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SHIP2 multiple functions: A balance between a negative control of PtdIns(3,4,5)P<sub>3</sub> level, a positive control of PtdIns(3,4)P<sub>2</sub> production, and intrinsic docking properties.
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- Journal of Cellular Biochemistry, 2011, v. 112, n. 9, p. 2203, doi. 10.1002/jcb.23146
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- Article
Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis.
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- Frontiers in Molecular Neuroscience, 2021, v. 13, p. N.PAG, doi. 10.3389/fnmol.2020.583755
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- Article
Protein phosphatase 2A PR130/B"α1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.
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- FASEB Journal, 2010, v. 24, n. 2, p. 538, doi. 10.1096/fj.09-140228
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- Article
The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.
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- Pflügers Archiv: European Journal of Physiology, 2011, v. 462, n. 6, p. 871, doi. 10.1007/s00424-011-1028-0
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- Article
Phosphoinositide phosphatases in a network of signalling reactions.
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- Pflügers Archiv: European Journal of Physiology, 2007, v. 455, n. 1, p. 31, doi. 10.1007/s00424-007-0304-5
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- Article
Actin-based confinement of calcium responses during Shigella invasion.
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- Nature Communications, 2013, v. 4, n. 3, p. 1567, doi. 10.1038/ncomms2561
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- Article
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.
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- Science Signaling, 2018, v. 11, n. 548, p. 1, doi. 10.1126/scisignal.aap8608
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- Article
D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism.
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- EMBO Journal, 1997, v. 16, n. 8, p. 1943, doi. 10.1093/emboj/16.8.1943
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- Article
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.
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- Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02745-7
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- Article
Astrocytic IP<sub>3</sub>/Ca<sup>2+</sup> Signaling Modulates Theta Rhythm and REM Sleep.
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- Frontiers in Neural Circuits, 2017, v. 11, p. 1, doi. 10.3389/fncir.2017.00003
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- Article
Interaction of the Two Structural Domains of Calmodulin with Mature and Immature Rat Brain Microtubules.
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- Journal of Neurochemistry, 1990, v. 55, n. 5, p. 1683, doi. 10.1111/j.1471-4159.1990.tb04956.x
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- Article
Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.
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- Biochemical Journal, 2013, v. 455, n. 2, p. 195, doi. 10.1042/BJ20130644
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- Article
Overexpression of inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) in neurons of APP mice leads to an increase of Amyloid Beta production.
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- 2011
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- Abstract
Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal.
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- PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0014710
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- Article
Distribution of the neurons containing inositol 1,4,5-trisphosphate 3-kinase and its messenger RNA in the developing rat brain.
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- Journal of Comparative Neurology, 1993, v. 327, n. 4, p. 618, doi. 10.1002/cne.903270412
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- Article
Thyrotropin Stimulates the Generation of Inositol 1,4,5-Trisphosphate in Human Thyroid Cells.
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- Journal of Clinical Endocrinology & Metabolism, 2006, v. 91, n. 3, p. 1099, doi. 10.1210/jc.2005-1324
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- Article
Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease.
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- Frontiers in Neuroscience, 2021, v. 14, p. N.PAG, doi. 10.3389/fnins.2021.614855
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- Article
SHIP2 interaction with the cytoskeletal protein Vinexin.
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- FEBS Journal, 2005, v. 272, n. 23, p. 6052, doi. 10.1111/j.1742-4658.2005.04996.x
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- Article
Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts.
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- FEBS Journal, 2005, v. 272, n. 10, p. 2512, doi. 10.1111/j.1742-4658.2005.04672.x
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- Article
The lipid phosphatase SHIP2 controls insulin sensitivity.
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- Nature, 2001, v. 409, n. 6816, p. 92, doi. 10.1038/35051094
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- Article
When worlds collide: inositol pyrophosphates and phosphoinositides intersect at the plasma membrane.
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- Biochemical Journal, 2013, v. 453, n. 3, p. e3, doi. 10.1042/BJ20130785
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- Article
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development.
