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Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation.
Published in:
Scientific Reports, 2017, p. 45465, doi. 10.1038/srep45465
By:
- Heinz, Sabrina;
- Freyberger, Alexius;
- Lawrenz, Bettina;
- Schladt, Ludwig;
- Schmuck, Gabriele;
- Ellinger-Ziegelbauer, Heidrun
Publication type:
Article
Evaluation of Toxicogenomics Approaches for Assessing the Risk of Nongenotoxic Carcinogenicity in Rat Liver.
Published in:
PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097678
By:
- Eichner, Johannes;
- Wrzodek, Clemens;
- Römer, Michael;
- Ellinger-Ziegelbauer, Heidrun;
- Zell, Andreas
Publication type:
Article
Cross-Platform Toxicogenomics for the Prediction of Non-Genotoxic Hepatocarcinogenesis in Rat.
Published in:
PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097640
By:
- Römer, Michael;
- Eichner, Johannes;
- Metzger, Ute;
- Templin, Markus F.;
- Plummer, Simon;
- Ellinger-Ziegelbauer, Heidrun;
- Zell, Andreas
Publication type:
Article
Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells.
Published in:
Genes to Cells, 2000, v. 5, n. 6, p. 491, doi. 10.1046/j.1365-2443.2000.00337.x
By:
- Ellinger-Ziegelbauer, Heidrun;
- Karasuyama, Hajime;
- Yamada, Eitaro;
- Tsujikawa, Kazutake;
- Todokoro, Kazuo;
- Nishida, Eisuke
Publication type:
Article
Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR.
Published in:
BMC Biotechnology, 2018, v. 18, p. 1, doi. 10.1186/s12896-018-0415-4
By:
- Wolfinger, Russell D.;
- Beedanagari, Sudheer;
- Boitier, Eric;
- Chen, Tao;
- Couttet, Philippe;
- Ellinger-Ziegelbauer, Heidrun;
- Guillemain, Gregory;
- Mariet, Claire;
- Mouritzen, Peter;
- O’Lone, Raegan;
- Pine, P. Scott;
- Sharapova, Tatiana;
- Yan, Jian;
- Yuen, Peter S.;
- Thompson, Karol L.
Publication type:
Article
Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver.
Published in:
Toxicological Sciences, 2004, v. 77, n. 1, p. 19, doi. 10.1093/toxsci/kfh016
By:
- Ellinger-Ziegelbauer, Heidrun;
- Stuart, Barry;
- Wahle, Brad;
- Bomann, Werner;
- Ahr, Hans-Jürgen
Publication type:
Article
Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability.
Published in:
PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0169976
By:
- Brooks, Marjory B.;
- Turk, James R.;
- Guerrero, Abraham;
- Narayanan, Padma K.;
- Nolan, John P.;
- Besteman, Elizabeth G.;
- Wilson, Dennis W.;
- Thomas, Roberta A.;
- Fishman, Cindy E.;
- Thompson, Karol L.;
- Ellinger-Ziegelbauer, Heidrun;
- Pierson, Jennifer B.;
- Paulman, April;
- Chiang, Alan Y.;
- Schultze, Albert E.
Publication type:
Article
Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems.
Published in:
Altex, 2018, v. 35, n. 3, p. 353, doi. 10.14573/altex.1710081
By:
- Pamies, David;
- Bal-Price, Anna;
- Chesné, Christophe;
- Coecke, Sandra;
- Dinnyes, Andras;
- Eskes, Chantra;
- Grillari, Regina;
- Gstraunthaler, Gerhard;
- Hartung, Thomas;
- Jennings, Paul;
- Leist, Marcel;
- Martin, Ulrich;
- Passier, Robert;
- Schwamborn, Jens C.;
- Stacey, Glyn N.;
- Ellinger-Ziegelbauer, Heidrun;
- Daneshian, Mardas
Publication type:
Article
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart.
