Works matching AU Fairlamb, Alan H.

Results: 52

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis.

Published in:

Science Translational Medicine, 2012, v. 4, n. 119, p. 1, doi. 10.1126/scitranslmed.3003326

By:

Wyllie, Susan;
Patterson, Stephen;
Stojanovski, Laste;
Simeons, Frederick R. C.;
Norval, Suzanne;
Kime, Robert;
Read, Kevin D.;
Fairlamb, Alan H.

Publication type:

Article

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

Published in:

EMBO Journal, 1997, v. 16, n. 10, p. 2590, doi. 10.1093/emboj/16.10.2590

By:

Dumas, Carole;
Ouellette, Marc;
Tovar, Jorge;
Cunningham, Mark L.;
Fairlamb, Alan H.;
Tamar, Samira;
Olivier, Martin;
Papadopoulou, Barbara

Publication type:

Article

Very Short and Efficient Syntheses of the Spermine Alkaloid Kukoamine A and Analogs Using Isolable Succinimidyl Cinnamates.

Published in:

Chemistry Letters, 2005, v. 34, n. 2, p. 264, doi. 10.1246/cl.2005.264

By:

Garnelis, Thomas;
Athanassopoulos, Constantinos M.;
Papaioannou, Dionissios;
Eggleston, Ian M.;
Fairlamb, Alan H.

Publication type:

Article

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.

Published in:

Molecular Microbiology, 2006, v. 61, n. 6, p. 1457, doi. 10.1111/j.1365-2958.2006.05332.x

By:

Dawson, Alice;
Gibellini, Federica;
Sienkiewicz, Natasha;
Tulloch, Lindsay B.;
Fyfe, Paul K.;
McLuskey, Karen;
Fairlamb, Alan H.;
Hunter, William N.

Publication type:

Article

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.

Published in:

Molecular Microbiology, 2006, v. 59, n. 4, p. 1239, doi. 10.1111/j.1365-2958.2006.05022.x

By:

Ariza, Antonio;
Vickers, Tim J.;
Greig, Neil;
Armour, Kirsten A.;
Dixon, Mark J.;
Eggleston, Ian M.;
Fairlamb, Alan H.;
Bond, Charles S.

Publication type:

Article

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.

Published in:

Molecular Microbiology, 1998, v. 29, n. 2, p. 653, doi. 10.1046/j.1365-2958.1998.00968.x

By:

Tovar, Jorge;
Wilkinson, Shane;
Mottram, Jeremy C.;
Fairlamb, Alan H.

Publication type:

Article

Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003518

By:

Perry, Meghan R.;
Prajapati, Vijay K.;
Menten, Joris;
Raab, Andrea;
Feldmann, Joerg;
Chakraborti, Dipankar;
Sundar, Shyam;
Fairlamb, Alan H.;
Boelaert, Marleen;
Picado, Albert

Publication type:

Article

Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003518

By:

Perry, Meghan R.;
Prajapati, Vijay K.;
Menten, Joris;
Raab, Andrea;
Feldmann, Joerg;
Chakraborti, Dipankar;
Sundar, Shyam;
Fairlamb, Alan H.;
Boelaert, Marleen;
Picado, Albert

Publication type:

Article

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 11, p. 1, doi. 10.1371/journal.pntd.0001932

By:

De Rycker, Manu;
O'Neill, Sandra;
Joshi, Dhananjay;
Campbell, Lorna;
Gray, David W.;
Fairlamb, Alan H.

Publication type:

Article

A Static-Cidal Assay for <i>Trypanosoma brucei</i> to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 11, p. 1, doi. 10.1371/journal.pntd.0001932

By:

De Rycker, Manu;
O'Neill, Sandra;
Joshi, Dhananjay;
Campbell, Lorna;
Gray, David W.;
Fairlamb, Alan H.

Publication type:

Article

A comparative study of methylglyoxal metabolism in trypanosomatids.

Published in:

FEBS Journal, 2009, v. 276, n. 2, p. 376, doi. 10.1111/j.1742-4658.2008.06788.x

By:

Greig, Neil;
Wyllie, Susan;
Patterson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.

Published in:

FEBS Journal, 2008, v. 275, n. 21, p. 5408, doi. 10.1111/j.1742-4658.2008.06670.x

By:

Oza, Sandra L.;
Chen, Shoujun;
Wyllie, Susan;
Coward, James K.;
Fairlamb, Alan H.

Publication type:

Article

A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.

Published in:

FEBS Journal, 2007, v. 274, n. 21, p. 5643, doi. 10.1111/j.1742-4658.2007.06087.x

By:

König, Janine;
Fairlamb, Alan H.

