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Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10856, doi. 10.3390/ijms221910856
By:
- Palmaers, Natalie E.;
- Wiegand, Steffen B.;
- Herzog, Christine;
- Echtermeyer, Frank G.;
- Eberhardt, Mirjam J.;
- Leffler, Andreas
Publication type:
Article
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Published in:
Nature Medicine, 2012, v. 18, n. 9, p. 1445, doi. 10.1038/nm0912-1445c
By:
- Bierhaus, Angelika;
- Fleming, Thomas;
- Stoyanov, Stoyan;
- Leffler, Andreas;
- Babes, Alexandru;
- Neacsu, Cristian;
- Sauer, Susanne K;
- Eberhardt, Mirjam;
- Schnölzer, Martina;
- Lasischka, Felix;
- Neuhuber, Winfried L;
- Kichko, Tatjana I;
- Konrade, Ilze;
- Elvert, Ralf;
- Mier, Walter;
- Pirags, Valdis;
- Lukic, Ivan K;
- Morcos, Michael;
- Dehmer, Thomas;
- Rabbani, Naila
Publication type:
Article
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Published in:
Nature Medicine, 2012, v. 18, n. 6, p. 926, doi. 10.1038/nm.2750
By:
- Bierhaus, Angelika;
- Fleming, Thomas;
- Stoyanov, Stoyan;
- Leffler, Andreas;
- Babes, Alexandru;
- Neacsu, Cristian;
- Sauer, Susanne K;
- Eberhardt, Mirjam;
- Schnölzer, Martina;
- Lasischka, Felix;
- Neuhuber, Winfried L;
- Kichko, Tatjana I;
- Konrade, Ilze;
- Elvert, Ralf;
- Mier, Walter;
- Pirags, Valdis;
- Lukic, Ivan K;
- Morcos, Michael;
- Dehmer, Thomas;
- Rabbani, Naila
Publication type:
Article
Lactate is a potent inhibitor of the capsaicin receptor TRPV1.
Published in:
Scientific Reports, 2016, p. 36740, doi. 10.1038/srep36740
By:
- de la Roche, Jeanne;
- Walther, Isabella;
- Leonow, Waleria;
- Hage, Axel;
- Eberhardt, Mirjam;
- Fischer, Martin;
- Reeh, Peter W.;
- Sauer, Susanne;
- Leffler, Andreas
Publication type:
Article
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.
Published in:
Scientific Reports, 2016, p. 28763, doi. 10.1038/srep28763
By:
- Moparthi, Lavanya;
- Kichko, Tatjana I.;
- Eberhardt, Mirjam;
- Högestätt, Edward D.;
- Kjellbom, Per;
- Johanson, Urban;
- Reeh, Peter W.;
- Leffler, Andreas;
- Filipovic, Milos R.;
- Zygmunt, Peter M.
Publication type:
Article
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.
Published in:
EMBO Journal, 2012, v. 31, n. 19, p. 3795, doi. 10.1038/emboj.2012.207
By:
- Vetter, Irina;
- Touska, Filip;
- Hess, Andreas;
- Hinsbey, Rachel;
- Sattler, Simon;
- Lampert, Angelika;
- Sergejeva, Marina;
- Sharov, Anastasia;
- Collins, Lindon S;
- Eberhardt, Mirjam;
- Engel, Matthias;
- Cabot, Peter J;
- Wood, John N;
- Vlachová, Viktorie;
- Reeh, Peter W;
- Lewis, Richard J;
- Zimmermann, Katharina
Publication type:
Article
Etomidate and propylene glycol activate nociceptive TRP ion channels.
Published in:
Molecular Pain, 2018, v. 14, p. 1, doi. 10.1177/1744806918811699
By:
- Niedermirtl, Florian;
- Eberhardt, Mirjam;
- Namer, Barbara;
- Leffler, Andreas;
- Nau, Carla;
- Reeh, Peter W.;
- Kistner, Katrin
Publication type:
Article
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Published in:
FASEB Journal, 2019, v. 33, n. 9, p. 10257, doi. 10.1096/fj.201802233R
By:
- Echtermeyer, Frank;
- Eberhardt, Mirjam;
- Risser, Linus;
- Herzog, Christine;
- Gueler, Faikah;
- Khalil, Mohammad;
- Engel, Matthias;
- Vondran, Florian;
- Leffler, Andreas
Publication type:
Article
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Published in:
