Works by Ecker, Jonas

Results: 26

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 121, doi. 10.1186/s40478-015-0201-7

By:

Ecker, Jonas;
Oehme, Ina;
Mazitschek, Ralph;
Korshunov, Andrey;
Kool, Marcel;
Hielscher, Thomas;
Kiss, Judit;
Selt, Florian;
Konrad, Carina;
Lodrini, Marco;
Deubzer, Hedwig E.;
von Deimling, Andreas;
Kulozik, Andreas E.;
Pfister, Stefan M.;
Witt, Olaf;
Milde, Till

Publication type:

Article

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40235-8

By:

Sigaud, Romain;
Albert, Thomas K.;
Hess, Caroline;
Hielscher, Thomas;
Winkler, Nadine;
Kocher, Daniela;
Walter, Carolin;
Münter, Daniel;
Selt, Florian;
Usta, Diren;
Ecker, Jonas;
Brentrup, Angela;
Hasselblatt, Martin;
Thomas, Christian;
Varghese, Julian;
Capper, David;
Thomale, Ulrich W.;
Hernáiz Driever, Pablo;
Simon, Michèle;
Horn, Svea

Publication type:

Article

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors.

Published in:

Brain Pathology, 2016, v. 26, n. 4, p. 506, doi. 10.1111/bpa.12326

By:

Selt, Florian;
Deiß, Alica;
Korshunov, Andrey;
Capper, David;
Witt, Hendrik;
van Tilburg, Cornelis M.;
Jones, David T. W.;
Witt, Ruth;
Sahm, Felix;
Reuss, David;
Kölsche, Christian;
Ecker, Jonas;
Oehme, Ina;
Hielscher, Thomas;
von Deimling, Andreas;
Kulozik, Andreas E.;
Pfister, Stefan M.;
Witt, Olaf;
Milde, Till

Publication type:

Article

Constitutional variants in PTEN: a frequent finding in patients with papillary tumors of the pineal region subtype B (PTPR-B) associated with isolated loss of chromosome 10.

Published in:

2025

By:

Hirsch, Steffen;
Rahmanzade, Ramin;
Grund, Kerstin;
Sutter, Christian;
Schramm, Kathrin;
Selt, Florian;
Ecker, Jonas;
Jones, Barbara C.;
Schrimpf, Daniel;
Demmert, Martin;
Guerreiro Stücklin, Ana S.;
Hernaiz Driever, Pablo;
Mezger, Markus;
Brecht, Ines;
Adib, Sasan D.;
Brummel, Bastian;
Sturm, Dominik;
Dikow, Nicola;
Hempel, Maja;
Milde, Till

Publication type:

Letter

Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 5, p. 667, doi. 10.1007/s00401-023-02558-0

By:

Bogumil, Henri;
Sill, Martin;
Schrimpf, Daniel;
Ismer, Britta;
Blume, Christina;
Rahmanzade, Ramin;
Hinz, Felix;
Cherkezov, Asan;
Banan, Rouzbeh;
Friedel, Dennis;
Reuss, David E.;
Selt, Florian;
Ecker, Jonas;
Milde, Till;
Pajtler, Kristian W.;
Schittenhelm, Jens;
Hench, Jürgen;
Frank, Stephan;
Boldt, Henning B.;
Kristensen, Bjarne Winther

Publication type:

Article

Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 1, p. 97, doi. 10.1007/s00401-022-02522-4

By:

Mynarek, Martin;
Obrecht, Denise;
Sill, Martin;
Sturm, Dominik;
Kloth-Stachnau, Katja;
Selt, Florian;
Ecker, Jonas;
von Hoff, Katja;
Juhnke, Björn-Ole;
Goschzik, Tobias;
Pietsch, Torsten;
Bockmayr, Michael;
Kool, Marcel;
von Deimling, Andreas;
Witt, Olaf;
Schüller, Ulrich;
Benesch, Martin;
Gerber, Nicolas U.;
Sahm, Felix;
Jones, David T. W.

