Works by Eldehna, Wagdy M.

Results: 122

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies.

Published in:

PLoS ONE, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.pone.0274081

By:

Gaber, Ahmed A.;
Sobhy, Mohamed;
Turky, Abdallah;
Eldehna, Wagdy M.;
El-Sebaey, Samiha A.;
El-Metwally, Souad A.;
El-Naggar, Abeer M.;
Ibrahim, Ibrahim M.;
Elkaeed, Eslam B.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.

Publication type:

Article

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway.

Published in:

PLoS ONE, 2022, v. 17, n. 9, p. 1, doi. 10.1371/journal.pone.0272362

By:

Taghour, Mohammed S.;
Elkady, Hazem;
Eldehna, Wagdy M.;
El-Deeb, Nehal;
Kenawy, Ahmed M.;
Elkaeed, Eslam B.;
Alsfouk, Bshra A.;
Alesawy, Mohamed S.;
Husein, Dalal Z.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.

Publication type:

Article

Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones.

Published in:

Crystals (2073-4352), 2020, v. 10, n. 6, p. 446, doi. 10.3390/cryst10060446

By:

Al-Warhi, Tarfah;
Said, Mohamed A.;
El Hassab, Mahmoud A.;
Aljaeed, Nada;
Ghabour, Hazem A.;
Almahli, Hadia;
Eldehna, Wagdy M.;
Abdel-Aziz, Hatem A.

Publication type:

Article

1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 1, p. 81, doi. 10.3390/ph17010081

By:

Elsawi, Ahmed E.;
Shahin, Mai I.;
Elbendary, Hager A.;
Al-Warhi, Tarfah;
Hassan, Fatma E.;
Eldehna, Wagdy M.

Publication type:

Article

Identification of Novel Cyanopyridones and Pyrido[2,3- D ]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 10, p. 1262, doi. 10.3390/ph15101262

By:

Al-Warhi, Tarfah;
Sallam, Al-Aliaa M.;
Hemeda, Loah R.;
El Hassab, Mahmoud A.;
Aljaeed, Nada;
Alotaibi, Ohoud J.;
Doghish, Ahmed S.;
Noshy, Mina;
Eldehna, Wagdy M.;
Ibrahim, Mona H.

Publication type:

Article

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2024, v. 39, n. 1, p. 1, doi. 10.1080/14756366.2023.2293639

By:

Elshibani, Fatma A.;
Alamami, Abdullah D.;
Mohammed, Hamdoon A.;
Rasheed, Rabab Ahmed;
El Sabban, Radwa M.;
Yehia, Mohamed A.;
Abdel Mageed, Sherif S.;
Majrashi, Taghreed A.;
Elkaeed, Eslam B.;
El Hassab, Mahmoud A.;
Eldehna, Wagdy M.;
El-Ashrey, Mohamed K.

Publication type:

Article

Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2024, v. 39, n. 1, p. 1, doi. 10.1080/14756366.2023.2292482

By:

Aly, Shaza H.;
Elissawy, Ahmed M.;
El Hassab, Mahmoud A.;
Majrashi, Taghreed A.;
Hassan, Fatma E.;
Elkaeed, Eslam B.;
Eldehna, Wagdy M.;
Singab, Abdel Nasser B.

Publication type:

Article

Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2278022

By:

Haffez, Hesham;
Elsayed, Nosaiba A.;
Ahmed, Marwa F.;
Fatahala, Samar S.;
Khaleel, Eman F.;
Badi, Rehab Mustafa;
Elkaeed, Eslam B.;
El Hassab, Mahmoud A.;
Hammad, Sherif F.;
Eldehna, Wagdy M.;
Masurier, Nicolas;
El-Haggar, Radwan

Publication type:

Article

Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2250575

By:

Hemeda, Loah R.;
El Hassab, Mahmoud A.;
Abdelgawad, Mohamed A.;
Khaleel, Eman F.;
Abdel-Aziz, Marwa M.;
Binjubair, Faizah A.;
Al-Rashood, Sara T.;
Eldehna, Wagdy M.;
El-Ashrey, Mohamed K.

