Works by Eizirik, Décio L

Results: 38

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Published in:

2005

By:

Welsh, Nils;
Cnop, Miriam;
Kharroubi, Ilham;
Bugliani, Marco;
Lupi, Roberto;
Marchetti, Piero;
Eizirik, Décio L.;
Eizirik, Décio L

Publication type:

journal article

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Published in:

2005

By:

Cardozo, Alessandra K.;
Ortis, Fernanda;
Storling, Joachim;
Feng, Ying-Mei;
Rasschaert, Joanne;
Tonnesen, Morten;
Van Eylen, Françoise;
Mandrup-Poulsen, Thomas;
Herchuelz, André;
Eizirik, Décio L.;
Van Eylen, Françoise;
Herchuelz, André;
Eizirik, Décio L

Publication type:

journal article

Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.

Published in:

2003

By:

Kutlu, Burak;
Cardozo, Alessandra K.;
Darville, Martine I.;
Eizirik, Décio L.;
Kruhøffer, Mogens;
Magnusson, Nils;
Ørntoft, Torben;
Kruhøffer, Mogens;
Ørntoft, Torben;
Eizirik, Décio L

Publication type:

journal article

Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.

Published in:

2003

By:

Kutlu, Burak;
Darville, Martine I.;
Cardozo, Alessandra K.;
Eizirik, Décio L.;
Eizirik, Décio L

Publication type:

journal article

When one becomes many—Alternative splicing in β‐cell function and failure.

Published in:

Diabetes, Obesity & Metabolism, 2018, v. 20, p. 77, doi. 10.1111/dom.13388

By:

Alvelos, Maria Inês;
Juan‐Mateu, Jonàs;
Colli, Maikel Luis;
Turatsinze, Jean‐Valéry;
Eizirik, Décio L.

Publication type:

Article

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Published in:

Life Science Alliance, 2021, v. 4, n. 3, p. 1, doi. 10.26508/lsa.202000825

By:

Alvelos, Maria Inês;
Brüggemann, Mirko;
Sutandy, F. X. Reymond;
Juan-Mateu, Jonàs;
Colli, Maikel Luis;
Busch, Anke;
Lopes, Miguel;
Castela, Ângela;
Aartsma-Rus, Annemieke;
König, Julian;
Zarnack, Kathi;
Eizirik, Décio L.

Publication type:

Article

tRNA Methyltransferase Homolog Gene <i>TRMT10A</i> Mutation in Young Onset Diabetes and Primary Microcephaly in Humans.

Published in:

PLoS Genetics, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.pgen.1003888

By:

Igoillo-Esteve, Mariana;
Genin, Anne;
Lambert, Nelle;
Désir, Julie;
Pirson, Isabelle;
Abdulkarim, Baroj;
Simonis, Nicolas;
Drielsma, Anais;
Marselli, Lorella;
Marchetti, Piero;
Vanderhaeghen, Pierre;
Eizirik, Décio L.;
Wuyts, Wim;
Julier, Cécile;
Chakera, Ali J.;
Ellard, Sian;
Hattersley, Andrew T.;
Abramowicz, Marc;
Cnop, Miriam

Publication type:

Article

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines.

Published in:

PLoS Genetics, 2012, v. 8, n. 3, p. 1, doi. 10.1371/journal.pgen.1002552

By:

Eizirik, Décio L.;
Sammeth, Michael;
Bouckenooghe, Thomas;
Bottu, Guy;
Sisino, Giorgia;
Igoillo-Esteve, Mariana;
Ortis, Fernanda;
Santin, Izortze;
Colli, Maikel L.;
Barthson, Jenny;
Bouwens, Luc;
Hughes, Linda;
Gregory, Lorna;
Lunter, Gerton;
Marselli, Lorella;
Marchetti, Piero;
McCarthy, Mark I.;
Cnop, Miriam

Publication type:

Article

Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41534-w

By:

Zhang, Jing;
Zou, Yuan;
Chen, Longmin;
Sun, Fei;
Xu, Qianqian;
Zhou, Qing;
Wang, Yi;
Luo, Xi;
Wang, Na;
Li, Yang;
Zhang, Shu;
Xiong, Fei;
Yang, Ping;
Liu, Shiwei;
Yang, Tao;
Weng, Jianping;
Eizirik, Décio L.;
Yan, Jinhua;
Zhou, Zhiguang;
Wang, Cong-Yi

Publication type:

Article

Mechanisms of Coxsackievirus-Induced Damage to Human Pancreatic β-Cells.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2000, v. 85, n. 1, p. 432, doi. 10.1210/jcem.85.1.6306

By:

ROIVAINEN, MERJA;
RASILAINEN, SUVI;
YLIPAASTO, PETRI;
NISSINEN, RIIKKA;
USTINOV, JARKKO;
BOUWENS, LUC;
EIZIRIK, DÉCIO L.;
HOVI, TAPANI;
OTONKOSKI, TIMO

Publication type:

Article

Mechanisms of Defective Glucose-Induced Insulin Release in Human Pancreatic Islets Transplanted to Diabetic Nude Mice.

