platinum Complexes as Metalloshielding Agents for Heparan Sulfate.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 25, p. 6606, doi. 10.1002/chem.201706030

By:

Gorle, Anil Kumar;
Katner, Samantha J.;
Johnson, Wyatt E.;
Lee, Daniel E.;
Daniel, A. Gerard;
Ginsburg, Eric P.;
von Itzstein, Mark;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Structural Factors Affecting Binding of Platinum Anticancer Agents with Phospholipids: Influence of Charge and Phosphate Clamp Formation.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 18, p. 4643, doi. 10.1002/chem.201705822

By:

Gorle, Anil Kumar;
Zhang, Junyong;
Liu, Qin;
Berners‐Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Radiation induces ESCRT pathway dependent CD44v3<sup>+</sup> extracellular vesicle production stimulating pro-tumor fibroblast activity in breast cancer.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.913656

By:

Clark, Gene Chatman;
Hampton, James David;
Koblinski, Jennifer E.;
Quinn, Bridget;
Mahmoodi, Sitara;
Metcalf, Olga;
Chunqing Guo;
Peterson, Erica;
Fisher, Paul B.;
Farrell, Nicholas P.;
Xiang- Yang Wang;
Mikkelsen, Ross B.

Publication type:

Article

Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma.

Published in:

International Journal of Cancer, 2011, v. 128, n. 4, p. 787, doi. 10.1002/ijc.25394

By:

Gwak, Ho-Shin;
Shingu, Takashi;
Chumbalkar, Vaibhav;
Hwang, Yeo-Hyeon;
DeJournett, Robert;
Latha, Khatri;
Koul, Dimpy;
Alfred Yung, W. K.;
Powis, Garth;
Farrell, Nicholas P.;
Bögler, Oliver

Publication type:

Article

The dynamics of zinc sites in proteins: electronic basis for coordination sphere expansion at structural sites.

Published in:

Metallomics, 2014, v. 6, n. 12, p. 2230, doi. 10.1039/c4mt00213j

By:

Daniel, A. Gerard;
Farrell, Nicholas P.

Publication type:

Article

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins.

Published in:

ChemMedChem, 2014, v. 9, n. 6, p. 1155, doi. 10.1002/cmdc.201402052

By:

Ma, Erin S. F.;
Daniel, A. Gerard;
Farrell, Nicholas P.

Publication type:

Article

DNA Reactivity Profile of trans-Platinum Planar Amine Derivatives.

Published in:

ChemMedChem, 2011, v. 6, n. 7, p. 1283, doi. 10.1002/cmdc.201100032

By:

Musetti, Caterina;
Nazarov, Alexey A.;
Farrell, Nicholas P.;
Sissi, Claudia

Publication type:

Article

Diversity in Gold Finger Structure Elucidated by Traveling-Wave Ion Mobility Mass Spectrometry.

Published in:

Angewandte Chemie, 2017, v. 129, n. 16, p. 4535, doi. 10.1002/ange.201612494

By:

Du, Zhifeng;
de Paiva, Raphael E. F.;
Nelson, Kristina;
Farrell, Nicholas P.

Publication type:

Article

Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity.

Published in:

Angewandte Chemie, 2014, v. 126, n. 47, p. 13026, doi. 10.1002/ange.201408012

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3.

Published in:

Angewandte Chemie, 2014, v. 126, n. 16, p. 4182, doi. 10.1002/ange.201311114

By:

Daniel, A. Gerard;
Peterson, Erica J.;
Farrell, Nicholas P.

Publication type:

Article

Rücktitelbild: The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3 (Angew. Chem. 16/2014).

Published in:

Angewandte Chemie, 2014, v. 126, n. 16, p. 4336, doi. 10.1002/ange.201401105

By:

Daniel, A. Gerard;
Peterson, Erica J.;
Farrell, Nicholas P.

Publication type:

Article

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 22, p. 13474, doi. 10.1093/nar/gku1157

By:

Prisecaru, Andreea;
Molphy, Zara;
Kipping, Ralph G.;
Peterson, Erica J.;
Yun Qu;
Kellett, Andrew;
Farrell, Nicholas P.

Publication type:

Article

DNA Interstrand Cross-Links of an Antitumor Trinuclear Platinum(II) Complex: Thermodynamic Analysis and Chemical Probing.