Publication type:

Article

New approach to screening drugs for activity against African trypanosomes.

Published in:

Nature, 1977, v. 265, n. 5591, p. 270, doi. 10.1038/265270a0

By:

FAIRLAMB, ALAN H.;
OPPERDOES, FRED R.;
BORST, PIET

Publication type:

Article

Extrachromosomal, Homologous Expression of Trypanothione Reductase and Its Complementary mRNA in Trypanosoma Cruzi.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 3, p. 2942, doi. 10.1093/nar/24.15.2942

By:

Tovar, Jorge;
Fairlamb, Alan H.

Publication type:

Article

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 1, p. 1, doi. 10.1371/journal.pntd.0001932

By:

De Rycker, Manu;
O¿Neill, Sandra;
Joshi, Dhananjay;
Campbell, Lorna;
Gray, David W.;
Fairlamb, Alan H.

Publication type:

Article

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 9, p. 1, doi. 10.1371/journal.pntd.0001227

By:

Perry, Meghan R.;
Wyllie, Susan;
Prajapati, Vijay Kumar;
Feldmann, Joerg;
Sundar, Shyam;
Boelaert, Marleen;
Fairlamb, Alan H.

Publication type:

Article

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

Published in:

2011

By:

Perry, Meghan R.;
Wyllie, Susan;
Prajapati, Vijay Kumar;
Feldmann, Joerg;
Sundar, Shyam;
Boelaert, Marleen;
Fairlamb, Alan H.

Publication type:

Opinion

Arsenical-resistant trypanosomes lack an unusual adenosine transporter.

Published in:

Nature, 1993, v. 361, n. 6408, p. 173, doi. 10.1038/361173a0

By:

Carter, Nicola S.;
Fairlamb, Alan H.

Publication type:

Article

Trypanosoma Cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals.

Published in:

Free Radical Research, 2001, v. 34, n. 4, p. 363, doi. 10.1080/10715760100300311

By:

Gutierrez-Correa, Jose;
Fairlamb, Alan H.;
Stoppani, Andres O.M.

Publication type:

Article

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.

Published in:

Molecular Microbiology, 2015, v. 95, n. 1, p. 143, doi. 10.1111/mmi.12853

By:

Ong, Han B.;
Lee, Wai S.;
Patterson, Stephen;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Trypanosoma brucei ( UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.

Published in:

Molecular Microbiology, 2013, v. 90, n. 2, p. 443, doi. 10.1111/mmi.12376

By:

Ong, Han B.;
Sienkiewicz, Natasha;
Wyllie, Susan;
Patterson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome.

Published in:

Molecular Microbiology, 2012, v. 86, n. 1, p. 51, doi. 10.1111/j.1365-2958.2012.08189.x

By:

Jones, Deuan C.;
Alphey, Magnus S.;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice.

Published in:

Molecular Microbiology, 2010, v. 77, n. 3, p. 658, doi. 10.1111/j.1365-2958.2010.07236.x

By:

Sienkiewicz, Natasha;
Ong, Han B.;
Fairlamb, Alan H.

Publication type:

Article

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Published in:

Molecular Microbiology, 2009, v. 74, n. 3, p. 529, doi. 10.1111/j.1365-2958.2009.06761.x

By:

Wyllie, Susan;
Oza, Sandra L.;
Patterson, Stephen;
Spinks, Daniel;
Thompson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes.

Published in:

Molecular Microbiology, 2008, v. 69, n. 2, p. 520, doi. 10.1111/j.1365-2958.2008.06305.x

By:

Sienkiewicz, Natasha;
Jarosławski, Szymon;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8‐Nitroquinolin‐2(1H)‐one Scaffold Using Palladium‐Catalysed Cross‐Coupling Reactions.

Published in:

ChemMedChem, 2018, v. 13, n. 20, p. 2217, doi. 10.1002/cmdc.201800456

By:

Pedron, Julien;
Boudot, Clotilde;
Bourgeade‐Delmas, Sandra;
Sournia‐Saquet, Alix;
Paloque, Lucie;
Rastegari, Maryam;
Abdoulaye, Mansour;
El‐Kashef, Hussein;
Bonduelle, Colin;
Pratviel, Geneviève;
Wyllie, Susan;
Fairlamb, Alan H.;
Courtioux, Bertrand;
Verhaeghe, Pierre;
Valentin, Alexis

Publication type:

Article

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors.

Published in:

ChemMedChem, 2012, v. 7, n. 1, p. 95, doi. 10.1002/cmdc.201100420

By:

Spinks, Daniel;
Torrie, Leah S.;
Thompson, Stephen;
Harrison, Justin R.;
Frearson, Julie A.;
Read, Kevin D.;
Fairlamb, Alan H.;
Wyatt, Paul G.;
Gilbert, Ian H.

