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Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-01072-8
By:
- Ibanez, Laura;
- Bahena, Jorge A.;
- Yang, Chengran;
- Dube, Umber;
- Farias, Fabiana H. G.;
- Budde, John P.;
- Bergmann, Kristy;
- Brenner-Webster, Carol;
- Morris, John C.;
- Perrin, Richard J.;
- Cairns, Nigel J.;
- O'Donnell, John;
- Álvarez, Ignacio;
- Diez-Fairen, Monica;
- Aguilar, Miquel;
- Miller, Rebecca;
- Davis, Albert A.;
- Pastor, Pau;
- Kotzbauer, Paul;
- Campbell, Meghan C.
Publication type:
Article
Metabolomic and lipidomic signatures in autosomal dominant and late‐onset Alzheimer's disease brains.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 5, p. 1785, doi. 10.1002/alz.12800
By:
- Novotny, Brenna C.;
- Fernandez, Maria Victoria;
- Wang, Ciyang;
- Budde, John P.;
- Bergmann, Kristy;
- Eteleeb, Abdallah M.;
- Bradley, Joseph;
- Webster, Carol;
- Ebl, Curtis;
- Norton, Joanne;
- Gentsch, Jen;
- Dube, Umber;
- Wang, Fengxian;
- Morris, John C.;
- Bateman, Randall J.;
- Perrin, Richard J.;
- McDade, Eric;
- Xiong, Chengjie;
- Chhatwal, Jasmeer;
- Goate, Alison
Publication type:
Article
A comprehensive analysis of dementia cerebrospinal fluid biomarkers using GWAs, polygenic risk scores and Mendelian randomization in Parkinson's disease: Genetics/atypical and other dementias.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043233
By:
- Ibanez, Laura;
- Bahena, Jorge Alberto;
- Dube, Umber;
- Farias, Fabiana H.G.;
- Yang, Chengran;
- Harari, Oscar;
- Cruchaga, Carlos;
- Benitez, Bruno A.
Publication type:
Article
Alzheimer‐associated circular RNA circHOMER1 regulates synaptic gene expression and cognition: Molecular and cell biology: Neurodegeneration versus neuroprotection.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042335
By:
- Dube, Umber;
- Harari, Oscar;
- Zimmerman, Amber;
- Hafez, Alexander;
- Brigman, Jonathan;
- Cruchaga, Carlos;
- Mellios, Nikolaos;
- Benitez, Bruno A.
Publication type:
Article
P4‐106: INTEGRATIVE ANALYSIS POINTS TO AGFG2 AS A NOVEL PLAYER IN THE PATHOLOGY OF ALZHEIMER DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1315, doi. 10.1016/j.jalz.2019.06.3767
By:
- Fernandez, Victoria;
- Del-Aguila, Jorge L.;
- Li, Zeran;
- Dube, Umber;
- Davenport, Richard;
- Bradley, Joseph;
- Mihindukulasuriya, Kathie A.;
- Farias, Fabiana H.G.;
- Budde, John P.;
- Norton, Joanne;
- Gentsch, Jen;
- Morris, John C.;
- Harari, Oscar;
- Cruchaga, Carlos
Publication type:
Article
P3‐116: TMEM106B PROTECTIVE VARIANT ASSOCIATED WITH INCREASED NEURONAL PROPORTION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P974, doi. 10.1016/j.jalz.2019.06.3144
By:
- Li, Zeran;
- Farias, Fabiana H.G.;
- Dube, Umber;
- Del-Aguila, Jorge L.;
- Fernandez, Victoria;
- Ibanez, Laura;
- Budde, John P.;
- Wang, Fengxian;
- Lake, Allison M.;
- Robles, Yuetiva;
- Perez, James;
- Yang, Chengran;
- Mihindukulasuriya, Kathie A.;
- Bradley, Joseph;
- Davenport, Richard;
- Bergmann, Kristy;
- Dougherty, Joseph D.;
- Harari, Oscar;
- Cruchaga, Carlos
Publication type:
Article
P2‐137: AN E‐QTL META‐ANALYSIS OF BRAIN CORTICAL TISSUE ACROSS FIVE CONSORTIUM‐BASED STUDIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P625, doi. 10.1016/j.jalz.2019.06.2544
By:
- Perez, James A.;
- Mihindukulasuriya, Kathie A.;
- Farias, Fabiana H.G.;
- Li, Zeran;
- Dube, Umber;
- Budde, John P.;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
O5‐04‐03: IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES AND POTENTIALLY NOVEL DRUGS FOR FRONTOTEMPORAL LOBAR DEMENTIA WITH TAU INCLUSIONS BY A DEPENDABLE ANALYSIS APPROACH.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1651, doi. 10.1016/j.jalz.2018.06.3015
