Works by Economou, Anastassios

Results: 41

Disorder-order folding transitions underlie catalysis in the helicase motor of SecA.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 7, p. 594, doi. 10.1038/nsmb1108

By:

Keramisanou, Dimitra;
Biris, Nikolaos;
Gelis, Ioannis;
Sianidis, Georgios;
Karamanou, Spyridoula;
Economou, Anastassios;
Kalodimos, Charalampos G.

Publication type:

Article

Bacterial protein secretion through the translocase nanomachine.

Published in:

Nature Reviews Microbiology, 2007, v. 5, n. 11, p. 839, doi. 10.1038/nrmicro1771

By:

Papanikou, Effrosyni;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models.

Published in:

Cell Death & Disease, 2020, v. 11, n. 9, p. 1, doi. 10.1038/s41419-020-02944-6

By:

Vervloessem, Tamara;
Sasi, Binu K.;
Xerxa, Elena;
Karamanou, Spyridoula;
Kale, Justin;
La Rovere, Rita M.;
Chakraborty, Supriya;
Sneyers, Flore;
Vogler, Meike;
Economou, Anastassios;
Laurenti, Luca;
Andrews, David W.;
Efremov, Dimitar G.;
Bultynck, Geert

Publication type:

Article

Cross‐linked peptide identification: A computational forest of algorithms.

Published in:

Mass Spectrometry Reviews, 2018, v. 37, n. 6, p. 738, doi. 10.1002/mas.21559

By:

Yılmaz, Şule;
Shiferaw, Genet A.;
Rayo, Josep;
Economou, Anastassios;
Martens, Lennart;
Vandermarliere, Elien

Publication type:

Article

Evolutionary adaptation of the protein folding pathway for secretability.

Published in:

EMBO Journal, 2022, v. 41, n. 23, p. 1, doi. 10.15252/embj.2022111344

By:

Smets, Dries;
Tsirigotaki, Alexandra;
Smit, Jochem H;
Krishnamurthy, Srinath;
Portaliou, Athina G;
Vorobieva, Anastassia;
Vranken, Wim;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic Escherichia coli.

Published in:

EMBO Journal, 2017, v. 36, n. 23, p. 3517, doi. 10.15252/embj.201797515

By:

Portaliou, Athina G;
Tsolis, Konstantinos C;
Loos, Maria S;
Balabanidou, Vassileia;
Rayo, Josep;
Tsirigotaki, Alexandra;
Crepin, Valerie F;
Frankel, Gad;
Kalodimos, Charalampos G;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Protein secretion biotechnology using Streptomyces lividans: Large-scale production of functional trimeric tumor necrosis factor α.

Published in:

Biotechnology & Bioengineering, 2001, v. 72, n. 6, p. 611, doi. 10.1002/1097-0290(20010320)72:6<611::AID-BIT1026>3.0.CO;2-0

By:

Pozidis, Charalambos;
Lammertyn, Elke;
Politou, Anastasia S.;
Anné, Jozef;
Tsiftsoglou, Asterios S.;
Sianidis, Giorgos;
Economou, Anastassios

Publication type:

Article

Extensive Reannotation of the Genome of the Model Streptomycete Streptomyces lividans TK24 Based on Transcriptome and Proteome Information.

Published in:

Frontiers in Microbiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fmicb.2021.604034

By:

Droste, Julian;
Rückert, Christian;
Kalinowski, Jörn;
Hamed, Mohamed Belal;
Anné, Jozef;
Simoens, Kenneth;
Bernaerts, Kristel;
Economou, Anastassios;
Busche, Tobias

Publication type:

Article

SecA: a tale of two protomers.

Published in:

Molecular Microbiology, 2010, v. 76, n. 5, p. 1070, doi. 10.1111/j.1365-2958.2010.07176.x

By:

Sardis, Marios Frantzeskos;
Economou, Anastassios

Publication type:

Article

Assembly of the translocase motor onto the preprotein-conducting channel.

Published in:

Molecular Microbiology, 2008, v. 70, n. 2, p. 311, doi. 10.1111/j.1365-2958.2008.06402.x

By:

Karamanou, Spyridoula;
Bariami, Vassiliki;
Papanikou, Efrosyni;
Kalodimos, Charalampos G.;
Economou, Anastassios

Publication type:

Article

Double hexameric ring assembly of the type III protein translocase ATPase HrcN.

Published in:

Molecular Microbiology, 2006, v. 61, n. 1, p. 119, doi. 10.1111/j.1365-2958.2006.05219.x

By:

Müller, Shirley A.;
Pozidis, Charalambos;
Stone, Remington;
Meesters, Christian;
Chami, Mohamed;
Engel, Andreas;
Economou, Anastassios;
Stahlberg, Henning

Publication type:

Article

Sec, drugs and rock’n’roll: antibiotic targeting of bacterial protein translocation.

