Works by Duthaler, Urs

Results: 40

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00257

By:

Grünig, David;
Duthaler, Urs;
Krähenbühl, Stephan

Publication type:

Article

Dose Adjustment in Patients with Liver Cirrhosis – Comparison of Two Different Modeling Approaches.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 6, p. 1346, doi. 10.1002/cpt.2897

By:

Ozbey, Agustos C.;
Bachmann, Fabio;
Duthaler, Urs;
Annaert, Pieter;
Fowler, Stephen;
Umehara, Kenichi;
Parrott, Neil;
Krähenbühl, Stephan

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 822, doi. 10.1002/cpt.2821

By:

Holze, Friederike;
Becker, Anna M.;
Kolaczynska, Karolina E.;
Duthaler, Urs;
Liechti, Matthias E.

Publication type:

Article

Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 886, doi. 10.1002/cpt.2487

By:

Becker, Anna M.;
Holze, Friederike;
Grandinetti, Tanja;
Klaiber, Aaron;
Toedtli, Vanja E.;
Kolaczynska, Karolina E.;
Duthaler, Urs;
Varghese, Nimmy;
Eckert, Anne;
Grünblatt, Edna;
Liechti, Matthias E.

Publication type:

Article

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1505, doi. 10.1002/cpt.2141

By:

Bachmann, Fabio;
Duthaler, Urs;
Meyer zu Schwabedissen, Henriette E.;
Puchkov, Maxim;
Huwyler, Jörg;
Haschke, Manuel;
Krähenbühl, Stephan

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 3, p. 658, doi. 10.1002/cpt.2057

By:

Holze, Friederike;
Liechti, Matthias E.;
Hutten, Nadia R.P.W.;
Mason, Natasha L.;
Dolder, Patrick C.;
Theunissen, Eef L.;
Duthaler, Urs;
Feilding, Amanda;
Ramaekers, Johannes G.;
Kuypers, Kim P.C.

Publication type:

Article

PGC-1β modulates statin-associated myotoxicity in mice.

Published in:

Archives of Toxicology, 2019, v. 93, n. 2, p. 487, doi. 10.1007/s00204-018-2369-7

By:

Singh, François;
Zoll, Joffrey;
Duthaler, Urs;
Charles, Anne-Laure;
Panajatovic, Miljenko V.;
Laverny, Gilles;
McWilliams, Thomas G.;
Metzger, Daniel;
Geny, Bernard;
Krähenbühl, Stephan;
Bouitbir, Jamal

Publication type:

Article

Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.

Published in:

Nephrology Dialysis Transplantation, 2019, v. 34, n. 4, p. 692, doi. 10.1093/ndt/gfy285

By:

Leuppi-Taegtmeyer, Anne;
Duthaler, Urs;
Hammann, Felix;
Schmid, Yasmin;
Dickenmann, Michael;
Amico, Patricia;
Jehle, Andreas W;
Kalbermatter, Stefan;
Lenherr, Christoph;
Schwabedissen, Henriette E Meyer zu;
Haschke, Manuel;
Liechti, Matthias E;
Krähenbühl, Stephan

Publication type:

Article

Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants.

Published in:

Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02477-4

By:

Vogt, Severin B.;
Ley, Laura;
Erne, Livio;
Straumann, Isabelle;
Becker, Anna M.;
Klaiber, Aaron;
Holze, Friederike;
Vandersmissen, Anja;
Mueller, Lorenz;
Duthaler, Urs;
Rudin, Deborah;
Luethi, Dino;
Varghese, Nimmy;
Eckert, Anne;
Liechti, Matthias E.

Publication type:

Article

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans.

Published in:

Pharmaceutics, 2021, v. 13, n. 3, p. 401, doi. 10.3390/pharmaceutics13030401

By:

Schittny, Andreas;
Waldner, Samuel;
Duthaler, Urs;
Vorobyev, Alexander;
Abramovich, Rimma;
Krähenbühl, Stephan;
Puchkov, Maxim;
Huwyler, Jörg;
Timmins, Peter

Publication type:

Article

PGC‐1α plays a pivotal role in simvastatin‐induced exercise impairment in mice.