Published in:
Archives of Toxicology, 2019, v. 93, n. 9, p. 2603, doi. 10.1007/s00204-019-02519-1
By:
- Heinz, Sabrina;
- Freyberger, Alexius;
- Lawrenz, Bettina;
- Schladt, Ludwig;
- Schmuck, Gabriele;
- Ellinger-Ziegelbauer, Heidrun
Publication type:
Article
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Published in:
Archives of Toxicology, 2018, v. 92, n. 12, p. 3517, doi. 10.1007/s00204-018-2352-3
By:
- Grinberg, Marianna;
- Hellwig, Birte;
- Rahnenführer, Jörg;
- Sachinidis, Agapios;
- Ellinger-Ziegelbauer, Heidrun;
- Stöber, Regina M.;
- Albrecht, Wiebke;
- Edlund, Karolina;
- Schug, Markus;
- Godoy, Patricio;
- Cadenas, Cristina;
- Marchan, Rosemarie;
- Hengstler, Jan G.;
- Lampen, Alfonso;
- Braeuning, Albert;
- Buhrke, Thorsten;
- Oberemm, Axel;
- Leist, Marcel;
- Kamp, Hennicke;
- Gardner, Iain
Publication type:
Article
Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
Published in:
Archives of Toxicology, 2017, v. 91, n. 10, p. 3427, doi. 10.1007/s00204-017-1953-6
By:
- Klaus, Valentina;
- Bastek, Heinke;
- Damme, Katja;
- Collins, Leonard;
- Frötschl, Roland;
- Benda, Norbert;
- Lutter, Dominik;
- Ellinger-Ziegelbauer, Heidrun;
- Swenberg, James;
- Dietrich, Daniel;
- Stemmer, Kerstin
Publication type:
Article
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes.
Published in:
Archives of Toxicology, 2013, v. 87, n. 2, p. 337, doi. 10.1007/s00204-012-0999-8
By:
- Schug, Markus;
- Stöber, Regina;
- Heise, Tanja;
- Mielke, Hans;
- Gundert-Remy, Ursula;
- Godoy, Patricio;
- Reif, Raymond;
- Blaszkewicz, Meinolf;
- Ellinger-Ziegelbauer, Heidrun;
- Ahr, Hans-Jürgen;
- Selinski, Silvia;
- Günther, Georgia;
- Marchan, Rosemarie;
- Sachinidis, Agapios;
- Nüssler, Andreas;
- Oberemm, Axel;
- Hengstler, Jan G.
Publication type:
Article
Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data.
Published in:
Archives of Toxicology, 2012, v. 86, n. 11, p. 1703, doi. 10.1007/s00204-012-0946-8
By:
- Doktorova, Tatyana;
- Ellinger-Ziegelbauer, Heidrun;
- Vinken, Mathieu;
- Vanhaecke, Tamara;
- Delft, Joost;
- Kleinjans, Jos;
- Ahr, Hans-Juergen;
- Rogiers, Vera
Publication type:
Article
Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.
Published in:
Archives of Toxicology, 2012, v. 86, n. 9, p. 1399, doi. 10.1007/s00204-012-0847-x
By:
- Doktorova, Tatyana;
- Ellinger-Ziegelbauer, Heidrun;
- Vinken, Mathieu;
- Vanhaecke, Tamara;
- Delft, Joost;
- Kleinjans, Jos;
- Ahr, Hans-Juergen;
- Rogiers, Vera
Publication type:
Article
Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model.
