Works by Dota, Corina

Results: 22

A Randomized, Double‐Blind, Placebo‐ and Positive‐Controlled, Three‐Way Crossover Study in Healthy Participants to Investigate the Effect of Savolitinib on the QTc Interval.

Published in:

Clinical Pharmacology in Drug Development, 2021, v. 10, n. 5, p. 521, doi. 10.1002/cpdd.896

By:

Sahota, Tarjinder;
Dota, Corina D.;
Vik, Torbjörn;
Yan, Weili;
Verheijen, Remy B.;
Walker, Stephen;
Li, Yan;
Goldwater, Ronald;
Ghiorghiu, Dana;
Mellemgaard, Anders;
Ahmed, Ghada F.

Publication type:

Article

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 310, doi. 10.1002/cpt.2029

By:

Vargas, Hugo M.;
Rolf, Michael G.;
Wisialowski, Todd A.;
Achanzar, William;
Bahinski, Anthony;
Bass, Alan;
Benson, Charles T;
Chaudhary, Khuram W.;
Couvreur, Nicolas;
Dota, Corina;
Engwall, Michael J;
Michael Foley, C.;
Gallacher, David;
Greiter‐Wilke, Andrea;
Guillon, Jean‐Michel;
Guth, Brian;
Himmel, Herbert M.;
Hegele‐Hartung, Christa;
Ito, Maki;
Jenkinson, Stephen

Publication type:

Article

Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 2, p. 141, doi. 10.1007/s00280-023-04555-2

By:

Någård, Mats;
Ah-See, Mei-Lin;
Strauss, James;
Wise-Draper, Trisha;
Safran, Howard P.;
Nadeau, Laura;
Edenfield, William J.;
Lewis, Lionel D.;
Rekić, Dinko;
Dota, Corina;
Ottesen, Lone H.;
Li, Yan;
Mugundu, Ganesh M.

Publication type:

Article

Olaparib does not cause clinically relevant QT/QTc interval prolongation in patients with advanced solid tumours: results from two phase I studies.

Published in:

2016

By:

Swaisland, Helen;
Plummer, Ruth;
So, Karen;
Garnett, Sally;
Bannister, Wendy;
Fabre, Marc-Antoine;
Dota, Corina;
Fielding, Anitra

Publication type:

journal article

The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.

Published in:

Pharmacology Research & Perspectives, 2024, v. 12, n. 2, p. 1, doi. 10.1002/prp2.1184

By:

Parkinson, Joanna;
Sundell, Jesper;
Rekić, Dinko;
Nelander, Karin;
Ericsson, Hans;
Ebrahimi, Ahmad;
Dota, Corina;
Sunnåker, Mikael

Publication type:

Article

Verinurad does not prolong QTc interval: a thorough QT study using concentration–QTc modelling.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 6, p. 1747, doi. 10.1111/bcp.15637

By:

Parkinson, Joanna;
Dota, Corina;
Källgren, Christian;
Gottfridsson, Christer;
Bjursell, Magnus;
Perl, Shira;
Kӧrnicke, Thomas;
Rekić, Dinko;
Johansson, Susanne

Publication type:

Article

AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 11, p. 4839, doi. 10.1111/bcp.15425

By:

Rekić, Dinko;
Azarov, Ivan;
Knöchel, Jane;
Sokolov, Victor;
Nilsson, Catarina;
Wernevik, Linda;
Han, David;
Rydén‐Bergsten, Tina;
Ebrahimi, Ahmad;
Dota, Corina;
Carlsson, Björn

Publication type:

Article

Concentration‐QT modelling in early clinical oncology settings: Simulation evaluation of performance.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 3, p. 1010, doi. 10.1111/bcp.15047

By:

Cantet, Gael;
Berges, Alienor;
O'Sullivan, Rhianna;
Cohen‐Rabbie, Sarit;
Dota, Corina;
Dubois, Vincent;
Benoist, Guillemette E.;
Tomkinson, Helen;
Rekić, Dinko;
Parkinson, Joanna;
Schalkwijk, Stein

Publication type:

Article

Concentration‐QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 2, p. 858, doi. 10.1111/bcp.15006

By:

Voronova, Veronika;
Cullberg, Marie;
Delff, Philip;
Parkinson, Joanna;
Dota, Corina;
Schiavon, Gaia;
Maroj, Brijesh;
Rekić, Dinko;
Cheung, S. Y. Amy

Publication type:

Article

An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data.

Published in:

Toxicological Sciences, 2017, v. 159, n. 1, p. 94, doi. 10.1093/toxsci/kfx125

By:

Pollard, Christopher E.;
Skinner, Matthew;
Lazic, Stanley E.;
Prior, Helen M.;
Conlon, Kelly M.;
Valentin, Jean-Pierre;
Dota, Corina

Publication type:

Article

Inter- and Intraday Variability in Major Electrocardiogram Intervals and Amplitudes in Healthy Men and Women.

