Works by Edgerton, Dale S.

Results: 33

Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.

Published in:

2016

By:

Winnick, Jason J.;
Kraft, Guillaume;
Gregory, Justin M.;
Edgerton, Dale S.;
Williams, Phillip;
Hajizadeh, Ian A.;
Kamal, Maahum Z.;
Smith, Marta;
Farmer, Ben;
Scott, Melanie;
Neal, Doss;
Donahue, E. Patrick;
Allen, Eric;
Cherrington, Alan D.

Publication type:

journal article

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.

Published in:

2011

By:

Ramnanan, Christopher J.;
Saraswathi, Viswanathan;
Smith, Marta S.;
Donahue, E. Patrick;
Farmer, Ben;
Farmer, Tiffany D.;
Neal, Doss;
Williams, Philip E.;
Lautz, Margaret;
Mari, Andrea;
Cherrington, Alan D.;
Edgerton, Dale S.

Publication type:

journal article

Insulin's direct effects on the liver dominate the control of hepatic glucose production.

Published in:

2006

By:

Edgerton, Dale S.;
Lautz, Margaret;
Scott, Melanie;
Everett, Carrie A.;
Stettler, Kathryn M.;
Neal, Doss W.;
Chu, Chang A.;
Cherrington, Alan D.

Publication type:

journal article

Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes.

Published in:

Nutrition & Diabetes, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41387-019-0090-0

By:

Gregory, Justin M.;
Muldowney, James A.;
Engelhardt, Brian G.;
Tyree, Regina;
Marks-Shulman, Pam;
Silver, Heidi J.;
Donahue, E. Patrick;
Edgerton, Dale S.;
Winnick, Jason J.

Publication type:

Article

A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.

Published in:

PLoS ONE, 2023, v. 18, n. 12, p. 1, doi. 10.1371/journal.pone.0296400

By:

Gregory, Justin M.;
Kraft, Guillaume;
Dalla Man, Chiara;
Slaughter, James C.;
Scott, Melanie F.;
Hastings, Jon R.;
Edgerton, Dale S.;
Moore, Mary C.;
Cherrington, Alan D.

Publication type:

Article

Glucagon's yin and yang effects on hepatic glucose production.

Published in:

Nature Medicine, 2013, v. 19, n. 6, p. 674, doi. 10.1038/nm.3202

By:

Edgerton, Dale S;
Cherrington, Alan D

Publication type:

Article

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes.

Published in:

2015

By:

Gregory, Justin M.;
Kraft, Guillaume;
Scott, Melanie F.;
Neal, Doss W.;
Farmer, Ben;
Smith, Marta S.;
Hastings, Jon R.;
Allen, Eric J.;
Donahue, E. Patrick;
Rivera, Noelia;
Winnick, Jason J.;
Edgerton, Dale S.;
Nishimura, Erica;
Fledelius, Christian;
Brand, Christian L.;
Cherrington, Alan D.

Publication type:

journal article

Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?

Published in:

2015

By:

Edgerton, Dale S.;
Cherrington, Alan D.

Publication type:

Opinion

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog.

Published in:

Diabetes, 2014, v. 63, n. 11, p. 3946, doi. 10.2337/db14-0266

By:

Edgerton, Dale S.;
Moore, Mary C.;
Winnick, Jason J.;
Scott, Melanie;
Farmer, Ben;
Naver, Helle;
Jeppesen, Claus B.;
Madsen, Peter;
Kjeldsen, Thomas B.;
Nishimura, Erica;
Brand, Christian L.;
Cherrington, Alan D.

Publication type:

Article

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog.

Published in:

Diabetes, 2013, v. 62, n. 1, p. 74, doi. 10.2337/db12-0148

By:

Ramnanan, Christopher J.;
Kraft, Guillaume;
Smith, Marta S.;
Farmer, Ben;
Neal, Doss;
Williams, Phillip E.;
Lautz, Margaret;
Farmer, Tiffany;
Donahue, E. Patrick;
Cherrington, Alan D.;
Edgerton, Dale S.

Publication type:

Article

Glucagon as a Critical Factor in the Pathology of Diabetes.

Published in:

2011

By:

Edgerton, Dale S.;
Cherrington, Alan D.

