Works by Donehower, Lawrence A.

Results: 60

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation.

Published in:

PLoS Biology, 2007, v. 5, n. 8, p. 1750, doi. 10.1371/journal.pbio.0050201

By:

Chambers, Stuart M.;
Shaw, Chad A.;
Gatza, Catherine;
Fisk, C. Joseph;
Donehower, Lawrence A.;
Goodell, Margaret A.

Publication type:

Article

WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation.

Published in:

Cell Cycle, 2020, v. 19, n. 4, p. 479, doi. 10.1080/15384101.2020.1717025

By:

Choi, Byung-Kwon;
Fujiwara, Kenichiro;
Dayaram, Tajhal;
Darlington, Yolanda;
Dickerson, Joshua;
Goodell, Margaret A.;
Donehower, Lawrence A.

Publication type:

Article

LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.

Published in:

Cell Cycle, 2017, v. 16, n. 2, p. 213, doi. 10.1080/15384101.2016.1261767

By:

Wamsley, J. Jacob;
Issaeva, Natalia;
An, Hanbing;
Lu, Xinyuan;
Donehower, Lawrence A.;
Yarbrough, Wendell G.

Publication type:

Article

Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.

Published in:

2015

By:

Roos, Alison;
Satterfield, Laura;
Zhao, Shuying;
Fuja, Daniel;
Shuck, Ryan;
Hicks, M John;
Donehower, Lawrence A;
Yustein, Jason T

Publication type:

journal article

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation.

Published in:

EMBO Journal, 1998, v. 17, n. 16, p. 4657, doi. 10.1093/emboj/17.16.4657

By:

Venkatachalam, Sundaresan;
Shi, Yu-Ping;
Jones, Stephen N.;
Vogel, Hannes;
Bradley, Allan;
Pinkel, Dan;
Donehower, Lawrence A.

Publication type:

Article

Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5- f]quinoline (IQ).

Published in:

Cancer Science, 2007, v. 98, n. 8, p. 1164, doi. 10.1111/j.1349-7006.2007.00517.x

By:

Hirata, Akihiro;
Tsukamoto, Tetsuya;
Yamamoto, Masami;
Takasu, Shinji;
Sakai, Hiroki;
Ban, Hisayo;
Yanai, Tokuma;
Masegi, Toshiaki;
Donehower, Lawrence A.;
Tatematsu, Masae

Publication type:

Article

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.

Published in:

Journal of Cancer Research & Clinical Oncology, 2003, v. 129, n. 6, p. 335, doi. 10.1007/s00432-003-0443-9

By:

Sakai, Hiroki;
Tsukamoto, Tetsuya;
Yamamoto, Masami;
Shirai, Norimitsu;
Iidaka, Takeshi;
Hirata, Akihiro;
Yanai, Tokuma;
Masegi, Toshiaki;
Donehower, Lawrence A.;
Tatematsu, Masae

Publication type:

Article

Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.

Published in:

Cancer Medicine, 2015, v. 4, n. 7, p. 977, doi. 10.1002/cam4.438

By:

Allen‐Rhoades, Wendy;
Kurenbekova, Lyazat;
Satterfield, Laura;
Parikh, Neha;
Fuja, Daniel;
Shuck, Ryan L.;
Rainusso, Nino;
Trucco, Matteo;
Barkauskas, Donald A.;
Jo, Eunji;
Ahern, Charlotte;
Hilsenbeck, Susan;
Donehower, Lawrence A.;
Yustein, Jason T.

Publication type:

Article

Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53[sup +/-] Mouse Model in Carcinogenicity Testing.

Published in:

Toxicologic Pathology, 2001, v. 29, p. 147, doi. 10.1080/019262301753178555

By:

Venkatachalam, Sundaresan;
Tyner, Stuart D.;
Pickering, Curtis R.;
Boley, Scott;
Recio, Leslie;
French, John E.;
Donehower, Lawrence A.

Publication type:

Article

The Nature of the Heterozygous Trp53 Knockout Model for Identification of Mutagenic Carcinogens.

