Works by Empting, Martin

Results: 38

Tandem ketone reduction in pepstatin biosynthesis reveals an F<sub>420</sub>H<sub>2</sub>–dependent statine pathway.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59785-0

By:

Mo, Jingjun;
Sikandar, Asfandyar;
Zhao, Haowen;
Bashiri, Ghader;
Huo, Liujie;
Empting, Martin;
Müller, Rolf;
Fu, Chengzhang

Publication type:

Article

Ein Apoptose-induzierendes Heptamer, das effizient den Todesrezeptor 5 bündelt.

Published in:

Angewandte Chemie, 2016, v. 128, n. 16, p. 5169, doi. 10.1002/ange.201511894

By:

Valldorf, Bernhard;
Fittler, Heiko;
Deweid, Lukas;
Ebenig, Aileen;
Dickgiesser, Stephan;
Sellmann, Carolin;
Becker, Janine;
Zielonka, Stefan;
Empting, Martin;
Avrutina, Olga;
Kolmar, Harald

Publication type:

Article

Peptid in Ketten: Einblicke in die Struktur-Aktivitäts-Beziehungen von Proteaseinhibitormimetika mit fixierten Amidkonformationen.

Published in:

Angewandte Chemie, 2012, v. 124, n. 15, p. 3768, doi. 10.1002/ange.201108983

By:

Tischler, Marco;
Nasu, Daichi;
Empting, Martin;
Schmelz, Stefan;
Heinz, Dirk W.;
Rottmann, Philipp;
Kolmar, Harald;
Buntkowsky, Gerd;
Tietze, Daniel;
Avrutina, Olga

Publication type:

Article

'Triazolbrücke': ein Disulfidbrückenersatz durch Ruthenium- katalysierte Bildung von 1,5-disubstituierten 1,2,3-Triazolen.

Published in:

Angewandte Chemie, 2011, v. 123, n. 22, p. 5313, doi. 10.1002/ange.201008142

By:

Empting, Martin;
Avrutina, Olga;
Meusinger, Reinhard;
Fabritz, Sebastian;
Reinwarth, Michael;
Biesalski, Markus;
Voigt, Stephan;
Buntkowsky, Gerd;
Kolmar, Harald

Publication type:

Article

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 37, p. 8894, doi. 10.1002/chem.201901640

By:

Kiefer, Alexander;
Bader, Chantal D.;
Held, Jana;
Esser, Anna;
Rybniker, Jan;
Empting, Martin;
Müller, Rolf;
Kazmaier, Uli

Publication type:

Article

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor.

Published in:

Journal of Peptide Science, 2014, v. 20, n. 6, p. 415, doi. 10.1002/psc.2629

By:

Fittler, Heiko;
Avrutina, Olga;
Empting, Martin;
Kolmar, Harald

Publication type:

Article

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0087851

By:

Schmitt, Christian;
Kail, Dagmar;
Mariano, Marica;
Empting, Martin;
Weber, Nadja;
Paul, Tamara;
Hartmann, Rolf W.;
Engel, Matthias

Publication type:

Article

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.

Published in:

FASEB Journal, 2020, v. 34, n. 1, p. 316, doi. 10.1096/fj.201901314RR

By:

Hollenhorst, Monika I.;
Jurastow, Innokentij;
Nandigama, Rajender;
Appenzeller, Silke;
Li, Lei;
Vogel, Jörg;
Wiederhold, Stephanie;
Althaus, Mike;
Empting, Martin;
Altmüller, Janine;
Hirsch, Anna K. H.;
Flockerzi, Veit;
Canning, Brendan J.;
Saliba, Antoine‐Emmanuel;
Krasteva‐Christ, Gabriela

Publication type:

Article

Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01484-4

By:

Kallergis, Georgios;
Asgari, Ehsannedin;
Empting, Martin;
Hirsch, Anna K. H.;
Klawonn, Frank;
McHardy, Alice C.

Publication type:

Article

1,2,3-Triazole: Multifunktionswerkzeuge für die Peptidchemie.

Published in:

Nachrichten aus der Chemie, 2013, v. 61, n. 1, p. 33, doi. 10.1002/nadc.201390008

By:

Empting, Martin

Publication type:

Article

Structural insights and biomedical potential of IgNAR scaffolds from sharks.