Publication type:

Article

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2234665

By:

ElNaggar, Mai H.;
Elgazar, Abdullah A.;
Gamal, Ghada;
Hamed, Shimaa M.;
Elsayed, Zainab M.;
El-Ashrey, Mohamed K.;
Abood, Amira;
El Hassab, Mahmoud A.;
Soliman, Ahmed M.;
El-Domany, Ramadan A.;
Badria, Farid A.;
Supuran, Claudiu T.;
Eldehna, Wagdy M.

Publication type:

Article

Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2224944

By:

Rabie, Omyma;
El-Nashar, Heba A. S.;
Majrashi, Taghreed A.;
Al‐Warhi, Tarfah;
El Hassab, Mahmoud A.;
Eldehna, Wagdy M.;
Mostafa, Nada M.

Publication type:

Article

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2203389

By:

Shaldam, Moataz A.;
Almahli, Hadia;
Angeli, Andrea;
Badi, Rehab Mustafa;
Khaleel, Eman F.;
Zain-Alabdeen, Abdelrahman I.;
Elsayed, Zainab M.;
Elkaeed, Eslam B.;
Salem, Rofaida;
Supuran, Claudiu T.;
Eldehna, Wagdy M.;
Tawfik, Haytham O.

Publication type:

Article

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2202357

By:

Al-Karmalawy, Ahmed A.;
El-Gamil, Dalia S.;
El-Shesheny, Rabeh;
Sharaky, Marwa;
Alnajjar, Radwan;
Kutkat, Omnia;
Moatasim, Yassmin;
Elagawany, Mohamed;
Al-Rashood, Sara T.;
Binjubair, Faizah A.;
Eldehna, Wagdy M.;
Noreddin, Ayman M.;
Zakaria, Mohamed Y.

Publication type:

Article

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2201407

By:

Badawi, Waleed A.;
Rashed, Mahmoud;
Nocentini, Alessio;
Bonardi, Alessandro;
Abd-Alhaseeb, Mohammad M.;
Al-Rashood, Sara T.;
Veerakanellore, Giri Babu;
Majrashi, Taghreed A.;
Elkaeed, Eslam B.;
Elgendy, Bahaa;
Gratteri, Paola;
Supuran, Claudiu T.;
Eldehna, Wagdy M.;
Elagawany, Mohamed

Publication type:

Article

Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2199950

By:

El-Nashar, Heba A. S.;
Sayed, Ahmed M.;
El-Sherief, Hany A. M.;
Rateb, Mostafa E.;
Akil, Lina;
Khadra, Ibrahim;
Majrashi, Taghreed A.;
Al-Rashood, Sara T.;
Binjubair, Faizah A.;
El Hassab, Mahmoud A.;
Eldehna, Wagdy M.;
Abdelmohsen, Usama Ramadan;
Mostafa, Nada M.

Publication type:

Article

Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2191163

By:

Elsayed, Zainab M.;
Almahli, Hadia;
Nocentini, Alessio;
Ammara, Andrea;
Supuran, Claudiu T.;
Eldehna, Wagdy M.;
Abou-Seri, Sahar M.

Publication type:

Article

WRH-2412 alleviates the progression of hepatocellular carcinoma through regulation of TGF-β/β-catenin/α-SMA pathway.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2185761

By:

Elewa, Mohammed A. F.;
Eldehna, Wagdy M.;
Hamdan, Ahmed M. E.;
Abd El-kawi, Samraa H.;
El-Kalaawy, Asmaa M.;
Majrashi, Taghreed A.;
Barghash, Reham F.;
Abdel-Aziz, Hatem A.;
Hashem, Khalid S.;
Al-Gayyar, Mohammed M. H.

Publication type:

Article

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029

By:

Farouk, Faten;
Elmaaty, Ayman Abo;
Elkamhawy, Ahmed;
Tawfik, Haytham O.;
Alnajjar, Radwan;
Abourehab, Mohammed A. S.;
Saleh, Mohamed A.;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2166036

By:

Al-Sanea, Mohammad M.;
Hamdi, Abdelrahman;
Mohamed, Ahmed A. B.;
El-Shafey, Hamed W.;
Moustafa, Mahmoud;
Elgazar, Abdullah A.;
Eldehna, Wagdy M.;
Ur Rahman, Hidayat;
Parambi, Della G. T.;
Elbargisy, Rehab M.;
Selim, Samy;
Bukhari, Syed Nasir Abbas;
Magdy Hendawy, Omnia;
Tawfik, Samar S.