Published in:

Expert Opinion on Therapeutic Targets, 2001, v. 5, n. 2, p. 141, doi. 10.1517/14728222.5.2.141

By:

Economou, Anastassios

Publication type:

Article

Protein Transport Across the Bacterial Plasma Membrane by the Sec Pathway.

Published in:

Protein Journal, 2019, v. 38, n. 3, p. 262, doi. 10.1007/s10930-019-09841-8

By:

Smets, Dries;
Loos, Maria S.;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Sequence of proteome profiles in preclinical and symptomatic Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 6, p. 946, doi. 10.1002/alz.12345

By:

Li, Xiaohang;
Tsolis, Konstantinos C.;
Koper, Marta J.;
Ronisz, Alicja;
Ospitalieri, Simona;
von Arnim, Christine A.F.;
Vandenberghe, Rik;
Tousseyn, Thomas;
Scheuerle, Angelika;
Economou, Anastassios;
Carpentier, Sebastien;
Otto, Markus;
Thal, Dietmar Rudolf

Publication type:

Article

Structural Basis of the Subcellular Topology Landscape of Escherichia coli.

Published in:

Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.01670

By:

Loos, Maria S.;
Ramakrishnan, Reshmi;
Vranken, Wim;
Tsirigotaki, Alexandra;
Tsare, Evrydiki-Pandora;
Zorzini, Valentina;
Geyter, Jozefien De;
Yuan, Biao;
Tsamardinos, Ioannis;
Klappa, Maria;
Schymkowitz, Joost;
Rousseau, Frederic;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Structures of chaperone-substrate complexes docked onto the export gate in a type III secretion system.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04137-4

By:

Qiong Xing;
Ke Shi;
Portaliou, Athina;
Rossi, Paolo;
Economou, Anastassios;
Kalodimos, Charalampos G.

Publication type:

Article

Escherichia coli SecA truncated at its termini is functional and dimeric

Published in:

FEBS Letters, 2005, v. 579, n. 5, p. 1267, doi. 10.1016/j.febslet.2005.01.025

By:

Karamanou, Spyridoula;
Sianidis, Giorgos;
Gouridis, Giorgos;
Pozidis, Charalambos;
Papanikolau, Yiannis;
Papanikou, Efrosyni;
Economou, Anastassios

Publication type:

Article

Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein.

Published in:

Microbial Cell Factories, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12934-018-1040-6

By:

Daniels, Wouter;
Bouvin, Jeroen;
Busche, Tobias;
Rückert, Christian;
Simoens, Kenneth;
Karamanou, Spyridoula;
Van Mellaert, Lieve;
Friðjónsson, Ólafur H.;
Nicolai, Bart;
Economou, Anastassios;
Kalinowski, Jörn;
Anné, Jozef;
Bernaerts, Kristel

Publication type:

Article

Comprehensive subcellular topologies of polypeptides in <italic>Streptomyces</italic>.

Published in:

Microbial Cell Factories, 2018, v. 17, p. 1, doi. 10.1186/s12934-018-0892-0

By:

Tsolis, Konstantinos C.;
Tsare, Evridiki-Pandora;
Orfanoudaki, Georgia;
Busche, Tobias;
Kanaki, Katerina;
Ramakrishnan, Reshmi;
Rousseau, Frederic;
Schymkowitz, Joost;
Rückert, Christian;
Kalinowski, Jörn;
Anné, Jozef;
Karamanou, Spyridoula;
Klapa, Maria I.;
Economou, Anastassios

Publication type:

Article

Large-scale production of a thermostable Rhodothermus marinus cellulase by heterologous secretion from Streptomyces lividans.

Published in:

Microbial Cell Factories, 2017, v. 16, p. 1, doi. 10.1186/s12934-017-0847-x

By:

Belal Hamed, Mohamed;
Karamanou, Spyridoula;
Ólafsdottir, Solveig;
Martins Basílio, Joana Sofia;
Simoens, Kenneth;
Tsolis, Kostantinos C.;
Van Mellaert, Lieve;
Guðmundsdóttir, Eik Elísabet;
Hreggvidsson, Gudmundur Oli;
Anné, Jozef;
Bernaerts, Kristel;
Fridjonsson, Olafur H.;
Economou, Anastassios

Publication type:

Article

A double point mutation at residues Ile14 and Val15 of Bcl‐2 uncovers a role for the BH4 domain in both protein stability and function.

