Works matching AU Elkamhawy, Ahmed
Results: 37
Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors with promising anti-melanoma activity: rational design, synthesis, in vitro and in silico screening: Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors: A. Elkamhawy et al
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- Archives of Pharmacal Research, 2025, v. 48, n. 2, p. 150, doi. 10.1007/s12272-025-01533-5
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- Article
Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations.
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- PeerJ, 2022, p. 1, doi. 10.7717/peerj.14120
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Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2242714
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Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2205043
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Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2202358
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Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029
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- Article
4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 994, doi. 10.1080/14756366.2022.2055553
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New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1572, doi. 10.1080/14756366.2021.1937143
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- Article
Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1568, doi. 10.1080/14756366.2020.1800666
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- Article
Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 1457, doi. 10.1080/14756366.2019.1652282
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Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 158, doi. 10.3109/14756366.2015.1004057
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- Article
Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update.
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- Biomedicines, 2022, v. 10, n. 2, p. 371, doi. 10.3390/biomedicines10020371
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Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity.
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- Biomedicines, 2021, v. 9, n. 9, p. 1131, doi. 10.3390/biomedicines9091131
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Design and Synthesis of New [1,2,3]Triazolo[4,5- d]pyrimidine Derivatives as Potential Antiproliferative Agents.
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- Bulletin of the Korean Chemical Society, 2015, v. 36, n. 7, p. 1863, doi. 10.1002/bkcs.10363
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- Article
Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR).
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- International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9450, doi. 10.3390/ijms24119450
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- Article
Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 17, p. 9903, doi. 10.3390/ijms23179903
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- Article
Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 5, p. 2540, doi. 10.3390/ijms23052540
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The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 12, p. 6535, doi. 10.3390/ijms22126535
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- Article
Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.
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- Molecular Diversity, 2025, v. 29, n. 1, p. 179, doi. 10.1007/s11030-024-10841-9
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Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening.
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- Molecules, 2021, v. 26, n. 17, p. 5324, doi. 10.3390/molecules26175324
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- Article
Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer.
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- Molecules, 2021, v. 26, n. 3, p. 553, doi. 10.3390/molecules26030553
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Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents.
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- Molecules, 2015, v. 20, n. 1, p. 1031, doi. 10.3390/molecules20011031
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- Article
Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress.
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- Antioxidants, 2021, v. 10, n. 10, p. 1641, doi. 10.3390/antiox10101641
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Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.
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- Antioxidants, 2021, v. 10, n. 10, p. 1604, doi. 10.3390/antiox10101604
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Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay.
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- Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.958379
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- Article
Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties.
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- Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091954
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- Article
Small Molecules in Parkinson's Disease Therapy: From Dopamine Pathways to New Emerging Targets.
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- Pharmaceuticals (14248247), 2024, v. 17, n. 12, p. 1688, doi. 10.3390/ph17121688
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Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 1, p. 43, doi. 10.3390/ph16010043
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Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091050
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New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070803
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Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 12, p. 1247, doi. 10.3390/ph14121247
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- Article
Chalcone‐based benzenesulfonamides as potent and selective inhibitors for human carbonic anhydrase II: Design, synthesis, in vitro, and in silico studies.
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- Archiv der Pharmazie, 2024, v. 357, n. 11, p. 1, doi. 10.1002/ardp.202400069
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Design of new captopril mimics as promising ACE inhibitors: ADME, pharmacophore, molecular docking and dynamics simulation with MM-PBSA and PCA calculations.
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- Journal of Taibah University for Science, 2023, v. 17, n. 1, p. 1, doi. 10.1080/16583655.2023.2210348
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- Article
Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in Vitro assessments with structure-activity relationship.
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- Journal of Biomolecular Structure & Dynamics, 2024, v. 42, n. 13, p. 6941, doi. 10.1080/07391102.2023.2240419
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- Article
Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations.
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- Metabolites (2218-1989), 2023, v. 13, n. 2, p. 141, doi. 10.3390/metabo13020141
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- Article
Correction: Elsherbeny et al. 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation. Life 2022, 12 , 876.
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- 2024
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- Correction Notice
2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation.
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- Life (2075-1729), 2022, v. 12, n. 6, p. 876, doi. 10.3390/life12060876
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- Article