Publication type:

Article

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 6, p. 1065, doi. 10.1007/s00401-021-02369-1

By:

Sievers, Philipp;
Stichel, Damian;
Sill, Martin;
Schrimpf, Daniel;
Sturm, Dominik;
Selt, Florian;
Ecker, Jonas;
Kazdal, Daniel;
Miele, Evelina;
Kranendonk, Mariëtte E. G.;
Tops, Bastiaan B. J.;
Kohlhof-Meinecke, Patricia;
Beschorner, Rudi;
Kramm, Christof M.;
Hasselblatt, Martin;
Reifenberger, Guido;
Capper, David;
Wesseling, Pieter;
Stenzinger, Albrecht;
Milde, Till

Publication type:

Article

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.

Published in:

Acta Neuropathologica, 2019, v. 138, n. 5, p. 827, doi. 10.1007/s00401-019-02039-3

By:

Stichel, Damian;
Schrimpf, Daniel;
Casalini, Belén;
Meyer, Jochen;
Wefers, Annika K.;
Sievers, Philipp;
Korshunov, Andrey;
Koelsche, Christian;
Reuss, David E.;
Reinhardt, Annekathrin;
Ebrahimi, Azadeh;
Fernández-Klett, Francisco;
Kessler, Tobias;
Sturm, Dominik;
Ecker, Jonas;
Milde, Till;
Herold-Mende, Christel;
Witt, Olaf;
Pfister, Stefan M.;
Wick, Wolfgang

Publication type:

Article

Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma.

Published in:

Journal of Personalized Medicine, 2020, v. 10, n. 4, p. 1, doi. 10.3390/jpm10040290

By:

Mayr, Lisa;
Guntner, Armin S.;
Madlener, Sibylle;
Schmook, Maria T.;
Peyrl, Andreas;
Azizi, Amedeo A.;
Dieckmann, Karin;
Reisinger, Dominik;
Stepien, Natalia M.;
Schramm, Kathrin;
Laemmerer, Anna;
Jones, David T. W.;
Ecker, Jonas;
Sahm, Felix;
Milde, Till;
Pajtler, Kristian W.;
Blattner-Johnson, Mirjam;
Strbac, Miroslav;
Dorfer, Christian;
Czech, Thomas

Publication type:

Article

Clinical outcome of pediatric medulloblastoma patients with Li–Fraumeni syndrome.

Published in:

Neuro-Oncology, 2023, v. 25, n. 12, p. 2273, doi. 10.1093/neuonc/noad114

By:

Kolodziejczak, Anna S;
Guerrini-Rousseau, Lea;
Planchon, Julien Masliah;
Ecker, Jonas;
Selt, Florian;
Mynarek, Martin;
Obrecht, Denise;
Sill, Martin;
Autry, Robert J;
Stutheit-Zhao, Eric;
Hirsch, Steffen;
Amouyal, Elsa;
Dufour, Christelle;
Ayrault, Olivier;
Torrejon, Jacob;
Waszak, Sebastian M;
Ramaswamy, Vijay;
Pentikainen, Virve;
Demir, Haci Ahmet;
Clifford, Steven C

Publication type:

Article

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.

Published in:

Clinical Epigenetics, 2019, v. 11, n. 1, p. 1, doi. 10.1186/s13148-019-0775-1

By:

van Tilburg, Cornelis M.;
Milde, Till;
Witt, Ruth;
Ecker, Jonas;
Hielscher, Thomas;
Seitz, Angelika;
Schenk, Jens-Peter;
Buhl, Juliane L.;
Riehl, Dennis;
Frühwald, Michael C.;
Pekrun, Arnulf;
Rossig, Claudia;
Wieland, Regina;
Flotho, Christian;
Kordes, Uwe;
Gruhn, Bernd;
Simon, Thorsten;
Linderkamp, Christin;
Sahm, Felix;
Taylor, Lenka

Publication type:

Article

Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data.

Published in:

Neuropathology & Applied Neurobiology, 2021, v. 47, n. 3, p. 406, doi. 10.1111/nan.12683

By:

Stichel, Damian;
Schrimpf, Daniel;
Sievers, Philipp;
Reinhardt, Annekathrin;
Suwala, Abigail K.;
Sill, Martin;
Reuss, David E.;
Korshunov, Andrey;
Casalini, Belén M.;
Sommerkamp, Alexander C.;
Ecker, Jonas;
Selt, Florian;
Sturm, Dominik;
Gnekow, Astrid;
Koch, Arend;
Simon, Michèle;
Hernáiz Driever, Pablo;
Schüller, Ulrich;
Capper, David;
Tilburg, Cornelis M.