Published in:

FEBS Journal, 2018, v. 285, n. 1, p. 127, doi. 10.1111/febs.14324

By:

Monaco, Giovanni;
La Rovere, Rita;
Karamanou, Spyridoula;
Welkenhuyzen, Kirsten;
Ivanova, Hristina;
Vandermarliere, Elien;
Di Martile, Marta;
Del Bufalo, Donatella;
De Smedt, Humbert;
Parys, Jan B.;
Economou, Anastassios;
Bultynck, Geert

Publication type:

Article

Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase.

Published in:

EMBO Reports, 2020, v. 21, n. 6, p. 1, doi. 10.15252/embr.201949054

By:

De Geyter, Jozefien;
Portaliou, Athina G;
Srinivasu, Bindu;
Krishnamurthy, Srinath;
Economou, Anastassios;
Karamanou, Spyridoula

Publication type:

Article

Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.

Published in:

EMBO Journal, 2001, v. 20, n. 5, p. 961, doi. 10.1093/emboj/20.5.961

By:

Sianidis, Georgios;
Karamanou, Spyridoula;
Vrontou, Eleftheria;
Boulias, Kostantinos;
Repanas, Kostantinos;
Kyrpides, Nikos;
Politou, Anastasia S.;
Economou, Anastassios

Publication type:

Article

Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 11, p. 666, doi. 10.1038/ja.2015.53

By:

De Waelheyns, Evelien;
Segers, Kenneth;
Sardis, Marios Frantzeskos;
Anné, Jozef;
Nicolaes, Gerry A F;
Economou, Anastassios

Publication type:

Article

Preprotein mature domains contain translocase targeting signals that are essential for secretion.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 5, p. 1357, doi. 10.1083/jcb.201609022

By:

Chatzi, Katerina E.;
Sardis, Marios Frantzeskos;
Tsirigotaki, Alexandra;
Koukaki, Marina;
Šoštarić, Nikolina;
Konijnenberg, Albert;
Sobott, Frank;
Kalodimos, Charalampos G.;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Callus organoids reveal distinct cartilage to bone transition mechanisms across donors and a role for biological sex.

Published in:

Bone Research, 2025, v. 13, n. 1, p. 1, doi. 10.1038/s41413-025-00418-z

By:

Decoene, Isaak;
Svitina, Hanna;
Belal Hamed, Mohamed;
Economou, Anastassios;
Stegen, Steve;
Luyten, Frank P.;
Papantoniou, Ioannis

Publication type:

Article

Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen.

Published in:

Microorganisms, 2021, v. 9, n. 3, p. 592, doi. 10.3390/microorganisms9030592

By:

Hamed, Mohamed Belal;
Burchacka, Ewa;
Angus, Liselotte;
Marchand, Arnaud;
De Geyter, Jozefien;
Loos, Maria S.;
Anné, Jozef;
Klaassen, Hugo;
Chaltin, Patrick;
Karamanou, Spyridoula;
Economou, Anastassios;
Maisetta, Giuseppantonio

Publication type:

Article

A Reporter System for Fast Quantitative Monitoring of Type 3 Protein Secretion in Enteropathogenic E. coli.

Published in:

Microorganisms, 2020, v. 8, n. 11, p. 1786, doi. 10.3390/microorganisms8111786

By:

Barkalita, Luit;
Portaliou, Athina G.;
Loos, Maria S.;
Yuan, Biao;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

A molecular switch in SecA protein couples ATP hydrolysis to protein translocation.

Published in:

Molecular Microbiology, 1999, v. 34, n. 5, p. 1133, doi. 10.1046/j.1365-2958.1999.01686.x

By:

Karamanou, Spyridoula;
Vrontou, Eleftheria;
Sianidis, George;
Baud, Catherine;
Roos, Tilmann;
Kuhn, Andreas;
Politou, Anastasia S;
Economou, Anastassios

Publication type:

Article

Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme.

Published in:

Molecular Microbiology, 1998, v. 27, n. 3, p. 511, doi. 10.1046/j.1365-2958.1998.00713.x

By:

Economou, Anastassios

Publication type:

Article

The C-terminal domain of the Rhizobium leguminosarum chitin synthase NodC is important for function and determines the orientation of the N-terminal region in the inner membrane.

Published in:

Molecular Microbiology, 1996, v. 19, n. 3, p. 443, doi. 10.1046/j.1365-2958.1996.382911.x

By:

Barny, Marie-Anne;
Schoonejans, Eric;
Economou, Anastassios;
Johnston, Andrew W. B.;
Downie, J. Allan

Publication type:

Article

Rapid label-free quantitative analysis of the E. coli BL21(DE3) inner membrane proteome.

