Works by Farooqi, I. Sadaf

Results: 80

Dopamine Modulates the Neural Representation of Subjective Value of Food in Hungry Subjects.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 50, p. 16902, doi. 10.1523/JNEUROSCI.2051-14.2014

By:

Medic, Nenad;
Ziauddeen, Hisham;
Vestergaard, Martin D.;
Henning, Elana;
Schultz, Wolfram;
Farooqi, I. Sadaf;
Fletcher, Paul C.

Publication type:

Article

Genetic architecture of human thinness compared to severe obesity.

Published in:

PLoS Genetics, 2019, v. 15, n. 1, p. 1, doi. 10.1371/journal.pgen.1007603

By:

Riveros-McKay, Fernando;
Mistry, Vanisha;
Bounds, Rebecca;
Hendricks, Audrey;
Keogh, Julia M.;
Thomas, Hannah;
Henning, Elana;
Corbin, Laura J.;
null, null;
O’Rahilly, Stephen;
Zeggini, Eleftheria;
Wheeler, Eleanor;
Barroso, Inês;
Farooqi, I. Sadaf

Publication type:

Article

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.

Published in:

PLoS Genetics, 2018, v. 14, n. 10, p. 1, doi. 10.1371/journal.pgen.1007591

By:

Hendricks, Audrey E.;
Billups, Stephen C.;
Pike, Hamish N. C.;
Farooqi, I. Sadaf;
Zeggini, Eleftheria;
Santorico, Stephanie A.;
Barroso, Inês;
Dupuis, Josée

Publication type:

Article

Molecular Genetic Analysis of Normosmic Hypogonadotropic Hypogonadism in a Turkish Population: Identification and Detailed Functional Characterization of a Novel Mutation in the Gonadotropin-Releasing Hormone Receptor Gene.

Published in:

Neuroendocrinology, 2006, v. 84, n. 5, p. 301, doi. 10.1159/000098147

By:

Topaloglu, A. Kemal;
Zhi-Liang Lu;
Farooqi, I. Sadaf;
Mungan, Neslihan O.;
Yuksel, Bilgin;
O'Rahilly, Stephen;
Millar, Robert P.

Publication type:

Article

A frameshift mutation in MC4R associated with dominantly inherited human obesity.

Published in:

Nature Genetics, 1998, v. 20, n. 2, p. 111, doi. 10.1038/2404

By:

Yeo, Giles S.H.;
Farooqi, I. Sadaf;
Aminian, Shiva;
Halsall, David J.;
Stanhope, Richard G.;
O'Rahilly, Stephen

Publication type:

Article

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 12, p. 4732, doi. 10.1172/JCI62696

By:

Doche, Michael E.;
Bochukova, Elena G.;
Hsiao-Wen Su;
Pearce, Laura R.;
Keogh, Julia M.;
Henning, Elana;
Cline, Joel M.;
Dale, Anne;
Cheetham, Tim;
Barroso, Inês;
Argetsinger, Lawrence S.;
O'Rahilly, Stephen;
Liangyou Rui;
Christin Carter-Su;
Farooqi, I. Sadaf

Publication type:

Article

Genetic approaches to understanding human obesity.

Published in:

2011

By:

Ramachandrappa, Shwetha;
Farooqi, I. Sadaf

Publication type:

journal article

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

Published in:

2010

By:

Mitchell, Catherine S.;
Savage, David B.;
Dufour, Sylvie;
Schoenmakers, Nadia;
Murgatroyd, Peter;
Befroy, Douglas;
Halsall, David;
Northcott, Samantha;
Raymond-Barker, Philippa;
Curran, Suzanne;
Henning, Elana;
Keogh, Julia;
Owen, Penny;
Lazarus, John;
Rothman, Douglas L.;
Farooqi, I. Sadaf;
Shulman, Gerald I.;
Chatterjee, Krishna;
Petersen, Kitt Falk

Publication type:

journal article

High protein intake stimulates postprandial GLP1 and PYY release.

