Works by Dyrkheeva, Nadezhda S.

Results: 28

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy.
Published in:
Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 1415, doi. 10.1080/14756366.2018.1509210
By:
- Komarova, Anastasia O.;
- Drenichev, Mikhail S.;
- Dyrkheeva, Nadezhda S.;
- Kulikova, Irina V.;
- Oslovsky, Vladimir E.;
- Zakharova, Olga D.;
- Zakharenko, Alexandra L.;
- Mikhailov, Sergey N.;
- Lavrik, Olga I.
Publication type:
Article
New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 7, p. 973, doi. 10.3390/biom11070973
By:
- Dyrkheeva, Nadezhda S.;
- Filimonov, Aleksandr S.;
- Luzina, Olga A.;
- Zakharenko, Alexandra L.;
- Ilina, Ekaterina S.;
- Malakhova, Anastasia A.;
- Medvedev, Sergey P.;
- Reynisson, Jóhannes;
- Volcho, Konstantin P.;
- Zakian, Suren M.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair.
Published in:
Biomedicines, 2024, v. 12, n. 12, p. 2808, doi. 10.3390/biomedicines12122808
By:
- Khodyreva, Svetlana N.;
- Dyrkheeva, Nadezhda S.;
- Lavrik, Olga I.
Publication type:
Article
A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts.
Published in:
Cells (2073-4409), 2024, v. 13, n. 4, p. 302, doi. 10.3390/cells13040302
By:
- Khodyreva, Svetlana N.;
- Ilina, Ekaterina S.;
- Dyrkheeva, Nadezhda S.;
- Kochetkova, Alina S.;
- Yamskikh, Alexandra A.;
- Maltseva, Ekaterina A.;
- Malakhova, Anastasia A.;
- Medvedev, Sergey P.;
- Zakian, Suren M.;
- Lavrik, Olga I.
Publication type:
Article
Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents.
Published in:
Genes, 2023, v. 14, n. 10, p. 1931, doi. 10.3390/genes14101931
By:
- Zakharenko, Alexandra L.;
- Dyrkheeva, Nadezhda S.;
- Luzina, Olga A.;
- Filimonov, Aleksandr S.;
- Mozhaitsev, Evgenii S.;
- Malakhova, Anastasia A.;
- Medvedev, Sergey P.;
- Zakian, Suren M.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes.
Published in:
Chemistry (2624-8549), 2024, v. 6, n. 6, p. 1658, doi. 10.3390/chemistry6060101
By:
- Filimonov, Aleksandr S.;
- Mikhailova, Marina A.;
- Dyrkheeva, Nadezhda S.;
- Chernyshova, Irina A.;
- Kornienko, Tatyana E.;
- Naumenko, Konstantin A.;
- Anarbaev, Rashid O.;
- Nefedov, Andrey A.;
- Achara, Chigozie;
- Curtis, Anthony D. M.;
- Luzina, Olga A.;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.;
- Reynisson, Jóhannes
Publication type:
Article
Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA–protein crosslink with apurinic/apyrimidinic site in cellular extracts.
Published in:
IUBMB Life, 2024, v. 76, n. 11, p. 987, doi. 10.1002/iub.2890
By:
- Lebedeva, Natalia A.;
- Dyrkheeva, Nadezhda S.;
- Rechkunova, Nadejda I.;
- Lavrik, Olga I.
Publication type:
Article
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors—New Usnic Acid Derivatives.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1210, doi. 10.3390/ijms25021210
By:
- Kornienko, Tatyana E.;
- Chepanova, Arina A.;
- Zakharenko, Alexandra L.;
- Filimonov, Aleksandr S.;
- Luzina, Olga A.;
- Dyrkheeva, Nadezhda S.;
- Nikolin, Valeriy P.;
- Popova, Nelly A.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 23, p. 16798, doi. 10.3390/ijms242316798
By:
- Makeeva, Vladlena S.;
- Dyrkheeva, Nadezhda S.;
- Lavrik, Olga I.;
- Zakian, Suren M.;
- Malakhova, Anastasia A.
