Works matching AU Elkamhawy, Ahmed

Results: 38

Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 2, p. 141, doi. 10.3390/metabo13020141

By:

Elkamhawy, Ahmed;
Oh, Na Kyoung;
Gouda, Noha A.;
Abdellattif, Magda H.;
Alshammari, Saud O.;
Abourehab, Mohammed A. S.;
Alshammari, Qamar A.;
Belal, Amany;
Kim, Minkyoung;
Al-Karmalawy, Ahmed A.;
Lee, Kyeong

Publication type:

Article

Correction: Elsherbeny et al. 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation. Life 2022, 12 , 876.

Published in:

2024

By:

Elsherbeny, Mohamed H.;
Ammar, Usama M.;
Abdellattif, Magda H.;
Abourehab, Mohammed A. S.;
Abdeen, Ahmed;
Ibrahim, Samah F.;
Abdelrahaman, Doaa;
Mady, Wessam;
Roh, Eun Joo;
Elkamhawy, Ahmed

Publication type:

Correction Notice

Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors with promising anti-melanoma activity: rational design, synthesis, in vitro and in silico screening: Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors: A. Elkamhawy et al

Published in:

Archives of Pharmacal Research, 2025, v. 48, n. 2, p. 150, doi. 10.1007/s12272-025-01533-5

By:

Elkamhawy, Ahmed;
Ammar, Usama M.;
Kim, Minkyoung;
Gul, Anam Rana;
Park, Tae Jung;
Lee, Kyeong

Publication type:

Article

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2242714

By:

El-Kalyoubi, Samar;
Khalifa, Mohamed M.;
Abo-Elfadl, Mahmoud T.;
El-Sayed, Ahmed A.;
Elkamhawy, Ahmed;
Lee, Kyeong;
Al-Karmalawy, Ahmed A.

Publication type:

Article

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2205043

By:

Mourad, Mai A. E.;
Abo Elmaaty, Ayman;
Zaki, Islam;
Mourad, Ahmed A. E.;
Hofni, Amal;
Khodir, Ahmed E.;
Aboubakr, Esam M.;
Elkamhawy, Ahmed;
Roh, Eun Joo;
Al-Karmalawy, Ahmed A.

Publication type:

Article

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2202358

By:

Son, Seohyun;
Elkamhawy, Ahmed;
Gul, Anam Rana;
Al‐Karmalawy, Ahmed A.;
Alnajjar, Radwan;
Abdeen, Ahmed;
Ibrahim, Samah F.;
Alshammari, Saud O.;
Alshammari, Qamar A.;
Choi, Won Jun;
Park, Tae Jung;
Lee, Kyeong

Publication type:

Article

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029

By:

Farouk, Faten;
Elmaaty, Ayman Abo;
Elkamhawy, Ahmed;
Tawfik, Haytham O.;
Alnajjar, Radwan;
Abourehab, Mohammed A. S.;
Saleh, Mohamed A.;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 994, doi. 10.1080/14756366.2022.2055553

By:

Nada, Hossam;
Elkamhawy, Ahmed;
Abdellattif, Magda H.;
Angeli, Andrea;
Chang Hoon Lee;
Supuran, Claudiu T.;
Kyeong Lee

Publication type:

Article

New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1572, doi. 10.1080/14756366.2021.1937143

By:

Elkamhawy, Ahmed;
Ali, Eslam M. H.;
Lee, Kyeong

Publication type:

Article

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1568, doi. 10.1080/14756366.2020.1800666

By:

Elkamhawy, Ahmed;
Paik, Sora;
Kim, Hyeon Jeong;
Park, Jong-Hyun;
Londhe, Ashwini M.;
Lee, Kyeong;
Pae, Ae Nim;
Park, Ki Duk;
Roh, Eun Joo

Publication type:

Article

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 1457, doi. 10.1080/14756366.2019.1652282

By:

Al-Sanea, Mohammad M.;
Elkamhawy, Ahmed;
Paik, Sora;
Bua, Silvia;
Ha Lee, So;
Abdelgawad, Mohamed A.;
Roh, Eun Joo;
Eldehna, Wagdy M.;
Supuran, Claudiu T.

Publication type:

Article

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 158, doi. 10.3109/14756366.2015.1004057

By:

Elkamhawy, Ahmed;
Park, Jung-eun;
Cho, Nam-Chul;
Sim, Taebo;
Pae, Ae Nim;
Roh, Eun Joo

Publication type:

Article

Design and Synthesis of New [1,2,3]Triazolo[4,5- d]pyrimidine Derivatives as Potential Antiproliferative Agents.

Published in:

Bulletin of the Korean Chemical Society, 2015, v. 36, n. 7, p. 1863, doi. 10.1002/bkcs.10363

By:

Elkamhawy, Ahmed;
Al-Sanea, Mohammad M.;
Song, Chiman;
Sim, Taebo;
Roh, Eun Joo

Publication type:

Article

Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations.