Published in:

Obesity (19307381), 2013, v. 21, n. 8, p. 1602, doi. 10.1002/oby.20154

By:

Klaauw, Agatha A.;
Keogh, Julia M.;
Henning, Elana;
Trowse, Victoria M.;
Dhillo, Waljit S.;
Ghatei, Mohammad A.;
Farooqi, I. Sadaf

Publication type:

Article

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.

Published in:

Clinical Endocrinology, 2022, v. 96, n. 2, p. 270, doi. 10.1111/cen.14615

By:

Seelig, Eleonora;
Henning, Elana;
Keogh, Julia M.;
Gillett, Daniel;
Shin, Evelyn;
Buscombe, John;
van der Klaauw, Agatha A.;
Farooqi, I. Sadaf

Publication type:

Article

Genetic, molecular and physiological mechanisms involved in human obesity: Society for Endocrinology Medal Lecture 2012.

Published in:

Clinical Endocrinology, 2015, v. 82, n. 1, p. 23, doi. 10.1111/cen.12588

By:

Farooqi, Sadaf I.

Publication type:

Article

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis.

Published in:

Science Translational Medicine, 2025, v. 17, n. 781, p. 1, doi. 10.1126/scitranslmed.adr6459

By:

Xu, Baijie;
Lawler, Katherine;
Wyler, Steven C.;
Li, Li;
Swati;
Keogh, Julia M.;
Chen, Xiameng;
Wan, Rong;
Almeida, Amanda G.;
Kirsch, Susan;
Mountjoy, Kathleen G.;
Elmquist, Joel K.;
Farooqi, I. Sadaf;
Liu, Chen

Publication type:

Article

OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions.

Published in:

Obesity Facts: The European Journal of Obesity, 2020, v. 13, n. 1, p. 1, doi. 10.1159/000505342

By:

Alligier, Maud;
Barrès, Romain;
Blaak, Ellen E.;
Boirie, Yves;
Bouwman, Jildau;
Brunault, Paul;
Campbell, Kristina;
Clément, Karine;
Farooqi, I. Sadaf;
Farpour-Lambert, Nathalie J.;
Frühbeck, Gema;
Goossens, Gijs H.;
Hager, Jorg;
Halford, Jason C.G.;
Hauner, Hans;
Jacobi, David;
Julia, Chantal;
Langin, Dominique;
Natali, Andrea;
Neovius, Martin

Publication type:

Article

A Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.

Published in:

Journal of Neuroscience, 2023, v. 43, n. 47, p. 8000, doi. 10.1523/JNEUROSCI.1473-23.2023

By:

Khorisantono, Putu A.;
Fei-Yang Huang;
Sutcliffe, Michael P. F.;
Fletcher, Paul C.;
Farooqi, I. Sadaf;
Grabenhorst, Fabian

Publication type:

Article

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

Published in:

Nature Genetics, 2013, v. 45, n. 5, p. 513, doi. 10.1038/ng.2607

By:

Wheeler, Eleanor;
Huang, Ni;
Bochukova, Elena G;
Keogh, Julia M;
Lindsay, Sarah;
Garg, Sumedha;
Henning, Elana;
Blackburn, Hannah;
Loos, Ruth J F;
Wareham, Nick J;
O'Rahilly, Stephen;
Hurles, Matthew E;
Barroso, Inês;
Farooqi, I Sadaf

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2014, v. 19, n. 12, p. 1341, doi. 10.1038/mp.2014.126

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2013, v. 18, n. 12, p. 1287, doi. 10.1038/mp.2012.154

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Published in:

Human Molecular Genetics, 2003, v. 12, n. 5, p. 561, doi. 10.1093/hmg/ddg057

By:

Yeo, Giles S.H.;
Lank, Emma J.;
Farooqi, I. Sadaf;
Keogh, Julia;
Challis, Benjamin G.;
O'Rahilly, Stephen

Publication type:

Article

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Published in:

Human Molecular Genetics, 2002, v. 11, n. 17, p. 1997, doi. 10.1093/hmg/11.17.1997

By:

