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The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.
Published in:
Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00311
By:
- Maneckaf, Destiny-Love;
- Vanderperref, Benoît;
- Fon, Edward A.;
- Durcan, Thomas M.
Publication type:
Article
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Published in:
Brain: A Journal of Neurology, 2024, v. 147, n. 2, p. 427, doi. 10.1093/brain/awad298
By:
- Dorion, Marie-France;
- Yaqubi, Moein;
- Senkevich, Konstantin;
- Kieran, Nicholas W;
- MacDonald, Adam;
- Chen, Carol X Q;
- Luo, Wen;
- Wallis, Amber;
- Shlaifer, Irina;
- Hall, Jeffery A;
- Dudley, Roy W R;
- Glass, Ian A;
- Laboratory, Birth Defects Research;
- Stratton, Jo Anne;
- Fon, Edward A;
- Bartels, Tim;
- Antel, Jack P;
- Gan-or, Ziv;
- Durcan, Thomas M;
- Healy, Luke M
Publication type:
Article
Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-22158-4
By:
- Sheta, Razan;
- Teixeira, Maxime;
- Idi, Walid;
- Pierre, Marion;
- de Rus Jacquet, Aurelie;
- Emond, Vincent;
- Zorca, Cornelia E.;
- Vanderperre, Benoît;
- Durcan, Thomas M.;
- Fon, Edward A.;
- Calon, Frédéric;
- Chahine, Mohamed;
- Oueslati, Abid
Publication type:
Article
Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders.
Published in:
Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00047
By:
- Han, Chanshuai;
- Chaineau, Mathilde;
- Chen, Carol X.-Q.;
- Beitel, Lenore K.;
- Durcan, Thomas M.
Publication type:
Article
Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single‐Cell Resolution.
Published in:
Laser & Photonics Reviews, 2023, v. 17, n. 8, p. 1, doi. 10.1002/lpor.202300443
By:
- Englert, Ludwig;
- Lacalle‐Aurioles, María;
- Mohamed, Nguyen‐Vi;
- Lépine, Paula;
- Mathur, Meghna;
- Ntziachristos, Vasilis;
- Durcan, Thomas M.;
- Aguirre, Juan
Publication type:
Article
Editorial: The next generation of tools and technologies for studying human neurons in a dish.
Published in:
Frontiers in Cellular Neuroscience, 2023, p. 01, doi. 10.3389/fncel.2023.1196543
By:
- Durcan, Thomas M.;
- Axtman, Alison D.
Publication type:
Article
Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.
Published in:
Journal of Neurochemistry, 2024, v. 168, n. 8, p. 1546, doi. 10.1111/jnc.15967
By:
- Tullo, Stephanie;
- Miranda, Aline S.;
- del Cid‐Pellitero, Esther;
- Lim, Mei Peng;
- Gallino, Daniel;
- Attaran, Anoosha;
- Patel, Raihaan;
- Novikov, Vladislav;
- Park, Megan;
- Beraldo, Flavio H.;
- Luo, Wen;
- Shlaifer, Irina;
- Durcan, Thomas M.;
- Bussey, Timothy J.;
- Saksida, Lisa M.;
- Fon, Edward A.;
- Prado, Vania F.;
- Prado, Marco A. M.;
- Chakravarty, M. Mallar
Publication type:
Article
Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine.
Published in:
Biomolecules (2218-273X), 2024, v. 14, n. 7, p. 857, doi. 10.3390/biom14070857
By:
- Coulombe, Benoit;
- Chapleau, Alexandra;
- Macintosh, Julia;
- Durcan, Thomas M.;
- Poitras, Christian;
- Moursli, Yena A.;
- Faubert, Denis;
- Pinard, Maxime;
- Bernard, Geneviève
Publication type:
Article
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Published in:
EMBO Journal, 2014, v. 33, n. 21, p. 2473, doi. 10.15252/embj.201489729
By:
- Durcan, Thomas M;
- Tang, Matthew Y;
- Pérusse, Joëlle R;
- Dashti, Eman A;
- Aguileta, Miguel A;
- McLelland, Gian‐Luca;
- Gros, Priti;
- Shaler, Thomas A;
- Faubert, Denis;
- Coulombe, Benoit;
- Fon, Edward A
Publication type:
Article
Structure-based design and characterization of Parkin-activating mutations.