Published in:

Pacing & Clinical Electrophysiology, 2003, v. 26, n. 1, p. 361, doi. 10.1046/j.1460-9592.2003.00050.x

By:

DOTA, CORINA D.;
EDVARDSSON, NILS;
SCHÜTZER, KAJS-MARIE;
OLOFSSON, EVA LAVIK;
MALM, ANDERS;
MORSING, TOMAS;
FAGER, GUNNAR

Publication type:

Article

The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".

Published in:

2014

By:

Darpo, Borje;
Sarapa, Nenad;
Garnett, Christine;
Benson, Charles;
Dota, Corina;
Ferber, Georg;
Jarugula, Venkateswar;
Johannesen, Lars;
Keirns, James;
Krudys, Kevin;
Ortemann-Renon, Catherine;
Riley, Steve;
Rogers-Subramaniam, Danise;
Stockbridge, Norman

Publication type:

journal article

The IQ-CSRC Prospective Clinical Phase 1 Study: 'Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?'.

Published in:

Annals of Noninvasive Electrocardiology, 2014, v. 19, n. 1, p. 70, doi. 10.1111/anec.12128

By:

Darpo, Borje;
Sarapa, Nenad;
Garnett, Christine;
Benson, Charles;
Dota, Corina;
Ferber, Georg;
Jarugula, Venkateswar;
Johannesen, Lars;
Keirns, James;
Krudys, Kevin;
Ortemann‐Renon, Catherine;
Riley, Steve;
Rogers‐Subramaniam, Danise;
Stockbridge, Norman

Publication type:

Article

Assessment of Ventricular Repolarization Variability with the DeltaT50 Method Improves Identification of Patients with Congenital Long QT Syndromes.

Published in:

Annals of Noninvasive Electrocardiology, 2013, v. 18, n. 3, p. 240, doi. 10.1111/anec.12016

By:

Abrahamsson, Christina;
Dota, Corina;
Skallefell, Bo;
Carlsson, Leif;
Frison, Lars;
Berggren, Anders;
Edvardsson, Nils;
Duker, Göran

Publication type:

Article

PC-Based ECG waveform recognition-validation of novel software against a reference ECG database.

Published in:

2009

By:

Dota CD;
Edvardsson N;
Skallefell B;
Fager G;
Dota, Corina-Dana;
Edvardsson, Nils;
Skallefell, Bo;
Fager, Gunnar

Publication type:

journal article

PC-Based ECG Waveform Recognition—Validation of Novel Software Against a Reference ECG Database.

Published in:

Annals of Noninvasive Electrocardiology, 2009, v. 14, p. S42, doi. 10.1111/j.1542-474X.2008.00263.x

By:

Dota, Corina-Dana;
Edvardsson, Nils;
Skallefell, Bo;
Fager, Gunnar

Publication type:

Article

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.

Published in:

2002

By:

Dota C;
Skallefell B;
Edvardsson N;
Fager G;
Dota, Corina;
Skallefell, Bo;
Edvardsson, Nils;
Fager, Gunnar

Publication type:

journal article

Computer-Based Analysis of Dynamic QT Changes: Toward High Precision and Individual Rate Correction.

Published in:

Annals of Noninvasive Electrocardiology, 2002, v. 7, n. 4, p. 289, doi. 10.1111/j.1542-474X.2002.tb00177.x

By:

Dota, Corina;
Skallefell, Bo;
Edvardsson, Nils;
Fager, Gunnar

Publication type:

Article

Concentration–QT modeling demonstrates that the selective mineralocorticoid receptor modulator, balcinrenone (AZD9977), does not prolong QT interval.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 2, p. 292, doi. 10.1002/psp4.13272

By:

Sundell, Jesper;
Rekic, Dinko;
Melin, Johanna;
Johansson, Susanne;
Ebrahimi, Ahmad;
Dota, Corina;
Parkinson, Joanna

Publication type:

Article

QT Prolongation Risk Assessment in Oncology: Lessons Learned From Small‐Molecule New Drug Applications Approved During 2011‐2019.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 8, p. 1106, doi. 10.1002/jcph.1844

By:

Cohen‐Rabbie, Sarit;
Berges, Alienor C.;
Rekić, Dinko;
Parkinson, Joanna;
Dota, Corina;
Tomkinson, Helen K.

Publication type:

Article

Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, n. 1, p. 125, doi. 10.1002/jcph.1502

By:

Darpo, Borje;
Benson, Charles;
Brown, Randy;
Dota, Corina;
Ferber, Georg;
Ferry, Jim;
Jarugula, Venkat;
Keirns, James;
Ortemann‐Renon, Catherine;
Pham, Thuan;
Riley, Steve;
Sarapa, Nenad;
Ticktin, Mark;
Zareba, Wojciech;
Couderc, Jean‐Philippe

Publication type:

Article

Can Bias Evaluation Provide Protection Against False-Negative Results in QT Studies Without a Positive Control Using Exposure-Response Analysis?

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 1, p. 85, doi. 10.1002/jcph.779

By:

Ferber, Georg;
Zhou, Meijian;
Dota, Corina;
Garnett, Christine;
Keirns, James;
Malik, Marek;
Stockbridge, Norman;
Darpo, Borje

Publication type:

Article