Works by Efferth, Thomas

Results: 287

Substantial Effects of Carotenoids on Skin Health: A Mechanistic Perspective.

Published in:

Phytotherapy Research, 2025, v. 39, n. 6, p. 2513, doi. 10.1002/ptr.8480

By:

Varghese, Ressin;
Emerson, Arnold;
Vannier, Brigitte;
George Priya Doss, C.;
Priyadharshini, Rossyda;
Efferth, Thomas;
Ramamoorthy, Siva

Publication type:

Article

Improvement of resveratrol production from waste residue of grape seed by biotransformation of edible immobilized Aspergillus oryzae cells and negative pressure cavitation bioreactor using biphasic ionic liquid aqueous system pretreatment.

Published in:

Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2017, v. 102, p. 177, doi. 10.1016/j.fbp.2016.11.009

By:

Shuang Jin;
Bingyou Yang;
Yupeng Cheng;
Jinyan Tan;
Haixue Kuang;
Yujie Fu;
Xiuyun Bai;
Hailong Xie;
Yuan Gao;
Chen Lv;
Efferth, Thomas

Publication type:

Article

Synthesis and Cytotoxicity of 1,4-Dihydropyridines and an Unexpected 1,3-Oxazin-6-one.

Published in:

Helvetica Chimica Acta, 2016, v. 99, n. 4, p. 310, doi. 10.1002/hlca.201500265

By:

Sandjo, Louis Pergaud;
Kuete, Victor;
Nana, Frederic;
Kirsch, Gilbert;
Efferth, Thomas

Publication type:

Article

PLECTRANTHUS: FROM TRADITIONAL MEDICINE TO BRAIN TUMOR THERAPY WITH DITERPENES.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, p. 9, doi. 10.29228/jrp.381

By:

María DOMÍNGUEZ-MARTÍN, Eva;
MAGALHÃES, Mariana;
SITAREK, Przemysław;
María DÍAZ-LANZA, Ana;
GÓMEZ, Ana M.;
EFFERTH, Thomas;
CABRAL, Célia;
RIJO, Patricia

Publication type:

Article

PLECTRANTHUS: FROM TRADITIONAL MEDICINE TO BRAIN TUMOR THERAPY WITH DITERPENES.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, p. 9, doi. 10.29228/jrp.381

By:

DOMÍNGUEZ-MARTÍN, Eva María;
MAGALHÃES, Mariana;
SITAREK, Przemysław;
DÍAZ-LANZA, Ana María;
GÓMEZ, Ana M.;
EFFERTH, Thomas;
CABRAL, Célia;
RIJO, Patricia

Publication type:

Article

Editorial: III Bio.Natural-bioactive natural products research meeting: pharmacology perspectives.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1517673

By:

Rijo, Patricia;
Barros, Lillian;
Efferth, Thomas

Publication type:

Article

2′-<italic>O</italic>-Galloylhyperin Isolated From <italic>Pyrola incarnata</italic> Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways <italic>in Vitro</italic> and <italic>Vivo</italic>

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.00679

By:

Wang, Peng;
Gao, Chang;
Guo, Na;
Zhang, Sun-Dong;
Wang, Wei;
Yao, Li-Ping;
Zhang, Jing;
Efferth, Thomas;
Fu, Yu-Jie

Publication type:

Article

Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00481

By:

Saeed, Mohamed E. M.;
Mahmoud, Nuha;
Sugimoto, Yoshikazu;
Efferth, Thomas;
Abdel-Aziz, Heba

Publication type:

Article

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00355

By:

Kadioglu, Onat;
Saeed, Mohamed;
Kuete, Victor;
Greten, Henry J.;
Efferth, Thomas

Publication type:

Article

Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00143

By:

Dawood, Mona;
Hamdoun, Sami;
Efferth, Thomas

Publication type:

Article

Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00711

By:

Kadioglu, Onat;
Ariel Chan;
Cong Ling Qiu, Alena;
Kam Wai Wong, Vincent;
Colligs, Vanessa;
Wecklein, Sabine;
Rached, Halima Freund-Henni;
Efferth, Thomas;
Wen-Luan Wendy Hsiao