Publication type:

Opinion

Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo.

Published in:

Diabetes, 2010, v. 59, n. 6, p. 1302, doi. 10.2337/db09-1625

By:

Ramnanan, Christopher J.;
Edgerton, Dale S.;
Rivera, Noelia;
Irimia-Dominguez, Jose;
Farmer, Ben;
Neal, Doss W.;
Lautz, Margaret;
Donahue, E. Patrick;
Meyer, Catalina M.;
Roach, Peter J.;
Cherrington, Alan D.

Publication type:

Article

Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo.

Published in:

Diabetes, 2009, v. 58, n. 12, p. 2766, doi. 10.2337/db09-0328

By:

Edgerton, Dale S.;
Ramnanan, Christopher J.;
Grueter, Carrie A.;
Johnson, Kathryn M. S.;
Lautz, Margaret;
Neal, Doss W.;
Williams, Phillip E.;
Cherrington, Alan D.

Publication type:

Article

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog.

Published in:

Diabetes, 2009, v. 58, n. 1, p. 243, doi. 10.2337/db08-0515

By:

Edgerton, Dale S.;
Johnson, Kathryn M. S.;
Neal, Doss W.;
Scott, Melanie;
Hobbs, Charles H.;
Zhang, Xia;
Duttaroy, Alokesh;
Cherrington, Alan D.

Publication type:

Article

Triglyceride Uptake and Lipoprotein Lipase-Generated Fatty Acid Spillover in the Splanchnic Bed of Dogs.

Published in:

Diabetes, 2007, v. 56, n. 7, p. 1850, doi. 10.2337/db06-1657

By:

Nelson, Robert H.;
Edgerton, Dale S.;
Basu, Rita;
Roesner, Justin C.;
Cherrington, Alan D.;
Miles, John M.

Publication type:

Article

Intraportally Delivered Glucose and Glucagon-Like Peptide-1 Determine Distribution of Glucose Uptake.

Published in:

Diabetes, 2007, v. 56, p. A371

By:

Johnson, Kathryn M.;
Edgerton, Dale S.;
Rodewald, Tiffany D.;
Farmer, Ben;
Neal, Doss;
Scott, Melanie;
Smith, Marta;
Hajizadeh, Susan;
Donahue, Patrick;
Poffenberger, Greg;
Snead, Wanda;
Cherrington, Alan D.

Publication type:

Article

Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo.

Published in:

Diabetes, 2006, v. 55, n. 12, p. 3604, doi. 10.2337/db06-0718

By:

Edgerton, Dale S.;
Cherrington, Alan D.;
Williams, Phillip;
Neal, Doss W.;
Scott, Melanie;
Bowen, Larry;
Wilson, Warren;
Hobbs, Charles H.;
Leach, Chet;
Mei-chang Kuo;
Strack, Thomas R.

Publication type:

Article

Splanchnic Cortisol Production in Dogs Occurs Primarily in the Liver.

Published in:

Diabetes, 2006, v. 55, n. 11, p. 3013, doi. 10.2337/db06-0601

By:

Basu, Rita;
Edgerton, Dale S.;
Singh, Ravinder J.;
Cherrington, Alan;
Rizza, Robert A.

Publication type:

Article

Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs.

Published in:

2005

By:

Edgerton, Dale S.;
Neal, Doss W.;
Scott, Melanie;
Bowen, Larry;
Wilson, Warren;
Hobbs, Charles H.;
Leach, Chet;
Sivakumaran, Shantha;
Strack, Thomas R.;
Cherrington, Alan D.

Publication type:

journal article

Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection.

Published in:

2004

By:

Cherrington, Alan D;
Neal, Doss W;
Edgerton, Dale S;
Glass, Dana;
Bowen, Larry;
Hobbs, Charles H;
Leach, Chet;
Rosskamp, Ralf;
Strack, Thomas R

Publication type:

journal article

Inhalation of Insulin in Dogs.

Published in:

Diabetes, 2004, v. 53, n. 4, p. 877, doi. 10.2337/diabetes.53.4.877

By:

Cherrington, Alan D.;
Neal, Doss W.;
Edgerton, Dale S.;
Glass, Dana;
Bowen, Larry;
Hobbs, Charles H.;
Leach, Chet;
Rosskamp, Ralf;
Strack, Thomas R.

