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Discovery and optimization of the first‐in‐class TDP‐43 PET tracer.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075525
By:
- Seredenina, Tamara;
- Vokali, Efthymia;
- Dreyfus, Nicolas;
- Chevallier, Elodie;
- Afroz, Tariq;
- Jaquier, Thomas;
- Serra, Andreia Monica;
- Clavel, Mathieu;
- Rathnam, Monisha;
- Melly, Tania;
- Kroth, Heiko;
- Pfeifer, Andrea;
- Kosco‐Vilbois, Marie
Publication type:
Article
Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human: Neuroimaging / evaluating treatments.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040558
By:
- Shcherbinin, Sergey;
- Kielbasa, William;
- Dubois, Susan;
- Lowe, Stephen L;
- Phipps, Krista M;
- Tseng, James;
- Kevin, Donnelly B;
- Natanegara, Fanni;
- Warner, Susan;
- Dreyfus, Nicolas;
- Lindsay‐Scott, Peter;
- Hawk, Mai Khanh;
- McDonald, Nicholas;
- Zhang, Xiaoyu;
- Gilmore, Julie A;
- Biglan, Kevin;
- Mergott, Dustin J;
- Russell, David;
- Gunn, Roger N;
- Constantinescu, Cristian
Publication type:
Article
A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme: Human/Human trials: Anti‐tau.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040473
By:
- Kielbasa, William;
- Phipps, Krista M;
- Tseng, James;
- Natanegara, Fanni;
- Cheng, Eden;
- Monk, Scott A.;
- Bundgaard, Christoffer;
- Kevin, Donnelly B.;
- Nuthall, Hugh Norman;
- McDonald, Nicholas;
- Lindsay‐Scott, Peter;
- Dreyfus, Nicolas;
- Hawk, Mai Khanh;
- Warner, Susan;
- Biglan, Kevin;
- Gilmore, Julie A.;
- Zhang, Xiaoyu;
- Mergott, Dustin J.;
- Lowe, Stephen L.
Publication type:
Article
From patent to patient.
Published in:
2010
By:
- Dreyfus, Nicolas;
- Lilly, Eli
Publication type:
Proceeding
PET ligands [<sup>18</sup>F]LSN3316612 and [<sup>11</sup>C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain.
Published in:
Science Translational Medicine, 2020, v. 12, n. 543, p. 1, doi. 10.1126/scitranslmed.aau2939
By:
- Lu, Shuiyu;
- Haskali, Mohammad B.;
- Ruley, Kevin M.;
- Dreyfus, Nicolas J.-F.;
- DuBois, Susan L.;
- Paul, Soumen;
- Liow, Jeih-San;
- Morse, Cheryl L.;
- Kowalski, Aneta;
- Gladding, Robert L.;
- Gilmore, Jeremy;
- Mogg, Adrian J.;
- Morin, S. Michelle;
- Lindsay-Scott, Peter J.;
- Ruble, J. Craig;
- Kant, Nancy A.;
- Shcherbinin, Sergey;
- Barth, Vanessa N.;
- Johnson, Michael P.;
- Cuadrado, Maria
Publication type:
Article

Found: 5

Discovery and optimization of the first‐in‐class TDP‐43 PET tracer.

Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human: Neuroimaging / evaluating treatments.

A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme: Human/Human trials: Anti‐tau.

From patent to patient.

PET ligands [<sup>18</sup>F]LSN3316612 and [<sup>11</sup>C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain.