Found: 8

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  • Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

    Published in:
    Angewandte Chemie, 2019, v. 131, n. 2, p. 525, doi. 10.1002/ange.201810179
    By:
    • Vazquez‐Rodriguez, Saleta;
    • Wright, Miranda;
    • Rogers, Catherine M.;
    • Cribbs, Adam P.;
    • Velupillai, Srikannathasan;
    • Philpott, Martin;
    • Lee, Henry;
    • Dunford, James E.;
    • Huber, Kilian V. M.;
    • Robers, Matthew B.;
    • Vasta, James D.;
    • Thezenas, Marie‐Laetitia;
    • Bonham, Sarah;
    • Kessler, Benedikt;
    • Bennett, James;
    • Fedorov, Oleg;
    • Raynaud, Florence;
    • Donovan, Adam;
    • Blagg, Julian;
    • Bavetsias, Vassilios
    Publication type:
    Article

  • Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone‐Relevant Cell Types.

    Published in:
    Journal of Bone & Mineral Research, 2018, v. 33, n. 12, p. 2091, doi. 10.1002/jbmr.3580
    By:
    • Roca‐Ayats, Neus;
    • Ng, Pei Ying;
    • Garcia‐Giralt, Natàlia;
    • Falcó‐Mascaró, Maite;
    • Cozar, Mónica;
    • Abril, Josep Francesc;
    • Quesada Gómez, José Manuel;
    • Prieto‐Alhambra, Daniel;
    • Nogués, Xavier;
    • Dunford, James E;
    • Russell, R Graham;
    • Baron, Roland;
    • Grinberg, Daniel;
    • Balcells, Susana;
    • Díez‐Pérez, Adolfo
    Publication type:
    Article

  • The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

    Published in:
    Journal of Bone & Mineral Research, 2017, v. 32, n. 9, p. 1860, doi. 10.1002/jbmr.3138
    By:
    • Lawson, Michelle A;
    • Chantry, Andrew D;
    • Paton-Hough, Julia;
    • Evans, Holly R;
    • Lath, Darren;
    • Tsoumpra, Maria K;
    • Ebetino, Frank H;
    • Russell, R Graham G;
    • Mazur, Adam;
    • Lundy, Mark W;
    • Dobson, Roy LM;
    • Quijano, Michael;
    • Jeans, Gwyn;
    • Kwaasi, Aaron A;
    • Dunford, James E;
    • Duan, Xuchen;
    • Triffitt, James T
    Publication type:
    Article

  • Bisphosphonates.

    Published in:
    Annals of the New York Academy of Sciences, 2007, v. 1117, p. 209, doi. 10.1196/annals.1402.089
    By:
    • RUSSELL, R. GRAHAM G.;
    • XIA, ZHIDAO;
    • DUNFORD, JAMES E.;
    • OPPERMANN, UDO;
    • KWAASI, AARON;
    • HULLEY, PHILIPPA A.;
    • KAVANAGH, KATHRYN L.;
    • TRIFFITT, JAMES T.;
    • LUNDY, MARK W.;
    • PHIPPS, ROGER J.;
    • BARNETT, BOBBY L.;
    • COXON, FRASER P.;
    • ROGERS, MICHAEL J.;
    • WATTS, NELSON B.;
    • EBETINO, FRANK H.
    Publication type:
    Article

  • GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.

    Published in:
    2020
    By:
    • Foley, A. Reghan;
    • Zou, Yaqun;
    • Dunford, James E.;
    • Rooney, Jachinta;
    • Chandra, Goutam;
    • Xiong, Hui;
    • Straub, Volker;
    • Voit, Thomas;
    • Romero, Norma;
    • Donkervoort, Sandra;
    • Hu, Ying;
    • Markello, Thomas;
    • Horn, Adam;
    • Qebibo, Leila;
    • Dastgir, Jahannaz;
    • Meilleur, Katherine G.;
    • Finkel, Richard S.;
    • Fan, Yanbin;
    • Mamchaoui, Kamel;
    • Duguez, Stephanie
    Publication type:
    journal article

  • Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

    Published in:
    Angewandte Chemie International Edition, 2019, v. 58, n. 2, p. 515, doi. 10.1002/anie.201810179
    By:
    • Vazquez‐Rodriguez, Saleta;
    • Wright, Miranda;
    • Rogers, Catherine M.;
    • Cribbs, Adam P.;
    • Velupillai, Srikannathasan;
    • Philpott, Martin;
    • Lee, Henry;
    • Dunford, James E.;
    • Huber, Kilian V. M.;
    • Robers, Matthew B.;
    • Vasta, James D.;
    • Thezenas, Marie‐Laetitia;
    • Bonham, Sarah;
    • Kessler, Benedikt;
    • Bennett, James;
    • Fedorov, Oleg;
    • Raynaud, Florence;
    • Donovan, Adam;
    • Blagg, Julian;
    • Bavetsias, Vassilios
    Publication type:
    Article

  • Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases.

    Published in:
    PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007113
    By:
    • Pilka, Ewa S.;
    • Niesen, Frank H.;
    • Wen Hwa Lee;
    • Yasser El-Hawari;
    • Dunford, James E.;
    • Kochan, Grazyna;
    • Wsol, Vladimir;
    • Martin, Hans-Joerg;
    • Maser, Edmund;
    • Oppermann, Udo
    Publication type:
    Article

  • Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases.

    Published in:
    Journal of Bone & Mineral Research, 2006, v. 21, n. 5, p. 684, doi. 10.1359/jbmr.060118
    By:
    • Dunford, James E;
    • Rogers, Michael J;
    • Ebetino, Frank H;
    • Phipps, Roger J;
    • Coxon, Fraser P
    Publication type:
    Article