By:
- Jiang, Shan;
- Li, Zeran;
- Harari, Oscar;
- Budde, John P.;
- Dube, Umber;
- Del Aguila, Jorge;
- Cruchaga, Carlos;
- Karch, Celeste
Publication type:
Article
O4‐01‐04: CIRCULAR RNAS IN ALZHEIMER'S DISEASE BRAIN TISSUES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1401, doi. 10.1016/j.jalz.2018.06.2912
By:
- Dube, Umber;
- Del-Aguila, Jorge L.;
- Li, Zeran;
- Budde, John P.;
- Jiang, S.H.A.N.;
- Harari, Oscar;
- Cruchaga, Carlos
Publication type:
Article
P2‐105: NOMINATION OF NOVEL CANDIDATE GENES FOR FAMILIAL LATE ONSET ALZHEIMER DISEASE AFTER EVALUATION OF GENE‐BASED FAMILY‐BASED METHODS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P709, doi. 10.1016/j.jalz.2018.06.791
By:
- Fernandez, Maria Victoria;
- Budde, John P.;
- Del-Aguila, Jorge L.;
- Ibanez, Laura;
- Deming, Yuetiva;
- Harari, Oscar;
- Li, Zeran;
- Dube, Umber;
- Norton, Joanne;
- Morris, John C.;
- Goate, Alison M.;
- Cruchaga, Carlos
Publication type:
Article
P1‐173: BRAIN TRANSCRIPTOMICS STUDY REVEALS DIFFERENTIAL EXPRESSION OF THE THREE TREM2 TRANSCRIPT IN AD AND TREM2 MUTATION CARRIERS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P345, doi. 10.1016/j.jalz.2018.06.177
By:
- Del-Aguila, Jorge L.;
- Li, Zeran;
- Dube, Umber;
- Budde, John P.;
- Morris, John C.;
- Harari, Oscar;
- Cruchaga, Carlos
Publication type:
Article
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.
Published in:
Alzheimer's Research & Therapy, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13195-019-0524-x
By:
- Del-Aguila, Jorge L.;
- Li, Zeran;
- Dube, Umber;
- Mihindukulasuriya, Kathie A.;
- Budde, John P.;
- Fernandez, Maria Victoria;
- Ibanez, Laura;
- Bradley, Joseph;
- Wang, Fengxian;
- Bergmann, Kristy;
- Davenport, Richard;
- Morris, John C.;
- Holtzman, David M.;
- Perrin, Richard J.;
- Benitez, Bruno A.;
- Dougherty, Joseph;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease.
Published in:
Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00230
By:
- Ibanez, Laura;
- Dube, Umber;
- Davis, Albert A.;
- Fernandez, Maria V.;
- Budde, John;
- Cooper, Breanna;
- Diez-Fairen, Monica;
- Ortega-Cubero, Sara;
- Pastor, Pau;
- Perlmutter, Joel S.;
- Cruchaga, Carlos;
- Benitez, Bruno A.
Publication type:
Article
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.
Published in:
PLoS Genetics, 2017, v. 13, n. 11, p. 1, doi. 10.1371/journal.pgen.1007045
By:
- Fernández, Maria Victoria;
- Kim, Jong Hun;
- Budde, John P.;
- Black, Kathleen;
- Medvedeva, Alexandra;
- Saef, Ben;
- Deming, Yuetiva;
- Del-Aguila, Jorge;
- Ibañez, Laura;
- Dube, Umber;
- Harari, Oscar;
- Norton, Joanne;
- Chasse, Rachel;
- Morris, John C.;
- Goate, Alison;
- null, null;
- Cruchaga, Carlos
Publication type:
Article
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP.
Published in:
Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0319-z
By:
- Jiang, Shan;
- Wen, Natalie;
- Li, Zeran;
- Dube, Umber;
- Del Aguila, Jorge;
- Budde, John;
- Martinez, Rita;
- Hsu, Simon;
- Fernandez, Maria V.;
- Cairns, Nigel J.;
- Dominantly Inherited Alzheimer Network (DIAN);
- International FTD-Genomics Consortium (IFGC);
- Harari, Oscar;
- Cruchaga, Carlos;
- Karch, Celeste M.
Publication type:
Article
Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.
Published in:
2017
By:
- Ibanez, Laura;
- Dube, Umber;
- Saef, Benjamin;
- Budde, John;
- Black, Kathleen;
- Medvedeva, Alexandra;
- Del-Aguila, Jorge L.;
- Davis, Albert A.;
- Perlmutter, Joel S.;
- Harari, Oscar;
- Benitez, Bruno A.;
- Cruchaga, Carlos
Publication type:
journal article
APOE genotype regulates pathology and disease progression in synucleinopathy.
Published in:
Science Translational Medicine, 2020, v. 12, n. 529, p. 1, doi. 10.1126/scitranslmed.aay3069
By:
- Davis, Albert A.;
- Inman, Casey E.;
- Wargel, Zachary M.;
- Dube, Umber;
- Freeberg, Brittany M.;
- Galluppi, Alexander;
- Haines, Jessica N.;
- Dhavale, Dhruva D.;
- Miller, Rebecca;
- Choudhury, Fahim A.;
- Sullivan, Patrick M.;
- Cruchaga, Carlos;
- Perlmutter, Joel S.;
- Ulrich, Jason D.;
- Benitez, Bruno A.;
- Kotzbauer, Paul T.;
- Holtzman, David M.
Publication type:
Article
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Published in:
Science Translational Medicine, 2019, v. 11, n. 505, p. 1, doi. 10.1126/scitranslmed.aau2291
By:
- Deming, Yuetiva;
- Filipello, Fabia;
- Cignarella, Francesca;
- Cantoni, Claudia;
- Hsu, Simon;
- Mikesell, Robert;
- Li, Zeran;
- Del-Aguila, Jorge L;
- Dube, Umber;
- Farias, Fabiana Geraldo;
- Bradley, Joseph;
- Budde, John;
- Ibanez, Laura;
- Fernandez, Maria Victoria;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Heslegrave, Amanda;
- Johansson, Per M;
- Svensson, Johan;
- Nellgård, Bengt
Publication type:
Article
Correction to: Overlapping genetic architecture between Parkinson disease and melanoma.
Published in:
2020
By:
- Dube, Umber;
- Ibanez, Laura;
- Budde, John P.;
- Benitez, Bruno A.;
- Davis, Albert A.;
- Harari, Oscar;
- Iles, Mark M.;
- Law, Matthew H.;
- Brown, Kevin M.;
- 23andMe Research Team;
- Agee, Michelle;
- Alipanahi, Babak;
- Auton, Adam;
- Bell, Robert K.;
- Bryc, Katarzyna;
- Elson, Sarah L.;
- Fontanillas, Pierre;
- Furlotte, Nicholas A.;
- Hinds, David A.;
- Huber, Karen E.
Publication type:
Correction Notice
Overlapping genetic architecture between Parkinson disease and melanoma.
Published in:
Acta Neuropathologica, 2020, v. 139, n. 2, p. 347, doi. 10.1007/s00401-019-02110-z
By:
- Dube, Umber;
- Ibanez, Laura;
- Budde, John P.;
- Benitez, Bruno A.;
- Davis, Albert A.;
- Harari, Oscar;
- Iles, Mark M.;
- Law, Matthew H.;
- Brown, Kevin M.;
- 23andMe Research Team;
- Agee, Michelle;
- Alipanahi, Babak;
- Auton, Adam;
- Bell, Robert K.;
- Bryc, Katarzyna;
- Elson, Sarah L.;
- Fontanillas, Pierre;
- Furlotte, Nicholas A.;
- Hinds, David A.;
- Huber, Karen E.
Publication type:
Article
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Published in:
Acta Neuropathologica, 2020, v. 139, n. 1, p. 45, doi. 10.1007/s00401-019-02066-0
By:
- Li, Zeran;
- Farias, Fabiana H. G.;
- Dube, Umber;
- Del-Aguila, Jorge L.;
- Mihindukulasuriya, Kathie A.;
- Fernandez, Maria Victoria;
- Ibanez, Laura;
- Budde, John P.;
- Wang, Fengxian;
- Lake, Allison M.;
- Deming, Yuetiva;
- Perez, James;
- Yang, Chengran;
- Bahena, Jorge A.;
- Qin, Wei;
- Bradley, Joseph L.;
- Davenport, Richard;
- Bergmann, Kristy;
- Morris, John C.;
- Perrin, Richard J.
Publication type:
Article
Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
Published in:
Genome Medicine, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13073-018-0551-4
By:
- Li, Zeran;
- Del-Aguila, Jorge L.;
- Dube, Umber;
- Budde, John;
- Martinez, Rita;
- Black, Kathleen;
- Xiao, Qingli;
- Cairns, Nigel J.;
- The Dominantly Inherited Alzheimer Network (DIAN);
- Dougherty, Joseph D.;
- Lee, Jin-Moo;
- Morris, John C.;
- Bateman, Randall J.;
- Karch, Celeste M.;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.
Published in:
Molecular Neurodegeneration, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s13024-019-0319-3
By:
- Del-Aguila, Jorge L.;
- Benitez, Bruno A.;
- Li, Zeran;
- Dube, Umber;
- Mihindukulasuriya, Kathie A.;
- Budde, John P.;
- Farias, Fabiana H. G.;
- Fernández, Maria Victoria;
- Ibanez, Laura;
- Jiang, Shan;
- Perrin, Richard J.;
- Cairns, Nigel J.;
- Morris, John C.;
- Harari, Oscar;
- Cruchaga, Carlos
Publication type:
Article

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