Challis, Benjamin G.;
Pritchard, Lynn E.;
Creemers, John W.M.;
Delplanque, Jerome;
Keogh, Julia M.;
Luan, Jian'an;
Wareham, Nicholas J.;
Yeo, Giles S.H.;
Bhattacharyya, Sumit;
Froguel, Phillipe;
White, Anne;
Farooqi, I. Sadaf;
O'Rahilly, Stephen

Publication type:

Article

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33367-w

By:

LaPierre, Mary P.;
Lawler, Katherine;
Godbersen, Svenja;
Farooqi, I. Sadaf;
Stoffel, Markus

Publication type:

Article

Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 43, p. 14346, doi. 10.1523/JNEUROSCI.3323-10.2010

By:

Fletcher, Paul C.;
Napolitano, Antonella;
Skeggs, Andrew;
Miller, Sam R.;
Delafont, Bruno;
Cambridge, Victoria C.;
de Wit, Sanne;
Nathan, Pradeep J.;
Brooke, Allison;
O'Rahilly, Stephen;
Farooqi, I. Sadaf;
Builmore, Edward T.

Publication type:

Article

CNS Leptin Action Modulates Immune Response and Survival in Sepsis.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 17, p. 6036, doi. 10.1523/JNEUROSCI.4875-09.2010

By:

Tschöp, Johannes;
Nogueiras, Ruben;
Haas-Lockie, Sarah;
Kasten, Kevin R.;
Castañeda, Tamara R.;
Huber, Nadine;
Guanciale, Kelsey;
Perez-Tilve, Diego;
Habegger, Kirk;
Ottaway, Nickki;
Woods, Stephen C.;
Oldfield, Brian;
Clarke, Iain;
Chua Jr., Streamson;
Sadaf Farooqi, I.;
O'Rahilly, Stephen;
Caldwell, Charles C.;
Tschöp, Matthias H.

Publication type:

Article

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

Published in:

2007

By:

Farooqi, I Sadaf;
Volders, Karolien;
Stanhope, Richard;
Heuschkel, Robert;
White, Anne;
Lank, Emma;
Keogh, Julia;
O'Rahilly, Stephen;
Creemers, John W M

Publication type:

journal article

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.

Published in:

2004

By:

Gibson, William T;
Farooqi, I Sadaf;
Moreau, Mary;
DePaoli, Alex M;
Lawrence, Elizabeth;
O'Rahilly, Stephen;
Trussell, Rebecca A

Publication type:

journal article

Proopiomelanocortin and energy balance: insights from human and murine genetics.

Published in:

2004

By:

Coll, Anthony P;
Farooqi, I Sadaf;
Challis, Benjamin G;
Yeo, Giles S H;
O'Rahilly, Stephen

Publication type:

journal article

Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition?

Published in:

2003

By:

Franks, Paul W;
Farooqi, I Sadaf;
Luan, Jian'an;
Wong, Man-Yu;
Halsall, Ian;
O'Rahilly, Stephen;
Wareham, Nicholas J

Publication type:

journal article

Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.

Published in:

2003

By:

Haqq, Andrea M;
Farooqi, I Sadaf;
O'Rahilly, Stephen;
Stadler, Diane D;
Rosenfeld, Ron G;
Pratt, Katherine L;
LaFranchi, Stephen H;
Purnell, Jonathan Q

Publication type:

journal article

Melanocortin receptors weigh in.

Published in:

Nature Medicine, 2004, v. 10, n. 4, p. 351, doi. 10.1038/nm0404-351

By:

O'Rahilly, Stephen;
Yeo, Giles S. H.;
Farooqi, I. Sadaf

Publication type:

Article

A Metabolomic Signature of Acute Caloric Restriction.

Published in:

2017

By:

Collet, Tinh-Hai;
Sonoyama, Takuhiro;
Henning, Elana;
Keogh, Julia M;
Ingram, Brian;
Kelway, Sarah;
Guo, Lining;
Farooqi, I Sadaf

Publication type:

journal article

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.