Published in:
Archives of Toxicology, 2012, v. 86, n. 4, p. 571, doi. 10.1007/s00204-011-0780-4
By:
- Jennings, Paul;
- Weiland, Christina;
- Limonciel, Alice;
- Bloch, Katarzyna;
- Radford, Robert;
- Aschauer, Lydia;
- McMorrow, Tara;
- Wilmes, Anja;
- Pfaller, Walter;
- Ahr, Hans;
- Slattery, Craig;
- Lock, Edward;
- Ryan, Michael;
- Ellinger-Ziegelbauer, Heidrun
Publication type:
Article
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13226, doi. 10.3390/ijms241713226
By:
- Kraehling, Jan R.;
- Benardeau, Agnes;
- Schomber, Tibor;
- Popp, Laura;
- Vienenkoetter, Julia;
- Ellinger-Ziegelbauer, Heidrun;
- Pavkovic, Mira;
- Hartmann, Elke;
- Siudak, Krystyna;
- Freyberger, Alexius;
- Hagelschuer, Ina;
- Mathar, Ilka;
- Hueser, Joerg;
- Hahn, Michael G.;
- Geiss, Volker;
- Eitner, Frank;
- Sandner, Peter
Publication type:
Article
Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Published in:
Toxicological Sciences, 2022, v. 188, n. 1, p. 4, doi. 10.1093/toxsci/kfac041
By:
- Corton, J Christopher;
- Mitchell, Constance A;
- Auerbach, Scott;
- Bushel, Pierre;
- Ellinger-Ziegelbauer, Heidrun;
- Escobar, Patricia A;
- Froetschl, Roland;
- Harrill, Alison H;
- Johnson, Kamin;
- Klaunig, James E;
- Pandiri, Arun R;
- Podtelezhnikov, Alexei A;
- Rager, Julia E;
- Tanis, Keith Q;
- Laan, Jan Willem van der;
- Vespa, Alisa;
- Yauk, Carole L;
- Pettit, Syril D;
- Sistare, Frank D
Publication type:
Article
Urinary miRNA Profiles in Chronic Kidney Injury—Benefits of Extracellular Vesicle Enrichment and miRNAs as Potential Biomarkers for Renal Fibrosis, Glomerular Injury, and Endothelial Dysfunction.
Published in:
Toxicological Sciences, 2022, v. 187, n. 1, p. 35, doi. 10.1093/toxsci/kfac028
By:
- Petzuch, Barbara;
- Bénardeau, Agnès;
- Hofmeister, Lucas;
- Meyer, Jutta;
- Hartmann, Elke;
- Pavkovic, Mira;
- Mathar, Ilka;
- Sandner, Peter;
- Ellinger-Ziegelbauer, Heidrun
Publication type:
Article
Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron.
Published in:
Toxicological Sciences, 2021, v. 180, n. 1, p. 1, doi. 10.1093/toxsci/kfaa181
By:
- Chorley, Brian N;
- Ellinger-Ziegelbauer, Heidrun;
- Tackett, Michael;
- Simutis, Frank J;
- Harrill, Alison H;
- McDuffie, James;
- Atabakhsh, Elnaz;
- Nassirpour, Rounak;
- Whiteley, Laurence O;
- Léonard, Jean-François;
- Carswell, Gleta K;
- Harpur, Ernie;
- Chen, Connie L;
- Gautier, Jean-Charles
Publication type:
Article
Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.
Published in:
Toxicological Sciences, 2017, v. 158, n. 2, p. 367, doi. 10.1093/toxsci/kfx104
By:
- Pouché, Lucie;
- Vitobello, Antonio;
- Römer, Michael;
- Glogovac, Milica;
- MacLeod, A. Kenneth;
- Ellinger-Ziegelbauer, Heidrun;
- Westphal, Magdalena;
- Dubost, Valérie;
- Stiehl, Daniel Philipp;
- Dumotier, Bérengère;
- Fekete, Alexander;
- Moulin, Pierre;
- Zell, Andreas;
- Schwarz, Michael;
- Moreno, Rita;
- Huang, Jeffrey T. J.;
- Elcombe, Cliff R.;
- Henderson, Colin J.;
- Wolf, C. Roland;
- Moggs, Jonathan G.
Publication type:
Article
Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites.