Published in:

Journal of Clinical Endocrinology & Metabolism, 1997, v. 82, n. 8, p. 2660, doi. 10.1210/jcem.82.8.4150

By:

EIZIRIK, DÉCIO L.;
JANSSON, LEIF;
FLODSTRÖM, MALIN;
HELLERSTRÖM, CLAES;
ANDERSSON, ARNE

Publication type:

Article

Genetic regulation of RNA splicing in human pancreatic islets.

Published in:

Genome Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13059-022-02757-0

By:

Atla, Goutham;
Bonàs-Guarch, Silvia;
Cuenca-Ardura, Mirabai;
Beucher, Anthony;
Crouch, Daniel J. M.;
Garcia-Hurtado, Javier;
Moran, Ignasi;
the T2DSystems Consortium;
Cnop, Miriam;
Eliasson, Lena;
Esguerra, Jonathan Lou S.;
Eizirik, Décio L.;
Groop, Leif;
Jensen, Thomas S.;
Hansen, Torben;
Marchetti, Piero;
Mercader, Josep M.;
Mulder, Hindrik;
Stabile-Barnett, Chris R.;
Thirion, Christian

Publication type:

Article

Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 3, p. 1442, doi. 10.1210/jc.2009-2322

By:

Ladrière, Laurence;
Igoillo-Esteve, Mariana;
Cunha, Daniel A.;
Brion, Jean-Pierre;
Bugliani, Marco;
Marchetti, Piero;
L. Eizirik, Décio;
Cnop, Miriam

Publication type:

Article

DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.

Published in:

European Journal of Endocrinology, 2021, v. 184, n. 3, p. 459, doi. 10.1530/EJE-20-0636

By:

Lytrivi, Maria;
Senée, Valérie;
Salpea, Paraskevi;
Fantuzzi, Federica;
Philippi, Anne;
Abdulkarim, Baroj;
Toshiaki Sawatani;
Marín-Cañas, Sandra;
Pachera, Nathalie;
Degavre, Anne;
Singh, Pratibha;
Derbois, Céline;
Lechner, Doris;
Ladrière, Laurence;
Igoillo-Esteve, Mariana;
Cosentino, Cristina;
Marselli, Lorella;
Deleuze, Jean-François;
Marchetti, Piero;
Eizirik, Décio L.

Publication type:

Article

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.

Published in:

Annals of Neurology, 2012, v. 72, n. 6, p. 971, doi. 10.1002/ana.23698

By:

Cnop, Miriam;
Igoillo-Esteve, Mariana;
Rai, Myriam;
Begu, Audrey;
Serroukh, Yasmina;
Depondt, Chantal;
Musuaya, Anyishai E.;
Marhfour, Ihsane;
Ladrière, Laurence;
Moles Lopez, Xavier;
Lefkaditis, Dionysios;
Moore, Fabrice;
Brion, Jean-Pierre;
Cooper, J. Mark;
Schapira, Anthony H. V.;
Clark, Anne;
Koeppen, Arnulf H.;
Marchetti, Piero;
Pandolfo, Massimo;
Eizirik, Décio L.

Publication type:

Article

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival.

Published in:

Diabetes, 2018, v. 67, n. 3, p. 423, doi. 10.2337/db17-0736

By:

Juan-Mateu, Jonàs;
Alvelos, Maria Inês;
Turatsinze, Jean-Valéry;
Villate, Olatz;
Lizarraga-Mollinedo, Esther;
Grieco, Fabio Arturo;
Marroquí, Laura;
Bugliani, Marco;
Marchetti, Piero;
Eizirik, Décio L.

Publication type:

Article

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

Published in:

2017

By:

Grieco, Fabio Arturo;
Sebastiani, Guido;
Juan-Mateu, Jonas;
Villate, Olatz;
Marroqui, Laura;
Ladrière, Laurence;
Tugay, Ksenya;
Regazzi, Romano;
Bugliani, Marco;
Marchetti, Piero;
Dotta, Francesco;
Eizirik, Décio L.

Publication type:

journal article

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.