Publication type:

Article

Optimisation of the Anti- Trypanosoma brucei Activity of the Opioid Agonist U50488.

Published in:

ChemMedChem, 2011, v. 6, n. 10, p. 1832, doi. 10.1002/cmdc.201100278

By:

Smith, Victoria C.;
Cleghorn, Laura A. T.;
Woodland, Andrew;
Spinks, Daniel;
Hallyburton, Irene;
Collie, Iain T.;
Yi Mok, N.;
Norval, Suzanne;
Brenk, Ruth;
Fairlamb, Alan H.;
Frearson, Julie A.;
Read, Kevin D.;
Gilbert, Ian H.;
Wyatt, Paul G.

Publication type:

Article

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1.

Published in:

ChemMedChem, 2011, v. 6, n. 2, p. 302, doi. 10.1002/cmdc.201000450

By:

Spinks, Daniel;
Ong, Han B.;
Mpamhanga, Chidochangu P.;
Shanks, Emma J.;
Robinson, David A.;
Collie, Iain T.;
Read, Kevin D.;
Frearson, Julie A.;
Wyatt, Paul G.;
Brenk, Ruth;
Fairlamb, Alan H.;
Gilbert, Ian H.

Publication type:

Article

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase.

Published in:

ChemMedChem, 2011, v. 6, n. 2, p. 321, doi. 10.1002/cmdc.201000442

By:

Walton, Jeffrey G. A.;
Jones, Deuan C.;
Kiuru, Paula;
Durie, Alastair J.;
Westwood, Nicholas J.;
Fairlamb, Alan H.

Publication type:

Article

Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)

Published in:

ChemMedChem, 2011, v. 6, n. 2, p. 209, doi. 10.1002/cmdc.201190000

By:

Walton, Jeffrey G. A.;
Jones, Deuan C.;
Kiuru, Paula;
Durie, Alastair J.;
Westwood, Nicholas J.;
Fairlamb, Alan H.;
Spinks, Daniel;
Ong, Han B.;
Mpamhanga, Chidochangu P.;
Shanks, Emma J.;
Robinson, David A.;
Collie, Iain T.;
Read, Kevin D.;
Frearson, Julie A.;
Wyatt, Paul G.;
Brenk, Ruth;
Gilbert, Ian H.;
Ruda, Gian Filippo;
Nguyen, Corinne;
Ziemkowski, Przemysław

Publication type:

Article

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei.

Published in:

ChemMedChem, 2009, v. 4, n. 12, p. 2060, doi. 10.1002/cmdc.200900262

By:

Spinks, Daniel;
Shanks, Emma J.;
Cleghorn, Laura A. T.;
McElroy, Stuart;
Jones, Deuan;
James, Daniel;
Fairlamb, Alan H.;
Frearson, Julie A.;
Wyatt, Paul G.;
Gilbert, Ian H.

Publication type:

Article

Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

Published in:

ChemMedChem, 2009, v. 4, n. 8, p. 1209, doi. 10.1002/cmdc.200990035

By:

Richardson, John L.;
Nett, Isabelle R. E.;
Jones, Deuan C.;
Abdille, Mohamed H.;
Gilbert, Ian H.;
Fairlamb, Alan H.;
Patterson, Stephen;
Shanks, Emma J.;
Frearson, Julie A.;
Wyatt, Paul G.

Publication type:

Article

Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase.

Published in:

ChemMedChem, 2009, v. 4, n. 8, p. 1341, doi. 10.1002/cmdc.200900098

By:

Patterson, Stephen;
Jones, Deuan C.;
Shanks, Emma J.;
Frearson, Julie A.;
Gilbert, Ian H.;
Wyatt, Paul G.;
Fairlamb, Alan H.

Publication type:

Article

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis.

Published in:

ChemMedChem, 2009, v. 4, n. 8, p. 1333, doi. 10.1002/cmdc.200900097

By:

Richardson, John L.;
Nett, Isabelle R. E.;
Jones, Deuan C.;
Abdille, Mohamed H.;
Gilbert, Ian H.;
Fairlamb, Alan H.

Publication type:

Article

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.

