Works by Enza Lacivita

Results: 42

Towards metabolically stable 5-HT receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.

Published in:

Experimental Brain Research, 2013, v. 230, n. 4, p. 569, doi. 10.1007/s00221-013-3498-0

By:

Lacivita, Enza;
De Giorgio, Paola;
Patarnello, Daniela;
Niso, Mauro;
Colabufo, Nicola;
Berardi, Francesco;
Perrone, Roberto;
Satala, Grzegorz;
Duszynska, Beata;
Bojarski, Andrzej;
Leopoldo, Marcello

Publication type:

Article

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures.

Published in:

Cells (2073-4409), 2023, v. 12, n. 21, p. 2570, doi. 10.3390/cells12212570

By:

Tylek, Kinga;
Trojan, Ewa;
Leśkiewicz, Monika;
Ghafir El Idrissi, Imane;
Lacivita, Enza;
Leopoldo, Marcello;
Basta-Kaim, Agnieszka

Publication type:

Article

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways.

Published in:

Cells (2073-4409), 2021, v. 10, n. 9, p. 2373, doi. 10.3390/cells10092373

By:

Tylek, Kinga;
Trojan, Ewa;
Leśkiewicz, Monika;
Regulska, Magdalena;
Bryniarska, Natalia;
Curzytek, Katarzyna;
Lacivita, Enza;
Leopoldo, Marcello;
Basta-Kaim, Agnieszka

Publication type:

Article

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures.

Published in:

Cells (2073-4409), 2021, v. 10, n. 6, p. 1524, doi. 10.3390/cells10061524

By:

Trojan, Ewa;
Tylek, Kinga;
Leśkiewicz, Monika;
Lasoń, Władysław;
Brandenburg, Lars-Ove;
Leopoldo, Marcello;
Lacivita, Enza;
Basta-Kaim, Agnieszka

Publication type:

Article

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 9, p. 1238, doi. 10.3390/ph17091238

By:

Ghafir El Idrissi, Imane;
Santo, Angela;
Lacivita, Enza;
Leopoldo, Marcello

Publication type:

Article

Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 6, p. 695, doi. 10.3390/ph17060695

By:

Brunetti, Leonardo;
Francavilla, Fabio;
Leopoldo, Marcello;
Lacivita, Enza

Publication type:

Article

Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 161, doi. 10.3390/ph15020161

By:

Cristiano, Claudia;
Volpicelli, Floriana;
Crispino, Marianna;
Lacivita, Enza;
Russo, Roberto;
Leopoldo, Marcello;
Calignano, Antonio;
Perrone-Capano, Carla

Publication type:

Article

Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome.

Published in:

Frontiers in Behavioral Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnbeh.2015.00086

By:

De Filippis, Bianca;
Chiodi, Valentina;
Adriani, Walter;
Lacivita, Enza;
Mallozzi, Cinzia;
Leopoldo, Marcello;
Domenici, Maria Rosaria;
Fuso, Andrea;
Laviola, Giovanni

Publication type:

Article

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.

Published in:

Frontiers in Behavioral Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnbeh.2015.00065

By:

Costa, Lara;
Sardone, Lara M.;
Lacivita, Enza;
Leopoldo, Marcello;
Ciranna, Lucia

Publication type:

Article

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.

Published in:

Frontiers in Behavioral Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnbeh.2015.00062

By:

Speranza, Luisa;
Giuliano, Teresa;
Volpicelli, Floriana;
De Stefano, M. Egle;
Lombardi, Loredana;
Chambery, Angela;
Lacivita, Enza;
Leopoldo, Marcello;
Bellenchi, Gian C.;
di Porzio, Umberto;
Crispino, Marianna;
Perrone-Capano, Carla

Publication type:

Article

Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study.

Published in:

Frontiers in Behavioral Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnbeh.2014.00427

By:

Altabella, Luisa;
Sbriccoli, Marco;
Zoratto, Francesca;
Poleggi, Anna;
Vinci, Ramona;
Lacivita, Enza;
Leopoldo, Marcello;
Laviola, Giovanni;
Cardone, Franco;
Canese, Rossella;
Adriani, Walter

Publication type:

Article

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1035, doi. 10.3390/ijms22031035

By:

Podlewska, Sabina;
Bugno, Ryszard;
Lacivita, Enza;
Leopoldo, Marcello;
Bojarski, Andrzej J.;
Handzlik, Jadwiga

Publication type:

Article

Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT 7 Receptor.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 24, p. 9629, doi. 10.3390/ijms21249629

By:

Tempio, Alessandra;
Niso, Mauro;
Laera, Luna;
Trisolini, Lucia;
Favia, Maria;
Ciranna, Lucia;
Marzulli, Domenico;
Petrosillo, Giuseppe;
Pierri, Ciro Leonardo;
Lacivita, Enza;
Leopoldo, Marcello

Publication type:

Article

Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 11, p. 2506, doi. 10.1038/npp.2014.105

By:

De Filippis, Bianca;
Nativio, Paola;
Fabbri, Alessia;
Ricceri, Laura;
Adriani, Walter;
Lacivita, Enza;
Leopoldo, Marcello;
Passarelli, Francesca;
Fuso, Andrea;
Laviola, Giovanni

Publication type:

Article

Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist.

Published in:

Psychopharmacology, 2015, v. 232, n. 1, p. 75, doi. 10.1007/s00213-014-3639-6

By:

Canese, Rossella;
Zoratto, Francesca;
Altabella, Luisa;
Porcari, Paola;
Mercurio, Laura;
de Pasquale, Francesco;
Butti, Erica;
Martino, Gianvito;
Lacivita, Enza;
Leopoldo, Marcello;
Laviola, Giovanni;
Adriani, Walter

Publication type:

Article

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00353

By:

Costa, Lara;
Sardone, Lara Maria;
Bonaccorso, Carmela Maria;
D'Antoni, Simona;
Spatuzza, Michela;
Gulisano, Walter;
Tropea, Maria Rosaria;
Puzzo, Daniela;
Leopoldo, Marcello;
Lacivita, Enza;
Catania, Maria Vincenza;
Ciranna, Lucia

Publication type:

Article

Stimulation of 5- HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas.

Published in:

Synapse, 2015, v. 69, n. 11, p. 533, doi. 10.1002/syn.21846

By:

Nativio, Paola;
Zoratto, Francesca;
Romano, Emilia;
Lacivita, Enza;
Leopoldo, Marcello;
Pascale, Esterina;
Passarelli, Francesca;
Laviola, Giovanni;
Adriani, Walter

Publication type:

Article

Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats.

Published in:

Synapse, 2014, v. 68, n. 4, p. 159, doi. 10.1002/syn.21724

By:

Ruocco, Lucia A.;
Romano, Emilia;
Treno, Concetta;
lacivita, Enza;
Claudio, Arra;
Gironi‐Carnevale, Ugo A.;
Travaglini, Domenica;
Leopoldo, Marcello;
Laviola, Giovanni;
Sadile, Adolfo G.;
Adriani, Walter

Publication type:

Article

Serotonin 5- HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons.

Published in:

Journal of Neurochemistry, 2017, v. 141, n. 5, p. 647, doi. 10.1111/jnc.13962

By:

Speranza, Luisa;
Labus, Josephine;
Volpicelli, Floriana;
Guseva, Daria;
Lacivita, Enza;
Leopoldo, Marcello;
Bellenchi, Gian Carlo;
Porzio, Umberto;
Bijata, Monika;
Perrone‐Capano, Carla;
Ponimaskin, Evgeni

Publication type:

Article

Serotonin 5‐HT7 receptors require cyclin‐dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome.

Published in:

European Journal of Neuroscience, 2021, v. 54, n. 1, p. 4124, doi. 10.1111/ejn.15246

By:

Costa, Lara;
Tempio, Alessandra;
Lacivita, Enza;
Leopoldo, Marcello;
Ciranna, Lucia

Publication type:

Article

5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn.

Published in:

Frontiers in Molecular Neuroscience, 2022, v. 15, p. 1, doi. 10.3389/fnmol.2022.946159

By:

Comitato, Antonella;
Lacivita, Enza;
Leopoldo, Marcello;
Bardoni, Rita

Publication type:

Article

Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress.

Published in:

ChemMedChem, 2017, v. 12, n. 22, p. 1839, doi. 10.1002/cmdc.201700429

By:

Stama, Madia L.;
Lacivita, Enza;
Kirpotina, Liliya N.;
Niso, Mauro;
Perrone, Roberto;
Schepetkin, Igor A.;
Quinn, Mark T.;
Leopoldo, Marcello

Publication type:

Article

Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats.

Published in:

Reviews in the Neurosciences, 2014, v. 25, n. 3, p. 383, doi. 10.1515/revneuro-2014-0007

By:

Romano, Emilia;
Ruocco, Lucia A.;
Nativio, Paola;
Lacivita, Enza;
Ajmone-Cat, Maria A.;
Boatto, Giampiero;
Nieddu, Maria;
Tino, Angela;
Sadile, Adolfo G.;
Minghetti, Luisa;
Passarelli, Francesca;
Leopoldo, Marcello;
Laviola, Giovanni;
Adriani, Walter

Publication type:

Article

Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.