Published in:

mAbs (1942-0862), 2015, v. 7, n. 1, p. 15, doi. 10.4161/19420862.2015.989032

By:

Zielonka, Stefan;
Empting, Martin;
Grzeschik, Julius;
Könning, Doreen;
Barelle, Caroline J;
Kolmar, Harald

Publication type:

Article

Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?

Published in:

International Journal of Nanomedicine, 2024, v. 19, p. 3861, doi. 10.2147/IJN.S445955

By:

Nafee, Noha;
Gaber, Dina M;
Abouelfetouh, Alaa;
Alseqely, Mustafa;
Empting, Martin;
Schneider, Marc

Publication type:

Article

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Published in:

Journal of Molecular Modeling, 2014, v. 20, n. 6, p. 1, doi. 10.1007/s00894-014-2255-z

By:

Hutter, Michael;
Brengel, Christian;
Negri, Matthias;
Henn, Claudia;
Zimmer, Christina;
Hartmann, Rolf;
Empting, Martin;
Steinbach, Anke

Publication type:

Article

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73459-5

By:

Murgia, Xabier;
Kany, Andreas M.;
Herr, Christian;
Ho, Duy-Khiet;
De Rossi, Chiara;
Bals, Robert;
Lehr, Claus-Michael;
Hirsch, Anna K. H.;
Hartmann, Rolf W.;
Empting, Martin;
Röhrig, Teresa

Publication type:

Article

Concepts and Core Principles of Fragment-Based Drug Design.

Published in:

Molecules, 2019, v. 24, n. 23, p. 4309, doi. 10.3390/molecules24234309

By:

Kirsch, Philine;
Hartman, Alwin M.;
Hirsch, Anna K. H.;
Empting, Martin;
Stockman, Brian J.

Publication type:

Article

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle.

Published in:

Advanced Science, 2023, v. 10, n. 5, p. 1, doi. 10.1002/advs.202204443

By:

Hamed, Mostafa M.;
Abdelsamie, Ahmed S.;
Rox, Katharina;
Schütz, Christian;
Kany, Andreas M.;
Röhrig, Teresa;
Schmelz, Stefan;
Blankenfeldt, Wulf;
Arce‐Rodriguez, Alejandro;
Borrero‐de Acuña, José Manuel;
Jahn, Dieter;
Rademacher, Jessica;
Ringshausen, Felix C.;
Cramer, Nina;
Tümmler, Burkhard;
Hirsch, Anna K. H.;
Hartmann, Rolf W.;
Empting, Martin

Publication type:

Article

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023).

Published in:

Advanced Science, 2023, v. 10, n. 5, p. 1, doi. 10.1002/advs.202370027

By:

Hamed, Mostafa M.;
Abdelsamie, Ahmed S.;
Rox, Katharina;
Schütz, Christian;
Kany, Andreas M.;
Röhrig, Teresa;
Schmelz, Stefan;
Blankenfeldt, Wulf;
Arce‐Rodriguez, Alejandro;
Borrero‐de Acuña, José Manuel;
Jahn, Dieter;
Rademacher, Jessica;
Ringshausen, Felix C.;
Cramer, Nina;
Tümmler, Burkhard;
Hirsch, Anna K. H.;
Hartmann, Rolf W.;
Empting, Martin

Publication type:

Article

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 1, p. 1, doi. 10.1007/s11095-018-2521-3

By:

Castoldi, Arianna;
Empting, Martin;
De Rossi, Chiara;
Mayr, Karsten;
Dersch, Petra;
Hartmann, Rolf;
Müller, Rolf;
Gordon, Sarah;
Lehr, Claus-Michael

Publication type:

Article

Titelbild: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. 26/2020).

Published in:

Angewandte Chemie, 2020, v. 132, n. 26, p. 10285, doi. 10.1002/ange.202005838

By:

Ho, Duy‐Khiet;
Murgia, Xabier;
De Rossi, Chiara;
Christmann, Rebekka;
Hüfner de Mello Martins, Antonio G.;
Koch, Marcus;
Andreas, Anastasia;
Herrmann, Jennifer;
Müller, Rolf;
Empting, Martin;
Hartmann, Rolf W.;
Desmaele, Didier;
Loretz, Brigitta;
Couvreur, Patrick;
Lehr, Claus‐Michael

Publication type:

Article

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.

