Works by Engelman, Alan N.

Results: 38

HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 7, p. 1166, doi. 10.3390/v16071166

By:

Li, Min;
Li, Zhen;
Chen, Xuemin;
Cui, Yanxiang;
Engelman, Alan N.;
Craigie, Robert

Publication type:

Article

Brief Histories of Retroviral Integration Research and Associated International Conferences.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 4, p. 604, doi. 10.3390/v16040604

By:

Grandgenett, Duane P.;
Engelman, Alan N.

Publication type:

Article

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 9, p. 1883, doi. 10.3390/v14091883

By:

Singh, Parmit Kumar;
Li, Wen;
Bedwell, Gregory J.;
Fadel, Hind J.;
Poeschla, Eric M.;
Engelman, Alan N.

Publication type:

Article

Multimodal Functionalities of HIV-1 Integrase.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 5, p. 926, doi. 10.3390/v14050926

By:

Engelman, Alan N.;
Kvaratskhelia, Mamuka

Publication type:

Article

HIV Capsid and Integration Targeting.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 1, p. 125, doi. 10.3390/v13010125

By:

Engelman, Alan N.;
Sarafianos, Stefan G.

Publication type:

Article

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.

Published in:

PLoS Pathogens, 2022, v. 18, n. 8, p. 1, doi. 10.1371/journal.ppat.1010754

By:

Francis, Ashwanth C.;
Cereseto, Anna;
Singh, Parmit K.;
Shi, Jiong;
Poeschla, Eric;
Engelman, Alan N.;
Aiken, Christopher;
Melikyan, Gregory B.

Publication type:

Article

Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01855-2

By:

Pandey, Krishan K.;
Bera, Sibes;
Shi, Ke;
Rau, Michael J.;
Oleru, Amarachi V.;
Fitzpatrick, James A. J.;
Engelman, Alan N.;
Aihara, Hideki;
Grandgenett, Duane P.

Publication type:

Article

Spatial and Genomic Correlates of HIV-1 Integration Site Targeting.

Published in:

Cells (2073-4409), 2022, v. 11, n. 4, p. 655, doi. 10.3390/cells11040655

By:

Singh, Parmit Kumar;
Bedwell, Gregory J.;
Engelman, Alan N.

Publication type:

Article

Multivalent interactions essential for lentiviral integrase function.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29928-8

By:

Ballandras-Colas, Allison;
Chivukula, Vidya;
Gruszka, Dominika T.;
Shan, Zelin;
Singh, Parmit K.;
Pye, Valerie E.;
McLean, Rebecca K.;
Bedwell, Gregory J.;
Li, Wen;
Nans, Andrea;
Cook, Nicola J.;
Fadel, Hind J.;
Poeschla, Eric M.;
Griffiths, David J.;
Vargas, Javier;
Taylor, Ian A.;
Lyumkis, Dmitry;
Yardimci, Hasan;
Engelman, Alan N.;
Cherepanov, Peter

Publication type:

Article

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33662-6

By:

Wei, Guochao;
Iqbal, Naseer;
Courouble, Valentine V.;
Francis, Ashwanth C.;
Singh, Parmit K.;
Hudait, Arpa;
Annamalai, Arun S.;
Bester, Stephanie;
Huang, Szu-Wei;
Shkriabai, Nikoloz;
Briganti, Lorenzo;
Haney, Reed;
KewalRamani, Vineet N.;
Voth, Gregory A.;
Engelman, Alan N.;
Melikyan, Gregory B.;
Griffin, Patrick R.;
Asturias, Francisco;
Kvaratskhelia, Mamuka

Publication type:

Article

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 11, p. 1911, doi. 10.1002/pro.2997

By:

Deng, Nanjie;
Hoyte, Ashley;
Mansour, Yara E.;
Mohamed, Mosaad S.;
Fuchs, James R.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Levy, Ronald

Publication type:

Article

HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio.

Published in:

Retrovirology, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12977-021-00582-0

By:

Liu, Shuohui;
Koneru, Pratibha C.;
Li, Wen;
Pathirage, Chathuri;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Musier-Forsyth, Karin

Publication type:

Article

Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.

Published in:

PLoS Pathogens, 2019, v. 15, n. 12, p. 1, doi. 10.1371/journal.ppat.1008154

By:

Loyola, Lorenz;
Achuthan, Vasudevan;
Gilroy, Kathryn;
Borland, Gillian;
Kilbey, Anna;
Mackay, Nancy;
Bell, Margaret;
Hay, Jodie;
Aiyer, Sriram;
Fingerman, Dylan;
Villanueva, Rodrigo A.;
Cameron, Ewan;
Kozak, Christine A.;
Engelman, Alan N.;
Neil, James;
Roth, Monica J.