Publication type:

Article

Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-98514-x

By:

Selt, Florian;
Sigaud, Romain;
Korshunov, Andrey;
Capper, David;
Reuss, David;
von Deimling, Andreas;
Pajtler, Kristian W.;
van Tilburg, Cornelis M.;
Nesper-Brock, Martina;
Jones, David T. W.;
Pfister, Stefan M.;
Sahm, Felix;
Witt, Olaf;
Milde, Till;
Ecker, Jonas

Publication type:

Article

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.

Published in:

Neuro-Oncology, 2021, v. 23, n. 2, p. 226, doi. 10.1093/neuonc/noaa191

By:

Ecker, Jonas;
Thatikonda, Venu;
Sigismondo, Gianluca;
Selt, Florian;
Valinciute, Gintvile;
Oehme, Ina;
Müller, Carina;
Buhl, Juliane L;
Ridinger, Johannes;
Usta, Diren;
Qin, Nan;
Tilburg, Cornelis M van;
Herold-Mende, Christel;
Remke, Marc;
Sahm, Felix;
Westermann, Frank;
Kool, Marcel;
Wechsler-Reya, Robert J;
Chavez, Lukas;
Krijgsveld, Jeroen

Publication type:

Article

MEDU-01. HDACi AND PLK1i ACT SYNERGISTICALLY IN MYC-AMPLIFIED MEDULLOBLASTOMA.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii103, doi. 10.1093/neuonc/noz036.161

By:

Valinciute, Gintvile;
Ecker, Jonas;
Hielscher, Thomas;
Schmidt, Christin;
Remke, Marc;
Sigismondo, Gianluca;
Krijgsveld, Jeroen;
Pfister, Stefan;
Witt, Olaf;
Milde, Till

Publication type:

Article

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii83, doi. 10.1093/neuonc/noz036.083

By:

Jones, David;
Ismer, Britta;
Schrimpf, Daniel;
Reuss, David;
Stichel, Damien;
Casalini, Belen;
Schittenhelm, Jens;
Frank, Stephan;
Boldt, Henning;
Winther-Kristensen, Bjarne;
Sehested, Astrid Marie;
Scheie, David;
Korshunov, Andrey;
Ecker, Jonas;
Milde, Till;
Pajtler, Kristian;
Herold-Mende, Christel;
Witt, Olaf;
Wick, Wolfgang;
Pfister, Stefan M

Publication type:

Article

A synergistic interaction between HDAC‐ and PARP inhibitors in childhood tumors with chromothripsis.

Published in:

International Journal of Cancer, 2022, v. 151, n. 4, p. 590, doi. 10.1002/ijc.34027

By:

Khalid, Umar;
Simovic, Milena;
Hammann, Linda A.;
Iskar, Murat;
Wong, John K. L.;
Kumar, Rithu;
Jugold, Manfred;
Sill, Martin;
Bolkestein, Michiel;
Kolb, Thorsten;
Hergt, Michaela;
Devens, Frauke;
Ecker, Jonas;
Kool, Marcel;
Milde, Till;
Westermann, Frank;
Benner, Axel;
Lewis, Joe;
Dietrich, Sascha;
Pfister, Stefan M.

Publication type:

Article

Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells.

Published in:

Journal of Neuro-Oncology, 2024, v. 166, n. 1, p. 99, doi. 10.1007/s11060-023-04526-w

By:

Zeuner, Simon;
Vollmer, Johanna;
Sigaud, Romain;
Oppermann, Sina;
Peterziel, Heike;
ElHarouni, Dina;
Oehme, Ina;
Witt, Olaf;
Milde, Till;
Ecker, Jonas

Publication type:

Article

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.

Published in:

Journal of Neuro-Oncology, 2023, v. 165, n. 3, p. 467, doi. 10.1007/s11060-023-04500-6

By:

Selt, Florian;
El Damaty, Ahmed;
Schuhmann, Martin U.;
Sigaud, Romain;
Ecker, Jonas;
Sievers, Philipp;
Kocher, Daniela;
Herold-Mende, Christel;
Oehme, Ina;
von Deimling, Andreas;
Pfister, Stefan M.;
Sahm, Felix;
Jones, David T. W.;
Witt, Olaf;
Milde, Till

Publication type:

Article

Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.

