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Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors.
Published in:
Pharmaceutics, 2020, v. 12, n. 12, p. 1205, doi. 10.3390/pharmaceutics12121205
By:
- Griffith, Jessica I.;
- Rathi, Sneha;
- Zhang, Wenqiu;
- Zhang, Wenjuan;
- Drewes, Lester R.;
- Sarkaria, Jann N.;
- Elmquist, William F.
Publication type:
Article
Brain barriers virtual: an interim solution or future opportunity?
Published in:
Fluids & Barriers of the CNS, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12987-022-00314-2
By:
- Holder, Brianna M.;
- Tolan, Shaina E.;
- Heinrich, Kaleb K.;
- Miller, Kaitlin C.;
- Hudson, Natalie;
- Nehra, Geetika;
- Pizzo, Michelle E.;
- Storck, Steffen E.;
- Elmquist, William F.;
- Engelhardt, Britta;
- Loryan, Irena;
- Toborek, Michal;
- Bauer, Bjoern;
- Hartz, Anika M. S.;
- Kim, Brandon J.
Publication type:
Article
How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors.
Published in:
Pharmaceutical Research, 2023, v. 40, n. 11, p. 2731, doi. 10.1007/s11095-023-03574-1
By:
- Zhang, Wenjuan;
- Oh, Ju-Hee;
- Zhang, Wenqiu;
- Rathi, Sneha;
- Le, Jiayan;
- Talele, Surabhi;
- Sarkaria, Jann N.;
- Elmquist, William F.
Publication type:
Article
To Measure is to Know: A Perspective on the Work of Dr. Margareta Hammarlund-Udenaes.
Published in:
Pharmaceutical Research, 2022, v. 39, n. 7, p. 1297, doi. 10.1007/s11095-022-03225-x
By:
- Griffith, Jessica I.;
- Elmquist, William F.
Publication type:
Article
Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine.
Published in:
Pharmaceutical Research, 2018, v. 35, n. 9, p. 1, doi. 10.1007/s11095-018-2455-9
By:
- Kim, Minjee;
- Kizilbash, Sani H.;
- Laramy, Janice K.;
- Gampa, Gautham;
- Parrish, Karen E.;
- Sarkaria, Jann N.;
- Elmquist, William F.
Publication type:
Article
E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases.
Published in:
Investigational New Drugs, 2019, v. 37, n. 4, p. 636, doi. 10.1007/s10637-018-0668-8
By:
- Babiker, Hani M.;
- Byron, Sara A.;
- Hendricks, William P. D.;
- Elmquist, William F.;
- Gampa, Gautham;
- Vondrak, Jessica;
- Aldrich, Jessica;
- Cuyugan, Lori;
- Adkins, Jonathan;
- De Luca, Valerie;
- Tibes, Raoul;
- Borad, Mitesh J.;
- Marceau, Katie;
- Myers, Thomas J.;
- Paradiso, Linda J.;
- Liang, Winnie S.;
- Korn, Ronald L.;
- Cridebring, Derek;
- Von Hoff, Daniel D.;
- Carpten, John D.
Publication type:
Article
Multi-Parametric MRI and Texture Analysis to Visualize Spatial Histologic Heterogeneity and Tumor Extent in Glioblastoma.
Published in:
PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0141506
By:
- Hu, Leland S.;
- Ning, Shuluo;
- Eschbacher, Jennifer M.;
- Gaw, Nathan;
- Dueck, Amylou C.;
- Smith, Kris A.;
- Nakaji, Peter;
- Plasencia, Jonathan;
- Ranjbar, Sara;
- Price, Stephen J.;
- Tran, Nhan;
- Loftus, Joseph;
- Jenkins, Robert;
- O’Neill, Brian P.;
- Elmquist, William;
- Baxter, Leslie C.;
- Gao, Fei;
- Frakes, David;
- Karis, John P.;
- Zwart, Christine
Publication type:
Article
Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2007, v. 27, n. 5, p. 1033, doi. 10.1038/sj.jcbfm.9600414
By:
- Spitzenberger, Timothy J.;
- Heilman, David;
- Diekmann, Casey;
- Batrakova, Elena V.;
- Kabanov, Alexander V.;
- Gendelman, Howard E.;
- Elmquist, William F.;
- Persidsky, Yuri
Publication type:
Article
Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens.
