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Chlorambucil, vinblastine, procarbazine, and prednisone. An effective but less toxic regimen than MOPP for advanced-stage Hodgkin's disease.
Published in:
1989
By:
- Druker, Brian J.;
- Rosenthal, David S.;
- Canellos, George P.;
- Druker, B J;
- Rosenthal, D S;
- Canellos, G P
Publication type:
journal article
Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia.
Published in:
Oncogene, 2015, v. 34, n. 23, p. 2991, doi. 10.1038/onc.2014.243
By:
- Agarwal, A;
- MacKenzie, R J;
- Eide, C A;
- Davare, M A;
- Watanabe-Smith, K;
- Tognon, C E;
- Mongoue-Tchokote, S;
- Park, B;
- Braziel, R M;
- Tyner, J W;
- Druker, B J
Publication type:
Article
Chronic myelogenous leukaemia--new therapeutic principles.
Published in:
2001
By:
- O'Dwyer, Michael E.;
- Druker, Brian J.;
- O'Dwyer, M E;
- Druker, B J
Publication type:
journal article
CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway.
Published in:
Leukemia (08876924), 2013, v. 27, n. 10, p. 2094, doi. 10.1038/leu.2013.228
By:
- Prins, R C;
- Burke, R T;
- Tyner, J W;
- Druker, B J;
- Loriaux, M M;
- Spurgeon, S E
Publication type:
Article
Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors.
Published in:
Leukemia (08876924), 2012, v. 26, n. 5, p. 1140, doi. 10.1038/leu.2011.325
By:
- Traer, E;
- MacKenzie, R;
- Snead, J;
- Agarwal, A;
- Eiring, A M;
- O'Hare, T;
- Druker, B J;
- Deininger, M W
Publication type:
Article
Targeting survivin and p53 in pediatric acute lymphoblastic leukemia.
Published in:
Leukemia (08876924), 2012, v. 26, n. 4, p. 623, doi. 10.1038/leu.2011.249
By:
- Tyner, J W;
- Jemal, A M;
- Thayer, M;
- Druker, B J;
- Chang, B H
Publication type:
Article
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia.
Published in:
2010
By:
- Hochhaus, A;
- O'Brien, S G;
- Guilhot, F;
- Druker, B J;
- Branford, S;
- Foroni, L;
- Goldman, J M;
- Müller, M C;
- Radich, J P;
- Rudoltz, M;
- Mone, M;
- Gathmann, I;
- Hughes, T P;
- Larson, R A
Publication type:
Correction Notice
The function of the pleckstrin homology domain in BCR–ABL-mediated leukemogenesis.
Published in:
2010
By:
- Demehri, S.;
- O'Hare, T.;
- Eide, C. A.;
- Smith, C. A.;
- Tyner, J. W.;
- Druker, B. J.;
- Deininger, M. W. N.
Publication type:
Letter
Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.
Published in:
2009
By:
- Tyner, J. W.;
- Rutenberg-Schoenberg, M. L.;
- Erickson, H.;
- Willis, S. G.;
- O'Hare, T.;
- Deininger, M. W.;
- Druker, B. J.;
- Loriaux, M. M.
Publication type:
Letter
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia.
Published in:
Leukemia (08876924), 2009, v. 23, n. 6, p. 1054, doi. 10.1038/leu.2009.38
By:
- Hochhaus, A.;
- O'Brien, S. G.;
- Guilhot, F.;
- Druker, B. J.;
- Branford, S.;
- Foroni, L.;
- Goldman, J. M.;
- Müller, M. C.;
- Radich, J. P.;
- Rudoltz, M.;
- Mone, M.;
- Gathmann, I.;
- Hughes, T. P.;
- Larson, R. A.
Publication type:
Article
High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia.
Published in:
2009
By:
- Tyner, J. W.;
- Loriaux, M. M.;
- Erickson, H.;
- Eide, C. A.;
- Deininger, J.;
- MacPartlin, M.;
- Willis, S. G.;
- Lange, T.;
- Druker, B. J.;
- Kovacsovics, T.;
- Maziarz, R.;
- Gattermann, N.;
- Deininger, M. W.