Published in:

Acta Physiologica, 2020, v. 228, n. 4, p. 1, doi. 10.1111/apha.13402

By:

Panajatovic, Miljenko Valentin;
Singh, François;
Roos, Noëmi Johanna;
Duthaler, Urs;
Handschin, Christoph;
Krähenbühl, Stephan;
Bouitbir, Jamal

Publication type:

Article

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency.

Published in:

Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00345

By:

Bouitbir, Jamal;
Haegler, Patrizia;
Singh, François;
Joerin, Lorenz;
Felser, Andrea;
Duthaler, Urs;
Krähenbühl, Stephan

Publication type:

Article

Pharmacokinetics, pharmacodynamics and urinary recovery of oral lysergic acid diethylamide administration in healthy participants.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 1, p. 200, doi. 10.1111/bcp.15887

By:

Holze, Friederike;
Erne, Livio;
Duthaler, Urs;
Liechti, Matthias E.

Publication type:

Article

Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4‐methylaminoantipyrine.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 4, p. 1885, doi. 10.1111/bcp.15108

By:

Bachmann, Fabio;
Meyer zu Schwabedissen, Henriette E.;
Duthaler, Urs;
Krähenbühl, Stephan

Publication type:

Article

Effect of deglucuronidation on the results of the Basel phenotyping cocktail.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 12, p. 4608, doi. 10.1111/bcp.14874

By:

Bachmann, Fabio;
Duthaler, Urs;
Krähenbühl, Stephan

Publication type:

Article

Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 1466, doi. 10.1111/bcp.14553

By:

Scholz, Irene;
Liakoni, Evangelia;
Hammann, Felix;
Grafinger, Katharina Elisabeth;
Duthaler, Urs;
Nagler, Michael;
Krähenbühl, Stephan;
Haschke, Manuel

Publication type:

Article

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults.

Published in:

British Journal of Clinical Pharmacology, 2020, v. 86, n. 2, p. 352, doi. 10.1111/bcp.14157

By:

Suenderhauf, Claudia;
Berger, Benjamin;
Puchkov, Maxim;
Schmid, Yasmin;
Müller, Sabine;
Huwyler, Jörg;
Haschke, Manuel;
Krähenbühl, Stephan;
Duthaler, Urs

Publication type:

Article

Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 7, p. 1474, doi. 10.1111/bcp.13918

By:

Holze, Friederike;
Duthaler, Urs;
Vizeli, Patrick;
Müller, Felix;
Borgwardt, Stefan;
Liechti, Matthias E.

Publication type:

Article

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 3, p. 626, doi. 10.1111/bcp.13840

By:

Duthaler, Urs;
Suenderhauf, Claudia;
Karlsson, Mats O.;
Hussner, Janine;
Meyer zu Schwabedissen, Henriette;
Krähenbühl, Stephan;
Hammann, Felix

Publication type:

Article

Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study.

Published in:

Parasites & Vectors, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13071-021-04675-9

By:

Nicolas, Patricia;
Kiuru, Caroline;
Wagah, Martin G.;
Muturi, Martha;
Duthaler, Urs;
Hammann, Felix;
Maia, Marta;
Chaccour, Carlos

Publication type:

Article

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study.

Published in:

European Journal of Clinical Pharmacology, 2019, v. 75, n. 11, p. 1491, doi. 10.1007/s00228-019-02720-2

By:

Ziesenitz, Victoria C.;
Rodieux, Frédérique;
Atkinson, Andrew;
Borter, Carole;
Bielicki, Julia A.;
Haschke, Manuel;
Duthaler, Urs;
Bachmann, Fabio;
Erb, Thomas O.;
Gürtler, Nicolas;
Holland-Cunz, Stefan;
van den Anker, Johannes N.;
Gotta, Verena;
Pfister, Marc

Publication type:

Article

Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.620635

By:

Blaser, Lea S;
Duthaler, Urs;
Bouitbir, Jamal;
Leuppi-Taegtmeyer, Anne B;
Liakoni, Evangelia;
Dolf, Reto;
Mayr, Michael;
Drewe, Jürgen;
Krähenbühl, Stephan;
Haschke, Manuel

Publication type:

Article

The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.