Publication type:

Article

North African Medicinal Plants Traditionally Used in Cancer Therapy.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00383

By:

Alves-Silva, Jorge M.;
Romane, Abderrahmane;
Efferth, Thomas;
Salgueiro, Lígia

Publication type:

Article

Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00343

By:

Mbaveng, Armelle T.;
Kuete, Victor;
Efferth, Thomas

Publication type:

Article

Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00238

By:

Kadioglu, Onat;
Law, Betty Y. K.;
Mok, Simon W. F.;
Su-Wei Xu;
Efferth, Thomas;
Wong, Vincent K. W.

Publication type:

Article

Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibition by the Chinese Herbal Remedy Free and Easy Wanderer.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00181

By:

Chunlan Hong;
Schüffler, Anja;
Kauhl, Ulrich;
Jingming Cao;
Ching-Fen Wu;
Opatz, Till;
Thines, Eckhard;
Efferth, Thomas

Publication type:

Article

Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca.

Published in:

Journal of the Chinese Chemical Society, 2021, v. 68, n. 1, p. 159, doi. 10.1002/jccs.202000156

By:

Mohamed, Tarik A.;
Elshamy, Abdelsamed I.;
Abd‐ElGawad, Ahmed M.;
Hussien, Taha A.;
El‐Toumy, Sayed A.;
Efferth, Thomas;
Hegazy, Mohamed‐Elamir F.

Publication type:

Article

Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling.

Published in:

Natural Product Communications, 2021, v. 16, n. 2, p. 1, doi. 10.1177/1934578X21993350

By:

Özenver, Nadire;
Boulos, Joelle C.;
Efferth, Thomas

Publication type:

Article

Artificial intelligence-directed acupuncture: a review.

Published in:

Chinese Medicine, 2022, v. 17, n. 1, p. 1, doi. 10.1186/s13020-022-00636-1

By:

Wang, Yulin;
Shi, Xiuming;
Efferth, Thomas;
Shang, Dong

Publication type:

Article

West meets east: open up a dialogue on phytomedicine.

Published in:

Chinese Medicine, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13020-021-00467-6

By:

Li, Xiuzhu;
Chen, Weijie;
Simal-Gandara, Jesus;
Georgiev, Milen I.;
Li, Hongyi;
Hu, Hao;
Wu, Xu;
Efferth, Thomas;
Wang, Shengpeng

Publication type:

Article

The Antiviral Activities of Artemisinin and Artesunate.

Published in:

Clinical Infectious Diseases, 2008, v. 47, n. 6, p. 804, doi. 10.1086/591195

By:

Efferth, Thomas;
Romero, Marta R.;
Wolf, Dana G.;
Stamminger, Thomas;
Marin, Jose J. G.;
Marschall, Manfred

Publication type:

Article

Artesunate as a Potent Antiviral Agent in a Patient with Late Drug-Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation.

Published in:

Clinical Infectious Diseases, 2008, v. 46, n. 9, p. 1455, doi. 10.1086/587106

By:

Shapira, Michael Y.;
Resnick, Igor B.;
Chou, Sunwen;
Neumann, Avidan U.;
Lurain, Nell S.;
Stamminger, Thomas;
Caplan, Orit;
Saleh, Niveen;
Efferth, Thomas;
Marschall, Manfred;
Wolf, Dana G.

Publication type:

Article

A promising fusion: Traditional Chinese medicine and probiotics in the quest to overcome osteoporosis.

Published in:

FASEB Journal, 2025, v. 39, n. 5, p. 1, doi. 10.1096/fj.202403209R

By:

Fan, Kangcheng;
Hua, Xin;
Wang, Shuwan;
Efferth, Thomas;
Tan, Shengnan;
Wang, Zhuo

Publication type:

Article

Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.

