Works by Ehrens, Alexandra

Results: 22

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 12, p. 1, doi. 10.1371/journal.pntd.0008930

By:

Schiefer, Andrea;
Hübner, Marc P.;
Krome, Anna;
Lämmer, Christine;
Ehrens, Alexandra;
Aden, Tilman;
Koschel, Marianne;
Neufeld, Helene;
Chaverra-Muñoz, Lillibeth;
Jansen, Rolf;
Kehraus, Stefan;
König, Gabriele M.;
Pogorevc, Domen;
Müller, Rolf;
Stadler, Marc;
Hüttel, Stephan;
Hesterkamp, Thomas;
Wagner, Karl;
Pfarr, Kenneth;
Hoerauf, Achim

Publication type:

Article

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008427

By:

Hübner, Marc P.;
Martin, Coralie;
Specht, Sabine;
Koschel, Marianne;
Dubben, Bettina;
Frohberger, Stefan J.;
Ehrens, Alexandra;
Fendler, Martina;
Struever, Dominique;
Mitre, Edward;
Vallarino-Lhermitte, Nathaly;
Gokool, Suzanne;
Lustigman, Sara;
Schneider, Manfred;
Townson, Simon;
Hoerauf, Achim;
Scandale, Ivan

Publication type:

Article

The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in Cameroon.

Published in:

PLoS ONE, 2023, v. 18, n. 6, p. 1, doi. 10.1371/journal.pone.0285689

By:

Lenz, Benjamin;
Andrew, Beng Amuam;
Ritter, Manuel;
Karunakaran, Indulekha;
Gandjui, Narcisse Victor Tchamatchoua;
Nchang, Lucy Cho;
Surendar, Jayagopi;
Ebob, Anita Obi Bate;
Ehrens, Alexandra;
Klarmann-Schulz, Ute;
Ricchiuto, Arcangelo;
Kuehlwein, Janina M.;
Fombad, Fanny Fri;
Ngwa, Ambe Marius;
Katcho, Tatiana Djikeussi;
Hoerauf, Achim;
Wanji, Samuel;
Hübner, Marc P.

Publication type:

Article

Eosinophils in filarial infections: Inducers of protection or pathology?

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.983812

By:

Ehrens, Alexandra;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2<sup>-/-</sup> Mice.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.863663

By:

Reichwald, Julia J.;
Risch, Frederic;
Neumann, Anna-Lena;
Frohberger, Stefan J.;
Scheunemann, Johanna F.;
Lenz, Benjamin;
Ehrens, Alexandra;
Strutz, Wiebke;
Schumak, Beatrix;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article

Corrigendum: Eosinophils and Neutrophils Eliminate Migrating Strongyloides ratti Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation.

Published in:

2022

By:

Ehrens, Alexandra;
Rüdiger, Nikolas;
Heepmann, Lennart;
Linnemann, Lara;
Hartmann, Wiebke;
Hübner, Marc P.;
Breloer, Minka

Publication type:

Correction Notice

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system.

Published in:

Frontiers in Microbiology, 2023, p. 1, doi. 10.3389/fmicb.2023.1213143

By:

Risch, Frederic;
Scheunemann, Johanna F.;
Reichwald, Julia J.;
Lenz, Benjamin;
Ehrens, Alexandra;
Gal, Joséphine;
Fercoq, Frédéric;
Koschel, Marianne;
Fendler, Martina;
Hoerauf, Achim;
Martin, Coralie;
Hübner, Marc P.

Publication type:

Article

Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis.

Published in:

PLoS Neglected Tropical Diseases, 2025, v. 19, n. 3, p. 1, doi. 10.1371/journal.pntd.0012889

By:

Schumacher, Pia Philippa;
Ajendra, Jesuthas;
Lenz, Benjamin;
Risch, Frederic;
Ehrens, Alexandra;
Nieto-Pérez, Celia;
Koschel, Marianne;
Aden, Tilman;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.

