Works by Fan, Heng-Yu

Results: 47

RNA G-quadruplex removal promotes a translational switch after meiosis resumption Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 8, p. 1, doi. 10.1093/nar/gkaf067

By:

Lu, Qiong-Wen;
Liu, Shao-Yuan;
Liao, Xiu-Quan;
Chen, Jing;
Jiang, Zhi-Yan;
Wu, Yu-Ke;
Fan, Heng-Yu;
Lu, Yu-Jing;
Sha, Qian-Qian

Publication type:

Article

Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency.

Published in:

Advanced Science, 2024, v. 11, n. 14, p. 1, doi. 10.1002/advs.202308496

By:

Zhang, Hua;
Wang, Yang;
Hu, Zhe‐Wei;
Wu, Yun‐Wen;
Chen, Nuo;
Zhu, Yi‐Min;
Yu, Yuan‐Song;
Fan, Heng‐Yu;
Wang, Hua‐Nan

Publication type:

Article

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.

Published in:

Advanced Science, 2021, v. 8, n. 10, p. 1, doi. 10.1002/advs.202003636

By:

Dai, Xing‐Xing;
Jiang, Yu;
Gu, Jia‐Hui;
Jiang, Zhi‐Yan;
Wu, Yun‐Wen;
Yu, Chao;
Yin, Hao;
Zhang, Jue;
Shi, Qing‐Hua;
Shen, Li;
Sha, Qian‐Qian;
Fan, Heng‐Yu

Publication type:

Article

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.

Published in:

Advanced Science, 2021, v. 8, n. 10, p. 1, doi. 10.1002/advs.202003636

By:

Dai, Xing‐Xing;
Jiang, Yu;
Gu, Jia‐Hui;
Jiang, Zhi‐Yan;
Wu, Yun‐Wen;
Yu, Chao;
Yin, Hao;
Zhang, Jue;
Shi, Qing‐Hua;
Shen, Li;
Sha, Qian‐Qian;
Fan, Heng‐Yu

Publication type:

Article

RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation.

Published in:

Advanced Science, 2019, v. 6, n. 15, p. N.PAG, doi. 10.1002/advs.201900295

By:

Liu, Hong‐Bin;
Muhammad, Tahir;
Guo, Yueshuai;
Li, Meng‐Jing;
Sha, Qian‐Qian;
Zhang, Chuan‐Xin;
Liu, Hui;
Zhao, Shi‐Gang;
Zhao, Han;
Zhang, Hao;
Du, Yan‐Zhi;
Sun, Kang;
Liu, Kui;
Lu, Gang;
Guo, Xue‐Jiang;
Sha, Jiahao;
Fan, Heng‐Yu;
Gao, Fei;
Chen, Zi‐Jiang

Publication type:

Article

DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.

Published in:

Cell Proliferation, 2024, v. 57, n. 10, p. 1, doi. 10.1111/cpr.13676

By:

Wei, Hongwei;
Wang, Zhijuan;
Huang, Yating;
Gao, Longwei;
Wang, Weiyong;
Liu, Shuang;
Sun, Yan‐Li;
Liu, Huiyu;
Weng, Yashuang;
Fan, Heng‐Yu;
Zhang, Meijia

Publication type:

Article

A long-acting recombinant FSH supports high-quality mouse follicle development and oocyte maturation in vitro by coordinating somatic and germ cell transcriptomes.

Published in:

Molecular Human Reproduction, 2023, v. 29, n. 6, p. 1, doi. 10.1093/molehr/gaad013

By:

Liu, Shao-Yuan;
Li, Yan-Chu;
Tian, Xin-Yi;
Zhou, Yong;
Guo, Kang-Ping;
Fan, Heng-Yu;
Liang, Xing-Wei;
Ou, Xiang-Hong;
Sha, Qian-Qian

Publication type:

Article

High salt primes a specific activation state of macrophages, M(Na).