Published in:

Toxicologic Pathology, 2001, v. 29, p. 24, doi. 10.1080/019262301753178456

By:

French, John;
Storer, Richard D.;
Donehower, Lawrence A.

Publication type:

Article

Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing.

Published in:

Toxicologic Pathology, 2001, v. 29, n. 1S, p. 147, doi. 10.1080/019262301753178555

By:

Venkatachalam, Sundaresan;
Tyner, Stuart D.;
Pickering, Curtis R.;
Boley, Scott;
Recio, Leslie;
French, John E.;
Donehower, Lawrence A.

Publication type:

Article

The Nature of the Heterozygous Trp53 Knockout Model for Identifi cation of Mutagenic Carcinogens.

Published in:

Toxicologic Pathology, 2001, v. 29, n. 1S, p. 24, doi. 10.1080/019262301753178456

By:

French, John;
Storer, Richard D.;
Donehower, Lawrence A.

Publication type:

Article

Cancer Prevention Studies in p53-Deficient Mice.

Published in:

Toxicologic Pathology, 2001, v. 29, n. 1, p. 137, doi. 10.1080/019262301301418946

By:

Hursting, Stephen D.;
Perkins, Susan N.;
Donehower, Lawrence A.;
Davis, Barbara J.

Publication type:

Article

The Cancer Genome Atlas Pan-Cancer analysis project.

Published in:

Nature Genetics, 2013, v. 45, n. 10, p. 1113, doi. 10.1038/ng.2764

By:

Chang, Kyle;
Creighton, Chad J;
Davis, Caleb;
Donehower, Lawrence;
Drummond, Jennifer;
Wheeler, David;
Ally, Adrian;
Balasundaram, Miruna;
Birol, Inanc;
Butterfield, Yaron S N;
Chu, Andy;
Chuah, Eric;
Chun, Hye-Jung E;
Dhalla, Noreen;
Guin, Ranabir;
Hirst, Martin;
Hirst, Carrie;
Holt, Robert A;
Jones, Steven J M;
Lee, Darlene

Publication type:

Article

P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.

Published in:

Breast Cancer Research & Treatment, 2011, v. 130, n. 2, p. 399, doi. 10.1007/s10549-010-1308-y

By:

Fuchs-Young, Robin;
Shirley, Stephanie;
Lambertz, Isabel;
Colby, Jennifer;
Tian, Jie;
Johnston, Dennis;
Gimenez-Conti, Irma;
Donehower, Lawrence;
Conti, Claudio;
Hursting, Stephen

Publication type:

Article

Combinatorial therapy discovery using mixed integer linear programming.

Published in:

Bioinformatics, 2014, v. 30, n. 10, p. 1456, doi. 10.1093/bioinformatics/btu046

By:

Pang, Kaifang;
Wan, Ying-Wooi;
Choi, William T.;
Donehower, Lawrence A.;
Sun, Jingchun;
Pant, Dhruv;
Liu, Zhandong

Publication type:

Article

Suppression of thymic lymphomas and increased nonthymic lymphomagenesis in Trp53-deficient mice lacking inducible nitric oxide synthase gene.

Published in:

International Journal of Cancer, 2004, v. 111, n. 6, p. 819, doi. 10.1002/ijc.20350

By:

Tatemichi, Masayuki;
Tazawa, Hiroshi;
Masuda, Mitsuharu;
Saleem, Mohammad;
Wada, Sayori;
Donehower, Lawrence A.;
Ohgaki, Hiroko;
Ohshima, Hiroshi

Publication type:

Article

Dephosphorylation of γH2AX by WIP1.

Published in:

Cell Cycle, 2010, v. 9, n. 11, p. 2092, doi. 10.4161/cc.9.11.11810

By:

Sung-Hwan Moon;
Thuy-Ai Nguyen;
Darlington, Yolanda;
Xiongbin Lu;
Donehower, Lawrence A.

Publication type:

Article

Tumor Suppressor Dosage Regulates Stem Cell Dynamics during Aging.

Published in:

Cell Cycle, 2007, v. 6, n. 1, p. 52, doi. 10.4161/cc.6.1.3667

By:

Gatza, Catherine;
Moore, Lynette;
Dumble, Melissa;
Donehower, Lawrence A.

