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The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.
- Published in:
- Frontiers in Neuroscience, 2017, p. 1, doi. 10.3389/fnins.2017.00702
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- Publication type:
- Article
Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 49, p. 16419, doi. 10.1523/JNEUROSCI.3317-10.2010
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- Publication type:
- Article
Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 48, p. 16419, doi. 10.1523/JNEUROSCI.3317-10.2010
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- Publication type:
- Article
Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 48, p. 12798, doi. 10.1523/JNEUROSCI.4101-08.2008
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- Publication type:
- Article
Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3β Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 10, p. 2624, doi. 10.1523/JNEUROSCI.5245-07.2008
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- Publication type:
- Article
Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 50, p. 13635, doi. 10.1523/JNEUROSCI.3949-07.2007
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- Publication type:
- Article
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
- Published in:
- FASEB Journal, 2009, v. 23, n. 8, p. 2595, doi. 10.1096/fj.08-122424
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- Publication type:
- Article
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice.
- Published in:
- Translational Psychiatry, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41398-022-01881-6
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- Publication type:
- Article
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s diseaselike pathology.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01444-0
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- Publication type:
- Article
PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 595, p. 1, doi. 10.1126/scitranslmed.aba7394
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- Publication type:
- Article
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
- Published in:
- Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01280-w
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- Publication type:
- Article
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
- Published in:
- Molecular Neurodegeneration, 2010, v. 5, p. 45, doi. 10.1186/1750-1326-5-45
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- Publication type:
- Article
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus.
- Published in:
- PLoS Biology, 2020, v. 18, n. 8, p. 1, doi. 10.1371/journal.pbio.3000851
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- Publication type:
- Article
Signatures of disrupted synaptic maintenance in the entorhinal cortex of both pathology‐free APOE4 carriers and aged APOE4 mice: Molecular and cell biology/synaptic disruption.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046192
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- Publication type:
- Article
Cell‐type specific selective vulnerability to pathological tau in Alzheimer's disease: Molecular and cell biology/tau.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043149
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- Publication type:
- Article
Investigating the contribution of an intronic variation at the trim11 locus to pathological and clinical heterogeneity in progressive supranuclear palsy: Molecular and cell biology/protein clearance/recycling.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042936
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- Publication type:
- Article
Extracellular vesicles derived from postmortem human brain tissue contain seed‐competent C‐terminal tau fragments, and provide proteomic clues to the identity of selectively vulnerable cell populations in human tauopathies: Molecular and cell biology: Tau‐related mechanisms
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042870
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- Publication type:
- Article
Deficiency of WFS1 increases vulnerability to pathological tau in vitro and in vivo: Molecular and cell biology/tau.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042085
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- Publication type:
- Article
P3‐175: APOE4 INDUCES REGION‐SPECIFIC DYSFUNCTION IN THE ENTORHINAL CORTEX OF AGED APOE4 MICE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P997, doi. 10.1016/j.jalz.2019.06.3204
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- Publication type:
- Article
O2‐01‐04: CELL TYPE–SPECIFIC TAU HOMEOSTASIS SIGNATURES ASSOCIATED WITH SELECTIVE VULNERABILITY OF EXCITATORY NEURONS TO TAU PATHOLOGY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P609, doi. 10.1016/j.jalz.2018.06.2642
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- Publication type:
- Article
P1‐094: UNILATERAL FOCUSED ULTRASOUND‐INDUCED BLOOD‐BRAIN BARRIER OPENING ALTERS THE PATHOLOGICAL PROFILE OF THE 3XTG ALZHEIMER'S MOUSE MODEL.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P307, doi. 10.1016/j.jalz.2018.06.096
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- Publication type:
- Article
P1‐022: ATTENUATION OF Aβ‐ASSOCIATED HYPERACTIVITY IN THE ENTORHINAL CORTEX AMELIORATES HIPPOCAMPAL PLAQUE BURDEN.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P273, doi. 10.1016/j.jalz.2018.06.023
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- Publication type:
- Article
UNILATERAL FOCUSED ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING RE-DISTRIBUTES HYPERPHOSPHORYLATED TAU IN AN ALZHEIMER’S MOUSE MODEL.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P593, doi. 10.1016/j.jalz.2017.07.228
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- Publication type:
- Article
APOE4 INDUCES ENTORHINAL CORTEX HYPERMETABOLISM IN THE ABSENCE OF OVERT ALZHEIMER’S DISEASE PATHOLOGY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P204, doi. 10.1016/j.jalz.2017.07.070
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- Publication type:
- Article
Phospholipase D2 ablation ameliorates Alzheimer-linked synaptic dysfunction and cognitive deficits: Mechanistic insights from lipidomic analysis
- Published in:
- 2010
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- Publication type:
- Abstract
Comparative lipid profiling of Alzheimer mouse models
- Published in:
- 2010
- By:
- Publication type:
- Abstract
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.
- Published in:
- Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01494-6
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- Publication type:
- Article
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61142-8
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- Publication type:
- Article
Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 12, p. 3090, doi. 10.1523/JNEUROSCI.4854-06.2007
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- Publication type:
- Article
Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients.
- Published in:
- Theranostics, 2023, v. 13, n. 12, p. 4102, doi. 10.7150/thno.79898
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- Publication type:
- Article
Is tau aggregation toxic or protective?
- Published in:
- 2008
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- Publication type:
- journal article
Is Tau Aggregation Toxic or Protective?
- Published in:
- Journal of Alzheimer's Disease, 2008, v. 14, n. 4, p. 453, doi. 10.3233/JAD-2008-14415
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- Publication type:
- Article
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
- Published in:
- Nature Neuroscience, 2014, v. 17, n. 2, p. 304, doi. 10.1038/nn.3606
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- Publication type:
- Article
Mechanisms of Protein Seeding in Neurodegenerative Diseases.
- Published in:
- JAMA Neurology, 2013, v. 70, n. 3, p. 304, doi. 10.1001/jamaneurol.2013.1453
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- Publication type:
- Article
3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.
- Published in:
- PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0159463
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- Publication type:
- Article
Memory dysfunction in mild cognitive impairment (MCI) and early Alzheimer disease (AD) dementia is closely associated with synapse loss, and shows significant correlation with pathological tau in synapses and inflammatory glial cell responses in postmortem human brain
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078600
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- Publication type:
- Article
Memory dysfunction in mild cognitive impairment (MCI) and early Alzheimer disease (AD) dementia is closely associated with synapse loss, and shows significant correlation with pathological tau in synapses and inflammatory glial cell responses in postmortem human brain
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078600
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- Publication type:
- Article
Methods in Prioritizing Pathways and Targets from Expression Data.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.066331
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- Publication type:
- Article
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051680
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- Publication type:
- Article
Spatial transcriptomics of human middle temporal gyrus reveals layer‐specific gene expression in early Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.050540
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- Publication type:
- Article