Published in:

FASEB Journal, 2022, v. 36, n. 8, p. 1, doi. 10.1096/fj.202200261R

By:

Ting Li;
Bo Yan;
Xiujuan Xiao;
Li Zhou;
Jin Zhang;
Qiang Yuan;
Letian Shan;
Huiling Wu;
Efferth, Thomas

Publication type:

Article

Health(care) in the Crisis: Reflections in Science and Society on Opioid Addiction.

Published in:

International Journal of Environmental Research & Public Health, 2021, v. 18, n. 1, p. 341, doi. 10.3390/ijerph18010341

By:

Damiescu, Roxana;
Banerjee, Mita;
Lee, David Y. W.;
Paul, Norbert W.;
Efferth, Thomas

Publication type:

Article

Comprehensive Overview on Multiple Strategies Fighting COVID-19.

Published in:

International Journal of Environmental Research & Public Health, 2020, v. 17, n. 16, p. 5813, doi. 10.3390/ijerph17165813

By:

Khalifa, Shaden A. M.;
Mohamed, Briksam S.;
Elashal, Mohamed H.;
Du, Ming;
Guo, Zhiming;
Zhao, Chao;
Musharraf, Syed Ghulam;
Boskabady, Mohammad H.;
El-Seedi, Haged H. R.;
Efferth, Thomas;
El-Seedi, Hesham R.

Publication type:

Article

Cytotoxic alkaloids from the root of Zanthoxylum paracanthum (mildbr) Kokwaro.

Published in:

Natural Product Research, 2022, v. 36, n. 10, p. 2518, doi. 10.1080/14786419.2021.1913586

By:

Omosa, Leonidah Kerubo;
Nchiozem-Ngnitedem, Vaderament-A;
Mukavi, Justus;
Atieno Okoko, Brenda;
Ombui Nyaboke, Helder;
Hashim, Ibrahim;
Obegi Matundura, Jackson;
Efferth, Thomas;
Spiteller, Michael

Publication type:

Article

Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells.

Published in:

Natural Product Research, 2021, v. 35, n. 4, p. 579, doi. 10.1080/14786419.2019.1587424

By:

Omosa, Leonidah Kerubo;
Mbogo, Gacheru Martin;
Korir, Eric;
Omole, Ruth;
Seo, Ean-Jeong;
Yenesew, Abiy;
Heydenreich, Matthias;
Midiwo, Jacob Ogweno;
Efferth, Thomas

Publication type:

Article

Anti-poliovirus activity of Nerium oleander aqueous extract.

Published in:

Natural Product Research, 2021, v. 35, n. 4, p. 633, doi. 10.1080/14786419.2019.1582046

By:

Sanna, Giuseppina;
Madeddu, Silvia;
Serra, Alessandra;
Collu, David;
Efferth, Thomas;
Hakkim, F. Lukmanul;
Rashan, Luay

Publication type:

Article

Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae).

Published in:

Natural Product Research, 2019, v. 33, n. 24, p. 3521, doi. 10.1080/14786419.2018.1486312

By:

Fotso W., Ghislain;
Na-Iya, Jean;
Mbaveng T., Armelle;
Ango Yves, Patrick;
Demirtas, Ibrahim;
Kuete, Victor;
Samuel, Yeboah;
Ngameni, Bathelemy;
Efferth, Thomas;
Ngadjui T., Bonaventure

Publication type:

Article

Cytotoxic flavonoids from two Lonchocarpus species.

Published in:

Natural Product Research, 2019, v. 33, n. 18, p. 2609, doi. 10.1080/14786419.2018.1462179

By:

Adem, Fozia A.;
Kuete, Victor;
Mbaveng, Armelle T.;
Heydenreich, Matthias;
Koch, Andreas;
Ndakala, Albert;
Irungu, Beatrice;
Yenesew, Abiy;
Efferth, Thomas

Publication type:

Article

Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.