Published in:

PLoS Pathogens, 2024, v. 20, n. 7, p. 1, doi. 10.1371/journal.ppat.1012382

By:

Tulloch, Lindsay B.;
Tinti, Michele;
Wall, Richard J.;
Weidt, Stefan K.;
Corpas- Lopez, Victoriano;
Dey, Gourav;
Smith, Terry K.;
Fairlamb, Alan H.;
Barrett, Michael P.;
Wyllie, Susan

Publication type:

Article

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Published in:

Nucleic Acids Research, 2015, v. 43, n. D1, p. D637, doi. 10.1093/nar/gku944

By:

Shameer, Sanu;
Logan-Klumpler, Flora J.;
Vinson, Florence;
Cottret, Ludovic;
Merlet, Benjamin;
Achcar, Fiona;
Boshart, Michael;
Berriman, Matthew;
Breitling, Rainer;
Bringaud, Frédéric;
Bütikofer, Peter;
Cattanach, Amy M.;
Bannerman-Chukualim, Bridget;
Creek, Darren J.;
Crouch, Kathryn;
de Koning, Harry P.;
Denise, Hubert;
Ebikeme, Charles;
Fairlamb, Alan H.;
Ferguson, Michael A. J.

Publication type:

Article

Validation of Trypanosoma cruzi inactivation techniques for laboratory use.

Published in:

PLoS ONE, 2024, v. 19, n. 4, p. 1, doi. 10.1371/journal.pone.0300021

By:

MacLean, Lorna M.;
Ariyanayagam, Mark;
Sastry, Lalitha;
Paterson, Christy;
De Rycker, Manu;
Fairlamb, Alan H.

Publication type:

Article

Triclosan is minimally effective in rodent malaria models.

Published in:

2011

By:

Baschong, Werner;
Wittlin, Sergio;
Inglis, Kirstine A;
Fairlamb, Alan H;
Croft, Simon L;
Kumar, T R Santha;
Fidock, David A;
Brun, Reto

Publication type:

Letter

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Published in:

Biochemical Journal, 2018, v. 475, n. 16, p. 2593, doi. 10.1042/BCJ20180232

By:

Roberts, Adam J.;
Dunne, Joanne;
Scullion, Paul;
Norval, Suzanne;
Fairlamb, Alan H.

Publication type:

Article

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.

Published in:

Biochemical Journal, 2014, v. 459, n. 2, p. 323, doi. 10.1042/BJ20131033

By:

ROBERTS, Adam J.;
TORRIE, Leah S.;
WYLLIE, Susan;
FAIRLAMB, Alan H.

Publication type:

Article

Infectious disease: Genomics decodes drug action.

Published in:

Nature, 2012, v. 482, n. 7384, p. 167, doi. 10.1038/482167a

By:

Fairlamb, Alan H.

Publication type:

Article

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.09744

By:

Patterson, Stephen;
Wyllie, Susan;
Norval, Suzanne;
Stojanovski, Laste;
Simeons, Frederick R. C.;
Auer, Jennifer L.;
Osuna-Cabello, Maria;
Read, Kevin D.;
Fairlamb, Alan H.

Publication type:

Article

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.

Published in:

2016

By:

Bruhn, David F.;
Wyllie, Susan;
Rodríguez-Cortés, Adaris;
Carrillo, Angela K.;
Rakesh;
Kiplin Guy, R.;
Fairlamb, Alan H.;
Lee, Richard E.;
Guy, R Kiplin

Publication type:

journal article

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.

Published in:

2016

By:

Wyllie, Susan;
Foth, Bernardo J.;
Kelner, Anna;
Sokolova, Antoaneta Y.;
Berriman, Matthew;
Fairlamb, Alan H.

Publication type:

journal article

The N-myristoylome of Trypanosoma cruzi.

Published in:

Scientific Reports, 2016, p. 31078, doi. 10.1038/srep31078

By:

Roberts, Adam J.;
Fairlamb, Alan H.

Publication type:

Article

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase.

Published in:

PLoS Neglected Tropical Diseases, 2016, v. 10, n. 5, p. 1, doi. 10.1371/journal.pntd.0004714

By:

Gibson, Marc W.;
Dewar, Simon;
Ong, Han B.;
Sienkiewicz, Natasha;
Fairlamb, Alan H.

Publication type:

Article

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 12, p. 1, doi. 10.1371/journal.pntd.0004299

By:

Jones, Deuan C.;
Foth, Bernardo J.;
Urbaniak, Michael D.;
Patterson, Stephen;
Ong, Han B.;
Berriman, Matthew;
Fairlamb, Alan H.

Publication type:

Article

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Published in:

Malaria Journal, 2017, v. 16, p. 1, doi. 10.1186/s12936-017-2085-4

By:

Hallyburton, Irene;
Grimaldi, Raffaella;
Woodland, Andrew;
Baragaña, Beatriz;
Luksch, Torsten;
Spinks, Daniel;
James, Daniel;
Leroy, Didier;
Waterson, David;
Fairlamb, Alan H.;
Wyatt, Paul G.;
Gilbert, Ian H.;
Frearson, Julie A.

Publication type:

Article