Published in:

2015

By:

Wabitsch, Martin;
Funcke, Jan-Bernd;
von Schnurbein, Julia;
Denzer, Friederike;
Lahr, Georgia;
Mazen, Inas;
El-Gammal, Mona;
Denzer, Christian;
Moss, Anja;
Debatin, Klaus-Michael;
Gierschik, Peter;
Mistry, Vanisha;
Keogh, Julia M;
Farooqi, I Sadaf;
Moepps, Barbara;
Fischer-Posovszky, Pamela

Publication type:

journal article

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues.

Published in:

2014

By:

van der Klaauw, Agatha A;
von dem Hagen, Elisabeth A H;
Keogh, Julia M;
Henning, Elana;
O'Rahilly, Stephen;
Lawrence, Andrew D;
Calder, Andrew J;
Farooqi, I Sadaf

Publication type:

journal article

Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

Published in:

2013

By:

van der Klaauw AA;
Keogh JM;
Henning E;
Blackwood A;
Haqq AM;
Purnell JQ;
Farooqi IS;
van der Klaauw, Agatha A;
Keogh, Julia M;
Henning, Elana;
Blackwood, Anthea;
Haqq, Andrea M;
Purnell, Jonathan Q;
Farooqi, I Sadaf

Publication type:

journal article

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.

Published in:

2011

By:

McCabe, Mark J;
Gaston-Massuet, Carles;
Tziaferi, Vaitsa;
Gregory, Louise C;
Alatzoglou, Kyriaki S;
Signore, Massimo;
Puelles, Eduardo;
Gerrelli, Dianne;
Farooqi, I Sadaf;
Raza, Jamal;
Walker, Joanna;
Kavanaugh, Scott I;
Tsai, Pei-San;
Pitteloud, Nelly;
Martinez-Barbera, Juan-Pedro;
Dattani, Mehul T

Publication type:

journal article

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.

Published in:

2011

By:

Martinelli, Carlos E;
Keogh, Julia M;
Greenfield, Jerry R;
Henning, Elana;
van der Klaauw, Agatha A;
Blackwood, Anthea;
O'Rahilly, Stephen;
Roelfsema, Ferdinand;
Camacho-Hübner, Cecilia;
Pijl, Hanno;
Farooqi, I Sadaf

Publication type:

journal article

Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.

Published in:

2008

By:

Creemers, John W M;
Lee, Yung Seng;
Oliver, Robert L;
Bahceci, Mithat;
Tuzcu, Alpaslan;
Gokalp, Deniz;
Keogh, Julia;
Herber, Stefan;
White, Anne;
O'Rahilly, Stephen;
Farooqi, I Sadaf

Publication type:

journal article

Obesity associated genetic variation in FTO is associated with diminished satiety.

Published in:

2008

By:

Wardle, Jane;
Carnell, Susan;
Haworth, Claire M A;
Farooqi, I Sadaf;
O'Rahilly, Stephen;
Plomin, Robert

Publication type:

journal article

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

Published in:

PLoS Biology, 2021, v. 19, n. 11, p. 1, doi. 10.1371/journal.pbio.3001255

By:

Agrawal, Neha;
Lawler, Katherine;
Davidson, Catherine M.;
Keogh, Julia M.;
Legg, Robert;
Barroso, Inês;
Farooqi, I. Sadaf;
Brand, Andrea H.

Publication type:

Article

Congenital leptin deficiency is associated with severe early-onset obesity in humans.

Published in:

Nature, 1997, v. 387, n. 6636, p. 903, doi. 10.1038/43185

By:

Montague, Carl T.;
Farooqi, I. Sadaf

Publication type:

Article

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.

Published in:

Nature Communications, 2016, v. 7, n. 10, p. 13055, doi. 10.1038/ncomms13055

By:

van der Klaauw, Agatha A.;
Keogh, Julia M.;
Henning, Elana;
Stephenson, Cheryl;
Kelway, Sarah;
Trowse, Victoria M.;
Subramanian, Naresh;
O'Rahilly, Stephen;
Fletcher, Paul C.;
Farooqi, I. Sadaf

Publication type:

Article

Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.

