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The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline.
Published in:
Stem Cell Research & Therapy, 2013, v. 4, p. 1, doi. 10.1186/scrt361
By:
- Sutherland, Margaret L.;
- Fabre, Kristin M.;
- Tagle, Danilo A.
Publication type:
Article
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45656-4
By:
- McAleer, Christopher W.;
- Pointon, Amy;
- Long, Christopher J.;
- Brighton, Rocky L.;
- Wilkin, Benjamin D.;
- Bridges, L. Richard;
- Narasimhan Sriram, Narasimham;
- Fabre, Kristin;
- McDougall, Robin;
- Muse, Victorine P.;
- Mettetal, Jerome T.;
- Srivastava, Abhishek;
- Williams, Dominic;
- Schnepper, Mark T.;
- Roles, Jeff L.;
- Shuler, Michael L.;
- Hickman, James J.;
- Ewart, Lorna
Publication type:
Article
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Published in:
PLoS Biology, 2022, v. 20, n. 5, p. 1, doi. 10.1371/journal.pbio.3001624
By:
- Singh, Dharaminder;
- Deosarkar, Sudhir P.;
- Cadogan, Elaine;
- Flemington, Vikki;
- Bray, Alysha;
- Zhang, Jingwen;
- Reiserer, Ronald S.;
- Schaffer, David K.;
- Gerken, Gregory B.;
- Britt, Clayton M.;
- Werner, Erik M.;
- Gibbons, Francis D.;
- Kostrzewski, Tomasz;
- Chambers, Christopher E.;
- Davies, Emma J.;
- Montoya, Antonio Ramos;
- Fok, Jacqueline H. L.;
- Hughes, David;
- Fabre, Kristin;
- Wagoner, Matthew P.
Publication type:
Article
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.
Published in:
Nature Communications, 2013, v. 4, n. 9, p. 2384, doi. 10.1038/ncomms3384
By:
- Li, Fei;
- Jiang, Changtao;
- Krausz, Kristopher W.;
- Li, Yunfei;
- Albert, Istvan;
- Hao, Haiping;
- Fabre, Kristin M.;
- Mitchell, James B.;
- Patterson, Andrew D.;
- Gonzalez, Frank J.
Publication type:
Article
Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.
Published in:
Radiation Research, 2018, v. 189, n. 5, p. 490, doi. 10.1667/RR14987.1
By:
- Cook, John A.;
- Naz, Sarwat;
- Anver, Miriam R.;
- Sowers, Anastasia L.;
- Fabre, Kristin;
- Krishna, Murali C.;
- Mitchell, James B.
Publication type:
Article
Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.
Published in:
Experimental Biology & Medicine, 2017, v. 242, n. 16, p. 1579, doi. 10.1177/1535370217715441
By:
- Ewart, Lorna;
- Fabre, Kristin;
- Chakilam, Ananthsrinivas;
- Dragan, Yvonne;
- Duignan, David B.;
- Eswaraka, Jeetu;
- Gan, Jinping;
- Guzzie-Peck, Peggy;
- Otieno, Monicah;
- Jeong, Claire G.;
- Keller, Douglas A.;
- de Morais, Sonia M.;
- Phillips, Jonathan A.;
- Proctor, William;
- Sura, Radhakrishna;
- Van Vleet, Terry;
- Watson, David;
- Will, Yvonne;
- Tagle, Danilo;
- Berridge, Brian
Publication type:
Article
Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue.
Published in:
Experimental Biology & Medicine, 2014, v. 239, n. 9, p. 1073, doi. 10.1177/1535370214538916
By:
- Fabre, Kristin M;
- Livingston, Christine;
- Tagle, Danilo A
Publication type:
Article

Found: 7

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline.

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue.