Found: 137
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Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
- Published in:
- 2005
- By:
- Publication type:
- journal article
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
- Published in:
- 2005
- By:
- Publication type:
- journal article
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
- Published in:
- 2003
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- Publication type:
- journal article
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
- Published in:
- 2003
- By:
- Publication type:
- journal article
Genetic regulation of RNA splicing in human pancreatic islets.
- Published in:
- Genome Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13059-022-02757-0
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- Publication type:
- Article
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.
- Published in:
- Annals of Neurology, 2012, v. 72, n. 6, p. 971, doi. 10.1002/ana.23698
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- Publication type:
- Article
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8<sup>+</sup> T Cells Across MHC Class I Restrictions in Humans and NOD Mice.
- Published in:
- 2020
- By:
- Publication type:
- journal article
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.
- Published in:
- Life Science Alliance, 2021, v. 4, n. 3, p. 1, doi. 10.26508/lsa.202000825
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- Publication type:
- Article
Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.
- Published in:
- 2016
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- Publication type:
- journal article
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.
- Published in:
- eLife, 2015, p. 1, doi. 10.7554/eLife.06990
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- Publication type:
- Article
Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.
- Published in:
- Biomolecules (2218-273X), 2021, v. 11, n. 2, p. 320, doi. 10.3390/biom11020320
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- Publication type:
- Article
Nova1 is a master regulator of alternative splicing in pancreatic beta cells.
- Published in:
- Nucleic Acids Research, 2014, v. 42, n. 18, p. 11818, doi. 10.1093/nar/gku861
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- Publication type:
- Article
Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.
- Published in:
- Stem Cell Research & Therapy, 2020, v. 11, n. 1, p. 1, doi. 10.1186/s13287-019-1523-3
- By:
- Publication type:
- Article
Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
- Published in:
- Clinical Epigenetics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13148-020-00906-5
- By:
- Publication type:
- Article
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.
- Published in:
- EMBO Journal, 2012, v. 31, n. 6, p. 1405, doi. 10.1038/emboj.2011.503
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- Publication type:
- Article
Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis.
- Published in:
- FASEB Journal, 2018, v. 32, n. 3, p. 1524, doi. 10.1096/fj.201700710R
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- Publication type:
- Article
The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress.
- Published in:
- Endocrinology, 2021, v. 162, n. 11, p. 1, doi. 10.1210/endocr/bqab173
- By:
- Publication type:
- Article
Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival.
- Published in:
- 1993
- By:
- Publication type:
- journal article
Repair of Pancreatic β-Cells.
- Published in:
- Diabetes, 1993, v. 42, n. 10, p. 1383, doi. 10.2337/diab.42.10.1383
- By:
- Publication type:
- Article
Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets.
- Published in:
- 1993
- By:
- Publication type:
- journal article
Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function.
- Published in:
- 1991
- By:
- Publication type:
- journal article
Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1.
- Published in:
- 1988
- By:
- Publication type:
- journal article
Reduced diabetogenic effect of streptozotocin in rats previously adapted to a high-protein, carbohydrate-free diet.
- Published in:
- 1984
- By:
- Publication type:
- journal article
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis.
- Published in:
- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-023-01437-1
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- Publication type:
- Article
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis.
- Published in:
- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-023-01437-1
- By:
- Publication type:
- Article
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.
- Published in:
- Molecules, 2018, v. 23, n. 9, p. 2100, doi. 10.3390/molecules23092100
- By:
- Publication type:
- Article
The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 15, p. 2465, doi. 10.3390/cells11152465
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- Publication type:
- Article
High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells.
- Published in:
- European Journal of Immunology, 2004, v. 34, n. 9, p. 2529, doi. 10.1002/eji.200324712
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- Publication type:
- Article
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
- Published in:
- Cell Death & Disease, 2019, v. 10, n. 4, p. N.PAG, doi. 10.1038/s41419-019-1518-0
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- Publication type:
- Article
MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.