Published in:

Cell Research, 2015, v. 25, n. 8, p. 893, doi. 10.1038/cr.2015.87

By:

Zhang, Wu-Chang;
Zheng, Xiao-Jun;
Du, Lin-Juan;
Sun, Jian-Yong;
Shen, Zhu-Xia;
Shi, Chaoji;
Sun, Shuyang;
Zhang, Zhiyuan;
Chen, Xiao-qing;
Qin, Mu;
Liu, Xu;
Tao, Jun;
Jia, Lijun;
Fan, Heng-yu;
Zhou, Bin;
Yu, Ying;
Ying, Hao;
Hui, Lijian;
Liu, Xiaolong;
Yi, Xianghua

Publication type:

Article

Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest.

Published in:

Human Mutation, 2022, v. 43, n. 12, p. 1909, doi. 10.1002/humu.24448

By:

Tong, Xiaomei;
Jin, Jiamin;
Hu, Zhanhong;
Zhang, Yingyi;
Fan, Heng‐Yu;
Zhang, Yin‐Li;
Zhang, Songying

Publication type:

Article

Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0154-z

By:

Zhang, Qianting;
Shao, Jingchen;
Fan, Heng-Yu;
Yu, Chao

Publication type:

Article

CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05930-x

By:

Sha, Qian-Qian;
Dai, Xing-Xing;
Jiang, Jun-Chao;
Yu, Chao;
Jiang, Yu;
Liu, Junping;
Ou, Xiang-Hong;
Zhang, Song-Ying;
Fan, Heng-Yu

Publication type:

Article

Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis.

Published in:

BioEssays, 2021, v. 43, n. 6, p. 1, doi. 10.1002/bies.202000335

By:

Zhao, Long‐Wen;
Fan, Heng‐Yu

Publication type:

Article

CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.

Published in:

EMBO Journal, 2018, v. 37, n. 24, p. N.PAG, doi. 10.15252/embj.201899333

By:

Sha, Qian‐Qian;
Yu, Jia‐Li;
Guo, Jing‐Xin;
Dai, Xing‐Xing;
Jiang, Jun‐Chao;
Zhang, Yin‐Li;
Yu, Chao;
Ji, Shu‐Yan;
Jiang, Yu;
Zhang, Song‐Ying;
Shen, Li;
Ou, Xiang‐Hong;
Fan, Heng‐Yu

Publication type:

Article

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

Published in:

EMBO Journal, 2018, v. 37, n. 18, p. 1, doi. 10.15252/embj.201898981

By:

Zhang, Yin‐Li;
Zhao, Long‐Wen;
Zhang, Jue;
Le, Rongrong;
Ji, Shu‐Yan;
Chen, Chuan;
Gao, Yawei;
Li, Dali;
Gao, Shaorong;
Fan, Heng‐Yu

Publication type:

Article

PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal‐to‐zygotic transition.

Published in:

EMBO Reports, 2020, v. 21, n. 8, p. 1, doi. 10.15252/embr.201949956

By:

Zhao, Long‐Wen;
Zhu, Ye‐Zhang;
Chen, Hao;
Wu, Yun‐Wen;
Pi, Shuai‐Bo;
Chen, Lu;
Shen, Li;
Fan, Heng‐Yu

Publication type:

Article

Correction: YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients.

Published in:

2016

By:

Xia, Yan;
Chang, Ting;
Wang, Yingmei;
Liu, Yixiong;
Li, Wenhui;
Li, Ming;
Fan, Heng-Yu

Publication type:

Correction Notice

Inhibitory effects of cAMP and protein kinase C on meiotic maturation and MAP kinase phosphorylation in porcine oocytes.

Published in:

Molecular Reproduction & Development, 2002, v. 63, n. 4, p. 480, doi. 10.1002/mrd.10194

By:

Fan, Heng-Yu;
Li, Man-Yu;
Tong, Chao;
Chen, Da-Yuan;
Xia, Guo-Liang;
Song, Xiang-Fen;
Schatten, Heide;
Sun, Qing-Yuan

Publication type:

Article

ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation.

