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Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process.
Published in:
2017
By:
- Bacalini, Maria Giulia;
- Deelen, Joris;
- Pirazzini, Chiara;
- De Cecco, Marco;
- Giuliani, Cristina;
- Lanzarini, Catia;
- Ravaioli, Francesco;
- Marasco, Elena;
- van Heemst, Diana;
- Suchiman, H. Eka D.;
- Slieker, Roderick;
- Giampieri, Enrico;
- Recchioni, Rina;
- Marcheselli, Fiorella;
- Salvioli, Stefano;
- Vitale, Giovanni;
- Olivieri, Fabiola;
- Spijkerman, Annemieke M. W.;
- Dollé, Martijn E. T.;
- Sedivy, John M.
Publication type:
journal article
Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data.
Published in:
2020
By:
- Pool, René;
- Hagenbeek, Fiona A.;
- Hendriks, Anne M.;
- van Dongen, Jenny;
- Willemsen, Gonneke;
- de Geus, Eco;
- Willems van Dijk, Ko;
- Verhoeven, Aswin;
- Suchiman, H. Eka;
- Beekman, Marian;
- Slagboom, P. Eline;
- Harms, Amy C.;
- Hankemeier, Thomas;
- Boomsma, Dorret I.;
- BBMRI Metabolomics Consortium
Publication type:
journal article
The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection.
Published in:
Twin Research & Human Genetics, 2013, v. 16, n. 1, p. 271, doi. 10.1017/thg.2012.140
By:
- Willemsen, Gonneke;
- Vink, Jacqueline M.;
- Abdellaoui, Abdel;
- den Braber, Anouk;
- van Beek, Jenny H. D. A.;
- Draisma, Harmen H. M.;
- van Dongen, Jenny;
- van ‘t Ent, Dennis;
- Geels, Lot M.;
- van Lien, Rene;
- Ligthart, Lannie;
- Kattenberg, Mathijs;
- Mbarek, Hamdi;
- de Moor, Marleen H. M.;
- Neijts, Melanie;
- Pool, Rene;
- Stroo, Natascha;
- Kluft, Cornelis;
- Suchiman, H. Eka D.;
- Slagboom, P. Eline
Publication type:
Article
The Netherlands Twin Register biobank: a resource for genetic epidemiological studies.
Published in:
2010
By:
- Willemsen, Gonneke;
- De Geus, Eco J. C.;
- Bartels, Meike;
- van Beijsterveldt, C. E. M. Toos;
- Brooks, Andy I.;
- Estourgie-van Burk, G. Frederique;
- Fugman, Douglas A.;
- Hoekstra, Chantal;
- Hottenga, Jouke-Jan;
- Kluft, Kees;
- Meijer, Piet;
- Montgomery, Grant W.;
- Rizzu, Patrizia;
- Sondervan, David;
- Smit, August B.;
- Spijker, Sabine;
- Suchiman, H. Eka D.;
- Tischfield, Jay A.;
- Lehner, Thomas;
- Slagboom, P. Eline
Publication type:
journal article
Vitamin D receptor gene polymorphisms have negligible effect on human height.
Published in:
2008
By:
- MacGregor, Stuart;
- Hottenga, Jouke-Jan;
- Lind, Penelope A.;
- Suchiman, H. Eka D.;
- Willemsen, Gonneke;
- Slagboom, P. Eline;
- Montgomery, Grant W.;
- Martin, Nicholas G.;
- Visscher, Peter M.;
- Boomsma, Dorret I.
Publication type:
journal article
Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice.
Published in:
Scientific Reports, 2017, p. 43261, doi. 10.1038/srep43261
By:
- Zwamborn, Ramona A. J.;
- Slieker, Roderick C.;
- Mulder, Petra C. A.;
- Zoetemelk, Inge;
- Verschuren, Lars;
- Suchiman, H. Eka D.;
- Toet, Karin H.;
- Droog, Simone;
- Slagboom, P. Eline;
- Kooistra, Teake;
- Kleemann, Robert;
- Heijmans, Bastiaan T.
Publication type:
Article
Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.
Published in:
Frontiers in Genetics, 2015, p. 1, doi. 10.3389/fgene.2015.00287
By:
- Suchiman, H. Eka D.;
- Slieker, Roderick C.;
- Kremer, Dennis;
- Slagboom, P. Eline;
- Heijmans, Bastiaan T.;
- Tobi, Elmar W.;
- Friso, Simonetta;
- Tost, Jorg
Publication type:
Article
Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.