Published in:

2004

By:

Gibson, William T.;
Ebersole, Barbara J.;
Bhattacharyya, Sumit;
Clayton, Peter;
Farooqi, I. Sadaf;
Sealfon, Stuart C.;
O'Rahilly, Stephen

Publication type:

Report

Obesity: from genes to behaviour.

Published in:

European Journal of Endocrinology, 2014, v. 171, n. 5, p. R191, doi. 10.1530/EJE-14-0684

By:

Farooqi, I. Sadaf

Publication type:

Article

Food addiction: is there a baby in the bathwater?

Published in:

Nature Reviews Neuroscience, 2012, v. 13, n. 7, p. 514, doi. 10.1038/nrn3212-c2

By:

Ziauddeen, Hisham;
Farooqi, I. Sadaf;
Fletcher, Paul C.

Publication type:

Article

Obesity and the brain: how convincing is the addiction model?

Published in:

Nature Reviews Neuroscience, 2012, v. 13, n. 4, p. 279, doi. 10.1038/nrn3212

By:

Ziauddeen, Hisham;
Farooqi, I. Sadaf;
Fletcher, Paul C.

Publication type:

Article

A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children.

Published in:

2006

By:

Cai, Guowen;
Cole, Shelley A.;
Butte, Nancy;
Bacino, Carlos;
Diego, Vincent;
Tan, Karen;
Göring, Harald H.;
O'Rahilly, Stephen;
Farooqi, I. Sadaf;
Comuzzie, Anthony G.;
Göring, Harald H

Publication type:

journal article

Evaluation of Prader-Willi Syndrome Gene MAGEL2 in Severe Childhood-Onset Obesity**.

Published in:

Obesity (19307381), 2005, v. 13, n. 10, p. 1841, doi. 10.1038/oby.2005.224

By:

O'Neill, Megan A.;
Farooqi, I. Sadaf;
Wevrick, Rachel

Publication type:

Article

Leptin Predicts a Worsening of the Features of the Metabolic Syndrome Independently of Obesity**.

Published in:

Obesity (19307381), 2005, v. 13, n. 8, p. 1476, doi. 10.1038/oby.2005.178

By:

Franks, Paul W.;
Brage, Soren;
Luan, Jian'an;
Ekelund, Ulf;
Rahman, Mushtaquar;
Farooqi, I. Sadaf;
Halsall, Ian;
O'Rahilly, Stephen;
Wareham, Nicholas J.

Publication type:

Article

Melanin-Concentrating Hormone Receptor Mutations and Human Obesity: Functional Analysis**.

Published in:

Obesity (19307381), 2004, v. 12, n. 5, p. 743, doi. 10.1038/oby.2004.89

By:

Gibson, William T.;
Pissios, Pavlos;
Trombly, Daniel J.;
Luan, Jian'an;
Keogh, Julia;
Wareham, Nicholas J.;
Maratos-Flier, Eleftheria;
O'Rahilly, Stephen;
Farooqi, I. Sadaf

Publication type:

Article

Energy expenditure in frontotemporal dementia: a behavioural and imaging study.

Published in:

2017

By:

Ahmed, Rebekah M.;
Landin-Romero, Ramon;
Collet, Tinh-Hai;
van der Klaauw, Agatha A.;
Devenney, Emma;
Henning, Elana;
Kiernan, Matthew C.;
Piguet, Olivier;
Farooqi, I. Sadaf;
Hodges, John R.

Publication type:

journal article

Is leptin an important physiological regulator of CRP?

Published in:

2007

By:

Farooqi, I. Sadaf;
O'Rahilly, Stephen

Publication type:

Letter

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.

Published in:

FASEB Journal, 2018, v. 32, n. 4, p. 1830, doi. 10.1096/fj.201700831R

By:

Lin Jiang;
Haoran Su;
Keogh, Julia M.;
Zheng Chen;
Henning, Elana;
Wilkinson, Paul;
Goodyer, Ian;
Farooqi, I. Sadaf;
Liangyou Rui

Publication type:

Article