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Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.88049
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- Publication type:
- Article
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38932-5
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- Publication type:
- Article
Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38934-3
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- Article
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33500-9
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- Publication type:
- Article
Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.75808
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- Publication type:
- Article
Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.75808
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- Publication type:
- Article
The phase of fat: Mechanisms and physiology of lipid storage.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0I217
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- Publication type:
- Article
The power of two: lessons from a scientific partnership.
- Published in:
- 2021
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- Publication type:
- journal article
O1‐01‐02: A NOVEL MURINE KNOCK‐IN MODEL FOR PROGRANULIN‐DEFICIENT FRONTOTEMPORAL DEMENTIA WITH NONSENSE‐MEDIATED MRNA DECAY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P212, doi. 10.1016/j.jalz.2018.06.2331
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- Publication type:
- Article
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
- Published in:
- 2017
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- Publication type:
- journal article
Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.
- Published in:
- Proteomics, 2016, v. 16, n. 21, p. 2759, doi. 10.1002/pmic.201600269
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- Publication type:
- Article
Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.
- Published in:
- 2016
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- Publication type:
- journal article
Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.14846
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- Publication type:
- Article
Contraction stimulates muscle glucose uptake independent of atypical PKC.
- Published in:
- Physiological Reports, 2015, v. 3, n. 11, p. 1, doi. 10.14814/phy2.12565
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- Publication type:
- Article
Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132575
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- Publication type:
- Article
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
- Published in:
- Nature Medicine, 2014, v. 20, n. 10, p. 1157, doi. 10.1038/nm.3672
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- Publication type:
- Article
Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity.
- Published in:
- Diabetes, 2014, v. 63, n. 8, p. 2690, doi. 10.2337/db13-1863
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- Publication type:
- Article
The biophysics and cell biology of lipid droplets.
- Published in:
- Nature Reviews Molecular Cell Biology, 2013, v. 14, n. 12, p. 775, doi. 10.1038/nrm3699
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- Publication type:
- Article
Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations.
- Published in:
- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076055
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- Publication type:
- Article
Balancing the fat: lipid droplets and human disease.
- Published in:
- EMBO Molecular Medicine, 2013, v. 5, n. 7, p. 905, doi. 10.1002/emmm.201100671
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- Publication type:
- Article
Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells.
- Published in:
- Journal of Neuroscience, 2013, v. 33, n. 21, p. 9202, doi. 10.1523/JNEUROSCI.5336-12.2013
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- Publication type:
- Article
Dissociation of Frontotemporal Dementia-Related Deficits and Neuroinflammation in Progranulin Haploinsufficient Mice.
- Published in:
- Journal of Neuroscience, 2013, v. 33, n. 12, p. 5352, doi. 10.1523/JNEUROSCI.6103-11.2013
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- Publication type:
- Article
DGAT1 mutation is linked to a congenital diarrheal disorder.
- Published in:
- Journal of Clinical Investigation, 2012, v. 122, n. 12, p. 4680, doi. 10.1172/JCI64873
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- Publication type:
- Article
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
- Published in:
- Nature Genetics, 2012, v. 44, n. 12, p. 1302, doi. 10.1038/ng.2434
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- Publication type:
- Article
Progranulin deficienc y promotes neuroinflammation and neuron loss following toxin-induced injury.
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- Journal of Clinical Investigation, 2012, v. 122, n. 11, p. 3955, doi. 10.1172/JCI63113
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- Publication type:
- Article
A guide to analysis of mouse energy metabolism.
- Published in:
- Nature Methods, 2012, v. 9, n. 1, p. 57, doi. 10.1038/nmeth.1806
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- Article
A new way to look at fat.
- Published in:
- Nature Methods, 2011, v. 8, n. 2, p. 132, doi. 10.1038/nmeth0211-132
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- Publication type:
- Article
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
- Published in:
- Nature Medicine, 2010, v. 16, n. 11, p. 1295, doi. 10.1038/nm.2238
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- Publication type:
- Article
MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia.
- Published in:
- PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010551
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- Publication type:
- Article
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
- Published in:
- Nature, 2010, v. 464, n. 7285, p. 121, doi. 10.1038/nature08778
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- Publication type:
- Article
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
- Published in:
- 2010
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- Publication type:
- journal article
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
- Published in:
- Nature Medicine, 2009, v. 15, n. 4, p. 442, doi. 10.1038/nm.1937
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- Publication type:
- Article
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
- Published in:
- 2008
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- Publication type:
- Letter
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
- Published in:
- 2007
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- Publication type:
- journal article
Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle.
- Published in:
- Journal of Physiology, 2007, v. 582, n. 3, p. 1289, doi. 10.1113/jphysiol.2007.136614
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- Publication type:
- Article
Adipocyte-Specific Knockout of PKC-lambda Impairs Insulin-Stimulated Glucose Transport and Induces a Metabolic Syndrome.
- Published in:
- Diabetes, 2007, v. 56, p. A35
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- Publication type:
- Article
Evidence that Hypothainmic Atypical Protein Kinase C Limits Food Intake.
- Published in:
- Diabetes, 2007, v. 56, p. A403
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- Publication type:
- Article
Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes.
- Published in:
- Experimental Biology & Medicine, 2005, v. 230, n. 9, p. 593, doi. 10.1177/153537020523000901
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- Publication type:
- Article
Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle.
- Published in:
- Journal of Physiology, 2004, v. 560, n. 3, p. 909, doi. 10.1113/jphysiol.2004.071373
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- Publication type:
- Article
Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.
- Published in:
- 2004
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- Publication type:
- journal article
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO4)3 in Obesity and Polycystic Ovary Syndrome.
- Published in:
- Metabolic Syndrome & Related Disorders, 2004, v. 2, n. 1, p. 49, doi. 10.1089/1540419041978872
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- Publication type:
- Article
Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinsitol-3, 4, 5-(PO[sub4])[sub3] Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance.
- Published in:
- Diabetes, 2003, v. 52, n. 8, p. 1926, doi. 10.2337/diabetes.52.8.1926
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- Publication type:
- Article
Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.
- Published in:
- 2003
- By:
- Publication type:
- journal article
Essential role of protein kinase Cζ in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes
- Published in:
- FEBS Letters, 2003, v. 536, n. 1-3, p. 161, doi. 10.1016/S0014-5793(03)00049-8
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- Publication type:
- Article
Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.
- Published in:
- 2002
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- Publication type:
- journal article
Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.
- Published in:
- 2002
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- Publication type:
- journal article
PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.
- Published in:
- 2002
- By:
- Publication type:
- journal article
Turning WAT into BAT gets rid of fat.
- Published in:
- Nature Medicine, 2001, v. 7, n. 10, p. 1102, doi. 10.1038/nm1001-1102
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- Publication type:
- Article
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
- Published in:
- Nature Medicine, 2000, v. 6, n. 12, p. 1341, doi. 10.1038/82153
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- Publication type:
- Article
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway.
- Published in:
- EMBO Journal, 2000, v. 19, n. 20, p. 5533, doi. 10.1093/emboj/19.20.5533
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- Article