Published in:

Angewandte Chemie, 2020, v. 132, n. 26, p. 10378, doi. 10.1002/ange.202001407

By:

Ho, Duy‐Khiet;
Murgia, Xabier;
De Rossi, Chiara;
Christmann, Rebekka;
Hüfner de Mello Martins, Antonio G.;
Koch, Marcus;
Andreas, Anastasia;
Herrmann, Jennifer;
Müller, Rolf;
Empting, Martin;
Hartmann, Rolf W.;
Desmaele, Didier;
Loretz, Brigitta;
Couvreur, Patrick;
Lehr, Claus‐Michael

Publication type:

Article

The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope.

Published in:

Marine Biotechnology, 2015, v. 17, n. 4, p. 386, doi. 10.1007/s10126-015-9642-z

By:

Zielonka, Stefan;
Empting, Martin;
Könning, Doreen;
Grzeschik, Julius;
Krah, Simon;
Becker, Stefan;
Dickgießer, Stephan;
Kolmar, Harald

Publication type:

Article

Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors.

Published in:

ChemBioChem, 2023, v. 24, n. 16, p. 1, doi. 10.1002/cbic.202300369

By:

Wu, Yingwen;
Zoller, Ben G. E.;
Kamal, Mohamed Ashraf Mostafa;
Hotop, Sven‐Kevin;
Lehr, Claus‐Michael;
Brönstrup, Mark;
Dersch, Petra;
Empting, Martin

Publication type:

Article

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment.

Published in:

Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00924

By:

Allegretta, Giuseppe;
Maurer, Christine K.;
Eberhard, Jens;
Maura, Damien;
Hartmann, Rolf W.;
Rahme, Laurence;
Empting, Martin

Publication type:

Article

Cover Picture: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. Int. Ed. 26/2020).

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10201, doi. 10.1002/anie.202005838

By:

Ho, Duy‐Khiet;
Murgia, Xabier;
De Rossi, Chiara;
Christmann, Rebekka;
Hüfner de Mello Martins, Antonio G.;
Koch, Marcus;
Andreas, Anastasia;
Herrmann, Jennifer;
Müller, Rolf;
Empting, Martin;
Hartmann, Rolf W.;
Desmaele, Didier;
Loretz, Brigitta;
Couvreur, Patrick;
Lehr, Claus‐Michael

Publication type:

Article

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10292, doi. 10.1002/anie.202001407

By:

Ho, Duy‐Khiet;
Murgia, Xabier;
De Rossi, Chiara;
Christmann, Rebekka;
Hüfner de Mello Martins, Antonio G.;
Koch, Marcus;
Andreas, Anastasia;
Herrmann, Jennifer;
Müller, Rolf;
Empting, Martin;
Hartmann, Rolf W.;
Desmaele, Didier;
Loretz, Brigitta;
Couvreur, Patrick;
Lehr, Claus‐Michael

Publication type:

Article

An Apoptosis-Inducing Peptidic Heptad That Efficiently Clusters Death Receptor 5.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 16, p. 5085, doi. 10.1002/anie.201511894

By:

Valldorf, Bernhard;
Fittler, Heiko;
Deweid, Lukas;
Ebenig, Aileen;
Dickgiesser, Stephan;
Sellmann, Carolin;
Becker, Janine;
Zielonka, Stefan;
Empting, Martin;
Avrutina, Olga;
Kolmar, Harald

Publication type:

Article

Single-domain antibodies for biomedical applications.

Published in:

Immunopharmacology & Immunotoxicology, 2016, v. 38, n. 1, p. 21, doi. 10.3109/08923973.2015.1102934

By:

Krah, Simon;
Schröter, Christian;
Zielonka, Stefan;
Empting, Martin;
Valldorf, Bernhard;
Kolmar, Harald

Publication type:

Article

Trendbericht Biochemie 2017: Pathoblocker – Ein neues Konzept gegen bakterielle Infektionen.

Published in:

Nachrichten aus der Chemie, 2018, v. 66, n. 3, p. 290, doi. 10.1002/nadc.20184071782

By:

Empting, Martin

Publication type:

Article

Trendbericht Biochemie 2017: Zellpenetration.