Nature Communications, 2014, v. 5, n. 7, p. 4381, doi. 10.1038/ncomms5381
By:
- Eberhardt, Mirjam;
- Dux, Maria;
- Namer, Barbara;
- Miljkovic, Jan;
- Cordasic, Nada;
- Will, Christine;
- Kichko, Tatjana I.;
- de la Roche, Jeanne;
- Fischer, Michael;
- Suárez, Sebastián A.;
- Bikiel, Damian;
- Dorsch, Karola;
- Leffler, Andreas;
- Babes, Alexandru;
- Lampert, Angelika;
- Lennerz, Jochen K.;
- Jacobi, Johannes;
- Martí, Marcelo A.;
- Doctorovich, Fabio;
- Högestätt, Edward D.
Publication type:
Article
Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.
Published in:
Molecular Pain, 2012, v. 8, n. 1, p. 69, doi. 10.1186/1744-8069-8-69
By:
- Klinger, Alexandra B.;
- Eberhardt, Mirjam;
- Link, Andrea S.;
- Namer, Barbara;
- Kutsche, Lisa K.;
- Schuy, E. Theresa;
- Sittl, Ruth;
- Hoffmann, Tali;
- Alzheimer, Christian;
- Huth, Tobias;
- Carr, Richard W.;
- Lampert, Angelika
Publication type:
Article
Molecular mechanisms of MrgprA3‐independent activation of the transient receptor potential ion channels TRPA1 and TRPV1 by chloroquine.
Published in:
British Journal of Pharmacology, 2023, v. 180, n. 17, p. 2214, doi. 10.1111/bph.16072
By:
- Fricke, Tabea C.;
- Pantke, Sebastian;
- Lüttmann, Bjarne;
- Echtermeyer, Frank G.;
- Herzog, Christine;
- Eberhardt, Mirjam J.;
- Leffler, Andreas
Publication type:
Article
Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom.
Published in:
Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0731-0
By:
- Achenbach, Johannes;
- Rhein, Mathias;
- Gombert, Sara;
- Meyer-Bockenkamp, Fiona;
- Buhck, Miro;
- Eberhardt, Mirjam;
- Leffler, Andreas;
- Frieling, Helge;
- Karst, Matthias
Publication type:
Article
TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons.
Published in:
PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0188008
By:
- Eberhardt, Mirjam;
- Stueber, Thomas;
- de la Roche, Jeanne;
- Herzog, Christine;
- Leffler, Andreas;
- Reeh, Peter W.;
- Kistner, Katrin
Publication type:
Article
CGRP and NO in the Trigeminal System: Mechanisms and Role in Headache Generation.
Published in:
Headache: The Journal of Head & Face Pain, 2012, v. 52, n. 9, p. 1411, doi. 10.1111/j.1526-4610.2012.02212.x
By:
- Messlinger, Karl;
- Lennerz, Jochen K.;
- Eberhardt, Mirjam;
- Fischer, Michael J.m.
Publication type:
Article

Found: 14

Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin.

Methylglyoxal modification of Na<sub>v</sub>1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.

Methylglyoxal modification of Na<sub>v</sub>1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.

Lactate is a potent inhibitor of the capsaicin receptor TRPV1.

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.

Etomidate and propylene glycol activate nociceptive TRP ion channels.

Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.

H<sub>2</sub>S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.

Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.

Molecular mechanisms of MrgprA3‐independent activation of the transient receptor potential ion channels TRPA1 and TRPV1 by chloroquine.

Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom.

TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons.

CGRP and NO in the Trigeminal System: Mechanisms and Role in Headache Generation.