Published in:
Breast Cancer Research & Treatment, 2006, v. 96, n. 3, p. 217, doi. 10.1007/s10549-005-9004-z
By:
- Mark Kirstein;
- Richard Brundage;
- William Elmquist;
- Rory Remmel;
- Paul Marker;
- Dan Guire;
- Douglas Yee
Publication type:
Article
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63494-7
By:
- Gampa, Gautham;
- Kenchappa, Rajappa S.;
- Mohammad, Afroz S.;
- Parrish, Karen E.;
- Kim, Minjee;
- Crish, James F.;
- Luu, Amanda;
- West, Rita;
- Hinojosa, Alfredo Quinones;
- Sarkaria, Jann N.;
- Rosenfeld, Steven S.;
- Elmquist, William F.
Publication type:
Article
Changes in the vasculature of human brain tumors: Implications for treatment.
Published in:
Neuro-Oncology, 2021, v. 23, n. 12, p. 1995, doi. 10.1093/neuonc/noab220
By:
- Zhang, Wenjuan;
- Talele, Surabhi;
- Sarkaria, Jann N;
- Elmquist, William F
Publication type:
Article
Baseline requirements for novel agents being considered for phase II/III brain cancer efficacy trials: conclusions from the Adult Brain Tumor Consortium's first workshop on CNS drug delivery.
Published in:
Neuro-Oncology, 2020, v. 22, n. 10, p. 1422, doi. 10.1093/neuonc/noaa142
By:
- Grossman, Stuart A;
- Romo, Carlos G;
- Rudek, Michelle A;
- Supko, Jeffrey;
- Fisher, Joy;
- Nabors, L Burt;
- Wen, Patrick Y;
- Peereboom, David M;
- Ellingson, Benjamin M;
- Elmquist, William;
- Barker, Fred G;
- Kamson, David;
- Sarkaria, Jann N;
- Timmer, William;
- Bindra, Ranjit S;
- Ye, Xiaobu
Publication type:
Article
Comments on: "Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity".
Published in:
Neuro-Oncology, 2020, v. 22, n. 9, p. 1404, doi. 10.1093/neuonc/noaa112
By:
- Tellingen, Olaf van;
- Gooijer, Mark C de;
- Sarkaria, Jann N;
- Elmquist, William F
Publication type:
Article
Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data.
Published in:
Neuro-Oncology, 2018, v. 20, n. 2, p. 184, doi. 10.1093/neuonc/nox175
By:
- Sarkaria, Jann N.;
- Hu, Leland S.;
- Parney, Ian F.;
- Pafundi, Deanna H.;
- Brinkmann, Debra H.;
- Laack, Nadia N.;
- Giannini, Caterina;
- Burns, Terence C.;
- Kizilbash, Sani H.;
- Laramy, Janice K.;
- Swanson, Kristin R.;
- Kaufmann, Timothy J.;
- Brown, Paul D.;
- Agar, Nathalie Y. R.;
- Galanis, Evanthia;
- Buckner, Jan C.;
- Elmquist, William F.
Publication type:
Article
Radiogenomics to characterize regional genetic heterogeneity in glioblastoma.
Published in:
Neuro-Oncology, 2017, v. 19, n. 1, p. 128, doi. 10.1093/neuonc/now135
By:
- Hu, Leland S.;
- Shuluo Ning;
- Eschbacher, Jennifer M.;
- Baxter, Leslie C.;
- Gaw, Nathan;
- Ranjbar, Sara;
- Plasencia, Jonathan;
- Dueck, Amylou C.;
- Sen Peng;
- Smith, Kris A.;
- Nakaji, Peter;
- Karis, John P.;
- Quarles, C. Chad;
- Wu, Teresa;
- Loftus, Joseph C.;
- Jenkins, Robert B.;
- Sicotte, Hugues;
- Kollmeyer, Thomas M.;
- O'Neill, Brian P.;
- Elmquist, William
Publication type:
Article
Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma.
Published in:
Neuro-Oncology, 2016, v. 18, n. 1, p. 27, doi. 10.1093/neuonc/nov164
By:
- Oberoi, Rajneet K.;
- Parrish, Karen E.;
- Sio, Terence T.;
- Mittapalli, Rajendar K.;
- Elmquist, William F.;
- Sarkaria, Jann N.
Publication type:
Article
CNS Anticancer Drug Discovery and Development Conference White Paper.
Published in:
Neuro-Oncology, 2015, v. 17, p. vi1, doi. 10.1093/neuonc/nov169
By:
- Levin, Victor A.;
- Tonge, Peter J.;
- Gallo, James M.;
- Birtwistle, Marc R.;
- Dar, Arvin C.;
- Iavarone, Antonio;
- Paddison, Patrick J.;
- Heffron, Timothy P.;
- Elmquist, William F.;
- Lachowicz, Jean E.;
- Johnson, Ted W.;
- White, Forest M.;
- Joohee Sul;
- Smith, Quentin R.;
- Wang Shen;
- Sarkaria, Jann N.;
- Samala, Ramakrishna;
- Wen, Patrick Y.;
- Berry, Donald A.;
- Petter, Russell C.
