Works by Elmore, Charles S.

Results: 69

Development and In Vitro Characterization of [ 3 H]GMC-058 as Radioligand for Imaging Parkinsonian-Related Proteinopathies.

Published in:

Cells (2073-4409), 2025, v. 14, n. 12, p. 869, doi. 10.3390/cells14120869

By:

Varrone, Andrea;
Sousa, Vasco C.;
Mugnaini, Manolo;
Biesinger, Sandra;
Nordvall, Gunnar;
Kingston, Lee;
Guzzetti, Ileana;
Elmore, Charles S.;
Sunnemark, Dan;
Saturnino Guarino, Dinahlee;
Finnema, Sjoerd J.;
Schou, Magnus

Publication type:

Article

The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2021, v. 64, n. 2, p. 65, doi. 10.1002/jlcr.3902

By:

Kingston, Lee;
Gu, Chungang;
Guo, Jian;
Swallow, Steve;
Elmore, Charles S.

Publication type:

Article

Synthesis of C‐14 labeled Rac‐(3R,2S)‐glycopyrronium bromide.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2020, v. 63, n. 10, p. 456, doi. 10.1002/jlcr.3864

By:

Bergare, Jonas;
Nixon, Neil;
Newsome, Jeffery;
Thunberg, Linda;
Elmore, Charles S.

Publication type:

Article

The synthesis of one H‐2 labeled and two H‐3 labeled leukotriene C4 synthase inhibitors.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2020, v. 63, n. 10, p. 434, doi. 10.1002/jlcr.3862

By:

Bergare, Jonas;
Kingston, Lee;
Guly, Dominic J.;
Dolan, James;
Lewis, Richard J.;
Elmore, Charles S.

Publication type:

Article

The synthesis of isotopologues of AZD7307: A selective β2‐adrenoreceptor agonist.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 11, p. 707, doi. 10.1002/jlcr.3778

By:

Kingston, Lee P.;
Hickey, Michael J.;
Elmore, Charles S.

Publication type:

Article

Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 11, p. 690, doi. 10.1002/jlcr.3743

By:

Czeskis, Boris;
Elmore, Charles S.;
Haight, Anthony;
Hesk, David;
Maxwell, Brad D.;
Miller, Scott A.;
Raglione, Thomas;
Schildknegt, Klaas;
Traverse, John F.;
Wang, Peng

Publication type:

Article

Synthesis of di‐docosahexaenoyl (C22:6)‐bis(monoacylglycerol) phosphate in unlabelled and C‐13 labelled forms for use as a biomarker of drug induced phospholipidosis.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 11, p. 695, doi. 10.1002/jlcr.3714

By:

Hickey, Michael J.;
Lindqvist, Johnny;
Ha, Young‐ Hwan;
Andersson, Håkan;
Elmore, Charles S.

Publication type:

Article

Synthesis, 3H‐labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 6, p. 265, doi. 10.1002/jlcr.3731

By:

Artelsmair, Markus;
Miranda‐Azpiazu, Patricia;
Kingston, Lee;
Bergare, Jonas;
Schou, Magnus;
Varrone, Andrea;
Elmore, Charles S.

Publication type:

Article

New trends and applications in carboxylation for isotope chemistry.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2018, v. 61, n. 13, p. 934, doi. 10.1002/jlcr.3633

By:

Bragg, Ryan A.;
Sardana, Malvika;
Artelsmair, Markus;
Elmore, Charles S.

Publication type:

Article

Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2018, v. 61, n. 5, p. 415, doi. 10.1002/jlcr.3602

By:

Artelsmair, Markus;
Gu, Chungang;
Lewis, Richard J.;
Elmore, Charles S.

Publication type:

Article

Synthesis of 2 C-14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 6, p. 294, doi. 10.1002/jlcr.3502

By:

Kingston, Lee;
Bergare, Jonas;
Lönn, Hans;
Ericsson, Cecilia;
Grönberg, Gunnar;
Chen, Song;
Elmore, Charles S.

Publication type:

Article

Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 4, p. 221, doi. 10.1002/jlcr.3495

By:

Hayes, Martin A.;
Roberts, Ieuan;
Grönberg, Gunnar;
Lv, Kexin;
Lin, Baorui;
Bergare, Jonas;
Elmore, Charles S.

Publication type:

Article

Isotope labelling by reduction of nitriles: Application to the synthesis of isotopologues of tolmetin and celecoxib.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 4, p. 213, doi. 10.1002/jlcr.3492

By:

Ellis ‐ Sawyer, Kate;
Bragg, Ryan A.;
Bushby, Nick;
Elmore, Charles S.;
Hickey, Michael J.

