Works by Fanning, Sean W.

Results: 20

Structural Determinants of the Binding and Activation of Estrogen Receptor α by Phenolic Thieno[2,3‐d]pyrimidines.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 9, p. 1, doi. 10.1002/hlca.202300097

By:

Reddy Sammeta, Vamshikrishna;
Anderson, Brian M.;
Norris, John D.;
Torrice, Chad D.;
Joiner, Carstyn;
Liu, Shubin;
Li, Haoxi;
Popov, Konstantin I.;
Fanning, Sean W.;
McDonnell, Donald P.;
Willson, Timothy M.

Publication type:

Article

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52032-y

By:

Safi, Rachid;
Wardell, Suzanne E.;
Watkinson, Paige;
Qin, Xiaodi;
Lee, Marissa;
Park, Sunghee;
Krebs, Taylor;
Dolan, Emma L.;
Blattler, Adam;
Tsuji, Toshiya;
Nayak, Surendra;
Khater, Marwa;
Fontanillo, Celia;
Newlin, Madeline A.;
Kirkland, Megan L.;
Xie, Yingtian;
Long, Henry;
Fink, Emma C.;
Fanning, Sean W.;
Runyon, Scott

Publication type:

Article

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.

Published in:

Endocrinology, 2024, v. 165, n. 6, p. 1, doi. 10.1210/endocr/bqae051

By:

Hancock, Govinda R;
Gertz, Jason;
Jeselsohn, Rinath;
Fanning, Sean W

Publication type:

Article

Next-Generation ERα Inhibitors for Endocrine-Resistant ER<sup>+</sup> Breast Cancer.

Published in:

Endocrinology, 2019, v. 160, n. 4, p. 759, doi. 10.1210/en.2018-01095

By:

Fanning, Sean W;
Greene, Geoffrey L

Publication type:

Article

Editorial: Hormone resistance in cancer.

Published in:

Frontiers in Endocrinology, 2023, p. 1, doi. 10.3389/fendo.2023.1272932

By:

Phoenix, John T.;
Budreika, Audris;
Kostlan, Raymond J.;
Hwang, Justin H.;
Fanning, Sean W.;
Kregel, Steven

Publication type:

Article

Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adk7786

By:

Cai, Yanyan;
Zhao, Peihua;
Wu, Fan;
Zhao, Huiyong;
Shao, Hong;
Marra, Antonio;
Patel, Payal;
O'Connell, Elizabeth;
Fink, Emma;
Miele, Matthew M.;
Li, Zhuoning;
De Stanchina, Elisa;
Cocco, Emiliano;
Razavi, Pedram;
Toska, Eneda;
Fanning, Sean W.;
Xu, Guotai;
Sablina, Anna A.;
Scaltriti, Maurizio;
Chandarlapaty, Sarat

Publication type:

Article

A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches.

Published in:

Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 9, p. 1619, doi. 10.1002/pro.696

By:

Murtaugh, Megan L.;
Fanning, Sean W.;
Sharma, Tressa M.;
Terry, Alexandra M.;
Horn, James R.

Publication type:

Article

An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.

Published in:

Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 7, p. 1196, doi. 10.1002/pro.648

By:

Fanning, Sean W.;
Horn, James R.

Publication type:

Article

Innentitelbild: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. 13/2016).

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4174, doi. 10.1002/ange.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4324, doi. 10.1002/ange.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

The Homeobox Transcription Factor NKX3.1 Displays an Oncogenic Role in Castration-Resistant Prostate Cancer Cells.

Published in:

Cancers, 2025, v. 17, n. 2, p. 306, doi. 10.3390/cancers17020306

By:

Budreika, Audris;
Phoenix, John T.;
Kostlan, Raymond J.;
Deegan, Carleen D.;
Ferrari, Marina G.;
Young, Kristen S.;
Fanning, Sean W.;
Kregel, Steven

Publication type:

Article

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.72512

By:

Hosfield, David J.;
Weber, Sandra;
Nan Sheng Li;
Suavage, Madline;
Joiner, Carstyn F.;
Hancock, Govinda R.;
Sullivan, Emily A.;
Ndukwe, Estelle;
Han, Ross;
Cush, Sydney;
Lainé, Muriel;
Mader, Sylvie C.;
Greene, Geoffrey L.;
Fanning, Sean W.

Publication type:

Article

Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.

Published in:

Breast Cancer Research, 2025, v. 27, n. 1, p. 1, doi. 10.1186/s13058-024-01945-z

By:

Young, K. S.;
Hancock, G. R.;
Fink, E. C.;
Zigrossi, A.;
Flowers, B.;
Cooper, D. A.;
Nguyen, V. T.;
Martinez, M. C.;
Mon, K. S.;
Bosland, M.;
Zak, D. R.;
Runde, A. P.;
Sharifi, M. N.;
Kastrati, I.;
Minh, D. D. L.;
Kregel, S.;
Fanning, Sean W.

Publication type:

Article

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.12792

By:

Fanning, Sean W.;
Mayne, Christopher G.;
Dharmarajan, Venkatasubramanian;
Carlson, Kathryn E.;
Martin, Teresa A.;
Novick, Scott J.;
Weiyi Toy;
Green, Bradley;
Panchamukhi, Srinivas;
Katzenellenbogen, Benita S.;
Tajkhorshid, Emad;
Griffin, Patrick R.;
Yang Shen;
Chandarlapaty, Sarat;
Katzenellenbogen, John A.;
Greene, Geoffrey L.

Publication type:

Article

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.

Published in:

Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abf1383

By:

Boudreau, Matthew W.;
Duraki, Darjan;
Wang, Lawrence;
Mao, Chengjian;
Kim, Ji Eun;
Henn, Madeline A.;
Tang, Bingtao;
Fanning, Sean W.;
Kiefer, Jeffrey;
Tarasow, Theodore M.;
Bruckheimer, Elizabeth M.;
Moreno, Ramon;
Mousses, Spyro;
Greene, Geoffrey L.;
Roy, Edward J.;
Park, Ben Ho;
Fan, Timothy M.;
Nelson, Erik R.;
Hergenrother, Paul J.;
Shapiro, David J.

Publication type:

Article

Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.

Published in:

2021

By:

Lainé, Muriel;
Fanning, Sean W;
Chang, Ya-Fang;
Green, Bradley;
Greene, Marianne E;
Komm, Barry;
Kurleto, Justyna D;
Phung, Linda;
Greene, Geoffrey L

Publication type:

journal article

Inside Cover: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. Int. Ed. 13/2016).

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4104, doi. 10.1002/anie.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4252, doi. 10.1002/anie.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.

Published in:

PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 10, p. 391, doi. 10.1093/protein/gzu033

By:

Fanning, Sean W.;
Walter, Richard;
Horn, James R.

Publication type:

Article

Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.

Published in:

Nature Biotechnology, 2023, v. 41, n. 4, p. 541, doi. 10.1038/s41587-022-01504-x

By:

Speltz, Thomas E.;
Qiao, Zeyu;
Swenson, Colin S.;
Shangguan, Xianghang;
Coukos, John S.;
Lee, Christopher W.;
Thomas, Deborah M.;
Santana, Jesse;
Fanning, Sean W.;
Greene, Geoffrey L.;
Moellering, Raymond E.

Publication type:

Article