Publication type:

Article

ΔNp63α Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse.

Published in:

Cell Cycle, 2006, v. 5, n. 17, p. 2005, doi. 10.4161/cc.5.17.3194

By:

Sommer, Matthias;
Poliak, Nina;
Upadhyay, Sunil;
Ratovitski, Edward;
Nelkin, Barry D.;
Donehower, Lawrence A.;
Sidransky, David

Publication type:

Article

53BP1 Oligomerization is Independent of its Methylation by PRMT1.

Published in:

Cell Cycle, 2005, v. 4, n. 12, p. 1854, doi. 10.4161/cc.4.12.2282

By:

Adams, Melissa M.;
Bin Wang;
Zhenfang Xia;
Morales, Julio C.;
Xiongbin Lu;
Donehower, Lawrence A.;
Bochar, Daniel A.;
Elledge, Stephen J.;
Carpenter, Phillip B.

Publication type:

Article

Reversal of the ATM/ATR-Mediated DNA Damage Response by the Oncogenic Phosphatase PPM1D.

Published in:

Cell Cycle, 2005, v. 4, n. 8, p. 1060, doi. 10.4161/cc.4.8.1876

By:

Xiongbin Lu;
Thuy-Ai Nguyen;
Donehower, Lawrence A.

Publication type:

Article

Homeostatic Regulation of Base Excision Repair by a p53-Induced Phosphatase.

Published in:

Cell Cycle, 2004, v. 3, n. 11, p. 1363, doi. 10.4161/cc.3.11.1241

By:

Xiongbin Lu;
Thuy-Ai Nguyen;
Appella, Ettore;
Donehower, Lawrence A.

Publication type:

Article

20 years studying p53 functions in genetically engineered mice.

Published in:

2009

By:

Donehower, Lawrence A.;
Lozano, Guillermina

Publication type:

review

Development of an HIV-Based cDNA expression cloning system

Published in:

Molecular Therapy, 2003, v. 8, n. 1, p. 167, doi. 10.1016/S1525-0016(03)00133-3

By:

van Maanen, Marc;
Tidwell, Jennie K.;
Donehower, Lawrence A.;
Sutton, Richard E.

Publication type:

Article

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice.

Published in:

Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12691

By:

Parikh, Neha;
Shuck, Ryan L.;
Gagea, Mihai;
Shen, Lanlan;
Donehower, Lawrence A.

Publication type:

Article

p53 knockout mice (–/–) are more susceptible than (+/–) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

Published in:

Carcinogenesis, 2000, v. 21, n. 10, p. 1891, doi. 10.1093/carcin/21.10.1891

By:

Yamamoto, Masami;
Tsukamoto, Tetsuya;
Sakai, Hiroki;
Shirai, Norimitsu;
Ohgaki, Hiroko;
Furihata, Chie;
Donehower, Lawrence A.;
Yoshida, Kenji;
Tatematsu, Masae

Publication type:

Article

miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.

Published in:

International Journal of Cancer, 2017, v. 141, n. 10, p. 2062, doi. 10.1002/ijc.30909

By:

Satterfield, Laura;
Shuck, Ryan;
Kurenbekova, Lyazat;
Allen‐Rhoades, Wendy;
Edwards, Dean;
Huang, Shixia;
Rajapakshe, Kimal;
Coarfa, Cristian;
Donehower, Lawrence A.;
Yustein, Jason T.

Publication type:

Article

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types.

Published in:

Nature Communications, 2014, v. 5, n. 11, p. 5274, doi. 10.1038/ncomms6274

By:

Xia, Zheng;
Donehower, Lawrence A.;
Cooper, Thomas A.;
Neilson, Joel R.;
Wheeler, David A.;
Wagner, Eric J.;
Li, Wei

Publication type:

Article

Insights into Aging Obtained from p53 Mutant Mouse Models.