Publication type:

Article

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2022.2157825

By:

El-Behairy, Mohammed Farrag;
Abd-Allah, Walaa Hamada;
Khalifa, Mohamed M.;
Nafie, Mohamed S.;
Saleh, Mohamed A.;
Abdel-Maksoud, Mohammed S.;
Al-Warhi, Tarfah;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2022.2154603

By:

El-Damasy, Ashraf K.;
Kim, Hyun Ji;
Nocentini, Alessio;
Seo, Seon Hee;
Eldehna, Wagdy M.;
Bang, Eun-Kyoung;
Supuran, Claudiu T.;
Keum, Gyochang

Publication type:

Article

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR<sup>WT</sup> and EGFR<sup>T790M</sup> inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 176, doi. 10.1080/14756366.2022.2135512

By:

Al-Warhi, Tarfah;
Al-Karmalawy, Ahmed A.;
Elmaaty, Ayman Abo;
Alshubramy, Maha A.;
Abdel-Motaal, Marwa;
Majrashi, Taghreed A.;
Asem, Medhat;
Nabil, Ahmed;
Eldehna, Wagdy M.;
Sharaky, Marwa

Publication type:

Article

The old world salsola as a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2036, doi. 10.1080/14756366.2022.2102005

By:

ElNaggar, Mai H.;
Eldehna, Wagdy M.;
Abourehab, Mohammed A. S.;
Abdel Bar, Fatma M.

Publication type:

Article

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1043, doi. 10.1080/14756366.2022.2056734

By:

Tawfik, Haytham O.;
Shaldam, Moataz A.;
Nocentini, Alessio;
Salem, Rofaida;
Almahli, Hadia;
Al-Rashood, Sara T.;
Supuran, Claudiu T.;
Eldehna, Wagdy M.

Publication type:

Article

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2191, doi. 10.1080/14756366.2022.2110869

By:

Elkaeed, Eslam B.;
Taghour, Mohammed S.;
Mahdy, Hazem A.;
Eldehna, Wagdy M.;
El-Deeb, Nehal M.;
Kenawy, Ahmed M.;
Alsfouk, Bshra A.;
Dahab, Mohammed A.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.;
El-Zahabi, Mohamed A.

Publication type:

Article

Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 39, doi. 10.1080/14756366.2021.1988944

By:

Elimam, Diaaeldin M.;
Elgazar, Abdullah A.;
El-Senduny, Fardous F.;
El-Domany, Ramadan A.;
Badria, Farid A.;
Eldehna, Wagdy M.

Publication type:

Article

Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 563, doi. 10.1080/14756366.2021.2022659

By:

El Hassab, Mahmoud A.;
Eldehna, Wagdy M.;
Al-Rashood, Sara T.;
Alharbi, Amal;
Eskandrani, Razan O.;
Alkahtani, Hamad M.;
Elkaeed, Eslam B.;
Abou-Seri, Sahar M.

Publication type:

Article

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1227, doi. 10.1080/14756366.2022.2062337

By:

Eldehna, Wagdy M.;
Maklad, Raed M.;
Almahli, Hadia;
Al-Warhi, Tarfah;
Elkaeed, Eslam B.;
Abourehab, Mohammed A. S.;
Abdel-Aziz, Hatem A.;
Kerdawy, Ahmed M. El

Publication type:

Article

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1974, doi. 10.1080/14756366.2022.2097445

By:

El-Kersh, Dina M.;
Mostafa, Nada M.;
Fayez, Shaimaa;
Al-Warhi, Tarfah;
Abourehab, Mohammed A. S.;
Eldehna, Wagdy M.;
Salem, Mohamed A.

Publication type:

Article

GC/MS analysis and potential synergistic effect of mandarin and marjoram oils on Helicobacter pylori.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1610, doi. 10.1080/14756366.2022.2081846

By:

Elkousy, Rawah H.;
Mostafa, Nada M.;
Abd-alkhalek, Ahmed M.;
El Hassab, Mahmoud A.;
Al-Rashood, Sara T.;
Eldehna, Wagdy M.;
Eldahshan, Omayma A.