Publication type:
Article
Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.
Published in:
Neuro-Oncology, 2015, v. 17, n. 9, p. 1210, doi. 10.1093/neuonc/nov081
By:
- Becker, Chani M.;
- Oberoi, Rajneet K.;
- McFarren, Stephan J.;
- Muldoon, Daniel M.;
- Pafundi, Deanna H.;
- Pokorny, Jenny L.;
- Brinkmann, Debra H.;
- Ohlfest, John R.;
- Sarkaria, Jann N.;
- Largaespada, David A.;
- Elmquist, William F.
Publication type:
Article
Unsanctifying the sanctuary: challenges and opportunities with brain metastases.
Published in:
Neuro-Oncology, 2015, v. 17, n. 5, p. 639, doi. 10.1093/neuonc/nov023
By:
- Puhalla, Shannon;
- Elmquist, William;
- Freyer, David;
- Kleinberg, Lawrence;
- Adkins, Chris;
- Lockman, Paul;
- McGregor, John;
- Muldoon, Leslie;
- Nesbit, Gary;
- Peereboom, David;
- Smith, Quentin;
- Walker, Sara;
- Neuwelt, Edward
Publication type:
Article
INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT PI3K/MTOR INHIBITORS.
Published in:
Neuro-Oncology, 2014, v. 16, n. suppl_3, p. iii33, doi. 10.1093/neuonc/nou208.40
By:
- Sarkaria, Jann N.;
- Pokorny, Jenny L.;
- Mladek, Ann C.;
- Parrish, Karen;
- Oberoi, Rajneet;
- Sio, Terence;
- Mittapalli, Rajendar K.;
- Elmquist, William F.
Publication type:
Article
Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium.
Published in:
Neuro-Oncology, 2004, v. 6, n. 1, p. 65, doi. 10.1215/S1152851703000103
By:
- Benjamin, Ramsis K.;
- Hochberg, Fred H.;
- Fox, Elizabeth;
- Bungay, Peter M.;
- Elmquist, William F.;
- Stewart, Clinton F.;
- Gallo, James M.;
- Collins, Jerry M.;
- Pelletier, Robert P.;
- de Groot, John F.;
- Hickner, Robert C.;
- Cavus, Idil;
- Grossman, Stuart A.;
- Colvin, O. Michael
Publication type:
Article
The influence of the blood–brain barrier in the treatment of brain tumours.
Published in:
Journal of Internal Medicine, 2022, v. 292, n. 1, p. 3, doi. 10.1111/joim.13440
By:
- Rathi, Sneha;
- Griffith, Jessica I.;
- Zhang, Wenjuan;
- Zhang, Wenqiu;
- Oh, Ju‐Hee;
- Talele, Surabhi;
- Sarkaria, Jann N.;
- Elmquist, William F.
Publication type:
Article
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.
Published in:
Neuro-Oncology Advances, 2023, v. 5, n. 1, p. 1, doi. 10.1093/noajnl/vdad066
By:
- Conage-Pough, Jason E;
- Stopka, Sylwia A;
- Oh, Ju-Hee;
- Mladek, Ann C;
- Burgenske, Danielle M;
- Regan, Michael S;
- Baquer, Gerard;
- Decker, Paul A;
- Carlson, Brett L;
- Bakken, Katrina K;
- Zhang, Jinqiang;
- Liu, Lily;
- Sun, Claire;
- Mu, Zhihua;
- Zhong, Wei;
- Tran, Nhan L;
- Elmquist, William F;
- Agar, Nathalie Y R;
- Sarkaria, Jann N;
- White, Forest M
Publication type:
Article
Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time.
Published in:
Neuro-Oncology Advances, 2023, v. 5, n. 1, p. 1, doi. 10.1093/noajnl/vdad033
By:
- Power, Erica A;
- Rechberger, Julian S;
- Zhang, Liang;
- Oh, Ju-Hee;
- Anderson, Jacob B;
- Nesvick, Cody L;
- Ge, Jizhi;
- Hinchcliffe, Edward H;
- Elmquist, William F;
- Daniels, David J
Publication type:
Article
Methodological and analytical considerations for intra-operative microdialysis.