Publication type:

Article

D614G and SARS-CoV-2 replication fitness.

Published in:

Signal Transduction & Targeted Therapy, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41392-021-00498-3

By:

Engelman, Kathleen D.;
Engelman, Alan N.

Publication type:

Article

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis.

Published in:

PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3001015

By:

Xu, Chaoyi;
Fischer, Douglas K.;
Rankovic, Sanela;
Li, Wen;
Dick, Robert A.;
Runge, Brent;
Zadorozhnyi, Roman;
Ahn, Jinwoo;
Aiken, Christopher;
Polenova, Tatyana;
Engelman, Alan N.;
Ambrose, Zandrea;
Rousso, Itay;
Perilla, Juan R.

Publication type:

Article

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.

Published in:

PLoS Pathogens, 2025, v. 21, n. 1, p. 1, doi. 10.1371/journal.ppat.1012862

By:

Huang, Szu-Wei;
Briganti, Lorenzo;
Annamalai, Arun S.;
Greenwood, Juliet;
Shkriabai, Nikoloz;
Haney, Reed;
Armstrong, Michael L.;
Wempe, Michael F.;
Singh, Satya Prakash;
Francis, Ashwanth C.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka

Publication type:

Article

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection.

Published in:

PLoS Pathogens, 2025, v. 21, n. 1, p. 1, doi. 10.1371/journal.ppat.1012354

By:

Rohlfes, Nicholas;
Radhakrishnan, Rajalingam;
Singh, Parmit K.;
Bedwell, Gregory J.;
Engelman, Alan N.;
Dharan, Adarsh;
Campbell, Edward M.

Publication type:

Article

Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 10, p. 1, doi. 10.1093/nar/gkaf449

By:

Lagadec, Floriane;
Singh, Parmit K;
Calmels, Christina;
Lapaillerie, Delphine;
Lindemann, Dirk;
Parissi, Vincent;
Cherepanov, Peter;
Engelman, Alan N;
Lesbats, Paul

Publication type:

Article

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 18, p. 11060, doi. 10.1093/nar/gkae769

By:

Jang, Sooin;
Bedwell, Gregory J;
Singh, Satya P;
Yu, Hyun Jae;
Arnarson, Bjarki;
Singh, Parmit K;
Radhakrishnan, Rajalingam;
Douglas, AidanDarian W;
Ingram, Zachary M;
Freniere, Christian;
Akkermans, Onno;
Sarafianos, Stefan G;
Ambrose, Zandrea;
Xiong, Yong;
Anekal, Praju V;
Montero Llopis, Paula;
KewalRamani, Vineet N;
Francis, Ashwanth C;
Engelman, Alan N

Publication type:

Article

B-to-A transition in target DNA during retroviral integration.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 15, p. 8898, doi. 10.1093/nar/gkac644

By:

Jóźwik, Ilona K;
Li, Wen;
Zhang, Da-Wei;
Wong, Doris;
Grawenhoff, Julia;
Ballandras-Colas, Allison;
Aiyer, Sriram;
Cherepanov, Peter;
Engelman, Alan N;
Lyumkis, Dmitry

Publication type:

Article

Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 12, p. 6687, doi. 10.1093/nar/gkac464

By:

Zhang, Qiong;
Wang, Shaobo;
Li, Wanyu;
Yau, Edwin;
Hui, Hui;
Singh, Parmit Kumar;
Achuthan, Vasudevan;
Young Karris, Maile Ann;
Engelman, Alan N;
Rana, Tariq M

Publication type:

Article

rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 13, p. 7330, doi. 10.1093/nar/gkab514

By:

Bedwell, Gregory J;
Jang, Sooin;
Li, Wen;
Singh, Parmit K;
Engelman, Alan N

Publication type:

Article

Factors that mold the nuclear landscape of HIV-1 integration.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 2, p. 621, doi. 10.1093/nar/gkaa1207

By:

Bedwell, Gregory J;
Engelman, Alan N

Publication type:

Article

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 9, p. 4663, doi. 10.1093/nar/gkz206

By:

Jang, Sooin;
Cook, Nicola J;
Pye, Valerie E;
Bedwell, Gregory J;
Dudek, Amanda M;
Singh, Parmit K;
Cherepanov, Peter;
Engelman, Alan N

Publication type:

Article

Multiplex single-cell visualization of nucleic acids and protein during HIV infection.

Published in:

Nature Communications, 2017, v. 8, n. 12, p. 1, doi. 10.1038/s41467-017-01693-z

By:

Puray-Chavez, Maritza;
Tedbury, Philip R.;
Huber, Andrew D.;
Ukah, Obiaara B.;
Yapo, Vincent;
Liu, Dandan;
Ji, Juan;
Wolf, Jennifer J.;
Engelman, Alan N.;
Sarafianos, Stefan G.