Publication type:

Article

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2256, doi. 10.1080/14756366.2022.2114079

By:

Abo-Ashour, Mahmoud F.;
Almahli, Hadia;
Bonardi, Alessandro;
Khalil, Amira;
Al-Warhi, Tarfah;
Al-Rashood, Sara T.;
Abdel-Aziz, Hatem A.;
Nocentini, Alessio;
Supuran, Claudiu T.;
Eldehna, Wagdy M.

Publication type:

Article

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2265, doi. 10.1080/14756366.2022.2104841

By:

Abdelsalam, Esraa A.;
Abd El-Hafeez, Amer Ali;
Eldehna, Wagdy M.;
El Hassab, Mahmoud A.;
Marzouk, Hala Mohamed M.;
Elaasser, Mahmoud M.;
Abou Taleb, Nageh A.;
Amin, Kamilia M.;
Abdel-Aziz, Hatem A.;
Ghosh, Pradipta;
Hammad, Sherif F.

Publication type:

Article

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1389, doi. 10.1080/14756366.2022.2070744

By:

Yousef, Reda G.;
Ibrahim, Albaraa;
Khalifa, Mohamed M.;
Eldehna, Wagdy M.;
Gobaara, Ibraheem M. M.;
Mehany, Ahmed B. M.;
Elkaeed, Eslam B.;
Alsfouk, Aisha A.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.

Publication type:

Article

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 531, doi. 10.1080/14756366.2021.2024528

By:

Eldehna, Wagdy M.;
Taghour, Mohammed S.;
Al-Warhi, Tarfah;
Nocentini, Alessio;
Elbadawi, Mostafa M.;
Mahdy, Hazem A.;
Abdelrahman, Mohamed A.;
Alotaibi, Ohoud J.;
Aljaeed, Nada;
Elimam, Diaaeldin M.;
Afarinkia, Kamyar;
Abdel-Aziz, Hatem A.;
Supuran, Claudiu T.

Publication type:

Article

Design and synthesis of thiazolidine-2/4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1903, doi. 10.1080/14756366.2022.2085693

By:

Taghour, Mohammed S.;
Elkady, Hazem;
Eldehna, Wagdy M.;
El-Deeb, Nehal M.;
Kenawy, Ahmed M.;
Elkaeed, Eslam B.;
Alsfouk, Aisha A.;
Alesawy, Mohamed S.;
Metwaly, Ahmed M.;
Eissa, Ibrahim. H.

Publication type:

Article

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2635, doi. 10.1080/14756366.2022.2124409

By:

Al-Warhi, Tarfah;
Elbadawi, Mostafa M.;
Bonardi, Alessandro;
Nocentini, Alessio;
Al-Karmalawy, Ahmed A.;
Aljaeed, Nada;
Alotaibi, Ohoud J.;
Abdel-Aziz, Hatem A.;
Supuran, Claudiu T.;
Eldehna, Wagdy M.

Publication type:

Article

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2206, doi. 10.1080/14756366.2022.2110868

By:

Yousef, Reda G.;
Elwan, Alaa;
Gobaara, Ibraheem M. M.;
Mehany, Ahmed B. M.;
Eldehna, Wagdy M.;
El-Metwally, Souad A.;
Alsfouk, Bshra A.;
Elkaeed, Eslam B.;
Metwaly, Ahmed M.;
Eissa, Ibrahim H.

Publication type:

Article

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 355, doi. 10.1080/14756366.2021.2015344

By:

Elbadawi, Mostafa M.;
Eldehna, Wagdy M.;
El-Hafeez, Amer Ali Abd;
Somaa, Warda R.;
Albohy, Amgad;
Al-Rashood, Sara T.;
Agama, Keli K.;
Elkaeed, Eslam B.;
Ghosh, Pradipta;
Pommier, Yves;
Abe, Manabu

Publication type:

Article

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1423, doi. 10.1080/14756366.2021.1944127

By:

Eldehna, Wagdy M.;
Salem, Rofaida;
Elsayed, Zainab M.;
Al-Warhi, Tarfah;
Knany, Hamada R.;
Ayyad, Rezk R.;
Traiki, Thamer Bin;
Abdulla, Maha-Hamadien;
Ahmad, Rehan;
Abdel-Aziz, Hatem A.;
El-Haggar, Radwan

Publication type:

Article

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 987, doi. 10.1080/14756366.2021.1915302

By:

Al-Sanea, Mohammad M.;
Al-Ansary, Ghada H.;
Elsayed, Zainab M.;
Maklad, Raed M.;
Elkaeed, Eslam B.;
Abdelgawad, Mohamed A.;
Bukhari, Syed Nasir Abbas;
Abdel-Aziz, Marwa M.;
Suliman, Howayda;
Eldehna, Wagdy M.