Publication type:

Article

The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 2, p. 124, doi. 10.1002/jlcr.3483

By:

Allen, Paul;
Bragg, Ryan A.;
Caffrey, Moya;
Ericsson, Cecilia;
Hickey, Michael J.;
Kingston, Lee P.;
Elmore, Charles S.

Publication type:

Article

The synthesis of tritium, carbon-14 and stable isotope labelled selective estrogen receptor degraders.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2016, v. 59, n. 11, p. 454, doi. 10.1002/jlcr.3437

By:

Bragg, Ryan A.;
Bushby, Nick;
Ericsson, Cecilia;
Kingston, Lee P.;
Ji, Hailong;
Elmore, Charles S.

Publication type:

Article

Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP).

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2016, v. 59, n. 9, p. 340, doi. 10.1002/jlcr.3409

By:

Lindelöf, Åsa;
Ericsson, Cecilia;
Simonsson, Roger;
Nilsson, Göran;
Grönberg, Gunnar;
Elmore, Charles S.

Publication type:

Article

Editorial.

Published in:

2016

By:

Maxwell, Brad D.;
Elmore, Charles S.

Publication type:

Editorial

Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2016, v. 59, n. 4, p. 136, doi. 10.1002/jlcr.3370

By:

Schenk, David J.;
Lockley, William J. S.;
Elmore, Charles S.;
Hesk, Dave;
Roberts, Drew

Publication type:

Article

Evaluation of UV-HPLC and mass spectrometry methods for specific activity determination.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 11, p. 645, doi. 10.1002/jlcr.3234

By:

Elmore, Charles S.;
Schenk, David J.;
Arent, Robert;
Kingston, Lee

Publication type:

Article

Synthesis of three alpha 7 agonists in labeled form.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 5, p. 342, doi. 10.1002/jlcr.3186

By:

Elmore, Charles S.;
Landvatter, Scott;
Dorff, Peter N.;
Powell, Mark E.;
Killick, David;
Blake, Timothy;
Hall, James;
Heys, J. Richard;
Harding, John;
Urbanek, Rebecca;
Ernst, Glen

Publication type:

Article

Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2013, v. 56, n. 6, p. 334, doi. 10.1002/jlcr.3028

By:

Simonsson, Roger;
Stenhagen, Gunnar;
Ericsson, Cecilia;
Elmore, Charles S.

Publication type:

Article

14Carbon monoxide made simple - novel approach to the generation, utilization, and scrubbing of 14carbon monoxide 14Carbon monoxide made simple - novel approach to the generation, utilization, and scrubbing of 14carbon monoxide

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2012, v. 55, n. 11, p. 411, doi. 10.1002/jlcr.2962

By:

Lindhardt, Anders T.;
Simonssen, Roger;
Taaning, Rolf H.;
Gøgsig, Thomas M.;
Nilsson, Göran N.;
Stenhagen, Gunnar;
Elmore, Charles S.;
Skrydstrup, Troels

Publication type:

Article

Preparation of two D2 partial agonists in C-14 and stable isotope labeled forms.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2012, v. 55, n. 9, p. 359, doi. 10.1002/jlcr.2951

By:

Elmore, Charles S.;
Powell, Mark E.;
Xiong, Hui;
Wu, Ye;
Wang, Lijuan;
Saunders, David;
Urbanek, Rebecca A.

Publication type:

Article

Synthesis of a delta opioid agonist in [2H6], [2H4], [11C], and [14C] labeled forms.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2011, v. 54, n. 14, p. 847, doi. 10.1002/jlcr.1939

By:

Elmore, Charles S.;
Brush, Kelly;
Schou, Magnus;
Palmer, William;
Dorff, Peter N.;
Powell, Mark E.;
Hoesch, Valerie;
Hall, James E.;
Hudzik, Thomas;
Halldin, Christer;
Dantzman, Cathy L.

Publication type:

Article

Synthesis of the NK3 receptor antagonist AZD2624 in C-14-, H-3- and C-13-labeled forms.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2011, v. 54, n. 5, p. 239, doi. 10.1002/jlcr.1858

By:

Elmore, Charles S.;
Dorff, Peter N.;
Powell, Mark E.;
Hall, James E.;
Simpson, Thomas R.

Publication type:

Article

Synthesis of [.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2011, v. 54, n. 3, p. 123, doi. 10.1002/jlcr.1829

By:

Dorff, Peter N.;
Powell, Mark E.;
Elmore, Charles S.