Published in:

PeerJ, 2022, p. 1, doi. 10.7717/peerj.14120

By:

Nada, Hossam;
Elkamhawy, Ahmed;
Kyeong Lee

Publication type:

Article

Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update.

Published in:

Biomedicines, 2022, v. 10, n. 2, p. 371, doi. 10.3390/biomedicines10020371

By:

Gouda, Noha A.;
Elkamhawy, Ahmed;
Cho, Jungsook

Publication type:

Article

Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity.

Published in:

Biomedicines, 2021, v. 9, n. 9, p. 1131, doi. 10.3390/biomedicines9091131

By:

Elsherbeny, Mohamed H.;
Elkamhawy, Ahmed;
Nada, Hossam;
Abdellattif, Magda H.;
Lee, Kyeong;
Roh, Eun Joo

Publication type:

Article

Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.958379

By:

Abdellattif, Magda H.;
Elkamhawy, Ahmed;
Hagar, Mohamed;
Ben Hadda, Taibi;
Shehab, Wesam S.;
Mansy, Wael;
Belal, Amany;
Arief, M. M. H.;
Hussien, Mostafa A.

Publication type:

Article

Pyrimidine scaffold dual‐target kinase inhibitors for cancer diseases: A review on design strategies, synthetic approaches, and structure–activity relationship (2018‒2023).

Published in:

Archiv der Pharmazie, 2025, v. 358, n. 1, p. 1, doi. 10.1002/ardp.202400163

By:

Song, Moeun;
Elkamhawy, Ahmed;
Noh, Woojeong;
Abdelazem, Ahmed Z.;
Park, Younggeun;
Sivaraman, Aneesh;
Bertleuova, Arailym;
Atef, Dalia;
Lee, Kyeong

Publication type:

Article

Chalcone‐based benzenesulfonamides as potent and selective inhibitors for human carbonic anhydrase II: Design, synthesis, in vitro, and in silico studies.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 11, p. 1, doi. 10.1002/ardp.202400069

By:

Lee, Hwa Young;
Elkamhawy, Ahmed;
Al‐Karmalawy, Ahmed A.;
Nada, Hossam;
Giovannuzzi, Simone;
Supuran, Claudiu T.;
Lee, Kyeong

Publication type:

Article

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5324, doi. 10.3390/molecules26175324

By:

Elkamhawy, Ahmed;
Ammar, Usama M.;
Paik, Sora;
Abdellattif, Magda H.;
Elsherbeny, Mohamed H.;
Lee, Kyeong;
Roh, Eun Joo

Publication type:

Article

Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer.

Published in:

Molecules, 2021, v. 26, n. 3, p. 553, doi. 10.3390/molecules26030553

By:

Nada, Hossam;
Elkamhawy, Ahmed;
Lee, Kyeong;
Muñoz-Torrero, Diego

Publication type:

Article

Design of new captopril mimics as promising ACE inhibitors: ADME, pharmacophore, molecular docking and dynamics simulation with MM-PBSA and PCA calculations.

Published in:

Journal of Taibah University for Science, 2023, v. 17, n. 1, p. 1, doi. 10.1080/16583655.2023.2210348

By:

Belal, Amany;
Elanany, Mohamed A.;
Al-Karmalawy, Ahmed A.;
Elkamhawy, Ahmed;
Abourehab, Mohammed A. S.;
Ghamry, Heba I.;
Mehany, Ahmed B. M.

Publication type:

Article

2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation.

Published in:

Life (2075-1729), 2022, v. 12, n. 6, p. 876, doi. 10.3390/life12060876

By:

Elsherbeny, Mohamed H.;
Ammar, Usama M.;
Abdellattif, Magda H.;
Abourehab, Mohammed A. S.;
Abdeen, Ahmed;
Ibrahim, Samah F.;
Abdelrahaman, Doaa;
Mady, Wessam;
Roh, Eun Joo;
Elkamhawy, Ahmed

Publication type:

Article

Small Molecules in Parkinson's Disease Therapy: From Dopamine Pathways to New Emerging Targets.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 12, p. 1688, doi. 10.3390/ph17121688

By:

Lee, Hwayoung;
Elkamhawy, Ahmed;
Rakhalskaya, Polina;
Lu, Qili;
Nada, Hossam;
Quan, Guofeng;
Lee, Kyeong

Publication type:

Article

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 1, p. 43, doi. 10.3390/ph16010043

By:

Elkamhawy, Ahmed;
Son, Seohyun;
Lee, Hwa Young;
El-Maghrabey, Mahmoud H.;
Hamd, Mohamed A. El;
Alshammari, Saud O.;
Abdelhameed, Abeer A.;
Alshammari, Qamar A.;
Abdeen, Ahmed;
Ibrahim, Samah F.;
Mahdi, Wael A.;
Alshehri, Sultan;
Alnajjar, Radwan;
Choi, Won Jun;
Al-Karmalawy, Ahmed A.;
Lee, Kyeong

Publication type:

Article

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091050

By:

Elkamhawy, Ahmed;
Paik, Sora;
Ali, Eslam M. H.;
Hassan, Ahmed H. E.;
Kang, So Jin;
Lee, Kyeong;
Roh, Eun Joo

Publication type:

Article

New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070803

By:

Kaddouri, Yassine;
Bouchal, Btissam;
Abrigach, Farid;
El Kodadi, Mohamed;
Bellaoui, Mohammed;
Elkamhawy, Ahmed;
Touzani, Rachid;
Abdellattif, Magda H.