Published in:

Chemistry - An Asian Journal, 2011, v. 6, n. 6, p. 1566, doi. 10.1002/asia.201000935

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

The trans Influence in the Modulation of Platinum Anticancer Agent Biology: The Effect of Nitrite Leaving Group on Aquation, Reactions with S-Nucleophiles and DNA Binding of Dinuclear and Trinuclear Compounds.

Published in:

Chemistry - A European Journal, 2010, v. 16, n. 30, p. 9175, doi. 10.1002/chem.200903578

By:

Montero, Eva I.;
Zhang, Junyong;
Moniodis, Joseph J.;
Berners-Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

Factors Affecting DNA-DNA Interstrand Cross-Links in the Antiparallel 3′-3′ Sense: A Comparison with the 5′-5′ Directional Isomer.

Published in:

Chemistry - A European Journal, 2009, v. 15, n. 37, p. 9365, doi. 10.1002/chem.200900958

By:

Ruhayel, Rasha A.;
Moniodis, Joseph J.;
Yang, Xiaohong;
Kasparkova, Jana;
Brabec, Viktor;
Berners-Price, Susan J.;
Farrell, Nicholas P.

Publication type:

Article

The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells.

Published in:

Neuro-Oncology, 2010, v. 12, n. 12, p. 1269, doi. 10.1093/neuonc/noq095

By:

Shingu, Takashi;
Chumbalkar, Vaibhav C.;
Gwak, Ho-Shin;
Fujiwara, Keishi;
Kondo, Seiji;
Farrell, Nicholas P.;
Bogler, Oliver

Publication type:

Article

Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma.

Published in:

Neuro-Oncology, 2006, v. 8, n. 3, p. 215, doi. 10.1215/15228517-2006-004

By:

Billecke, Christine;
Finniss, Susan;
Tahash, Laura;
Miller, Cathie;
Mikkelsen, Tom;
Farrell, Nicholas P.;
Oliver Bögler

Publication type:

Article

Gold‐Catalyzed C–S Aryl‐Group Transfer in Zinc Finger Proteins.

Published in:

Angewandte Chemie International Edition, 2018, v. 57, n. 30, p. 9305, doi. 10.1002/anie.201803082

By:

de Paiva, Raphael E. F.;
Du, Zhifeng;
Nakahata, Douglas H.;
Lima, Frederico A.;
Corbi, Pedro P.;
Farrell, Nicholas P.

Publication type:

Article

Substitution‐Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex‐Forming Templates.

Published in:

Angewandte Chemie International Edition, 2018, v. 57, n. 28, p. 8535, doi. 10.1002/anie.201803448

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

Diversity in Gold Finger Structure Elucidated by Traveling-Wave Ion Mobility Mass Spectrometry.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 16, p. 4464, doi. 10.1002/anie.201612494

By:

Du, Zhifeng;
de Paiva, Raphael E. F.;
Nelson, Kristina;
Farrell, Nicholas P.

Publication type:

Article

Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 47, p. 12812, doi. 10.1002/anie.201408012

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 16, p. 4098, doi. 10.1002/anie.201311114

By:

Daniel, A. Gerard;
Peterson, Erica J.;
Farrell, Nicholas P.

Publication type:

Article

Back Cover: The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3 (Angew. Chem. Int. Ed. 16/2014).

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 16, p. 4250, doi. 10.1002/anie.201401105

By:

Daniel, A. Gerard;
Peterson, Erica J.;
Farrell, Nicholas P.

Publication type:

Article

Structural consequences of a 3′ → 3′ DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2009, v. 14, n. 6, p. 969, doi. 10.1007/s00775-009-0509-5

By:

Yun Qu;
My-Chau Tran;
Farrell, Nicholas P.

Publication type:

Article

Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2003, v. 8, n. 1/2, p. 19, doi. 10.1007/s00775-002-0383-x

By:

Yun Qu;
Scarsdale, Neel J.;
My-Chau Tran;
Farrell, Nicholas P.

Publication type:

Article

Metal ions and the extracellular matrix in tumor migration.

Published in:

FEBS Journal, 2019, v. 286, n. 15, p. 2950, doi. 10.1111/febs.14986

By:

Stelling, Mariana P.;
Motta, Juliana M.;
Mashid, Marjon;
Johnson, Wyatt E.;
Pavão, Mauro S.;
Farrell, Nicholas P.

Publication type:

Article