Published in:

Reviews in the Neurosciences, 2014, v. 25, n. 3, p. 401, doi. 10.1515/revneuro-2014-0009

By:

Di Pilato, Pantaleo;
Niso, Mauro;
Adriani, Walter;
Romano, Emilia;
Travaglini, Domenica;
Berardi, Francesco;
Colabufo, Nicola A.;
Perrone, Roberto;
Laviola, Giovanni;
Lacivita, Enza;
Leopoldo, Marcello

Publication type:

Article

Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT7 Receptors.

Published in:

Headache: The Journal of Head & Face Pain, 2011, v. 51, n. 10, p. 1511, doi. 10.1111/j.1526-4610.2011.02011.x

By:

Martínez-García, Esther;
Leopoldo, Marcello;
Lacivita, Enza;
Terrón, José A.

Publication type:

Article

Synthesis and binding profile of constrained analogues of N-[4-(4-arylpiperazin-1-yl)butyl]-3-methoxybenzamides, a class of potent dopamine D3 receptor ligands.

Published in:

Journal of Pharmacy & Pharmacology, 2006, v. 58, n. 2, p. 209

By:

Marcello Leopoldo;
Enza Lacivita;
Nicola A. Colabufo;
Francesco Berardi;
Roberto Perrone

Publication type:

Article

Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT1A receptor.

Published in:

Journal of Pharmacy & Pharmacology, 2005, v. 57, n. 10, p. 1319

By:

Roberto Perrone;
Francesco Berardi;
Nicola A. Colabufo;
Enza Lacivita;
Carmela Larizza;
Marcello Leopoldo;
Vincenzo Tortorella

Publication type:

Article

Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 2, p. 247

By:

Marcello Leopoldo;
Francesco Berardi;
Nicola A. Colabufo;
Marialessandra Contino;
Enza Lacivita;
Roberto Perrone;
Vincenzo Tortorella

Publication type:

Article

Radiosynthesis and in vivo Evaluation of Carbon-11 (2 S)-3-(1 H-Indol-3-yl)-2-{[(4-methoxyphenyl)carbamoyl]amino}- N-{[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl}propanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation

Published in:

Chemistry & Biodiversity, 2016, v. 13, n. 7, p. 875, doi. 10.1002/cbdv.201500281

By:

Lacivita, Enza;
Stama, Madia Letizia;
Maeda, Jun;
Fujinaga, Masayuki;
Hatori, Akiko;
Zhang, Ming‐Rong;
Colabufo, Nicola A.;
Perrone, Roberto;
Higuchi, Makoto;
Suhara, Tetsuya;
Leopoldo, Marcello

Publication type:

Article

In Vitro and In Vivo Evaluation of N-{2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl}-3-[11C]methoxybenzamide, a Positron Emission Tomography (PET) Radioligand for Dopamine D4 Receptors, in Rodents.

Published in:

Chemistry & Biodiversity, 2014, v. 11, n. 9, p. 1298, doi. 10.1002/cbdv.201400178

By:

Leopoldo, Marcello;
Selivanova, Svetlana V.;
Müllerb, Adrienne;
Lacivita, Enza;
Schetz, John A.;
Ametamey, Simon M.

Publication type:

Article

Design, Synthesis, Lipophilic Properties, and Binding Affinities of Potential Ligands in Positron Emission Tomography (PET) for Visualization of Brain Dopamine D4 Receptors.

Published in:

Chemistry & Biodiversity, 2014, v. 11, n. 2, p. 299, doi. 10.1002/cbdv.201300194

By:

Lacivita, Enza;
De Giorgio, Paola;
Colabufo, Nicola A.;
Berardi, Francesco;
Perrone, Roberto;
Niso, Mauro;
Leopoldo, Marcello

Publication type:

Article

Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0083003

By:

Ruocco, Lucia A.;
Treno, Concetta;
Gironi Carnevale, Ugo A.;
Arra, Claudio;
Boatto, Gianpiero;
Nieddu, Maria;
Pagano, Cristina;
Illiano, Placido;
Barbato, Fabiana;
Tino, Angela;
Carboni, Ezio;
Laviola, Giovanni;
Lacivita, Enza;
Leopoldo, Marcello;
Adriani, Walter;
Sadile, Adolfo G.

Publication type:

Article

Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate.