Published in:

Journal of Neuro-Oncology, 2023, v. 164, n. 3, p. 617, doi. 10.1007/s11060-023-04445-w

By:

Vollmer, Johanna;
Ecker, Jonas;
Hielscher, Thomas;
Valinciute, Gintvile;
Ridinger, Johannes;
Jamaladdin, Nora;
Peterziel, Heike;
van Tilburg, Cornelis M.;
Oehme, Ina;
Witt, Olaf;
Milde, Till

Publication type:

Article

Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.

Published in:

Journal of Neuro-Oncology, 2023, v. 163, n. 1, p. 143, doi. 10.1007/s11060-023-04319-1

By:

Valinciute, Gintvile;
Ecker, Jonas;
Selt, Florian;
Hielscher, Thomas;
Sigaud, Romain;
Ridinger, Johannes;
Thatikonda, Venu;
Gatzweiler, Charlotte;
Robinson, Sarah;
Talbot, Julie;
Bernardi, Flavia;
Picard, Daniel;
Blattner-Johnson, Mirjam;
Schmid, Simone;
Jones, David T.;
van Tilburg, Cornelis M.;
Capper, David;
Kool, Marcel;
Remke, Marc;
Oehme, Ina

Publication type:

Article

Response to trametinib treatment in progressive pediatric low-grade glioma patients.

Published in:

Journal of Neuro-Oncology, 2020, v. 149, n. 3, p. 499, doi. 10.1007/s11060-020-03640-3

By:

Selt, Florian;
van Tilburg, Cornelis M.;
Bison, Brigitte;
Sievers, Philipp;
Harting, Inga;
Ecker, Jonas;
Pajtler, Kristian W.;
Sahm, Felix;
Bahr, Annabelle;
Simon, Michèle;
Jones, David T. W.;
Well, Lennart;
Mautner, Victor-Felix;
Capper, David;
Hernáiz Driever, Pablo;
Gnekow, Astrid;
Pfister, Stefan M.;
Witt, Olaf;
Milde, Till

Publication type:

Article

Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 4, p. 904, doi. 10.1002/cpt.3002

By:

Jamaladdin, Nora;
Sigaud, Romain;
Kocher, Daniela;
Kolodziejczak, Anna S.;
Nonnenbroich, Leo F.;
Ecker, Jonas;
Usta, Diren;
Benzel, Julia;
Peterziel, Heike;
Pajtler, Kristian W.;
van Tilburg, Cornelis M.;
Oehme, Ina;
Witt, Olaf;
Milde, Till

Publication type:

Article

Sarcoma classification by DNA methylation profiling.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20603-4

By:

Koelsche, Christian;
Schrimpf, Daniel;
Stichel, Damian;
Sill, Martin;
Sahm, Felix;
Reuss, David E.;
Blattner, Mirjam;
Worst, Barbara;
Heilig, Christoph E.;
Beck, Katja;
Horak, Peter;
Kreutzfeldt, Simon;
Paff, Elke;
Stark, Sebastian;
Johann, Pascal;
Selt, Florian;
Ecker, Jonas;
Sturm, Dominik;
Pajtler, Kristian W.;
Reinhardt, Annekathrin

Publication type:

Article

Retinoblastoma with late metastatic spread-a case report.

Published in:

2019

By:

Hofer, Silvia;
Diebold, Joachim;
Temming, Petra;
Lohmann, Dietmar;
Howell, Jeremy;
Moulin, Alexandre;
Beck‐Popovic, Maja;
Sahm, Felix;
Milde, Till;
Ecker, Jonas;
Beck-Popovic, Maja

Publication type:

Case Study

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25708-y

By:

Deng, Maximilian Y.;
Sturm, Dominik;
Pfaff, Elke;
Sill, Martin;
Stichel, Damian;
Balasubramanian, Gnana Prakash;
Tippelt, Stephan;
Kramm, Christof;
Donson, Andrew M.;
Green, Adam L.;
Jones, Chris;
Schittenhelm, Jens;
Ebinger, Martin;
Schuhmann, Martin U.;
Jones, Barbara C.;
van Tilburg, Cornelis M.;
Wittmann, Andrea;
Golanov, Andrey;
Ryzhova, Marina;
Ecker, Jonas

Publication type:

Article