Published in:
Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201419
By:
- Stevens, Michael U.;
- Croteau, Nathalie;
- Eldeeb, Mohamed A.;
- Antico, Odetta;
- Zhi Wei Zeng;
- Toth, Rachel;
- Durcan, Thomas M.;
- Springer, Wolfdieter;
- Fon, Edward A.;
- Muqit, Miratul M. K.;
- Trempe, Jean-François
Publication type:
Article
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01746-6
By:
- Jin, Jack Wuyang;
- Fan, Xuelai;
- del Cid-Pellitero, Esther;
- Liu, Xing-Xing;
- Zhou, Limin;
- Dai, Chunfang;
- Gibbs, Ebrima;
- He, Wenting;
- Li, Hongjie;
- Wu, Xiaobin;
- Hill, Austin;
- Leavitt, Blair R.;
- Cashman, Neil;
- Liu, Lidong;
- Lu, Jie;
- Durcan, Thomas M.;
- Dong, Zhifang;
- Fon, Edward A.;
- Wang, Yu Tian
Publication type:
Article
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.
Published in:
PLoS Biology, 2022, v. 20, n. 3, p. 1, doi. 10.1371/journal.pbio.3001578
By:
- Bérard, Morgan;
- Sheta, Razan;
- Malvaut, Sarah;
- Rodriguez-Aller, Raquel;
- Teixeira, Maxime;
- Idi, Walid;
- Turmel, Roxanne;
- Alpaugh, Melanie;
- Dubois, Marilyn;
- Dahmene, Manel;
- Sales, Charleen;
- Lamontagne-Proulx, Jérôme;
- St-Pierre, Marie-Kim;
- Tavassoly, Omid;
- Luo, Wen;
- Del Cid-Pellitero, Esther;
- Qazi, Raza;
- Jeong, Jae-Woong;
- Durcan, Thomas M.;
- Vallières, Luc
Publication type:
Article
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice.
Published in:
NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00601-1
By:
- Schorova, Lenka;
- Bedard, Nathalie;
- Khayachi, Anouar;
- Ho, Hung-Hsiang;
- Bolivar-Pedroso, Joao;
- Huynh, Julie;
- Piccirelli, Mikaela;
- Wang, Yifei;
- Plourde, Marie;
- Luo, Wen;
- del Cid-Pellitero, Esther;
- Shlaifer, Irina;
- Castellanos-Montiel, María José;
- Yu, Ziqi;
- Valenzuela, Dulce Valeria Carrillo;
- Lacalle-Aurioles, María;
- Kriz, Anita;
- Ye, Yihong;
- Durcan, Thomas M.;
- Wing, Simon S.
Publication type:
Article
Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis.
Published in:
Journal of Cell Biology, 2008, v. 181, n. 4, p. 595, doi. 10.1083/jcb.200711160
By:
- Durcan, Thomas M.;
- Halpin, Elizabeth S.;
- Rao, Trisha;
- Collins, Nicholas S.;
- Tribble, Emily K.;
- Hornick, Jessica E.;
- Hinchcliffe, Edward H.
Publication type:
Article
Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.91645
By:
- Ayoubi, Riham;
- Ryan, Joel;
- Biddle, Michael S.;
- Alshafie, Walaa;
- Fotouhi, Maryam;
- Bolivar, Sara Gonzalez;
- Moleon, Vera Ruiz;
- Eckmann, Peter;
- Worrall, Donovan;
- McDowell, Ian;
- Southern, Kathleen;
- Reintsch, Wolfgang;
- Durcan, Thomas M.;
- Brown, Claire;
- Bandrowski, Anita;
- Virk, Harvinder;
- Edwards, Aled M.;
- McPherson, Peter;
- Laflamme, Carl
Publication type:
Article
Centrosome biogenesis continues in the absence of microtubules during prolonged S-phase arrest.
Published in:
Journal of Cellular Physiology, 2010, v. 225, n. 2, p. 454, doi. 10.1002/jcp.22222
By:
- COLLINS, ELIZABETH S.;
- HORNICK, JESSICA E.;
- DURCAN, THOMAS M.;
- COLLINS, NICHOLAS S.;
- ARCHER, WILLIAM;
- KARANJEET, KUL B.;
- VAUGHAN, KEVIN T.;
- HINCHCLIFFE, EDWARD H.
Publication type:
Article
Centrosome duplication proceeds during mimosine-induced G<sub>1</sub> cell cycle arrest.
Published in:
Journal of Cellular Physiology, 2008, v. 215, n. 1, p. 182, doi. 10.1002/jcp.21298
By:
- Durcan, Thomas M.;
- Halpin, Elizabeth S.;
- Casaletti, Luciana;
- Vaughan, Kevin T.;
- Pierson, Maggie R.;
- Woods, Shane;
- Hinchcliffe, Edward H.
Publication type:
Article
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Published in:
Acta Neuropathologica, 2022, v. 144, n. 5, p. 881, doi. 10.1007/s00401-022-02491-8
By:
- Lackie, Rachel E.;
- de Miranda, Aline S.;
- Lim, Mei Peng;
- Novikov, Vladislav;
- Madrer, Nimrod;
- Karunatilleke, Nadun C.;
- Rutledge, Benjamin S.;
- Tullo, Stephanie;
- Brickenden, Anne;
- Maitland, Matthew E. R.;
- Greenberg, David;
- Gallino, Daniel;
- Luo, Wen;
- Attaran, Anoosha;
- Shlaifer, Irina;
- Del Cid Pellitero, Esther;
- Schild-Poulter, Caroline;
- Durcan, Thomas M.;
- Fon, Edward A.;
- Duennwald, Martin
Publication type:
Article
α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization.
Published in:
Cells (2073-4409), 2023, v. 12, n. 7, p. 1083, doi. 10.3390/cells12071083
By:
- Feller, Benjamin;
- Fallon, Aurélie;
- Luo, Wen;
- Nguyen, Phuong Trang;
- Shlaifer, Irina;
- Lee, Alfred Kihoon;
- Chofflet, Nicolas;
- Yi, Nayoung;
- Khaled, Husam;
- Karkout, Samer;
- Bourgault, Steve;
- Durcan, Thomas M.;
- Takahashi, Hideto
Publication type:
Article
An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids.
Published in:
Cells (2073-4409), 2023, v. 12, n. 4, p. 545, doi. 10.3390/cells12040545
By:
- Castellanos-Montiel, María José;
- Chaineau, Mathilde;
- Franco-Flores, Anna Kristyna;
- Haghi, Ghazal;
- Carrillo-Valenzuela, Dulce;
- Reintsch, Wolfgang E.;
- Chen, Carol X.-Q.;
- Durcan, Thomas M.
Publication type:
Article
Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease.
Published in:
Cells (2073-4409), 2022, v. 11, n. 3, p. 399, doi. 10.3390/cells11030399
By:
- Soubannier, Vincent;
- Chaineau, Mathilde;
- Gursu, Lale;
- Haghi, Ghazal;
- Franco Flores, Anna Kristyna;
- Rouleau, Guy;
- Durcan, Thomas M.;
- Stifani, Stefano
Publication type:
Article
Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures.
Published in:
Cells (2073-4409), 2020, v. 9, n. 11, p. 2434, doi. 10.3390/cells9112434
By:
- Zhang, Issan;
- Lépine, Paula;
- Han, Chanshuai;
- Lacalle-Aurioles, María;
- Chen, Carol X.-Q.;
- Haag, Rainer;
- Durcan, Thomas M.;
- Maysinger, Dusica
Publication type:
Article
The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS.
Published in:
Frontiers in Cellular Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fncel.2020.594975
By:
- Castellanos-Montiel, María José;
- Chaineau, Mathilde;
- Durcan, Thomas M.