Published in:

2015

By:

Abdulkarim, Baroj;
Nicolino, Marc;
Igoillo-Esteve, Mariana;
Daures, Mathilde;
Romero, Sophie;
Philippi, Anne;
Senée, Valérie;
Lopes, Miguel;
Cunha, Daniel A.;
Harding, Heather P.;
Derbois, Céline;
Bendelac, Nathalie;
Hattersley, Andrew T.;
Eizirik, Décio L.;
Ron, David;
Cnop, Miriam;
Julier, Cécile

Publication type:

journal article

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate.

Published in:

Diabetes, 2014, v. 63, n. 6, p. 1978, doi. 10.2337/db13-1383

By:

Cnop, Miriam;
Abdulkarim, Baroj;
Bottu, Guy;
Cunha, Daniel A.;
Igoillo-Esteve, Mariana;
Masini, Matilde;
Turatsinze, Jean-Valery;
Griebel, Thasso;
Villate, Olatz;
Santin, Izortze;
Bugliani, Marco;
Ladriere, Laurence;
Marselli, Lorella;
McCarthy, Mark I.;
Marchetti, Piero;
Sammeth, Michael;
Eizirik, Décio L.

Publication type:

Article

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress--Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis.

Published in:

Diabetes, 2012, v. 61, n. 11, p. 2763, doi. 10.2337/db12-0123

By:

Cunha, Daniel A.;
Igoillo-Esteve, Mariana;
Gurzov, Esteban N.;
Germano, Carla M.;
Naamane, Najib;
Marhfour, Ihsane;
Fukaya, Makiko;
Vanderwinden, Jean-Marie;
Gysemans, Conny;
Mathieu, Chantal;
Marselli, Lorella;
Marchetti, Piero;
Harding, Heather P.;
Ron, David;
Eizirik, Décio L.;
Cnop, Miriam

Publication type:

Article

Heterozygous Inactivation of the Na/Ca Exchange Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass.

Published in:

Diabetes, 2011, v. 60, n. 8, p. 2076, doi. 10.2337/db10-0924

By:

Nguidjoe, Evrard;
Sokolow, Sophie;
Bigabwa, Serge;
Pachera, Nathalie;
D'Amico, Eva;
Allagnat, Florent;
Vanderwinden, Jean-Marie;
Sener, Abdullah;
Manto, Mario;
Depreter, Marianne;
Mast, Jan;
Joanny, Geraldine;
Montanya, Eduard;
Rahier, Jacques;
Cardozo, Alessandra K.;
Eizirik, Décio L.;
Schurmans, Stéphane;
Herchuelz, André

Publication type:

Article

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Published in:

2009

By:

Cunha DA;
Ladrière L;
Ortis F;
Igoillo-Esteve M;
Gurzov EN;
Lupi R;
Marchetti P;
Eizirik DL;
Cnop M;
Cunha, Daniel A;
Ladrière, Laurence;
Ortis, Fernanda;
Igoillo-Esteve, Mariana;
Gurzov, Esteban N;
Lupi, Roberto;
Marchetti, Piero;
Eizirik, Décio L;
Cnop, Miriam

Publication type:

journal article

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB.

Published in:

Diabetes, 2009, v. 58, n. 12, p. 2851, doi. 10.2337/db09-0685

By:

Cunha, Daniel A.;
Ladrière, Laurence;
Ortis, Fernanda;
Igoillo-Esteve, Mariana;
Gurzov, Esteban N.;
Lupi, Roberto;
Marchetti, Piero;
Eizirik, Décio L.;
Cnop, Miriam

Publication type:

Article

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Published in:

2009

By:

Moore F;
Colli ML;
Cnop M;
Esteve MI;
Cardozo AK;
Cunha DA;
Bugliani M;
Marchetti P;
Eizirik DL;
Moore, Fabrice;
Colli, Maikel L;
Cnop, Miriam;
Esteve, Mariana Igoillo;
Cardozo, Alessandra K;
Cunha, Daniel A;
Bugliani, Marco;
Marchetti, Piero;
Eizirik, Décio L

Publication type:

journal article

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-ϒ-Induced Pancreatic β-Cell Apoptosis.

Published in:

Diabetes, 2009, v. 58, n. 6, p. 1283, doi. 10.2337/db08-1510

By:

Moore, Fabrice;
Colli, Maikel L.;
Cnop, Miriam;
Esteve, Mariana Igoillo;
Cardozo, Alessandra K.;
Cunha, Daniel A.;
Bugliani, Marco;
Marchetti, Piero;
Eizirik, Décio L.

Publication type:

Article

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells.

Published in:

Diabetes, 2007, v. 56, n. 4, p. 1069, doi. 10.2337/db06-1253

By:

Pirot, Pierre;
Ortis, Fernanda;
Cnop, Miriam;
Ma, Yanjun;
Hendershot, Linda M.;
Eizirik, Décio L.;
Cardozo, Alessandra K.