Publication type:
Letter
An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia.
Published in:
2008
By:
- Agarwal, A.;
- Eide, C. A.;
- Harlow, A.;
- Corbin, A. S.;
- Mauro, M. J.;
- Druker, B. J.;
- Corless, C. L.;
- Heinrich, M. C.;
- Deininger, M. W.
Publication type:
Case Study
Bruton's tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells.
Published in:
Leukemia (08876924), 2008, v. 22, n. 7, p. 1354, doi. 10.1038/leu.2008.126
By:
- MacPartlin, M;
- Smith, A M;
- Druker, B J;
- Honigberg, L A;
- Deininger, M W
Publication type:
Article
Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia.
Published in:
Leukemia (08876924), 2008, v. 22, n. 6, p. 1184, doi. 10.1038/leu.2008.65
By:
- Sherbenou, D. W.;
- Hantschel, O.;
- Turaga, L.;
- Kaupe, I.;
- Willis, S.;
- Bumm, T.;
- Press, R. D.;
- Superti-Furga, G.;
- Druker, B. J.;
- Deininger, M. W.
Publication type:
Article
Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib.
Published in:
Leukemia (08876924), 2007, v. 21, n. 3, p. 489, doi. 10.1038/sj.leu.2404554
By:
- Sherbenou, D. W.;
- Wong, M. J.;
- Humayun, A.;
- McGreevey, L. S.;
- Harrell, P.;
- Yang, R.;
- Mauro, M.;
- Heinrich, M. C.;
- Press, R. D.;
- Druker, B. J.;
- Deininger, M. W.
Publication type:
Article
A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib.
Published in:
Leukemia (08876924), 2005, v. 19, n. 11, p. 1859, doi. 10.1038/sj.leu.2403935
By:
- Crossman, L. C.;
- O'Hare, T.;
- Lange, T.;
- Willis, S. G.;
- Stoffregen, E. P.;
- Corbin, A. S.;
- O'Brien, S. G.;
- Heinrich, M. C.;
- Druker, B. J.;
- Middleton, P. G.;
- Deininger, M. W. N.
Publication type:
Article
Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells.
Published in:
Leukemia (08876924), 2005, v. 19, n. 11, p. 1896, doi. 10.1038/sj.leu.2403949
By:
- Chuah, C.;
- Barnes, D. J.;
- Kwok, M.;
- Corbin, A.;
- Deininger, M. W. N.;
- Druker, B. J.;
- Melo, J. V.
Publication type:
Article
e8a2 BCR-ABL: more frequent than other atypical BCR-ABL variants?
Published in:
2005
By:
- Demehri, S.;
- Paschka, P.;
- Schultheis, B.;
- Lange, T.;
- Koizumi, T.;
- Sugimoto, T.;
- Branford, S.;
- Lim, L.-C.;
- Kegel, T.;
- Martinelli, G.;
- Hochhaus, A.;
- Druker, B. J.;
- Deininger, M. W. N.
Publication type:
Letter
Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography.
Published in:
Leukemia (08876924), 2004, v. 18, n. 4, p. 864, doi. 10.1038/sj.leu.2403307
By:
- Deininger, M. W. N.;
- McGreevey, L.;
- WilIis, S.;
- Bainbridge, T. M.;
- Druker, B. J.;
- Heinrich, M. C.
Publication type:
Article
Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate.
Published in:
Leukemia (08876924), 2003, v. 17, n. 3, p. 481, doi. 10.1038/sj.leu.2402848
By:
- O'Dwyer, M E;
- Gatter, K M;
- Loriaux, M;
- Druker, B J;
- Olson, S B;
- Magenis, R E;
- Lawce, H;
- Mauro, M J;
- Maziarz, R T;
- Braziel, R M
Publication type:
Article

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