Published in:

Parasites & Vectors, 2019, v. 12, n. 1, p. 1, doi. 10.1186/s13071-019-3502-z

By:

Frohberger, Stefan J.;
Ajendra, Jesuthas;
Surendar, Jayagopi;
Stamminger, Wiebke;
Ehrens, Alexandra;
Buerfent, Benedikt C.;
Gentil, Katrin;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article

Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry.

Published in:

Analytical & Bioanalytical Chemistry, 2017, v. 409, n. 28, p. 6549, doi. 10.1007/s00216-017-0603-4

By:

Yefremova, Yelena;
Melder, F.;
Danquah, Bright;
Opuni, Kwabena;
Koy, Cornelia;
Ehrens, Alexandra;
Frommholz, David;
Illges, Harald;
Koelbel, Knut;
Sobott, Frank;
Glocker, Michael

Publication type:

Article

Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.

Published in:

Frontiers in Microbiology, 2024, p. 1, doi. 10.3389/fmicb.2024.1346068

By:

Hegde, Shrilakshmi;
Marriott, Amy E.;
Pionnier, Nicolas;
Steven, Andrew;
Bulman, Christina;
Gunderson, Emma;
Voge, Ian;
Kosche, Marianne;
Ehrens, Alexandra;
Lustigman, Sara;
Voronin, Denis;
Tricoche, Nancy;
Hoerauf, Achim;
Hübner, Marc P.;
Sankanari, Judy;
Aljayyoussi, Ghaith;
Gusovsky, Fabian;
Dagley, Jessica;
Hong, David W.;
O'Neil, Paul

Publication type:

Article

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Published in:

Science Translational Medicine, 2019, v. 11, n. 491, p. N.PAG, doi. 10.1126/scitranslmed.aav3523

By:

Bakowski, Malina A.;
Shiroodi, Roohollah Kazem;
Liu, Renhe;
Olejniczak, Jason;
Yang, Baiyuan;
Gagaring, Kerstin;
Guo, Hui;
White, Pamela M.;
Chappell, Laura;
Debec, Alain;
Landmann, Frédéric;
Dubben, Bettina;
Lenz, Franziska;
Struever, Dominique;
Ehrens, Alexandra;
Frohberger, Stefan J.;
Sjoberg, Hanna;
Pionnier, Nicolas;
Murphy, Emma;
Archer, John

Publication type:

Article

Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations.

Published in:

Pharmaceutics, 2024, v. 16, n. 3, p. 386, doi. 10.3390/pharmaceutics16030386

By:

Becker, Tim;
Heitkötter, Jan;
Krome, Anna K.;
Schiefer, Andrea;
Pfarr, Kenneth;
Ehrens, Alexandra;
Grosse, Miriam;
Sandargo, Birthe;
Stammberger, Ingo;
Stadler, Marc;
Hübner, Marc P.;
Kehraus, Stefan;
Hoerauf, Achim;
Wagner, Karl G.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus.

Published in:

Pharmaceutics, 2023, v. 15, n. 1, p. 131, doi. 10.3390/pharmaceutics15010131

By:

Rox, Katharina;
Becker, Tim;
Schiefer, Andrea;
Grosse, Miriam;
Ehrens, Alexandra;
Jansen, Rolf;
Aden, Tilman;
Kehraus, Stefan;
König, Gabriele M.;
Krome, Anna K.;
Hübner, Marc P.;
Wagner, Karl G.;
Stadler, Marc;
Pfarr, Kenneth;
Hoerauf, Achim

Publication type:

Article

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A.

Published in:

Pharmaceutics, 2022, v. 14, n. 8, p. 1657, doi. 10.3390/pharmaceutics14081657

By:

Becker, Tim;
Krome, Anna K.;
Vahdati, Sahel;
Schiefer, Andrea;
Pfarr, Kenneth;
Ehrens, Alexandra;
Aden, Tilman;
Grosse, Miriam;
Jansen, Rolf;
Alt, Silke;
Hesterkamp, Thomas;
Stadler, Marc;
Hübner, Marc P.;
Kehraus, Stefan;
König, Gabriele M.;
Hoerauf, Achim;
Wagner, Karl G.