Published in:
European Journal of Human Genetics, 2003, v. 11, n. 11, p. 845, doi. 10.1038/sj.ejhg.5201053
By:
- Beekman, Marian;
- Heijmans, Bastiaan T.;
- Martin, Nicholas G.;
- Whitfield, John B.;
- Pedersen, Nancy L.;
- DeFaire, Ulf;
- Snieder, Harold;
- Lakenberg, Nico;
- Suchiman, H. Eka D.;
- de Knijff, Peter;
- Frants, Rune R.;
- van Ommen, Gert Jan B;
- Kluft, Cornelis;
- Vogler, George P.;
- Boomsma, Dorret I.;
- Slagboom, P. Eline
Publication type:
Article
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array.
Published in:
Epigenetics & Chromatin, 2013, v. 6, n. 1, p. 1, doi. 10.1186/1756-8935-6-26
By:
- Slieker, Roderick C.;
- Bos, Steffan D.;
- Goeman, Jelle J.;
- Bovée, Judith V.M.G.;
- Talens, Rudolf P.;
- van der Breggen, Ruud;
- Suchiman, H. Eka D.;
- Lameijer, Eric-Wubbo;
- Putter, Hein;
- van den Akker, Erik B.;
- Zhang, Yanju;
- Wouter Jukema, J.;
- Eline Slagboom, P;
- Meulenbelt, Ingrid;
- Heijmans, Bastiaan T.
Publication type:
Article
A data‐driven methodology reveals novel myofiber clusters in older human muscles.
Published in:
FASEB Journal, 2020, v. 34, n. 4, p. 5525, doi. 10.1096/fj.201902350R
By:
- Raz, Yotam;
- Akker, Erik B.;
- Roest, Tijmen;
- Riaz, Muhammad;
- Rest, Ondine;
- Suchiman, H. Eka D.;
- Lakenberg, Nico;
- Stassen, Stefanie A.;
- Putten, Maaike;
- Feskens, Edith J. M.;
- Reinders, Marcel J. T.;
- Goeman, Jelle;
- Beekman, Marian;
- Raz, Vered;
- Slagboom, Pieternella Eline
Publication type:
Article
Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants.
Published in:
Rheumatology, 2023, v. 62, n. 2, p. 894, doi. 10.1093/rheumatology/keac272
By:
- Hoolwerff, Marcella van;
- Tuerlings, Margo;
- Wijnen, Imke J L;
- Suchiman, H Eka D;
- Cats, Davy;
- Mei, Hailiang;
- Nelissen, Rob G H H;
- Zwaag, Henrike M J van der Linden–van der;
- Ramos, Yolande F M;
- Almeida, Rodrigo Coutinho de;
- Meulenbelt, Ingrid
Publication type:
Article
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
Published in:
Rheumatology, 2023, v. 62, n. 1, p. 457, doi. 10.1093/rheumatology/keac202
By:
- Houtman, Evelyn;
- Tuerlings, Margo;
- Suchiman, H Eka D;
- Lakenberg, Nico;
- Cornelis, Frederique M F;
- Mei, Hailiang;
- Broekhuis, Demiën;
- Nelissen, Rob G H H;
- Almeida, Rodrigo Coutinho de;
- Ramos, Yolande F M;
- Lories, Rik J;
- Cruz, Luis J;
- Meulenbelt, Ingrid
Publication type:
Article
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis.
Published in:
Rheumatology, 2022, v. 61, n. 7, p. 3023, doi. 10.1093/rheumatology/keab826
By:
- Tuerlings, Margo;
- Hoolwerff, Marcella van;
- Bokkum, Jessica M van;
- Suchiman, H Eka D;
- Lakenberg, Nico;
- Broekhuis, Demiën;
- Nelissen, Rob G H H;
- Ramos, Yolande F M;
- Mei, Hailiang;
- Cats, Davy;
- Almeida, Rodrigo Coutinho de;
- Meulenbelt, Ingrid
Publication type:
Article
role of TNFRSF11B in development of osteoarthritic cartilage.
Published in:
Rheumatology, 2022, v. 61, n. 2, p. 856, doi. 10.1093/rheumatology/keab440
By:
- Ruiz, Alejandro Rodríguez;
- Tuerlings, Margo;
- Das, Ankita;
- Almeida, Rodrigo Coutinho de;
- Suchiman, H Eka D;
- Nelissen, Rob G H H;
- Ramos, Yolande F M;
- Meulenbelt, Ingrid
Publication type:
Article
Small nucleoli are a cellular hallmark of longevity.