Published in:
Fluids & Barriers of the CNS, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12987-023-00497-2
By:
- Riviere-Cazaux, Cecile;
- Rajani, Karishma;
- Rahman, Masum;
- Oh, Juhee;
- Brown, Desmond A.;
- White, Jaclyn F.;
- Himes, Benjamin T.;
- Jusue-Torres, Ignacio;
- Rodriguez, Moses;
- Warrington, Arthur E.;
- Kizilbash, Sani H.;
- Elmquist, William F.;
- Burns, Terry C.
Publication type:
Article
Methodological and analytical considerations for intra-operative microdialysis.
Published in:
Fluids & Barriers of the CNS, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12987-023-00497-2
By:
- Riviere-Cazaux, Cecile;
- Rajani, Karishma;
- Rahman, Masum;
- Oh, Juhee;
- Brown, Desmond A.;
- White, Jaclyn F.;
- Himes, Benjamin T.;
- Jusue-Torres, Ignacio;
- Rodriguez, Moses;
- Warrington, Arthur E.;
- Kizilbash, Sani H.;
- Elmquist, William F.;
- Burns, Terry C.
Publication type:
Article
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05035-2
By:
- Riviere-Cazaux, Cecile;
- Carlstrom, Lucas P.;
- Rajani, Karishma;
- Munoz-Casabella, Amanda;
- Rahman, Masum;
- Gharibi-Loron, Ali;
- Brown, Desmond A.;
- Miller, Kai J.;
- White, Jaclyn J.;
- Himes, Benjamin T.;
- Jusue-Torres, Ignacio;
- Ikram, Samar;
- Ransom, Seth C.;
- Hirte, Renee;
- Oh, Ju-Hee;
- Elmquist, William F.;
- Sarkaria, Jann N.;
- Vaubel, Rachael A.;
- Rodriguez, Moses;
- Warrington, Arthur E.
Publication type:
Article
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.
Published in:
Science Translational Medicine, 2024, v. 16, n. 734, p. 1, doi. 10.1126/scitranslmed.adj5962
By:
- Chen, Jiajia;
- Laverty, Daniel J.;
- Talele, Surabhi;
- Bale, Ashwin;
- Carlson, Brett L.;
- Porath, Kendra A.;
- Bakken, Katrina K.;
- Burgenske, Danielle M.;
- Decker, Paul A.;
- Vaubel, Rachael A.;
- Eckel-Passow, Jeanette E.;
- Bhargava, Rohit;
- Lou, Zhenkun;
- Hamerlik, Petra;
- Harley, Brendan;
- Elmquist, William F.;
- Nagel, Zachary D.;
- Gupta, Shiv K.;
- Sarkaria, Jann N.
Publication type:
Article
Lisdexamfetamine Pharmacokinetic Comparison Between Patients Who Underwent Roux-en-Y Gastric Bypass and Nonsurgical Controls.
Published in:
Obesity Surgery, 2021, v. 31, n. 10, p. 4289, doi. 10.1007/s11695-020-04969-4
By:
- Steffen, Kristine J.;
- Mohammad, Afroz S.;
- Roerig, James L.;
- Mitchell, James E.;
- Nelson, Carrie;
- Orcutt, Molly;
- Zhang, Wenqiu;
- Erickson, Ann L.;
- Elmquist, William F.
Publication type:
Article
Bayesian Approach to Estimate AUC, Partition Coefficient and Drug Targeting Index for Studies with Serial Sacrifice Design.
Published in:
Pharmaceutical Research, 2014, v. 31, n. 3, p. 649, doi. 10.1007/s11095-013-1187-0
By:
- Wang, Tianli;
- Baron, Kyle;
- Zhong, Wei;
- Brundage, Richard;
- Elmquist, William
Publication type:
Article
AAPS-FDA Workshop White Paper: Microdialysis Principles, Application and Regulatory Perspectives.
Published in:
Pharmaceutical Research, 2007, v. 24, n. 5, p. 1014, doi. 10.1007/s11095-006-9206-z
By:
- Chandra Chaurasia;
- Markus Müller;
- Edward Bashaw;
- Eva Benfeldt;
- Jan Bolinder;
- Ross Bullock;
- Peter Bungay;
- Elizabeth DeLange;
- Hartmut Derendorf;
- William Elmquist;
- Margareta Hammarlund-Udenaes;
- Christian Joukhadar;
- Dean Kellogg;
- Craig Lunte;
- Carl Nordstrom;
- Hans Rollema;
- Ronald Sawchuk;
- Belinda Cheung;
- Vinod Shah;
- Lars Stahle
Publication type:
Article

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