Published in:
Toxicological Sciences, 2016, v. 154, n. 1, p. 115, doi. 10.1093/toxsci/kfw143
By:
- Thompson, Karol L.;
- Boitier, Eric;
- Tao Chen;
- Couttet, Philippe;
- Ellinger-Ziegelbauer, Heidrun;
- Goetschy, Manuela;
- Guillemain, Gregory;
- Kanki, Masayuki;
- Kelsall, Janet;
- Mariet, Claire;
- de La Moureyre-Spire, Catherine;
- Mouritzen, Peter;
- Nassirpour, Rounak;
- O'Lone, Raegan;
- Pine, P. Scott;
- Rosenzweig, Barry A.;
- Sharapova, Tatiana;
- Smith, Aaron;
- Uchiyama, Hidefumi;
- Jian Yan
Publication type:
Article
Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.
Published in:
Toxicological Sciences, 2016, v. 150, n. 1, p. 3, doi. 10.1093/toxsci/kfv260
By:
- Church, Rachel J.;
- Otieno, Monicah;
- McDuffie, James Eric;
- Singh, Bhanu;
- Sonee, Manisha;
- Hall, LeRoy;
- Watkins, Paul B.;
- Ellinger-Ziegelbauer, Heidrun;
- Harrill, Alison H.
Publication type:
Article
Glomerulonephritis-Induced Changes in Urinary and Kidney MicroRNA Profiles in Rats.
Published in:
Toxicological Sciences, 2015, v. 145, n. 2, p. 348, doi. 10.1093/toxsci/kfv053
By:
- Pavkovic, Mira;
- Riefke, Björn;
- Frisk, Anna-Lena;
- Gröticke, Ina;
- Ellinger-Ziegelbauer, Heidrun
Publication type:
Article
Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors.
Published in:
Toxicological Sciences, 2014, v. 139, n. 2, p. 501, doi. 10.1093/toxsci/kfu038
By:
- Luisier, Raphaëlle;
- Lempiäinen, Harri;
- Scherbichler, Nina;
- Braeuning, Albert;
- Geissler, Miriam;
- Dubost, Valerie;
- Müller, Arne;
- Scheer, Nico;
- Chibout, Salah-Dine;
- Hara, Hisanori;
- Picard, Frank;
- Theil, Diethilde;
- Couttet, Philippe;
- Vitobello, Antonio;
- Grenet, Olivier;
- Grasl-Kraupp, Bettina;
- Ellinger-Ziegelbauer, Heidrun;
- Thomson, John P.;
- Meehan, Richard R.;
- Elcombe, Clifford R.
Publication type:
Article
Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies.
Published in:
Toxicological Sciences, 2010, v. 116, n. 1, p. 8, doi. 10.1093/toxsci/kfq029
By:
- Hoffmann, Dana;
- Adler, Melanie;
- Vaidya, Vishal S.;
- Rached, Eva;
- Mulrane, Laoighse;
- Gallagher, William M.;
- Callanan, John J.;
- Gautier, Jean C.;
- Matheis, Katja;
- Staedtler, Frank;
- Dieterle, Frank;
- Brandenburg, Arnd;
- Sposny, Alexandra;
- Hewitt, Philip;
- Ellinger-Ziegelbauer, Heidrun;
- Bonventre, Joseph V.;
- Dekant, Wolfgang;
- Mally, Angela
Publication type:
Article
Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms.
Published in:
Toxicological Sciences, 2009, v. 110, n. 2, p. 341, doi. 10.1093/toxsci/kfp103
By:
- Heidrun Ellinger-Ziegelbauer;
- Jennifer M. Fostel;
- Chinami Aruga;
- Daniel Bauer;
- Eric Boitier;
- Shibing Deng;
- Donna Dickinson;
- Anne-Celine Le Fevre;
- Albert J. Fornace;
- Olivier Grenet;
- Yizhong Gu;
- Jean-Christophe Hoflack;
- Masako Shiiyama;
- Roger Smith;
- Ronald D. Snyder;
- Catherine Spire;
- Gotaro Tanaka;
- Jiri Aubrecht
Publication type:
Article

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