Published in:

Natural Product Research, 2019, v. 33, n. 12, p. 1809, doi. 10.1080/14786419.2018.1437432

By:

Tundis, Rosa;
Loizzo, Monica R.;
Bonesi, Marco;
Peruzzi, Lorenzo;
Efferth, Thomas

Publication type:

Article

Phytochemical and pharmacological properties of essential oils from <italic>Cedrus</italic> species.

Published in:

Natural Product Research, 2018, v. 32, n. 12, p. 1415, doi. 10.1080/14786419.2017.1346648

By:

Saab, Antoine M.;
Gambari, Roberto;
Sacchetti, Gianni;
Guerrini, Alessandra;
Lampronti, Ilaria;
Tacchini, Massimo;
El Samrani, Antoine;
Medawar, Samir;
Makhlouf, Hassane;
Tannoury, Mona;
Abboud, Jihad;
Diab-Assaf, Mona;
Kijjoa, Anake;
Tundis, Rosa;
Aoun, Jawad;
Efferth, Thomas

Publication type:

Article

Cytotoxicity of an unprecedented brominated oleanolide and a new furoceramide from the Cameroonian spice, Echinops giganteus.

Published in:

Natural Product Research, 2016, v. 30, n. 22, p. 2529, doi. 10.1080/14786419.2015.1120724

By:

Sandjo, Louis P.;
Kuete, Victor;
Siwe, Xavier N.;
Poumale, Herve M. P.;
Efferth, Thomas

Publication type:

Article

Phytochemical profile and bioactivity of traditional ayurvedic decoctions and hydro-alcoholic macerations of Boerhaavia diffusa L. and Curculigo orchioides Gaertn.

Published in:

Natural Product Research, 2015, v. 29, n. 22, p. 2071, doi. 10.1080/14786419.2014.1003299

By:

Tacchini, Massimo;
Spagnoletti, Antonella;
Marieschi, Matteo;
Caligiani, Augusta;
Bruni, Renato;
Efferth, Thomas;
Sacchetti, Gianni;
Guerrini, Alessandra

Publication type:

Article

Unprecedented new nonadecyl para-hydroperoxycinnamate isolated from Erythrina excelsa and its cytotoxic activity.

Published in:

Natural Product Research, 2015, v. 29, n. 10, p. 921, doi. 10.1080/14786419.2014.959519

By:

Kwamou, Guy M.N.;
Sandjo, Louis P.;
Kuete, Victor;
Wandja, Anaelle A.K.;
Tankeo, Simplice B.;
Efferth, Thomas;
Nkengfack, Augustin E.

Publication type:

Article

Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases.

Published in:

Clinical & Experimental Metastasis, 2002, v. 19, n. 5, p. 385, doi. 10.1023/A:1016361924216

By:

Volm, Manfred;
Koomägi, Reet;
Mattern, Jürgen;
Efferth, Thomas

Publication type:

Article

Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4.

Published in:

Archives of Toxicology, 2024, v. 98, n. 2, p. 525, doi. 10.1007/s00204-023-03648-4

By:

Rosellini, Matteo;
Omer, Ejlal A.;
Schulze, Alicia;
Ali, Nadeen T.;
Boulos, Joelle C.;
Marini, Federico;
Küpper, Jan-Heiner;
Efferth, Thomas

Publication type:

Article

Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation.

Published in:

Archives of Toxicology, 2021, v. 95, n. 7, p. 2485, doi. 10.1007/s00204-021-03058-4

By:

Kadioglu, Onat;
Klauck, Sabine M.;
Fleischer, Edmond;
Shan, Letian;
Efferth, Thomas

Publication type:

Article

Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion.

Published in:

Archives of Toxicology, 2021, v. 95, n. 3, p. 959, doi. 10.1007/s00204-021-02979-4

By:

Kadioglu, Onat;
Saeed, Mohamed;
Mahmoud, Nuha;
Azawi, Shaymaa;
Mrasek, Kristin;
Liehr, Thomas;
Efferth, Thomas

Publication type:

Article

Anti-Inflammatory and Cancer-Preventive Potential of Chamomile (Matricaria chamomilla L.): A Comprehensive In Silico and In Vitro Study.