Published in:

Clinical Pharmacokinetics, 2023, v. 62, n. 8, p. 1141, doi. 10.1007/s40262-023-01261-3

By:

Duthaler, Urs;
Bachmann, Fabio;
Ozbey, Agustos C.;
Umehara, Kenichi;
Parrott, Neil;
Fowler, Stephen;
Krähenbühl, Stephan

Publication type:

Article

Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel PhenotypingCocktail Differently.

Published in:

Clinical Pharmacokinetics, 2022, v. 61, n. 7, p. 1039, doi. 10.1007/s40262-022-01119-0

By:

Duthaler, Urs;
Bachmann, Fabio;
Suenderhauf, Claudia;
Grandinetti, Tanja;
Pfefferkorn, Florian;
Haschke, Manuel;
Hruz, Petr;
Bouitbir, Jamal;
Krähenbühl, Stephan

Publication type:

Article

Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist.

Published in:

Clinical Pharmacokinetics, 2021, v. 60, n. 10, p. 1349, doi. 10.1007/s40262-021-01028-8

By:

Berger, Benjamin;
Dingemanse, Jasper;
Sabattini, Giancarlo;
Delahaye, Stéphane;
Duthaler, Urs;
Muehlan, Clemens;
Krähenbühl, Stephan

Publication type:

Article

Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells.

Published in:

Toxicological Sciences, 2018, v. 164, n. 2, p. 477, doi. 10.1093/toxsci/kfy101

By:

Grünig, David;
Felser, Andrea;
Duthaler, Urs;
Bouitbir, Jamal;
Krähenbühl, Stephan

Publication type:

Article

Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants.

Published in:

International Journal of Neuropsychopharmacology, 2023, v. 26, n. 2, p. 97, doi. 10.1093/ijnp/pyac075

By:

Becker, Anna M;
Klaiber, Aaron;
Holze, Friederike;
Istampoulouoglou, Ioanna;
Duthaler, Urs;
Varghese, Nimmy;
Eckert, Anne;
Liechti, Matthias E

Publication type:

Article

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.

Published in:

Journal of Mass Spectrometry, 2011, v. 46, n. 2, p. 172, doi. 10.1002/jms.1883

By:

Duthaler, Urs;
Keiser, Jennifer;
Huwyler, Jörg

Publication type:

Article

Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes.

Published in:

Malaria Journal, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12936-023-04624-0

By:

Kern, Charlotte;
Müller, Pie;
Chaccour, Carlos;
Liechti, Matthias E.;
Hammann, Felix;
Duthaler, Urs

Publication type:

Article

Effects of 3,4-Methylenedioxymethamphetamine on Conditioned Fear Extinction and Retention in a Crossover Study in Healthy Subjects.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.906639

By:

Vizeli, Patrick;
Straumann, Isabelle;
Duthaler, Urs;
Varghese, Nimmy;
Eckert, Anne;
Paulus, Martin P.;
Risbrough, Victoria;
Liechti, Matthias E.

Publication type:

Article

In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1391689

By:

Thomann, Jan;
Kolaczynska, Karolina E.;
Stoeckmann, Oliver V.;
Rudin, Deborah;
Vizeli, Patrick;
Hoener, Marius C.;
Pryce, Christopher R.;
Vollenweider, Franz X.;
Liechti, Matthias E.;
Duthaler, Urs

Publication type:

Article

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.00774

By:

Berger, Benjamin;
Bachmann, Fabio;
Duthaler, Urs;
Krähenbühl, Stephan;
Haschke, Manuel

Publication type:

Article

Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use.