Publication type:

Article

The synthesis and use of [.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2011, v. 54, n. 2, p. 59, doi. 10.1002/jlcr.1809

By:

Elmore, Charles S.

Publication type:

Article

Synthesis of triphenylsilyl[.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2011, v. 54, n. 1, p. 51, doi. 10.1002/jlcr.1808

By:

Elmore, Charles S.;
Dorff, Peter N.

Publication type:

Article

Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin-11(10H)-one, and dibenzo[b,f][1,4]oxazepin-11(10H)-one in C-14 labeled form by [14C]carbonylation.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2010, v. 53, n. 13, p. 787, doi. 10.1002/jlcr.1802

By:

Elmore, Charles S.;
Dorff, Peter N.;
Richard Heys, J.

Publication type:

Article

Meta-substituent effects on organoiridium-catalyzed ortho-hydrogen isotope exchange.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2009, v. 52, n. 6, p. 189, doi. 10.1002/jlcr.1588

By:

Heys, J. Richard;
Elmore, Charles S.

Publication type:

Article

Synthesis of a 14C-labeled FPTase inhibitor via a Pd-catalyzed cyanation with Zn(14CN)2 and via bromo[14C]acetic acid.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2008, v. 51, n. 12, p. 399, doi. 10.1002/jlcr.1545

By:

Ho, Jonathan Z.;
Elmore, Charles S.;
Braun, Matthew P.

Publication type:

Article

Syntheses of AZ12320927 labeled with H-3, C-14, and H-2.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2008, v. 51, n. 9, p. 343, doi. 10.1002/jlcr.1534

By:

Elmore, Charles S.;
Powell, Mark E.;
Heys, J. Richard

Publication type:

Article

Synthesis of two isotopically labeled 5-HT1B antagonists.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2007, v. 50, n. 5/6, p. 412, doi. 10.1002/jlcr.1164

By:

Elmore, Charles S.;
Hall, James E.;
Ye, Xiaomei;
Richard Heys, J.

Publication type:

Article

Investigation of isotopic exchange reactions using N-heterocyclic iridium (I) complexes.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2007, v. 50, n. 5/6, p. 523, doi. 10.1002/jlcr.1239

By:

Powell, Mark E.;
Elmore, Charles S.;
Dorff, Peter N.;
Heys, J. Richard

Publication type:

Article

Use of fluorous and solid-phase electrophiles as scavengers for excess amine in the preparation of sulfur-35 labelled radioligands.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2005, v. 48, n. 3, p. 203, doi. 10.1002/jlcr.915

By:

Zhang, Andy Shiqiang;
Elmore, Charles S.;
Egan, Marjorie A.;
Melillo, David G.;
Dean, Dennis C.

Publication type:

Article

The syntheses of [14C] and [13C2,15N3]aprepitant.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2004, v. 47, n. 12, p. 837, doi. 10.1002/jlcr.872

By:

Elmore, Charles S.;
Dean, Dennis C.;
Zhang, Yong;
Mellilo, David G.

Publication type:

Article

Synthesis of two non-peptidyl GnRH receptor antagonists via [14C]carbonylation.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2003, v. 46, n. 10, p. 993

By:

Charles S. Elmore;
Dennis C. Dean;
Robert J. DeVita;
David G. Melillo

Publication type:

Article

Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2002, v. 45, n. 1, p. 29, doi. 10.1002/jlcr.537

By:

Elmore, Charles S.;
Dean, Dennis C.;
Zhang, Yong;
Gibson, Carter;
Jenkins, Herb;
Jones, Allen N.;
Melillo, David G.

Publication type:

Article

The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates.

Published in:

Molecular Imaging, 2017, v. 16, p. 1, doi. 10.1177/1536012117731258

By:

Shu-fei Lin;
Bois, Frederic;
Holden, Daniel;
Nabulsi, Nabeel;
Pracitto, Richard;
Hong Gao;
Kapinos, Michael;
Jo-ku Teng;
Shirali, Anupama;
Ropchan, Jim;
Carson, Richard E.;
Elmore, Charles S.;
Vasdev, Neil;
Yiyun Huang

Publication type:

Article

Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 5, p. 1, doi. 10.1002/anie.202417179

By:

Smith, Blair I. P.;
Knight, Nathan M. L.;
Knox, Gary J.;
Lindsay, David M.;
Paterson, Laura C.;
Bergare, Jonas;
Elmore, Charles S.;
Bragg, Ryan A.;
Kerr, William J.