Published in:

Proteomics, 2016, v. 16, n. 1, p. 85, doi. 10.1002/pmic.201500304

By:

Papanastasiou, Malvina;
Orfanoudaki, Georgia;
Kountourakis, Nikos;
Koukaki, Marina;
Sardis, Marios Frantzeskos;
Aivaliotis, Michalis;
Tsolis, Konstantinos C.;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Multi-Omics and Targeted Approaches to Determine the Role of Cellular Proteases in Streptomyces Protein Secretion.

Published in:

Frontiers in Microbiology, 2018, p. 1, doi. 10.3389/fmicb.2018.01174

By:

Busche, Tobias;
Tsolis, Konstantinos C.;
Koepff, Joachim;
Rebets, Yuriy;
Rückert, Christian;
Hamed, Mohamed B.;
Bleidt, Arne;
Wiechert, Wolfgang;
Lopatniuk, Mariia;
Yousra, Ahmed;
Anné, Jozef;
Karamanou, Spyridoula;
Oldiges, Marco;
Kalinowski, Jörn;
Luzhetskyy, Andriy;
Economou, Anastassios

Publication type:

Article

Enhanced protein secretion in reduced genome strains of Streptomyces lividans.

Published in:

Microbial Cell Factories, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12934-023-02269-x

By:

Hamed, Mohamed Belal;
Busche, Tobias;
Simoens, Kenneth;
Carpentier, Sebastien;
Kormanec, Jan;
Van Mellaert, Lieve;
Anné, Jozef;
Kalinowski, Joern;
Bernaerts, Kristel;
Karamanou, Spyridoula;
Economou, Anastassios

Publication type:

Article

Signal peptides are allosteric activators of the protein translocase.

Published in:

Nature, 2009, v. 462, n. 7271, p. 363, doi. 10.1038/nature08559

By:

Gouridis, Giorgos;
Karamanou, Spyridoula;
Gelis, Ioannis;
Kalodimos, Charalampos G.;
Economou, Anastassios

Publication type:

Article

Structural biology: Clamour for a kiss.

Published in:

Nature, 2008, v. 455, n. 7215, p. 879, doi. 10.1038/455879a

By:

Economou, Anastassios

Publication type:

Article

Helicase Motif III in SecA is essential for coupling preprotein binding to translocation ATPase.

Published in:

EMBO Reports, 2004, v. 5, n. 8, p. 807, doi. 10.1038/sj.embor.7400206

By:

Papanikou, Efrosyni;
Karamanou, Spyridoula;
Baud, Catherine;
Sianidis, Giorgos;
Frank, Miriam;
Economou, Anastassios

Publication type:

Article

Breaking on through to the other side: protein export through the bacterial Sec system.

Published in:

Biochemical Journal, 2013, v. 449, n. 1, p. 25, doi. 10.1042/BJ20121227

By:

CHATZI, Katerina E.;
SARDIS, Marios F.;
KARAMANOU, Spyridoula;
ECONOMOU, Anastassios

Publication type:

Article

Fast and reliable strain characterization of Streptomyces lividans through micro-scale cultivation.

Published in:

Biotechnology & Bioengineering, 2017, v. 114, n. 9, p. 2011, doi. 10.1002/bit.26321

By:

Koepff, Joachim;
Keller, Matthias;
Tsolis, Konstantinos C.;
Busche, Tobias;
Rückert, Christian;
Hamed, Mohamed B.;
Anné, Jozef;
Kalinowski, Joern;
Wiechert, Wolfgang;
Economou, Anastassios;
Oldiges, Marco

Publication type:

Article

Preprotein-controlled catalysis in the helicase motor of SecA.

Published in:

EMBO Journal, 2007, v. 26, n. 12, p. 2904, doi. 10.1038/sj.emboj.7601721

By:

Karamanou, Spyridoula;
Gouridis, Giorgos;
Papanikou, Efrosyni;
Sianidis, Giorgos;
Gelis, Ioannis;
Keramisanou, Dimitra;
Vrontou, Eleftheria;
Kalodimos, Charalampos G;
Economou, Anastassios

Publication type:

Article

Chondrocyte protein co-synthesis network analysis links ECM mechanosensing to metabolic adaptation in osteoarthritis.

Published in:

Expert Review of Proteomics, 2021, v. 18, n. 7, p. 623, doi. 10.1080/14789450.2021.1962299

By:

Destouni, Aspasia;
Tsolis, Konstantinos C.;
Economou, Anastassios;
Papathanasiou, Ioanna;
Balis, Charalampos;
Mourmoura, Evanthia;
Tsezou, Aspasia

Publication type:

Article