Works by Eizirik, Decio L.
Results: 143
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
- Published in:
- 2005
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- Publication type:
- journal article
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
- Published in:
- 2005
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- Publication type:
- journal article
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
- Published in:
- 2003
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- Publication type:
- journal article
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
- Published in:
- 2003
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- Publication type:
- journal article
Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.
- Published in:
- Biomolecules (2218-273X), 2021, v. 11, n. 2, p. 320, doi. 10.3390/biom11020320
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- Publication type:
- Article
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
- Published in:
- Cell Death & Disease, 2019, v. 10, n. 4, p. N.PAG, doi. 10.1038/s41419-019-1518-0
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- Publication type:
- Article
MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.
- Published in:
- Cell Death & Disease, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41419-018-1268-4
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- Publication type:
- Article
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8<sup>+</sup> T Cells Across MHC Class I Restrictions in Humans and NOD Mice.
- Published in:
- 2020
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- Publication type:
- journal article
In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.
- Published in:
- BMC Bioinformatics, 2007, v. 8, p. 1, doi. 10.1186/1471-2105-8-55
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- Publication type:
- Article
Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.
- Published in:
- 2016
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- Publication type:
- journal article
Role of Receptor Binding and Gene Transcription for Both of Stimulatory and Inhibitory Effects of Interleukin-1 In Pancreatic β-Cells.
- Published in:
- Autoimmunity, 1992, v. 12, n. 2, p. 127, doi. 10.3109/08916939209150319
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- Publication type:
- Article
Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells.
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- Autoimmunity, 1991, v. 10, n. 3, p. 241, doi. 10.3109/08916939109001895
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- Publication type:
- Article
Interleukin-1β Induces an Early Decrease in Insulin Release, (Pro)Insulin Biosynthesis and Insulin Mrna in Mouse Pancreatic Islets by a Mechanism Dependent on Gene Transcription and Protein Synthesis.
- Published in:
- Autoimmunity, 1991, v. 10, n. 2, p. 107, doi. 10.3109/08916939109004814
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- Publication type:
- Article
Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.
- Published in:
- Stem Cell Research & Therapy, 2020, v. 11, n. 1, p. 1, doi. 10.1186/s13287-019-1523-3
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- Publication type:
- Article
Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets.
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- Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 3, p. 1442, doi. 10.1210/jc.2009-2322
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- Publication type:
- Article
Mechanisms of Coxsackievirus-Induced Damage to Human Pancreatic β-Cells.
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- Journal of Clinical Endocrinology & Metabolism, 2000, v. 85, n. 1, p. 432, doi. 10.1210/jcem.85.1.6306
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- Publication type:
- Article
Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance.
- Published in:
- PLoS Pathogens, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.ppat.1002267
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- Publication type:
- Article
The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 15, p. 2465, doi. 10.3390/cells11152465
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- Publication type:
- Article
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes.
- Published in:
- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 10, p. 1827, doi. 10.1111/dom.14104
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- Publication type:
- Article
When one becomes many—Alternative splicing in β‐cell function and failure.
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- Diabetes, Obesity & Metabolism, 2018, v. 20, p. 77, doi. 10.1111/dom.13388
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- Publication type:
- Article
Distinct gene expression pathways in islets from individuals with short‐ and long‐duration type 1 diabetes.
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- Diabetes, Obesity & Metabolism, 2018, v. 20, n. 8, p. 1859, doi. 10.1111/dom.13298
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- Publication type:
- Article
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 1, p. 135, doi. 10.1093/hmg/ddp474
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- Publication type:
- Article
Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
- Published in:
- Clinical Epigenetics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13148-020-00906-5
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- Publication type:
- Article
Stress du réticulum endoplasmique et apoptose de la cellule bêta dans le diabète: Chronique d'une mort annoncée.
- Published in:
- Médecine Sciences, 2014, v. 30, n. 5, p. 496, doi. 10.1051/medsci/20143005007
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- Publication type:
- Article
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
- Published in:
- EMBO Journal, 2012, v. 31, n. 6, p. 1405, doi. 10.1038/emboj.2011.503
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- Publication type:
- Article
DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.
- Published in:
- European Journal of Endocrinology, 2021, v. 184, n. 3, p. 459, doi. 10.1530/EJE-20-0636
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- Publication type:
- Article
Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells.
- Published in:
- Diabetes, 2010, v. 59, n. 2, p. 358, doi. 10.2337/db09-1159
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- Publication type:
- Article
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
- Published in:
- 2009
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- Publication type:
- journal article
Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB.
- Published in:
- Diabetes, 2009, v. 58, n. 12, p. 2851, doi. 10.2337/db09-0685
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- Publication type:
- Article
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
- Published in:
- 2009
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- Publication type:
- journal article
PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-ϒ-Induced Pancreatic β-Cell Apoptosis.
- Published in:
- Diabetes, 2009, v. 58, n. 6, p. 1283, doi. 10.2337/db08-1510
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- Publication type:
- Article
Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways.
- Published in:
- Diabetes, 2008, v. 57, n. 5, p. 1236, doi. 10.2337/db07-0844
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- Publication type:
- Article
Deletion of STAT-1 Pancreatic Islets Protects Against Streptozotocin-Induced Diabetes and Early Graft Failure but Not Against Late Rejection.
- Published in:
- Diabetes, 2007, v. 56, n. 8, p. 2169, doi. 10.2337/db07-0052
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- Publication type:
- Article
Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells.
- Published in:
- Diabetes, 2007, v. 56, n. 4, p. 1069, doi. 10.2337/db06-1253
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- Publication type:
- Article
Mechanisms of Pancreatic Β-cell Death in Type 1 and Type 2 Diabetes.
- Published in:
- Diabetes, 2005, v. 54, p. S97, doi. 10.2337/diabetes.54.suppl_2.S97
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- Publication type:
- Article
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
- Published in:
- 2005
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- Publication type:
- journal article
Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells.
- Published in:
- Diabetes, 2005, v. 54, n. 8, p. 2396, doi. 10.2337/diabetes.54.8.2396
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- Publication type:
- Article
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.
- Published in:
- 2003
- By:
- Publication type:
- journal article
Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.
- Published in:
- 2001
- By:
- Publication type:
- journal article
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
- Published in:
- 2001
- By:
- Publication type:
- journal article
Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.
- Published in:
- 2001
- By:
- Publication type:
- journal article
Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.
- Published in:
- 2001
- By:
- Publication type:
- journal article
Beta-Cell Apoptosis and Defense Mechanisms.
- Published in:
- Diabetes, 2001, v. 50, p. S64, doi. 10.2337/diabetes.50.2007.S64
- By:
- Publication type:
- Article
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
- Published in:
- 2000
- By:
- Publication type:
- journal article
Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.
- Published in:
- 2000
- By:
- Publication type:
- journal article
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.
- Published in:
- Diabetes, 1999, v. 48, n. 4, p. 706, doi. 10.2337/diabetes.48.4.706
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- Publication type:
- Article
Contribution of ductal cells to cytokine responses by human pancreatic islets.
- Published in:
- 1999
- By:
- Publication type:
- journal article
Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes.
- Published in:
- 1996
- By:
- Publication type:
- journal article
Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival.
- Published in:
- 1993
- By:
- Publication type:
- journal article
Repair of Pancreatic β-Cells.
- Published in:
- Diabetes, 1993, v. 42, n. 10, p. 1383, doi. 10.2337/diab.42.10.1383
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- Publication type:
- Article