Publication type:

Article

Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog.

Published in:

2002

By:

Edgerton, Dale S.;
Cardin, Sylvain;
Pan, Catherine;
Neal, Doss;
Farmer, Ben;
Converse, Margaret;
Cherrington, Alan D.

Publication type:

journal article

Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism.

Published in:

2001

By:

Edgerton, Dale S.;
Cardin, Sylvain;
Emshwiller, Maya;
Neal, Doss;
Chandramouli, Visvanathan;
Schumann, William C.;
Landau, Bernard R.;
Rossetti, Luciano;
Cherrington, Alan D.;
Edgerton, D S;
Cardin, S;
Emshwiller, M;
Neal, D;
Chandramouli, V;
Schumann, W C;
Landau, B R;
Rossetti, L;
Cherrington, A D

Publication type:

journal article

Safety of surgical denervation of the common hepatic artery in insulin‐resistant dogs.

Published in:

Physiological Reports, 2021, v. 9, n. 6, p. 1, doi. 10.14814/phy2.14805

By:

Kraft, Guillaume;
Scott, Melanie;
Allen, Eric;
Edgerton, Dale S.;
Farmer, Ben;
Azamian, Bobak R.;
Cherrington, Alan D.

Publication type:

Article

Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors.

Published in:

Diabetes, 2025, v. 74, n. 3, p. 270, doi. 10.2337/db24-0786

By:

Waterman, Hannah L.;
Moore, Mary Courtney;
Smith, Marta S.;
Farmer, Ben;
Yankey, Kalisha;
Scott, Melanie;
Edgerton, Dale S.;
Cherrington, Alan D.

Publication type:

Article

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog.

Published in:

Diabetes, 2023, v. 72, n. 2, p. 196, doi. 10.2337/db22-0471

By:

Kraft, Guillaume;
Coate, Katie C.;
Smith, Marta;
Farmer, Ben;
Scott, Melanie;
Hastings, Jon;
Cherrington, Alan D.;
Edgerton, Dale S.

Publication type:

Article

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog.

Published in:

2021

By:

Kraft, Guillaume;
Coate, Katie C.;
Smith, Marta;
Farmer, Ben;
Scott, Melanie;
Cherrington, Alan D.;
Edgerton, Dale S.

Publication type:

journal article

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-367-OR

By:

EDGERTON, DALE S.;
KRAFT, GUILLAUME;
FARMER, BEN;
SCOTT, MELANIE;
SMITH, MARTA S.;
CHERRINGTON, ALAN D.

Publication type:

Article

1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1801-P

By:

KRAFT, GUILLAUME;
MOORE, L. MERKLE;
FARMER, BEN;
SCOTT, MELANIE F.;
EDGERTON, DALE S.;
WILLIAMS, PHILLIP E.;
AZAMIAN, BOBAK;
CHERRINGTON, ALAN D.

Publication type:

Article

1849-P: Importance of Insulin's Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1849-P

By:

EDGERTON, DALE S.;
KRAFT, GUILLAUME;
FARMER, BEN;
SMITH, MARTA S.;
WILLIAMS, PHILLIP E.;
CHERRINGTON, ALAN D.

Publication type:

Article

1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1848-P

By:

EDGERTON, DALE S.;
KRAFT, GUILLAUME;
FARMER, BEN;
SMITH, MARTA S.;
CHERRINGTON, ALAN D.

Publication type:

Article

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog.

Published in:

Diabetes, 2019, v. 68, n. 6, p. 1143, doi. 10.2337/db18-1209

By:

Kraft, Guillaume;
Vrba, Anthony;
Scott, Melanie;
Allen, Eric;
Edgerton, Dale S.;
Williams, Phil E.;
Vafai, Scott B.;
Azamian, Bobak R.;
Cherrington, Alan D.

Publication type:

Article

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog.

Published in:

2019

By:

Kraft, Guillaume;
Vrba, Anthony;
Scott, Melanie;
Allen, Eric;
Edgerton, Dale S;
Williams, Phil E;
Vafai, Scott B;
Azamian, Bobak R;
Cherrington, Alan D

Publication type:

journal article