Publication type:

Article

Nickel Catalyzed Carbonylative Cross Coupling for Direct Access to Isotopically Labeled Alkyl Aryl Ketones.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 51, p. 1, doi. 10.1002/anie.202412247

By:

Mühlfenzl, Kim S.;
Enemærke, Vitus J.;
Gahlawat, Sahil;
Golbækdal, Peter I.;
Munksgaard‐Ottosen, Nikoline;
Neumann, Karoline T.;
Hopmann, Kathrin H.;
Norrby, Per‐Ola;
Elmore, Charles S.;
Skrydstrup, Troels

Publication type:

Article

The Future of (Radio)‐Labeled Compounds in Research and Development within the Life Science Industry.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 52, p. 1, doi. 10.1002/anie.202306019

By:

Derdau, Volker;
Elmore, Charles S.;
Hartung, Thomas;
McKillican, Bruce;
Mejuch, Tom;
Rosenbaum, Claudia;
Wiebe, Christine

Publication type:

Article

Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2024, v. 67, n. 4, p. 145, doi. 10.1002/jlcr.4089

By:

Bergare, Jonas;
Bailey, Christopher;
Sörensen, Henrik;
Grönberg, Gunnar;
Broberg, Karl;
Berglund, Monica;
Grecu, Tudor;
Sanchez, Carolina;
Emtenäs, Hans;
Bragg, Ryan A.;
Elmore, Charles S.

Publication type:

Article

Exploring the enzyme‐catalyzed synthesis of isotope labeled cyclopropanes.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2022, v. 65, n. 4, p. 86, doi. 10.1002/jlcr.3962

By:

Sardana, Malvika;
Mühlfenzl, Kim S.;
Wenker, Sylvia T. M.;
Åkesson, Christian;
Hayes, Martin A.;
Elmore, Charles S.;
Pithani, Subhash

Publication type:

Article

Visible‐Light Enabled Late‐Stage, Room‐Temperature Aminocarbonylation of Aryl Iodides with Labeled Carbon Monoxide.

Published in:

ChemistrySelect, 2022, v. 7, n. 46, p. 1, doi. 10.1002/slct.202203582

By:

Mühlfenzl, Kim S.;
Sardana, Malvika;
Skrydstrup, Troels;
Elmore, Charles S.

Publication type:

Article

Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines.

Published in:

Angewandte Chemie, 2025, v. 137, n. 5, p. 1, doi. 10.1002/ange.202417179

By:

Smith, Blair I. P.;
Knight, Nathan M. L.;
Knox, Gary J.;
Lindsay, David M.;
Paterson, Laura C.;
Bergare, Jonas;
Elmore, Charles S.;
Bragg, Ryan A.;
Kerr, William J.

Publication type:

Article

Nickel Catalyzed Carbonylative Cross Coupling for Direct Access to Isotopically Labeled Alkyl Aryl Ketones.

Published in:

Angewandte Chemie, 2024, v. 136, n. 51, p. 1, doi. 10.1002/ange.202412247

By:

Mühlfenzl, Kim S.;
Enemærke, Vitus J.;
Gahlawat, Sahil;
Golbækdal, Peter I.;
Munksgaard‐Ottosen, Nikoline;
Neumann, Karoline T.;
Hopmann, Kathrin H.;
Norrby, Per‐Ola;
Elmore, Charles S.;
Skrydstrup, Troels

Publication type:

Article

Die Zukunft (Radio‐)‐isotopenmarkierter Verbindungen in Forschung und Entwicklung der modernen Lebenswissenschaften.

Published in:

Angewandte Chemie, 2023, v. 135, n. 52, p. 1, doi. 10.1002/ange.202306019

By:

Derdau, Volker;
Elmore, Charles S.;
Hartung, Thomas;
McKillican, Bruce;
Mejuch, Tom;
Rosenbaum, Claudia;
Wiebe, Christine

Publication type:

Article

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids.

Published in:

Angewandte Chemie, 2020, v. 132, n. 32, p. 13592, doi. 10.1002/ange.202002341

By:

Destro, Gianluca;
Horkka, Kaisa;
Loreau, Olivier;
Buisson, David‐Alexandre;
Kingston, Lee;
Del Vecchio, Antonio;
Schou, Magnus;
Elmore, Charles S.;
Taran, Frédéric;
Cantat, Thibault;
Audisio, Davide

Publication type:

Article

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation.

Published in:

Angewandte Chemie, 2020, v. 132, n. 21, p. 8176, doi. 10.1002/ange.201916391

By:

Donslund, Aske S.;
Pedersen, Simon S.;
Gaardbo, Cecilie;
Neumann, Karoline T.;
Kingston, Lee;
Elmore, Charles S.;
Skrydstrup, Troels

Publication type:

Article