Publication type:
Article
Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury.
Published in:
Frontiers in Cellular Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fncel.2020.594304
By:
- Lacalle-Aurioles, María;
- Cassel de Camps, Camille;
- Zorca, Cornelia E.;
- Beitel, Lenore K.;
- Durcan, Thomas M.
Publication type:
Article
The use of a SOX10 reporter toward ameliorating oligodendrocyte lineage differentiation from human induced pluripotent stem cells.
Published in:
Glia, 2024, v. 72, n. 6, p. 1165, doi. 10.1002/glia.24524
By:
- Piscopo, Valerio E. C.;
- Chapleau, Alexandra;
- Blaszczyk, Gabriela J.;
- Sirois, Julien;
- You, Zhipeng;
- Soubannier, Vincent;
- Chen, Carol X.‐Q.;
- Bernard, Geneviève;
- Antel, Jack P.;
- Durcan, Thomas M.
Publication type:
Article
Cover Image, Volume 72, Issue 6.
Published in:
Glia, 2024, v. 72, n. 6, p. C1, doi. 10.1002/glia.24403
By:
- Piscopo, Valerio E. C.;
- Chapleau, Alexandra;
- Blaszczyk, Gabriela J.;
- Sirois, Julien;
- You, Zhipeng;
- Soubannier, Vincent;
- Chen, Carol X.‐Q.;
- Bernard, Geneviève;
- Antel, Jack P.;
- Durcan, Thomas M.
Publication type:
Article
Illumination of understudied ciliary kinases.
Published in:
Frontiers in Molecular Biosciences, 2024, p. 1, doi. 10.3389/fmolb.2024.1352781
By:
- Flax, Raymond G.;
- Rosston, Peter;
- Rocha, Cecilia;
- Anderson, Brian;
- Capener, Jacob L.;
- Durcan, Thomas M.;
- Drewry, David H.;
- Prinos, Panagiotis;
- Axtman, Alison D.
Publication type:
Article
The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 1, p. 141, doi. 10.1093/hmg/ddq452
By:
- Durcan, Thomas M.;
- Kontogiannea, Maria;
- Thorarinsdottir, Thorhildur;
- Fallon, Lara;
- Williams, Aislinn J.;
- Djarmati, Ana;
- Fantaneanu, Tadeu;
- Paulson, Henry L.;
- Fon, Edward A.
Publication type:
Article
The cell and molecular biology of neurodegenerative diseases: an overview.
Published in:
Frontiers in Neurology, 2013, v. 4, p. 1, doi. 10.3389/fneur.2013.00194
By:
- Montie, Heather L.;
- Durcan, Thomas M.
Publication type:
Article
Microfabricated dynamic brain organoid cocultures to assess the effects of surface geometry on assembloid formation.
Published in:
Biotechnology Journal, 2024, v. 19, n. 8, p. 1, doi. 10.1002/biot.202400070
By:
- Cassel de Camps, Camille;
- Rostami, Sabra;
- Xu, Vanessa;
- Li, Chen;
- Lépine, Paula;
- Durcan, Thomas M.;
- Moraes, Christopher
Publication type:
Article
An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 17, p. 9493, doi. 10.3390/ijms25179493
By:
- Gandy, Anelya;
- Maussion, Gilles;
- Al-Habyan, Sara;
- Nicouleau, Michael;
- You, Zhipeng;
- Chen, Carol X.-Q.;
- Abdian, Narges;
- Aprahamian, Nathalia;
- Krahn, Andrea I.;
- Larocque, Louise;
- Durcan, Thomas M.;
- Deneault, Eric
Publication type:
Article
The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases.
Published in:
Molecular Brain, 2024, v. 17, n. 1, p. 1, doi. 10.1186/s13041-024-01088-4
By:
- Coulombe, Benoit;
- Durcan, Thomas M.;
- Bernard, Geneviève;
- Moursli, Asmae;
- Poitras, Christian;
- Faubert, Denis;
- Pinard, Maxime
Publication type:
Article

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