Publication type:

Article

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Published in:

2020

By:

Francis, Ashwanth C.;
Marin, Mariana;
Singh, Parmit K.;
Achuthan, Vasudevan;
Prellberg, Mathew J.;
Palermino-Rowland, Kristina;
Lan, Shuiyun;
Tedbury, Philip R.;
Sarafianos, Stefan G.;
Engelman, Alan N.;
Melikyan, Gregory B.

Publication type:

Correction Notice

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17256-8

By:

Francis, Ashwanth C.;
Marin, Mariana;
Singh, Parmit K.;
Achuthan, Vasudevan;
Prellberg, Mathew J.;
Palermino-Rowland, Kristina;
Lan, Shuiyun;
Tedbury, Philip R.;
Sarafianos, Stefan G.;
Engelman, Alan N.;
Melikyan, Gregory B.

Publication type:

Article

Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.

Published in:

PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0137797

By:

Wang, Hao;
Shun, Ming-Chieh;
Dickson, Amy K.;
Engelman, Alan N.

Publication type:

Article

Key determinants of target DNA recognition by retroviral intasomes.

Published in:

Retrovirology, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12977-015-0167-3

By:

Serrao, Erik;
Ballandras-Colas, Allison;
Cherepanov, Peter;
Maertens, Goedele N.;
Engelman, Alan N.

Publication type:

Article

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.54311

By:

Elliott, Jennifer L.;
Eschbach, Jenna E.;
Koneru, Pratibha C.;
Wen Li;
Puray-Chavez, Maritza;
Townsend, Dana;
Lawson, Dana Q.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Kutluay, Sebla B.

Publication type:

Article

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.

Published in:

PLoS Pathogens, 2021, v. 17, n. 7, p. 1, doi. 10.1371/journal.ppat.1009671

By:

Maehigashi, Tatsuya;
Ahn, Seohyun;
Kim, Uk-Il;
Lindenberger, Jared;
Oo, Adrian;
Koneru, Pratibha C.;
Mahboubi, Bijan;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Kim, Kyungjin;
Kim, Baek

Publication type:

Article

Foreign DNA capture during CRISPR-Cas adaptive immunity.

Published in:

Nature, 2015, v. 527, n. 7579, p. 535, doi. 10.1038/nature15760

By:

Nuñez, James K.;
Harrington, Lucas B.;
Kranzusch, Philip J.;
Engelman, Alan N.;
Doudna, Jennifer A.

Publication type:

Article

Structural basis for retroviral integration into nucleosomes.

Published in:

Nature, 2015, v. 523, n. 7560, p. 366, doi. 10.1038/nature14495

By:

Maskell, Daniel P.;
Renault, Ludovic;
Serrao, Erik;
Lesbats, Paul;
Matadeen, Rishi;
Hare, Stephen;
Lindemann, Dirk;
Engelman, Alan N.;
Costa, Alessandro;
Cherepanov, Peter

Publication type:

Article

Cellular and molecular mechanisms of HIV-1 integration targeting.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 14, p. 2491, doi. 10.1007/s00018-018-2772-5

By:

Engelman, Alan N.;
Singh, Parmit K.

Publication type:

Article

Sites of retroviral DNA integration: From basic research to clinical applications.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2016, v. 51, n. 1, p. 26, doi. 10.3109/10409238.2015.1102859

By:

Serrao, Erik;
Engelman, Alan N.

Publication type:

Article

Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms.

Published in:

FEBS Journal, 2021, v. 288, n. 2, p. 427, doi. 10.1111/febs.15438

By:

Engelman, Alan N.;
Cherepanov, Peter

Publication type:

Article

Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Published in:

2016

By:

Zurnic, Irena;
Hütter, Sylvia;
Rzeha, Ute;
Helbig, Roger;
Stanke, Nicole;
Reh, Juliane;
Müllers, Erik;
Hamann, Martin V.;
Kern, Tobias;
Gerresheim, Gesche K.;
Lindel, Fabian;
Serrao, Erik;
Lesbats, Paul;
Engelman, Alan N.;
Cherepanov, Peter;
Lindemann, Dirk

Publication type:

Correction Notice

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Published in:

PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005860

By:

Zurnic, Irena;
Hütter, Sylvia;
Rzeha, Ute;
Stanke, Nicole;
Reh, Juliane;
Müllers, Erik;
Hamann, Martin V.;
Kern, Tobias;
Gerresheim, Gesche K.;
Lindel, Fabian;
Serrao, Erik;
Lesbats, Paul;
Engelman, Alan N.;
Cherepanov, Peter;
Lindemann, Dirk

Publication type:

Article