Published in:

Advanced Science, 2025, v. 12, n. 8, p. 1, doi. 10.1002/advs.202410305

By:

Rong, Yan;
Wu, Yu‐Ke;
Chen, Yingyan;
Liu, Qing;
Ai, Leilei;
Wu, Yun‐Wen;
Zhu, Yezhang;
Zhang, Yin‐Li;
Liu, Chengkan;
Ma, Yerong;
Tong, Xiaomei;
Jin, Jiamin;
Li, Xiaoxuan;
Zhou, Yan;
Ji, Shu‐Yan;
Zhang, Songying;
Fan, Heng‐Yu

Publication type:

Article

PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac<sup>4</sup>C Formation in Mammalian Cells.

Published in:

Advanced Science, 2024, v. 11, n. 47, p. 1, doi. 10.1002/advs.202400133

By:

Jiang, Zhi‐Yan;
Wu, Yu‐Ke;
Deng, Zuo‐Qi;
Chen, Lu;
Zhu, Yi‐Min;
Yu, Yuan‐Song;
Wu, Hong‐Bo;
Fan, Heng‐Yu

Publication type:

Article

Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42179-w

By:

Liu, Yang;
Zhao, Long-Wen;
Shen, Jing-Ling;
Fan, Heng-Yu;
Jin, Yan

Publication type:

Article

Revisiting ZAR proteins: the understudied regulator of female fertility and beyond.

Published in:

2022

By:

Wu, Yu-Ke;
Fan, Heng-Yu

Publication type:

Literature Review

CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner.

Published in:

Cellular & Molecular Life Sciences, 2020, v. 77, n. 15, p. 2997, doi. 10.1007/s00018-019-03322-y

By:

Sha, Qian-Qian;
Jiang, Yu;
Yu, Chao;
Xiang, Yunlong;
Dai, Xing-Xing;
Jiang, Jun-Chao;
Ou, Xiang-Hong;
Fan, Heng-Yu

Publication type:

Article

The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.

Published in:

Cellular & Molecular Life Sciences, 2020, v. 77, n. 11, p. 2181, doi. 10.1007/s00018-019-03280-5

By:

Zhang, Jue;
Zhang, Yin-Li;
Zhao, Long-Wen;
Pi, Shuai-Bo;
Zhang, Song-Ying;
Tong, Chao;
Fan, Heng-Yu

Publication type:

Article

NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 19, p. 10896, doi. 10.1093/nar/gkac594

By:

Chen, Lu;
Wang, Wen-Jing;
Liu, Qiang;
Wu, Yu-Ke;
Wu, Yun-Wen;
Jiang, Yu;
Liao, Xiu-Quan;
Huang, Fei;
Li, Yang;
Shen, Li;
Yu, Chao;
Zhang, Song-Ying;
Yan, Li-Ying;
Qiao, Jie;
Sha, Qian-Qian;
Fan, Heng-Yu

Publication type:

Article

Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 1, p. 458, doi. 10.1093/nar/gkab1213

By:

Zhao, Long-Wen;
Zhu, Ye-Zhang;
Wu, Yun-Wen;
Pi, Shuai-Bo;
Shen, Li;
Fan, Heng-Yu

Publication type:

Article

Oocyte meiosis-coupled poly(A) polymerase α phosphorylation and activation trigger maternal mRNA translation in mice.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 10, p. 5867, doi. 10.1093/nar/gkab431

By:

Jiang, Jun-Chao;
Zhang, Hua;
Cao, Lan-Rui;
Dai, Xing-Xing;
Zhao, Long-Wen;
Liu, Hong-Bin;
Fan, Heng-Yu

Publication type:

Article

Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 5, p. 2569, doi. 10.1093/nar/gkab107

By:

Sha, Qian-Qian;
Zhu, Ye-Zhang;
Xiang, Yunlong;
Yu, Jia-Li;
Fan, Xiao-Ying;
Li, Yan-Chu;
Wu, Yun-Wen;
Shen, Li;
Fan, Heng-Yu

Publication type:

Article

Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 2, p. 879, doi. 10.1093/nar/gkz1111

By:

Sha, Qian-Qian;
Zhu, Ye-Zhang;
Li, Sen;
Jiang, Yu;
Chen, Lu;
Sun, Xiao-Hong;
Shen, Li;
Ou, Xiang-Hong;
Fan, Heng-Yu

Publication type:

Article

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 21, p. 11387, doi. 10.1093/nar/gkz863

By:

Rong, Yan;
Ji, Shu-Yan;
Zhu, Ye-Zhang;
Wu, Yun-Wen;
Shen, Li;
Fan, Heng-Yu

Publication type:

Article

A combinatorial code for mRNA 3′-UTR-mediated translational control in the mouse oocyte.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 1, p. 328, doi. 10.1093/nar/gky971

By:

Dai, Xing-Xing;
Jiang, Jun-Chao;
Sha, Qian-Qian;
Jiang, Yu;
Ou, Xiang-Hong;
Fan, Heng-Yu

Publication type:

Article

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 11, p. e120, doi. 10.1093/nar/gkt258

By:

Qiu, Zhongwei;
Liu, Meizhen;
Chen, Zhaohua;
Shao, Yanjiao;
Pan, Hongjie;
Wei, Gaigai;
Yu, Chao;
Zhang, Long;
Li, Xia;
Wang, Ping;
Fan, Heng-Yu;
Du, Bing;
Liu, Bin;
Liu, Mingyao;
Li, Dali

Publication type:

Article

CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.

Published in:

Nature Communications, 2015, v. 6, n. 8, p. 8017, doi. 10.1038/ncomms9017

By:

Yu, Chao;
Ji, Shu-Yan;
Sha, Qian-Qian;
Sun, Qing-Yuan;
Fan, Heng-Yu

Publication type:

Article

Biallelic variants in MOS cause large polar body in oocyte and human female infertility.

Published in:

2022

By:

Zhang, Yin-Li;
Zheng, Wei;
Ren, Peipei;
Jin, Jiamin;
Hu, Zhanhong;
Liu, Qing;
Fan, Heng-Yu;
Gong, Fei;
Lu, Guang-Xiu;
Lin, Ge;
Zhang, Songying;
Tong, Xiaomei

Publication type:

journal article

Erratum. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK.

Published in:

2020

By:

Jin, Jiamin;
Ma, Yerong;
Tong, Xiaomei;
Yang, Weijie;
Dai, Yongdong;
Pan, Yibin;
Ren, Peipei;
Liu, Liu;
Fan, Heng-Yu;
Zhang, Yinli;
Zhang, Songying

Publication type:

journal article

Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK.

Published in:

2020

By:

Jin, Jiamin;
Ma, Yerong;
Tong, Xiaomei;
Yang, Weijie;
Dai, Yongdong;
Pan, Yibin;
Ren, Peipei;
Liu, Liu;
Fan, Heng-Yu;
Zhang, Yinli;
Zhang, Songying

Publication type:

journal article

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18680-6

By:

Sha, Qian-Qian;
Zheng, Wei;
Wu, Yun-Wen;
Li, Sen;
Guo, Lei;
Zhang, Shuoping;
Lin, Ge;
Ou, Xiang-Hong;
Fan, Heng-Yu

Publication type:

Article

YAP/TEAD Co-Activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0109575

By:

Xia, Yan;
Zhang, Yin-Li;
Yu, Chao;
Chang, Ting;
Fan, Heng-Yu

Publication type:

Article

YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0091770

By:

Xia, Yan;
Chang, Ting;
Wang, Yingmei;
Liu, Yixiong;
Li, Wenhui;
Li, Ming;
Fan, Heng-Yu

Publication type:

Article

CRL4<sup>DCAF13</sup> E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05185-4

By:

Ren, Peipei;
Tong, Xiaomei;
Li, Junjian;
Jiang, Huifang;
Liu, Siya;
Li, Xiang;
Lai, Mengru;
Yang, Weijie;
Rong, Yan;
Zhang, Yingyi;
Jin, Jiamin;
Ma, Yerong;
Pan, Weiwei;
Fan, Heng-Yu;
Zhang, Songying;
Zhang, Yin-Li

Publication type:

Article

Development and characterization of a novel long-acting recombinant follicle stimulating hormone agonist by fusing Fc to an FSH-β subunit.

Published in:

2016

By:

Yin-Li Zhang;
Kang-Ping Guo;
Shu-Yan Ji;
Xiao-Man Liu;
PilinWang;
Jie Wu;
Li Gao;
Tian-Qi Jiang;
Ting Xu;
Heng-Yu Fan;
Zhang, Yin-Li;
Guo, Kang-Ping;
Ji, Shu-Yan;
Liu, Xiao-Man;
Wang, Pilin;
Wu, Jie;
Gao, Li;
Jiang, Tian-Qi;
Xu, Ting;
Fan, Heng-Yu

Publication type:

journal article

CPEB3 Maintains Developmental Competence of the Oocyte.

Published in:

Cells (2073-4409), 2024, v. 13, n. 10, p. 850, doi. 10.3390/cells13100850

By:

Lamacova, Lucie;
Jansova, Denisa;
Jiang, Zongliang;
Dvoran, Michal;
Aleshkina, Daria;
Iyyappan, Rajan;
Jindrova, Anna;
Fan, Heng-Yu;
Jiao, Yuxuan;
Susor, Andrej

Publication type:

Article

Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34427-x

By:

Zhang, Jue;
Pi, Shuai-Bo;
Zhang, Nan;
Guo, Jing;
Zheng, Wei;
Leng, Lizhi;
Lin, Ge;
Fan, Heng-Yu

Publication type:

Article

Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30928-x

By:

Wu, Yun-Wen;
Li, Sen;
Zheng, Wei;
Li, Yan-Chu;
Chen, Lu;
Zhou, Yong;
Deng, Zuo-Qi;
Lin, Ge;
Fan, Heng-Yu;
Sha, Qian-Qian

Publication type:

Article

Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30928-x

By:

Wu, Yun-Wen;
Li, Sen;
Zheng, Wei;
Li, Yan-Chu;
Chen, Lu;
Zhou, Yong;
Deng, Zuo-Qi;
Lin, Ge;
Fan, Heng-Yu;
Sha, Qian-Qian

Publication type:

Article

Publisher Correction: Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.

Published in:

2022

By:

Wu, Yun-Wen;
Li, Sen;
Zheng, Wei;
Li, Yan-Chu;
Chen, Lu;
Zhou, Yong;
Deng, Zuo-Qi;
Lin, Ge;
Fan, Heng-Yu;
Sha, Qian-Qian

Publication type:

Correction Notice

Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30928-x

By:

Wu, Yun-Wen;
Li, Sen;
Zheng, Wei;
Li, Yan-Chu;
Chen, Lu;
Zhou, Yong;
Deng, Zuo-Qi;
Lin, Ge;
Fan, Heng-Yu;
Sha, Qian-Qian

Publication type:

Article

CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.

Published in:

Molecular Human Reproduction, 2014, v. 20, n. 9, p. 850, doi. 10.1093/molehr/gau040

By:

Zhang, Yin-Li;
Xia, Yan;
Yu, Chao;
Richards, JoAnne S.;
Liu, Junping;
Fan, Heng-Yu

Publication type:

Article