Publication type:

Article

Eosinophils and Neutrophils Eliminate Migrating Strongyloides ratti Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.715766

By:

Ehrens, Alexandra;
Rüdiger, Nikolas;
Heepmann, Lennart;
Linnemann, Lara;
Hartmann, Wiebke;
Hübner, Marc P.;
Breloer, Minka

Publication type:

Article

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 2, p. 1, doi. 10.1371/journal.pntd.0008119

By:

Frohberger, Stefan J.;
Fercoq, Frederic;
Neumann, Anna-Lena;
Surendar, Jayagopi;
Stamminger, Wiebke;
Ehrens, Alexandra;
Karunakaran, Indulekha;
Remion, Estelle;
Vogl, Thomas;
Hoerauf, Achim;
Martin, Coralie;
Hübner, Marc P.

Publication type:

Article

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 1, p. 1, doi. 10.1371/journal.pntd.0007957

By:

Ehrens, Alexandra;
Lunde, Christopher S.;
Jacobs, Robert T.;
Struever, Dominique;
Koschel, Marianne;
Frohberger, Stefan J.;
Lenz, Franziska;
Fendler, Martina;
Turner, Joseph D.;
Ward, Stephen A.;
Taylor, Mark J.;
Freund, Yvonne R.;
Stefanakis, Rianna;
Easom, Eric;
Li, Xianfeng;
Plattner, Jacob J.;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 8, p. 1, doi. 10.1371/journal.pntd.0007636

By:

Hübner, Marc P.;
Koschel, Marianne;
Struever, Dominique;
Nikolov, Venelin;
Frohberger, Stefan J.;
Ehrens, Alexandra;
Fendler, Martina;
Johannes, Iliana;
von Geldern, Thomas W.;
Marsh, Kennan;
Turner, Joseph D.;
Taylor, Mark J.;
Ward, Stephen A.;
Pfarr, Kenneth;
Kempf, Dale J.;
Hoerauf, Achim

Publication type:

Article

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 2, p. 1, doi. 10.1371/journal.pntd.0007159

By:

von Geldern, Thomas W.;
Morton, Howard E.;
Clark, Rick F.;
Brown, Brian S.;
Johnston, Kelly L.;
Ford, Louise;
Specht, Sabine;
Carr, Robert A.;
Stolarik, Deanne F.;
Ma, Junli;
Rieser, Matthew J.;
Struever, Dominique;
Frohberger, Stefan J.;
Koschel, Marianne;
Ehrens, Alexandra;
Turner, Joseph D.;
Hübner, Marc P.;
Hoerauf, Achim;
Taylor, Mark J.;
Ward, Stephen A.

Publication type:

Article

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 1, p. 1, doi. 10.1371/journal.pntd.0006320

By:

Hübner, Marc P.;
Ehrens, Alexandra;
Koschel, Marianne;
Dubben, Bettina;
Lenz, Franziska;
Frohberger, Stefan J.;
Specht, Sabine;
Hoerauf, Achim;
Quirynen, Ludo;
Lachau-Durand, Sophie;
Tekle, Fetene;
Baeten, Benny;
Engelen, Marc;
Mackenzie, Charles D.

Publication type:

Article

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.

Published in:

PLoS Pathogens, 2024, v. 20, n. 3, p. 1, doi. 10.1371/journal.ppat.1012071

By:

Lenz, Benjamin;
Ehrens, Alexandra;
Ajendra, Jesuthas;
Risch, Frederic;
Gal, Joséphine;
Neumann, Anna-Lena;
Reichwald, Julia J.;
Strutz, Wiebke;
McSorley, Henry J.;
Martin, Coralie;
Hoerauf, Achim;
Hübner, Marc P.

Publication type:

Article