Published in:

Nachrichten aus der Chemie, 2018, v. 66, n. 3, p. 294, doi. 10.1002/nadc.20184071749

By:

Avrutina, Olga;
Kolmar, Harald;
Empting, Martin

Publication type:

Article

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH‐like 2‐Heptyl‐3‐hydroxy‐4(1H)‐quinolone (PQS) Biosynthesis Enzyme PqsBC.

Published in:

ChemBioChem, 2018, v. 19, n. 14, p. 1531, doi. 10.1002/cbic.201800153

By:

Witzgall, Florian;
Depke, Tobias;
Hoffmann, Michael;
Empting, Martin;
Brönstrup, Mark;
Müller, Rolf;
Blankenfeldt, Wulf

Publication type:

Article

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.

Published in:

ChemBioChem, 2015, v. 16, n. 17, p. 2441, doi. 10.1002/cbic.201500447

By:

Fittler, Heiko;
Depp, Alexander;
Avrutina, Olga;
Dahms, Sven O.;
Than, Manuel E.;
Empting, Martin;
Kolmar, Harald

Publication type:

Article

Front Cover: Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence (ChemMedChem 2/2020).

Published in:

ChemMedChem, 2020, v. 15, n. 2, p. 176, doi. 10.1002/cmdc.201900684

By:

Zender, Michael;
Witzgall, Florian;
Kiefer, Alexander;
Kirsch, Benjamin;
Maurer, Christine K.;
Kany, Andreas M.;
Xu, Ningna;
Schmelz, Stefan;
Börger, Carsten;
Blankenfeldt, Wulf;
Empting, Martin

Publication type:

Article

Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence.

Published in:

ChemMedChem, 2020, v. 15, n. 2, p. 188, doi. 10.1002/cmdc.201900621

By:

Zender, Michael;
Witzgall, Florian;
Kiefer, Alexander;
Kirsch, Benjamin;
Maurer, Christine K.;
Kany, Andreas M.;
Xu, Ningna;
Schmelz, Stefan;
Börger, Carsten;
Blankenfeldt, Wulf;
Empting, Martin

Publication type:

Article

Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.

Published in:

ChemMedChem, 2017, v. 12, n. 19, p. 1616, doi. 10.1002/cmdc.201700363

By:

Brengel, Christian;
Thomann, Andreas;
Schifrin, Alexander;
Allegretta, Giuseppe;
Kamal, Ahmed A. M.;
Haupenthal, Jörg;
Schnorr, Isabell;
Cho, Sang Hyun;
Franzblau, Scott G.;
Empting, Martin;
Eberhard, Jens;
Hartmann, Rolf W.

Publication type:

Article

Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa.

Published in:

ChemMedChem, 2016, v. 11, n. 22, p. 2522, doi. 10.1002/cmdc.201600419

By:

Thomann, Andreas;
Brengel, Christian;
Börger, Carsten;
Kail, Dagmar;
Steinbach, Anke;
Empting, Martin;
Hartmann, Rolf W.

Publication type:

Article

Braces for the Peptide Backbone: Insights into Structure-Activity Relationships of Protease Inhibitor Mimics with Locked Amide Conformations.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 15, p. 3708, doi. 10.1002/anie.201108983

By:

Tischler, Marco;
Nasu, Daichi;
Empting, Martin;
Schmelz, Stefan;
Heinz, Dirk W.;
Rottmann, Philipp;
Kolmar, Harald;
Buntkowsky, Gerd;
Tietze, Daniel;
Avrutina, Olga

Publication type:

Article

'Triazole Bridge': Disulfide-Bond Replacement by Ruthenium-Catalyzed Formation of 1,5-Disubstituted 1,2,3-Triazoles.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 22, p. 5207, doi. 10.1002/anie.201008142

By:

Empting, Martin;
Avrutina, Olga;
Meusinger, Reinhard;
Fabritz, Sebastian;
Reinwarth, Michael;
Biesalski, Markus;
Voigt, Stephan;
Buntkowsky, Gerd;
Kolmar, Harald

Publication type:

Article

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor.

Published in:

Biological Chemistry, 2019, v. 400, n. 3, p. 333, doi. 10.1515/hsz-2018-0333

By:

Kamal, Ahmed Ashraf Moustafa;
Habib, Monica;
Haupenthal, Joerg;
Hartmann, Rolf Wolfgang;
Empting, Martin

Publication type:

Article