Publication type:
Article
New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9155, doi. 10.3390/ijms24119155
By:
- Khomenko, Tatyana M.;
- Zakharenko, Alexandra L.;
- Kornienko, Tatyana E.;
- Chepanova, Arina A.;
- Dyrkheeva, Nadezhda S.;
- Artemova, Anastasia O.;
- Korchagina, Dina V.;
- Achara, Chigozie;
- Curtis, Anthony;
- Reynisson, Jóhannes;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5781, doi. 10.3390/ijms24065781
By:
- Zakharenko, Alexandra L.;
- Luzina, Olga A.;
- Chepanova, Arina A.;
- Dyrkheeva, Nadezhda S.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5148, doi. 10.3390/ijms24065148
By:
- Dyrkheeva, Nadezhda S.;
- Malakhova, Anastasia A.;
- Zakharenko, Aleksandra L.;
- Okorokova, Larisa S.;
- Shtokalo, Dmitriy N.;
- Pavlova, Sophia V.;
- Medvedev, Sergey P.;
- Zakian, Suren M.;
- Nushtaeva, Anna A.;
- Tupikin, Alexey E.;
- Kabilov, Marsel R.;
- Khodyreva, Svetlana N.;
- Luzina, Olga A.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 3834, doi. 10.3390/ijms24043834
By:
- Ivankin, Dmitry I.;
- Kornienko, Tatyana E.;
- Mikhailova, Marina A.;
- Dyrkheeva, Nadezhda S.;
- Zakharenko, Alexandra L.;
- Achara, Chigozie;
- Reynisson, Jóhannes;
- Golyshev, Victor M.;
- Luzina, Olga A.;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11336, doi. 10.3390/ijms222111336
By:
- Dyrkheeva, Nadezhda S.;
- Filimonov, Aleksandr S.;
- Luzina, Olga A.;
- Orlova, Kristina A.;
- Chernyshova, Irina A.;
- Kornienko, Tatyana E.;
- Malakhova, Anastasia A.;
- Medvedev, Sergey P.;
- Zakharenko, Alexandra L.;
- Ilina, Ekaterina S.;
- Anarbaev, Rashid O.;
- Naumenko, Konstantin N.;
- Klabenkova, Kristina V.;
- Burakova, Ekaterina A.;
- Stetsenko, Dmitry A.;
- Zakian, Suren M.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7162, doi. 10.3390/ijms21197162
By:
- Gladkova, Elizaveta D.;
- Nechepurenko, Ivan V.;
- Bredikhin, Roman A.;
- Chepanova, Arina A.;
- Zakharenko, Alexandra L.;
- Luzina, Olga A.;
- Ilina, Ekaterina S.;
- Dyrkheeva, Nadezhda S.;
- Mamontova, Evgeniya M.;
- Anarbaev, Rashid O.;
- Reynisson, Jóhannes;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Published in:
Molecules, 2023, v. 28, n. 1, p. 323, doi. 10.3390/molecules28010323
By:
- Chernyshova, Irina A.;
- Zakharenko, Aleksandra L.;
- Kurochkin, Nikolay N.;
- Dyrkheeva, Nadezhda S.;
- Kornienko, Tatyana E.;
- Popova, Nelly A.;
- Nikolin, Valeriy P.;
- Ilina, Ekaterina S.;
- Zharkov, Timofey D.;
- Kupryushkin, Maxim S.;
- Oslovsky, Vladimir E.;
- Drenichev, Mikhail S.;
- Lavrik, Olga I.
Publication type:
Article
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
Published in:
Molecules, 2022, v. 27, n. 11, p. 3374, doi. 10.3390/molecules27113374
By:
- Munkuev, Aldar A.;
- Dyrkheeva, Nadezhda S.;
- Kornienko, Tatyana E.;
- Ilina, Ekaterina S.;
- Ivankin, Dmitry I.;
- Suslov, Evgeniy V.;
- Korchagina, Dina V.;
- Gatilov, Yuriy V.;
- Zakharenko, Alexandra L.;
- Malakhova, Anastasia A.;
- Reynisson, Jóhannes;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Published in:
Molecules, 2022, v. 27, n. 8, p. N.PAG, doi. 10.3390/molecules27082433
By:
- Dyrkheeva, Nadezhda S.;
- Chernyshova, Irina A.;
- Ivanov, Georgy A.;
- Porozov, Yuri B.;
- Zenchenko, Anastasia A.;
- Oslovsky, Vladimir E.;
- Zakharenko, Alexandra L.;
- Nasyrova, Darina I.;
- Likhatskaya, Galina N.;
- Mikhailov, Sergey N.;
- Lavrik, Olga I.;
- Drenichev, Mikhail S.
Publication type:
Article
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
Published in:
Molecules, 2022, v. 27, n. 1, p. 72, doi. 10.3390/molecules27010072
By:
- Salomatina, Oksana V.;
- Dyrkheeva, Nadezhda S.;
- Popadyuk, Irina I.;
- Zakharenko, Alexandra L.;
- Ilina, Ekaterina S.;
- Komarova, Nina I.;
- Reynisson, Jóhannes;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.;
- Volcho, Konstantin P.
Publication type:
Article
Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.
Published in:
Molecules, 2021, v. 26, n. 11, p. 3128, doi. 10.3390/molecules26113128
By:
- Munkuev, Aldar A.;
- Mozhaitsev, Evgenii S.;
- Chepanova, Arina A.;
- Suslov, Evgeniy V.;
- Korchagina, Dina V.;
- Zakharova, Olga D.;
- Ilina, Ekaterina S.;
- Dyrkheeva, Nadezhda S.;
- Zakharenko, Alexandra L.;
- Reynisson, Jóhannes;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.
Publication type:
Article
Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.