Publication type:

Article

Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 12, p. 1247, doi. 10.3390/ph14121247

By:

Lee, Kyeong;
Nada, Hossam;
Byun, Hyun Jung;
Lee, Chang Hoon;
Elkamhawy, Ahmed

Publication type:

Article

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR).

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9450, doi. 10.3390/ijms24119450

By:

Godesi, Sreenivasulu;
Lee, Joohan;
Nada, Hossam;
Quan, Guofeng;
Elkamhawy, Ahmed;
Choi, Yongseok;
Lee, Kyeong

Publication type:

Article

Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 17, p. 9903, doi. 10.3390/ijms23179903

By:

Nguyen, Phuong Linh;
Elkamhawy, Ahmed;
Choi, Young Hee;
Lee, Chang Hoon;
Lee, Kyeong;
Cho, Jungsook

Publication type:

Article

Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 5, p. 2540, doi. 10.3390/ijms23052540

By:

Elkamhawy, Ahmed;
Woo, Jiyu;
Nada, Hossam;
Angeli, Andrea;
Bedair, Tarek M.;
Supuran, Claudiu T.;
Lee, Kyeong

Publication type:

Article

The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 12, p. 6535, doi. 10.3390/ijms22126535

By:

Elkamhawy, Ahmed;
Lu, Qili;
Nada, Hossam;
Woo, Jiyu;
Quan, Guofeng;
Lee, Kyeong

Publication type:

Article

Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents.

Published in:

Molecules, 2015, v. 20, n. 1, p. 1031, doi. 10.3390/molecules20011031

By:

Al-Sanea, Mohammad M.;
Elkamhawy, Ahmed;
Zakaria, Ahmed;
Byung Sun Park;
Youngjoo Kwon;
So Ha Lee;
Sang Woo Lee;
In Tae Kim

Publication type:

Article

Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties.

Published in:

Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091954

By:

Amin, Kamelia M.;
El-Badry, Ossama M.;
Abdel Rahman, Doaa E.;
Abdellattif, Magda H.;
Abourehab, Mohammed A. S.;
El-Maghrabey, Mahmoud H.;
Elsaid, Fahmy G.;
El Hamd, Mohamed A.;
Elkamhawy, Ahmed;
Ammar, Usama M.

Publication type:

Article

Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.

Published in:

Molecular Diversity, 2025, v. 29, n. 1, p. 179, doi. 10.1007/s11030-024-10841-9

By:

Elkamhawy, Ahmed;
Oh, Jong Min;
Kim, Minkyoung;
El-Halaby, Lamiaa O.;
Abdellattif, Magda H.;
Al-Karmalawy, Ahmed A.;
Kim, Hoon;
Lee, Kyeong

Publication type:

Article

Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress.

Published in:

Antioxidants, 2021, v. 10, n. 10, p. 1641, doi. 10.3390/antiox10101641

By:

Elsherbeny, Mohamed H.;
Kim, Jushin;
Gouda, Noha A.;
Gotina, Lizaveta;
Cho, Jungsook;
Pae, Ae Nim;
Lee, Kyeong;
Park, Ki Duk;
Elkamhawy, Ahmed;
Roh, Eun Joo

Publication type:

Article

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.

Published in:

Antioxidants, 2021, v. 10, n. 10, p. 1604, doi. 10.3390/antiox10101604

By:

Elkamhawy, Ahmed;
Woo, Jiyu;
Gouda, Noha A.;
Kim, Jushin;
Nada, Hossam;
Roh, Eun Joo;
Park, Ki Duk;
Cho, Jungsook;
Lee, Kyeong

Publication type:

Article

Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in Vitro assessments with structure-activity relationship.

Published in:

Journal of Biomolecular Structure & Dynamics, 2024, v. 42, n. 13, p. 6941, doi. 10.1080/07391102.2023.2240419

By:

Al-Karmalawy, Ahmed A.;
Alnajjar, Radwan;
Elmaaty, Ayman Abo;
Binjubair, Faizah A.;
Al-Rashood, Sara T.;
Mansour, Basma S.;
Elkamhawy, Ahmed;
Eldehna, Wagdy M.;
Mansour, Khaled Ahmed

Publication type:

Article