Published in:

Frontiers in Behavioral Neuroscience, 2019, p. 1, doi. 10.3389/fnbeh.2019.00208

By:

Carbone, Cristiana;
Lo Russo, Sara Lucia Maria;
Lacivita, Enza;
Frank, Annika;
Alleva, Enrico;
Stark, Holger;
Saso, Luciano;
Leopoldo, Marcello;
Adriani, Walter

Publication type:

Article

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease.

Published in:

Molecular Neurobiology, 2021, v. 58, n. 12, p. 6203, doi. 10.1007/s12035-021-02543-2

By:

Trojan, Ewa;
Tylek, Kinga;
Schröder, Nicole;
Kahl, Iris;
Brandenburg, Lars-Ove;
Mastromarino, Margherita;
Leopoldo, Marcello;
Basta-Kaim, Agnieszka;
Lacivita, Enza

Publication type:

Article

Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges.

Published in:

ChemMedChem, 2025, v. 20, n. 6, p. 1, doi. 10.1002/cmdc.202400672

By:

Francavilla, Fabio;
Intranuovo, Francesca;
La Spada, Gabriella;
Lacivita, Enza;
Catto, Marco;
Graps, Elisabetta Anna;
Altomare, Cosimo Damiano

Publication type:

Article

Design, Synthesis, and Characterization of a Novel Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5‐HT1A Receptor.

Published in:

ChemMedChem, 2022, v. 17, n. 10, p. 1, doi. 10.1002/cmdc.202100759

By:

Garvey, Robert W.;
Lacivita, Enza;
Niso, Mauro;
Duszyńska, Beata;
Harris, Paul E.;
Leopoldo, Marcello

Publication type:

Article

P3‐047: OPTIMIZATION OF FORMYL PEPTIDE RECEPTOR 2 (FPR2) AGONISTS WITH NEUROPROTECTIVE PROPERTIES IN MODELS OF NEUROINFLAMMATION RELATED TO ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P944, doi. 10.1016/j.jalz.2019.06.3073

By:

Lacivita, Enza;
Mastromarino, Margherita;
Favia, Maria;
Schepetkin, Igor A.;
Kirpotina, Liliya;
Trojan, Ewa;
Leśkiewicz, Monika;
Quinn, Mark T.;
Basta-Kaim, Agnieszka;
Brandenburg, Lars-Ove;
Leopoldo, Marcello

Publication type:

Article

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties.

Published in:

Molecules, 2022, v. 27, n. 4, p. 1297, doi. 10.3390/molecules27041297

By:

Mastromarino, Margherita;
Niso, Mauro;
Abate, Carmen;
Proschak, Ewgenij;
Dubiel, Mariam;
Stark, Holger;
Castro, Marián;
Lacivita, Enza;
Leopoldo, Marcello

Publication type:

Article

σ 2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach.

Published in:

Molecules, 2021, v. 26, n. 12, p. 3743, doi. 10.3390/molecules26123743

By:

Abatematteo, Francesca Serena;
Niso, Mauro;
Lacivita, Enza;
Abate, Carmen

Publication type:

Article

Activation of 5‐HT7 receptor by administration of its selective agonist, LP‐211, modifies explorative‐curiosity behavior in rats in two paradigms which differ in visuospatial parameters.

Published in:

CNS Neuroscience & Therapeutics, 2018, v. 24, n. 8, p. 712, doi. 10.1111/cns.12812

By:

Carbone, Cristiana;
Adinolfi, Annalisa;
Cinque, Stefano;
Lacivita, Enza;
Alleva, Enrico;
Leopoldo, Marcello;
Adriani, Walter

Publication type:

Article

Interplay between Serotonin 5- HT1A and 5- HT7 Receptors in Depressive Disorders.

Published in:

CNS Neuroscience & Therapeutics, 2014, v. 20, n. 7, p. 582, doi. 10.1111/cns.12247

By:

Naumenko, Vladimir S.;
Popova, Nina K.;
Lacivita, Enza;
Leopoldo, Marcello;
Ponimaskin, Evgeni G.

Publication type:

Article

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models.

Published in:

Frontiers in Neuroscience, 2023, v. 17, p. 1, doi. 10.3389/fnins.2023.1087788

By:

Sharghi, Shirin;
Flunkert, Stefanie;
Daurer, Magdalena;
Rabl, Roland;
Chagnaud, Boris Philippe;
Leopoldo, Marcello;
Lacivita, Enza;
Hutter-Paier, Birgit;
Prokesch, Manuela

Publication type:

Article