Published in:

Biomedicines, 2024, v. 13, n. 7, p. 1484, doi. 10.3390/biomedicines12071484

By:

Drif, Assia I.;
Yücer, Rümeysa;
Damiescu, Roxana;
Ali, Nadeen T.;
Abu Hagar, Tobias H.;
Avula, Bharati;
Khan, Ikhlas A.;
Efferth, Thomas

Publication type:

Article

Artesunate Inhibits Metastatic Potential in Cisplatin-Resistant Bladder Cancer Cells by Altering Integrins.

Published in:

Cells (2073-4409), 2025, v. 14, n. 8, p. 570, doi. 10.3390/cells14080570

By:

Vakhrusheva, Olesya;
Zhao, Fuguang;
Markowitsch, Sascha Dennis;
Slade, Kimberly Sue;
Brandt, Maximilian Peter;
Tsaur, Igor;
Cinatl Jr., Jindrich;
Michaelis, Martin;
Efferth, Thomas;
Blaheta, Roman Alexander;
Haferkamp, Axel;
Juengel, Eva

Publication type:

Article

Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction.

Published in:

Cells (2073-4409), 2020, v. 9, n. 12, p. 2643, doi. 10.3390/cells9122643

By:

Zhao, Fuguang;
Vakhrusheva, Olesya;
Markowitsch, Sascha D.;
Slade, Kimberly S.;
Tsaur, Igor;
Cinatl Jr., Jindrich;
Michaelis, Martin;
Efferth, Thomas;
Haferkamp, Axel;
Juengel, Eva

Publication type:

Article

Identification of Novel Rare ABCC1 Transporter Mutations in Tumor Biopsies of Cancer Patients.

Published in:

Cells (2073-4409), 2020, v. 9, n. 2, p. 299, doi. 10.3390/cells9020299

By:

Kadioglu, Onat;
Saeed, Mohamed;
Munder, Markus;
Spuller, Andreas;
Greten, Henry Johannes;
Efferth, Thomas

Publication type:

Article

A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking.

Published in:

Cells (2073-4409), 2019, v. 8, n. 10, p. 1286, doi. 10.3390/cells8101286

By:

Kadioglu, Onat;
Efferth, Thomas

Publication type:

Article

The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells.

Published in:

Pharmaceutics, 2023, v. 15, n. 4, p. 1107, doi. 10.3390/pharmaceutics15041107

By:

Elbadawi, Mohamed;
Boulos, Joelle C.;
Dawood, Mona;
Zhou, Min;
Gul, Waseem;
ElSohly, Mahmoud A.;
Klauck, Sabine M.;
Efferth, Thomas

Publication type:

Article

Identification of Prognostic and Predictive Biomarkers and Druggable Targets among 205 Antioxidant Genes in 21 Different Tumor Types via Data-Mining.

Published in:

Pharmaceutics, 2023, v. 15, n. 2, p. 427, doi. 10.3390/pharmaceutics15020427

By:

Özenver, Nadire;
Efferth, Thomas

Publication type:

Article

Adaptogens in Long-Lasting Brain Fatigue: An Insight from Systems Biology and Network Pharmacology.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 2, p. 261, doi. 10.3390/ph18020261

By:

Panossian, Alexander;
Lemerond, Terrence;
Efferth, Thomas

Publication type:

Article

Pharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 1, p. 48, doi. 10.3390/ph18010048

By:

Banerjee, Mita;
Efferth, Thomas

Publication type:

Article

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 4, p. 483, doi. 10.3390/ph17040483

By:

Panossian, Alexander;
Lemerond, Terry;
Efferth, Thomas

Publication type:

Article

Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 1, p. 80, doi. 10.3390/ph17010080

By:

Abdalfattah, Sara;
Knorz, Caroline;
Ayoobi, Akhtar;
Omer, Ejlal A.;
Rosellini, Matteo;
Riedl, Max;
Meesters, Christian;
Efferth, Thomas

Publication type:

Article