- Published in:
- Cell Death & Disease, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41419-018-1268-4
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- Publication type:
- Article
ER Stress in Pancreatic β Cells: The Thin Red Line Between Adaptation and Failure.
- Published in:
- Science Signaling, 2010, v. 3, n. 110, p. 1, doi. 10.1126/scisignal.3110pe7
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- Publication type:
- Article
Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 3, p. 1442, doi. 10.1210/jc.2009-2322
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- Publication type:
- Article
Mechanisms of Coxsackievirus-Induced Damage to Human Pancreatic β-Cells.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 2000, v. 85, n. 1, p. 432, doi. 10.1210/jcem.85.1.6306
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- Publication type:
- Article
Mechanisms of Defective Glucose-Induced Insulin Release in Human Pancreatic Islets Transplanted to Diabetic Nude Mice.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 1997, v. 82, n. 8, p. 2660, doi. 10.1210/jcem.82.8.4150
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- Publication type:
- Article
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.
- Published in:
- BMC Genomics, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12864-020-07003-0
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- Publication type:
- Article
Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance.
- Published in:
- PLoS Pathogens, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.ppat.1002267
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- Publication type:
- Article
SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells.
- Published in:
- Journal of Molecular Medicine, 2020, v. 98, n. 12, p. 1795, doi. 10.1007/s00109-020-02006-6
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- Publication type:
- Article
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes.
- Published in:
- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 10, p. 1827, doi. 10.1111/dom.14104
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- Publication type:
- Article
When one becomes many—Alternative splicing in β‐cell function and failure.
- Published in:
- Diabetes, Obesity & Metabolism, 2018, v. 20, p. 77, doi. 10.1111/dom.13388
- By:
- Publication type:
- Article
Distinct gene expression pathways in islets from individuals with short‐ and long‐duration type 1 diabetes.
- Published in:
- Diabetes, Obesity & Metabolism, 2018, v. 20, n. 8, p. 1859, doi. 10.1111/dom.13298
- By:
- Publication type:
- Article
EuroDia: a beta-cell gene expression resource.
- Published in:
- Database: The Journal of Biological Databases & Curation, 2010, v. 2010, p. 1, doi. 10.1093/database/baq024
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- Publication type:
- Article
tRNA Methyltransferase Homolog Gene <i>TRMT10A</i> Mutation in Young Onset Diabetes and Primary Microcephaly in Humans.
- Published in:
- PLoS Genetics, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.pgen.1003888
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- Publication type:
- Article
<i>GLIS3</i>, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein <i>Bim</i>
- Published in:
- PLoS Genetics, 2013, v. 9, n. 5, p. 1, doi. 10.1371/journal.pgen.1003532
- By:
- Publication type:
- Article
New Approaches for in Silico Identification of Cytokine-Modified β Cell Gene Networks.
- Published in:
- Annals of the New York Academy of Sciences, 2004, v. 1037, n. 1, p. 41, doi. 10.1196/annals.1337.007
- By:
- Publication type:
- Article
Use of Microarray Analysis to Unveil Transcription Factor and Gene Networks Contributing to β Cell Dysfunction and Apoptosis.
- Published in:
- Annals of the New York Academy of Sciences, 2003, v. 1005, n. 1, p. 55, doi. 10.1196/annals.1288.007
- By:
- Publication type:
- Article
A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.
- Published in:
- NAR Genomics & Bioinformatics, 2022, v. 4, n. 4, p. 1, doi. 10.1093/nargab/lqac084
- By:
- Publication type:
- Article
A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.
- Published in:
- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.748679
- By:
- Publication type:
- Article
CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets.
- Published in:
- Diabetes, 2024, v. 73, n. 5, p. 728, doi. 10.2337/db23-0588
- By:
- Publication type:
- Article
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes.
- Published in:
- Diabetes, 2023, v. 72, n. 1, p. 85, doi. 10.2337/db22-0191
- By:
- Publication type:
- Article
The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets.
- Published in:
- 2022
- By:
- Publication type:
- journal article