Publication type:

Article

In silico identification of novel SARS-COV-2 2′-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 727, doi. 10.1080/14756366.2021.1885396

By:

El Hassab, Mahmoud A.;
Ibrahim, Tamer M.;
Al-Rashood, Sara T.;
Alharbi, Amal;
Eskandrani, Razan O.;
Eldehna, Wagdy M.

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Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 384, doi. 10.1080/14756366.2020.1868450

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Elsayed, Zainab M.;
Eldehna, Wagdy M.;
Abdel-Aziz, Marwa M.;
El Hassab, Mahmoud A.;
Elkaeed, Eslam B.;
Al-Warhi, Tarfah;
Abdel-Aziz, Hatem A.;
Abou-Seri, Sahar M.;
Mohammed, Eman R.

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Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 271, doi. 10.1080/14756366.2020.1862101

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Eldehna, Wagdy M.;
Al-Rashood, Sara T.;
Al-Warhi, Tarfah;
Eskandrani, Razan O.;
Alharbi, Amal;
El Kerdawy, Ahmed M.

Publication type:

Article

Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 320, doi. 10.1080/14756366.2020.1862100

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Eldehna, Wagdy M.;
Abo-Ashour, Mahmoud F.;
Al-Warhi, Tarfah;
Al-Rashood, Sara T.;
Alharbi, Amal;
Ayyad, Rezk R.;
Al-Khayal, Khayal;
Abdulla, Maha;
Abdel-Aziz, Hatem A.;
Ahmad, Rehan;
El-Haggar, Radwan

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Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1616, doi. 10.1080/14756366.2020.1806259

By:

Sabt, Ahmed;
Eldehna, Wagdy M.;
Al-Warhi, Tarfah;
Alotaibi, Ohoud J.;
Elaasser, Mahmoud M.;
Suliman, Howayda;
Abdel-Aziz, Hatem A.

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Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1300, doi. 10.1080/14756366.2020.1773814

By:

Al-Warhi, Tarfah;
Abo-Ashour, Mahmoud F.;
Almahli, Hadia;
Alotaibi, Ohoud J.;
Al-Sanea, Mohammad M.;
Al-Ansary, Ghada H.;
Ahmed, Hanaa Y.;
Elaasser, Mahmoud M.;
Eldehna, Wagdy M.;
Abdel-Aziz, Hatem A.

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Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 831, doi. 10.1080/14756366.2020.1743281

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Al-Rashood, Sara T.;
Hamed, Ahmed R.;
Hassan, Ghada S.;
Alkahtani, Hamad M.;
Almehizia, Abdulrahman A.;
Alharbi, Amal;
Al-Sanea, Mohammad M.;
Eldehna, Wagdy M.

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Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 298, doi. 10.1080/14756366.2019.1697250

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Abdelrahman, Mohamed A.;
Eldehna, Wagdy M.;
Nocentini, Alessio;
Ibrahim, Hany S.;
Almahli, Hadia;
Abdel-Aziz, Hatem A.;
Abou-Seri, Sahar M.;
Supuran, Claudiu T.

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Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 1457, doi. 10.1080/14756366.2019.1652282

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Al-Sanea, Mohammad M.;
Elkamhawy, Ahmed;
Paik, Sora;
Bua, Silvia;
Ha Lee, So;
Abdelgawad, Mohamed A.;
Roh, Eun Joo;
Eldehna, Wagdy M.;
Supuran, Claudiu T.

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Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents.

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Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 322, doi. 10.1080/14756366.2018.1547286

By:

Eldehna, Wagdy M.;
Hassan, Ghada S.;
Al-Rashood, Sara T.;
Al-Warhi, Tarfah;
Altyar, Ahmed E.;
Alkahtani, Hamad M.;
Almehizia, Abdulrahman A.;
Abdel-Aziz, Hatem A.

Publication type:

Article