Published in:
Nature Communications, 2017, v. 8, n. 8, p. 16083, doi. 10.1038/ncomms16083
By:
- Tiku, Varnesh;
- Jain, Chirag;
- Raz, Yotam;
- Nakamura, Shuhei;
- Heestand, Bree;
- Liu, Wei;
- Späth, Martin;
- Suchiman, H. Eka. D.;
- Müller, Roman-Ulrich;
- Slagboom, P. Eline;
- Partridge, Linda;
- Antebi, Adam
Publication type:
Article
Genetic and environmental influences interact with age and sex in shaping the human methylome.
Published in:
Nature Communications, 2016, v. 7, n. 4, p. 1, doi. 10.1038/ncomms11115
By:
- van Dongen, Jenny;
- Nivard, Michel G.;
- Willemsen, Gonneke;
- Hottenga, Jouke-Jan;
- Helmer, Quinta;
- Dolan, Conor V.;
- Ehli, Erik A.;
- Davies, Gareth E.;
- van Iterson, Maarten;
- Breeze, Charles E.;
- Beck, Stephan;
- Eka Suchiman, H.;
- Jansen, Rick;
- van Meurs, Joyce B.;
- Heijmans, Bastiaan T.;
- Eline Slagboom, P.;
- Boomsma, Dorret I.;
- Hoen, Peter A. C. 't;
- Pool, René;
- van Greevenbroek, Marleen M. J.
Publication type:
Article
Genome-wide analysis of constitutional DNA methylation in familial melanoma.
Published in:
Clinical Epigenetics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13148-020-00831-7
By:
- Salgado, Catarina;
- Gruis, Nelleke;
- BIOS Consortium;
- Bonder, Marc Jan;
- Luijk, René;
- Zhernakova, Dasha V.;
- Moed, Matthijs;
- Deelen, Patrick;
- Vermaat, Martijn;
- van Iterson, Maarten;
- van Dijk, Freerk;
- van Galen, Michiel;
- Bot, Jan;
- Jhamai, P. Mila;
- Verbiest, Michael;
- Suchiman, H. Eka D.;
- Verkerk, Marijn;
- van der Breggen, Ruud;
- van Rooij, Jeroen;
- Lakenberg, Nico
Publication type:
Article
RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets.
Published in:
Arthritis & Rheumatology, 2021, v. 73, n. 5, p. 789, doi. 10.1002/art.41600
By:
- Tuerlings, Margo;
- Hoolwerff, Marcella;
- Houtman, Evelyn;
- Suchiman, Eka H. E. D.;
- Lakenberg, Nico;
- Mei, Hailiang;
- Linden, Enrike H. M. J.;
- Nelissen, Rob R. G. H. H.;
- Ramos, Yolande Y. F. M.;
- Coutinho de Almeida, Rodrigo;
- Meulenbelt, Ingrid
Publication type:
Article
Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage.
Published in:
Arthritis & Rheumatology, 2020, v. 72, n. 11, p. 1845, doi. 10.1002/art.41396
By:
- Hoolwerff, Marcella;
- Metselaar, Paula I.;
- Tuerlings, Margo;
- Suchiman, H. Eka D.;
- Lakenberg, Nico;
- Ramos, Yolande F.M.;
- Cats, Davy;
- Nelissen, Rob G.H.H.;
- Broekhuis, Demiën;
- Mei, Hailiang;
- Almeida, Rodrigo Coutinho;
- Meulenbelt, Ingrid
Publication type:
Article
Transcriptional Associations of Osteoarthritis-Mediated Loss of Epigenetic Control in Articular Cartilage.
Published in:
Arthritis & Rheumatology, 2015, v. 67, n. 8, p. 2108, doi. 10.1002/art.39162
By:
- den Hollander, Wouter;
- Ramos, Yolande F. M.;
- Bomer, Nils;
- Elzinga, Stefan;
- van der Breggen, Ruud;
- Lakenberg, Nico;
- de Dijcker, Wesley J.;
- Suchiman, H. Eka D.;
- Duijnisveld, Bouke J.;
- Houwing‐Duistermaat, Jeanine J.;
- Slagboom, P. Eline;
- Bos, Steffan D.;
- Nelissen, Rob G. H. H.;
- Meulenbelt, Ingrid
Publication type:
Article
A Common Mineralocorticoid Receptor Polymorphism (I180V) Interacts with Life Events in Relation to Perfectionism in Eating Disorders: A Pilot Study.