Published in:
Molecules, 2020, v. 25, n. 16, p. 3694, doi. 10.3390/molecules25163694
By:
- Zakharenko, Alexandra L.;
- Drenichev, Mikhail S.;
- Dyrkheeva, Nadezhda S.;
- Ivanov, Georgy A.;
- Oslovsky, Vladimir E.;
- Ilina, Ekaterina S.;
- Chernyshova, Irina A.;
- Lavrik, Olga I.;
- Mikhailov, Sergey N.;
- Seley-Radtke, Katherine;
- Agrofoglio, Luigi A.
Publication type:
Article
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.
Published in:
Molecules, 2020, v. 25, n. 15, p. 3496, doi. 10.3390/molecules25153496
By:
- Il'ina, Irina V.;
- Dyrkheeva, Nadezhda S.;
- Zakharenko, Alexandra L.;
- Sidorenko, Alexander Yu.;
- Li-Zhulanov, Nikolay S.;
- Korchagina, Dina V.;
- Chand, Raina;
- Ayine-Tora, Daniel M.;
- Chepanova, Arina A.;
- Zakharova, Olga D.;
- Ilina, Ekaterina S.;
- Reynisson, Jóhannes;
- Malakhova, Anastasia A.;
- Medvedev, Sergey P.;
- Zakian, Suren M.;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.;
- Sippl, Wolfgang;
- Sousa, Maria Emília de
Publication type:
Article
New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
Published in:
Molecules, 2019, v. 24, n. 20, p. 3711, doi. 10.3390/molecules24203711
By:
- Filimonov, Aleksander S.;
- Chepanova, Arina A.;
- Luzina, Olga A.;
- Zakharenko, Alexandra L.;
- Zakharova, Olga D.;
- Ilina, Ekaterina S.;
- Dyrkheeva, Nadezhda S.;
- Kuprushkin, Maxim S.;
- Kolotaev, Anton V.;
- Khachatryan, Derenik S.;
- Patel, Jinal;
- Leung, Ivanhoe K.H.;
- Chand, Raina;
- Ayine-Tora, Daniel M.;
- Reynisson, Johannes;
- Volcho, Konstantin P.;
- Salakhutdinov, Nariman F.;
- Lavrik, Olga I.;
- Muñoz-Torrero, Diego;
- Luque, F. Javier
Publication type:
Article
Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
Published in:
PLoS ONE, 2023, v. 18, n. 11, p. 1, doi. 10.1371/journal.pone.0294683
By:
- Maltseva, Ekaterina A.;
- Vasil'eva, Inna A.;
- Moor, Nina A.;
- Kim, Daria V.;
- Dyrkheeva, Nadezhda S.;
- Kutuzov, Mikhail M.;
- Vokhtantsev, Ivan P.;
- Kulishova, Lilya M.;
- Zharkov, Dmitry O.;
- Lavrik, Olga I.
Publication type:
Article
Pre-steady state kinetics of DNA binding and abasic site hydrolysis by tyrosyl-DNA phosphodiesterase 1.
Published in:
Journal of Biomolecular Structure & Dynamics, 2017, v. 35, n. 11, p. 2314, doi. 10.1080/07391102.2016.1220331
By:
- Kuznetsov, Nikita A.;
- Lebedeva, Natalia A.;
- Kuznetsova, Alexandra A.;
- Rechkunova, Nadejda I.;
- Dyrkheeva, Nadezhda S.;
- Kupryushkin, Maxim S.;
- Stetsenko, Dmitry A.;
- Pyshnyi, Dmitrii V.;
- Fedorova, Olga S.;
- Lavrik, Olga I.
Publication type:
Article
Novel Peptide–Drug Conjugates with Dual Anticancer Activity.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 22, p. 12411, doi. 10.3390/ijms252212411
By:
- O'Flaherty, Siobhán;
- Luzina, Olga A.;
- Dyrkheeva, Nadezhda S.;
- Krier, Ysaline;
- Leprince, Jérôme;
- Zakharenko, Alexandra L.;
- Pokrovsky, Mikhail A.;
- Pokrovsky, Andrey G.;
- Lavrik, Olga I.;
- Salakhutdinov, Nariman F.;
- Varbanov, Mihayl;
- Devocelle, Marc;
- Volcho, Konstantin P.
Publication type:
Article
DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling.
Published in:
Nucleic Acids Research, 2019, v. 47, n. 15, p. 7767, doi. 10.1093/nar/gkz620
By:
- Krumkacheva, Olesya A;
- Shevelev, Georgiy Yu;
- Lomzov, Alexander A;
- Dyrkheeva, Nadezhda S;
- Kuzhelev, Andrey A;
- Koval, Vladimir V;
- Tormyshev, Victor M;
- Polienko, Yuliya F;
- Fedin, Matvey V;
- Pyshnyi, Dmitrii V;
- Lavrik, Olga I;
- Bagryanskaya, Elena G
Publication type:
Article
Capturing snapshots of APE1 processing DNA damage.
Published in:
Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 924, doi. 10.1038/nsmb.3105
By:
- Freudenthal, Bret D;
- Beard, William A;
- Cuneo, Matthew J;
- Dyrkheeva, Nadezhda S;
- Wilson, Samuel H
Publication type:
Article