Published in:

Journal of Clinical Pharmacology, 2024, v. 64, n. 10, p. 1295, doi. 10.1002/jcph.2462

By:

Dao, Kim;
Buettcher, Michael;
Golhen, Klervi;
Kost, Jonas;
Schittny, Andreas;
Duthaler, Urs;
Atkinson, Andrew;
Haefliger, David;
Guidi, Monia;
Bardinet, Carine;
Chtioui, Haithem;
Boulekbache, Abdelwahab;
Buclin, Thierry;
Huwyler, Jörg;
Pfister, Marc;
Rothuizen, Laura E.

Publication type:

Article

Pharmacokinetics‐Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study.

Published in:

Journal of Clinical Pharmacology, 2024, v. 64, n. 7, p. 810, doi. 10.1002/jcph.2428

By:

Anliker‐Ort, Marion;
Rodieux, Frédérique;
Ziesenitz, Victoria C.;
Atkinson, Andrew;
Bielicki, Julia A.;
Erb, Thomas O.;
Gürtler, Nicolas;
Holland‐Cunz, Stefan;
Duthaler, Urs;
Rudin, Deborah;
Haschke, Manuel;
van den Anker, John;
Pfister, Marc;
Gotta, Verena

Publication type:

Article

The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes.

Published in:

PLoS Pathogens, 2021, v. 17, n. 3, p. 1, doi. 10.1371/journal.ppat.1009382

By:

Duthaler, Urs;
Weber, Michael;
Hofer, Lorenz;
Chaccour, Carlos;
Maia, Marta;
Müller, Pie;
Krähenbühl, Stephan;
Hammann, Felix

Publication type:

Article

The effect of food on the pharmacokinetics of oral ivermectin.

Published in:

2020

By:

Duthaler, Urs;
Leisegang, Rory;
Karlsson, Mats O;
Krähenbühl, Stephan;
Hammann, Felix

Publication type:

journal article

Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions.

Published in:

2018

By:

Duthaler, Urs;
Berger, Benjamin;
Erb, Stefan;
Battegay, Manuel;
Letang, Emili;
Gaugler, Stefan;
Natamatungiro, Alex;
Mnzava, Dorcas;
Donzelli, Massimiliano;
Krähenbühl, Stephan;
Haschke, Manuel

Publication type:

journal article

Inter-individual variability in neural response to low doses of LSD.

Published in:

Translational Psychiatry, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41398-024-03013-8

By:

Hutten, Nadia R. P. W.;
Quaedflieg, Conny W. E. M.;
Mason, Natasha L.;
Theunissen, Eef L.;
Liechti, Matthias E.;
Duthaler, Urs;
Kuypers, Kim P. C.;
Bonnelle, Valerie;
Feilding, Amanda;
Ramaekers, Johannes G.

Publication type:

Article

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients.

Published in:

PLoS Neglected Tropical Diseases, 2016, v. 10, n. 5, p. 1, doi. 10.1371/journal.pntd.0004700

By:

Meister, Isabel;
Kovac, Jana;
Duthaler, Urs;
Odermatt, Peter;
Huwyler, Jörg;
Vanobberghen, Fiona;
Sayasone, Somphou;
Keiser, Jennifer

Publication type:

Article

BOHEMIA: Broad One Health Endectocide-based Malaria Intervention in Africa—a phase III cluster-randomized, open-label, clinical trial to study the safety and efficacy of ivermectin mass drug administration to reduce malaria transmission in two African settings

Published in:

Trials, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s13063-023-07098-2

By:

Chaccour, Carlos;
Casellas, Aina;
Hammann, Felix;
Ruiz-Castillo, Paula;
Nicolas, Patricia;
Montaña, Julia;
Mael, Mary;
Selvaraj, Prashant;
Duthaler, Urs;
Mrema, Sigilbert;
Kakolwa, Mwaka;
Lyimo, Issa;
Okumu, Fredros;
Marathe, Achla;
Schürch, Roger;
Elobolobo, Eldo;
Sacoor, Charfudin;
Saute, Francisco;
Xia, Kang;
Jones, Caroline

Publication type:

Article