Published in:
European Eating Disorders Review, 2014, v. 22, n. 6, p. 423, doi. 10.1002/erv.2319
By:
- Slof‐Op't Landt, Margarita C. T.;
- DeRijk, Roel H.;
- Son, Gabrielle E.;
- Suchiman, H. Eka D.;
- Meulenbelt, Ingrid;
- Slagboom, P. Eline;
- Van Furth, Eric F.
Publication type:
Article
DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01077-3
By:
- Roost, Matthias S.;
- Slieker, Roderick C.;
- Bialecka, Monika;
- van Iperen, Liesbeth;
- Gomes Fernandes, Maria M.;
- Nannan He;
- Suchiman, H. Eka D.;
- Szuhai, Karoly;
- Carlotti, Françoise;
- de Koning, Eelco J. P.;
- Mummery, Christine L.;
- Heijmans, Bastiaan T.;
- Chuva de Sousa Lopes, Susana M.
Publication type:
Article
DNA Methylation Landscapes of Human Fetal Development.
Published in:
PLoS Genetics, 2015, v. 11, n. 10, p. 1, doi. 10.1371/journal.pgen.1005583
By:
- Slieker, Roderick C.;
- Roost, Matthias S.;
- van Iperen, Liesbeth;
- Suchiman, H. Eka D.;
- Tobi, Elmar W.;
- Carlotti, Françoise;
- de Koning, Eelco J. P.;
- Slagboom, P. Eline;
- Heijmans, Bastiaan T.;
- Chuva de Sousa Lopes, Susana M.
Publication type:
Article
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis.
Published in:
Rheumatology & Therapy, 2021, v. 8, n. 1, p. 499, doi. 10.1007/s40744-021-00287-y
By:
- Houtman, Evelyn;
- van Hoolwerff, Marcella;
- Lakenberg, Nico;
- Suchiman, Eka H. D.;
- van der Linden-van der Zwaag, Enrike;
- Nelissen, Rob G. H. H.;
- Ramos, Yolande F. M.;
- Meulenbelt, Ingrid
Publication type:
Article
Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.
Published in:
2015
By:
- Tobi, Elmar W.;
- Slieker, Roderick C.;
- Stein, Aryeh D.;
- Suchiman, H. Eka D.;
- Slagboom, P. Eline;
- van Zwet, Erik W.;
- Heijmans, Bastiaan T.;
- Lumey, LH;
- Lumey, L H
Publication type:
journal article
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.
Published in:
International Journal of Epidemiology, 2014, v. 43, n. 3, p. 878, doi. 10.1093/ije/dyt267
By:
- Deelen, Joris;
- Beekman, Marian;
- Codd, Veryan;
- Trompet, Stella;
- Broer, Linda;
- Hägg, Sara;
- Fischer, Krista;
- Thijssen, Peter E;
- Suchiman, H Eka D;
- Postmus, Iris;
- Uitterlinden, André G;
- Hofman, Albert;
- de Craen, Anton J M;
- Metspalu, Andres;
- Pedersen, Nancy L;
- van Duijn, Cornelia M;
- Wouter Jukema, J;
- Houwing-Duistermaat, Jeanine J;
- Samani, Nilesh J;
- Eline Slagboom, P
Publication type:
Article
Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study.
Published in:
Behavior Genetics, 2011, v. 41, n. 1, p. 155, doi. 10.1007/s10519-010-9406-5
By:
- Van Beijsterveldt, Catherina E. M.;
- Middeldorp, Christel M.;
- Slof-Op't Landt, Margarita C. T.;
- Bartels, Meike;
- Hottenga, Jouke-Jan;
- Suchiman, H. Eka D.;
- Slagboom, P. Eline;
- Boomsma, Dorret I.
Publication type:
Article
Combined association and linkage analysis applied to the APOE locus.
Published in:
Genetic Epidemiology, 2004, v. 26, n. 4, p. 328, doi. 10.1002/gepi.10318
By:
- Marian Beekman;
- Daniëlle Posthuma;
- Bastiaan T. Heijmans;
- Nico Lakenberg;
- H. Eka D. Suchiman;
- Harold Snieder;
- Peter de Knijff;
- Rune R. Frants;
- Gert Jan B. van Ommen;
- Cornelis Kluft;
- George P. Vogler;
- P. Eline Slagboom;
- Dorret I. Boomsma
Publication type:
Article
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.