Publication type:

Article

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Published in:

2005

By:

Gysemans CA;
Ladrière L;
Callewaert H;
Rasschaert J;
Flamez D;
Levy DE;
Matthys P;
Eizirik DL;
Mathieu C;
Gysemans, Conny A;
Ladrière, Laurence;
Callewaert, Hanne;
Rasschaert, Joanne;
Flamez, Daisy;
Levy, David E;
Matthys, Patrick;
Eizirik, Décio L;
Mathieu, Chantal

Publication type:

journal article

Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells.

Published in:

Diabetes, 2005, v. 54, n. 8, p. 2396, doi. 10.2337/diabetes.54.8.2396

By:

Gysemans, Conny A.;
Ladrière, Laurence;
Callewaert, Hanne;
Rasschaert, Joanne;
Flamez, Daisy;
Levy, David E.;
Matthys, Patrick;
Eizirik, Décio L.;
Mathieu, Chantal

Publication type:

Article

Role of Receptor Binding and Gene Transcription for Both of Stimulatory and Inhibitory Effects of Interleukin-1 In Pancreatic β-Cells.

Published in:

Autoimmunity, 1992, v. 12, n. 2, p. 127, doi. 10.3109/08916939209150319

By:

Eizirik, Décio L.;
Tracey, Daniel E.;
Bendtzen, Klaus;
Sandler, Stellan

Publication type:

Article

Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells.

Published in:

Autoimmunity, 1991, v. 10, n. 3, p. 241, doi. 10.3109/08916939109001895

By:

Sandler, Stellan;
Eizirik, Décio L.;
Svensson, Carina;
Strandell, Eva;
Welsh, Michael;
Welsh, Nils

Publication type:

Article

Interleukin-1β Induces an Early Decrease in Insulin Release, (Pro)Insulin Biosynthesis and Insulin Mrna in Mouse Pancreatic Islets by a Mechanism Dependent on Gene Transcription and Protein Synthesis.

Published in:

Autoimmunity, 1991, v. 10, n. 2, p. 107, doi. 10.3109/08916939109004814

By:

Eizirik, Décio L.

Publication type:

Article

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 8, p. 2274, doi. 10.1093/hmg/ddu745

By:

Igoillo-Esteve, Mariana;
Gurgul-Convey, Ewa;
Hu, Amélie;
Romagueira, Laila;
Dos Santos, Bichara;
Abdulkarim, Baroj;
Chintawar, Satyan;
Marselli, Lorella;
Marchetti, Piero;
Jonas, Jean-Christophe;
Eizirik, Décio L.;
Pandolfo, Massimo;
Cnop, Miriam

Publication type:

Article

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Published in:

Islets, 2021, v. 13, n. 3/4, p. 51, doi. 10.1080/19382014.2021.1948282

By:

Alvelos, Maria Inês;
Szymczak, Florian;
Castela, Ângela;
Marín-Cañas, Sandra;
de Souza, Bianca Marmontel;
Gkantounas, Ioannis;
Colli, Maikel;
Fantuzzi, Federica;
Cosentino, Cristina;
Igoillo-Esteve, Mariana;
Marselli, Lorella;
Marchetti, Piero;
Cnop, Miriam;
Eizirik, Décio L.

Publication type:

Article

Repair of Pancreatic β-Cells.

Published in:

Diabetes, 1993, v. 42, n. 10, p. 1383, doi. 10.2337/diab.42.10.1383

By:

Eizirik, Décio L.;
Sandler, Stellan;
Palmer, Jerry P.

Publication type:

Article

Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets.

Published in:

1993

By:

Eizirik, Décio L.;
Björklund, Andreas;
Cagliero, Enrico;
Eizirik, D L;
Björklund, A;
Cagliero, E

Publication type:

journal article

Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function.

Published in:

1991

By:

Margulis, Boris A.;
Sandler, Stellan;
Eizirik, Décio L.;
Welsh, Nils;
Welsh, Michael;
Margulis, B A;
Sandler, S;
Eizirik, D L;
Welsh, N;
Welsh, M

Publication type:

journal article

Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1.

Published in:

1988

By:

Eizirik, Décio L.;
Strandell, Eva;
Bendtzen, Klaus;
Sandler, Stellan;
Eizirik, D L;
Strandell, E;
Bendtzen, K;
Sandler, S

Publication type:

journal article

Reduced diabetogenic effect of streptozotocin in rats previously adapted to a high-protein, carbohydrate-free diet.

Published in:

1984

By:

Eizirik, Décio L.;
Migliorini, Renato H.;
Eizirik, D L;
Migliorini, R H

Publication type:

journal article