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- Nature Immunology, 2003, v. 4, n. 11, p. 1136, doi. 10.1038/ni980
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- Article
SHIP2: Structure, Function and Inhibition.
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- ChemBioChem, 2017, v. 18, n. 3, p. 233, doi. 10.1002/cbic.201600541
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- Article
5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration.
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- ChemBioChem, 2010, v. 11, n. 3, p. 388, doi. 10.1002/cbic.200900545
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- Article
Benzene Polyphosphates as Tools for Cell Signalling: Inhibition of Inositol 1,4,5-Trisphosphate 5-Phosphatase and Interaction with the PH Domain of Protein Kinase Bα.
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- ChemBioChem, 2008, v. 9, n. 11, p. 1757, doi. 10.1002/cbic.200800104
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- Article
The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.
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- Journal of Cellular Physiology, 2008, v. 214, n. 1, p. 260, doi. 10.1002/jcp.21193
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- Article
Role of PRIP‐1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3‐mediated Ca2+ signaling.
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- Journal of Cellular Physiology, 2005, v. 202, n. 2, p. 422, doi. 10.1002/jcp.20136
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- Article
Ferroptosis Induction and YAP Inhibition as New Therapeutic Targets in Gastrointestinal Stromal Tumors (GISTs).
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- Cancers, 2022, v. 14, n. 20, p. 5050, doi. 10.3390/cancers14205050
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- Article
ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours.
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- Journal of Cellular & Molecular Medicine, 2012, v. 16, n. 2, p. 306, doi. 10.1111/j.1582-4934.2011.01315.x
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- Article
Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
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- Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 8a, p. 1536, doi. 10.1111/j.1582-4934.2009.00768.x
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- Article
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.
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- Brain: A Journal of Neurology, 2014, v. 137, n. 2, p. 537, doi. 10.1093/brain/awt344
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- Article
Biphenyl 2,3′,4,5′,6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca<sup>2+</sup> responses in rat hepatocytes.
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- FASEB Journal, 2007, v. 21, n. 7, p. 1481, doi. 10.1096/fj.06-7691com
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- Article
3-Hydroxybenzene 1,2,4-Trisphosphate, a Novel Second Messenger Mimic and unusual Substrate for Type-I myo-Inositol 1,4,5-Trisphosphate 5-Phosphatase: Synthesis and Physicochemistry.
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- ChemBioChem, 2006, v. 7, n. 11, p. 1696, doi. 10.1002/cbic.200600125
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- Article
Interaction of the Catalytic Domain of Inositol 1,4,5-Trisphosphate 3-Kinase A with Inositol Phosphate Analogues.
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- ChemBioChem, 2005, v. 6, n. 8, p. 1449, doi. 10.1002/cbic.200400443
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- Article
Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects.
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- Human Mutation, 2017, v. 38, n. 12, p. 1731, doi. 10.1002/humu.23321
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- Article
How does SHIP1/2 balance Ptd Ins(3,4) P<sub>2</sub> and does it signal independently of its phosphatase activity?
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- BioEssays, 2013, v. 35, n. 8, p. 733, doi. 10.1002/bies.201200168
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- Article
Reversible Ser/Thr SHIP phosphorylation: A new paradigm in phosphoinositide signalling?
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- BioEssays, 2012, v. 34, n. 8, p. 634, doi. 10.1002/bies.201100195
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- Article
Hyperplasia of Interstitial Cells of Cajal in Sprouty Homolog 4 Deficient Mice.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0124861
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- Article
The Shigella type III effector IpgD recodes Ca<sup>2+</sup> signals during invasion of epithelial cells.
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- EMBO Journal, 2017, v. 36, n. 17, p. 2567, doi. 10.15252/embj.201696272
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- Article
Lipid phosphatases SKIP and SHIP2 regulate fibronectin‐dependent cell migration in glioblastoma.
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- FEBS Journal, 2019, v. 286, n. 6, p. 1120, doi. 10.1111/febs.14769
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- Article
Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P<sub>3</sub> kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.
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- FEBS Journal, 2015, v. 282, n. 13, p. 2553, doi. 10.1111/febs.13300
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- Article