Published in:
Aging Cell, 2012, v. 11, n. 4, p. 694, doi. 10.1111/j.1474-9726.2012.00835.x
By:
- Talens, Rudolf P.;
- Christensen, Kaare;
- Putter, Hein;
- Willemsen, Gonneke;
- Christiansen, Lene;
- Kremer, Dennis;
- Suchiman, H. Eka D.;
- Slagboom, P. Eline;
- Boomsma, Dorret I.;
- Heijmans, Bastiaan T.
Publication type:
Article
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Published in:
Aging Cell, 2011, v. 10, n. 4, p. 686, doi. 10.1111/j.1474-9726.2011.00705.x
By:
- Deelen, Joris;
- Beekman, Marian;
- Uh, Hae-Won;
- Helmer, Quinta;
- Kuningas, Maris;
- Christiansen, Lene;
- Kremer, Dennis;
- van der Breggen, Ruud;
- Suchiman, H. Eka D.;
- Lakenberg, Nico;
- van den Akker, Erik B.;
- Passtoors, Willemijn M.;
- Tiemeier, Henning;
- van Heemst, Diana;
- de Craen, Anton J.;
- Rivadeneira, Fernando;
- de Geus, Eco J;
- Perola, Markus;
- van der Ouderaa, Frans J.;
- Gunn, David A.
Publication type:
Article
Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.
Published in:
2020
By:
- Hagenbeek, Fiona A.;
- Pool, René;
- van Dongen, Jenny;
- Draisma, H. M.;
- Jan Hottenga, Jouke;
- Willemsen, Gonneke;
- Abdellaoui, Abdel;
- Fedko, Iryna O.;
- den Braber, Anouk;
- Visser, Pieter Jelle;
- de Geus, Eco J. C. N.;
- Willems van Dijk, Ko;
- Verhoeven, Aswin;
- Suchiman, H. Eka;
- Beekman, Marian;
- Slagboom, P. Eline;
- van Duijn, Cornelia M.;
- BBMRI Metabolomics Consortium;
- Barkey Wolf, J. J. H.;
- Cats, D.
Publication type:
Correction Notice
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13770-6
By:
- Hagenbeek, Fiona A.;
- Pool, René;
- van Dongen, Jenny;
- Draisma, Harmen H. M.;
- Jan Hottenga, Jouke;
- Willemsen, Gonneke;
- Abdellaoui, Abdel;
- Fedko, Iryna O.;
- den Braber, Anouk;
- Visser, Pieter Jelle;
- de Geus, Eco J. C. N.;
- Willems van Dijk, Ko;
- Verhoeven, Aswin;
- Suchiman, H. Eka;
- Beekman, Marian;
- Slagboom, P. Eline;
- van Duijn, Cornelia M.;
- BBMRI Metabolomics Consortium;
- Barkey Wolf, J. J. H.;
- Cats, D.
Publication type:
Article
MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test.
Published in:
2019
By:
- Ruhaak, L. Renee;
- Smit, Nico P.M.;
- Pieterse, Mervin M.;
- Romijn, Fred P.H.T.M.;
- Cobbaert, Christa M.;
- Suchiman, H. Eka D.;
- Beekman, Marian
Publication type:
Letter to the Editor
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants.
Published in:
Arthritis Research & Therapy, 2021, v. 23, n. 1, p. 1, doi. 10.1186/s13075-021-02595-8
By:
- Houtman, Evelyn;
- Tuerlings, Margo;
- Riechelman, Janne;
- Suchiman, Eka H. E. D.;
- van der Wal, Robert J. P.;
- Nelissen, Rob G. H. H.;
- Mei, Hailiang;
- Ramos, Yolande F. M.;
- Coutinho de Almeida, Rodrigo;
- Meulenbelt, Ingrid
Publication type:
Article
Lipid metabolism in long-lived families: the Leiden Longevity Study.
Published in:
Age, 2011, v. 33, n. 2, p. 219, doi. 10.1007/s11357-010-9172-6
By:
- Vaarhorst, Anika A. M.;
- Beekman, Marian;
- Suchiman, Eka H. D.;
- Van Heemst, Diana;
- Houwing-Duistermaat, Jeanine J.;
- Westendorp, Rudi G. J.;
- Slagboom, P. Eline;
- Heijmans, Bastiaan T.
Publication type:
Article

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