Published in:

Annals of the New York Academy of Sciences, 2004, v. 1019, n. 1, p. 171, doi. 10.1196/annals.1297.027

By:

DUMBLE, MELISSA;
GATZA, CATHERINE;
TYNER, STUART;
VENKATACHALAM, SUNDARESAN;
DONEHOWER, LAWRENCE A.

Publication type:

Article

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.

Published in:

Oncogene, 2003, v. 22, n. 49, p. 7831, doi. 10.1038/sj.onc.1206985

By:

Moore, Lynette;
Venkatachalam, Sundaresan;
Vogel, Hannes;
Watt, Julie C;
Wu, Chao-Ling;
Steinman, Heather;
Jones, Stephen N;
Donehower, Lawrence A

Publication type:

Article

Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53.

Published in:

Oncogene, 2000, v. 19, n. 52, p. 5988, doi. 10.1038/sj.onc.1203993

By:

Cui, Xian-Shu;
Donehower, Lawrence A

Publication type:

Article

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression.

Published in:

Oncogene, 2000, v. 19, n. 13, p. 1635, doi. 10.1038/sj.onc.1203460

By:

Mussman, Jeffrey G;
Horn, Henning F;
Carroll, Patrick E;
Okuda, Masaru;
Tarapore, Pheruza;
Donehower, Lawrence A;
Fukasawa, Kenji

Publication type:

Article

Mouse models in tumor suppression.

Published in:

Oncogene, 1998, v. 17, n. 25, p. 3385, doi. 10.1038/sj.onc.1202573

By:

Ghebranious, Nader;
Donehower, Lawrence A

Publication type:

Article

EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 12, p. e70, doi. 10.1093/nar/gkac215

By:

Parvandeh, Saeid;
Donehower, Lawrence A;
Panagiotis, Katsonis;
Hsu, Teng-Kuei;
Asmussen, Jennifer K;
Lee, Kwanghyuk;
Lichtarge, Olivier

Publication type:

Article

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.

Published in:

EMBO Journal, 2006, v. 25, n. 6, p. 1406, doi. 10.1038/sj.emboj.7601030

By:

Frese, Kristopher K.;
Latorre, Isabel J.;
Sang-Hyuk Chung;
Caruana, Georgina;
Bernstein, Alan;
Jones, Stephen N.;
Donehower, Lawrence A.;
Justice, Monica J.;
Garner, Craig C.;
Javier, Ronald T.

Publication type:

Article

Coamplification of M yc/ P vt1 and homozygous deletion of N lrp1 locus are frequent genetics changes in mouse osteosarcoma.

Published in:

Genes, Chromosomes & Cancer, 2015, v. 54, n. 12, p. 796, doi. 10.1002/gcc.22291

By:

Rao, Pulivarthi H.;
Zhao, Shuying;
Zhao, Yi‐Jue;
Yu, Alexander;
Rainusso, Nino;
Trucco, Matteo;
Allen‐Rhoades, Wendy;
Satterfield, Laura;
Fuja, Daniel;
Borra, Vishnupriya J.;
Man, Tsz‐Kwong;
Donehower, Lawrence A.;
Yustein, Jason T.

Publication type:

Article

P53 mutant mice that display early ageing-associated phenotypes.

Published in:

Nature, 2002, v. 415, n. 6867, p. 45, doi. 10.1038/415045a

By:

Tyner, Stuart D.;
Venkatachalam, Sundaresan;
Choi, Jene;
Jones, Stephen;
Ghebranious, Nader;
Igelmann, Herbert;
Xiongbin Lu;
Soron, Gabrielle;
Cooper, Benjamin;
Brayton, Cory;
Sang Hee Park;
Thompson, Timothy;
Karsenty, Gerard;
Bradley, Allan;
Donehower, Lawrence A.

Publication type:

Article

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21081-y

By:

Zhang, Yiqun;
Chen, Fengju;
Donehower, Lawrence A.;
Scheurer, Michael E.;
Creighton, Chad J.

Publication type:

Article

WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0115635

By:

Richter, Mark;
Dayaram, Tajhal;
Gilmartin, Aidan G.;
Ganji, Gopinath;
Pemmasani, Sandhya Kiran;
Van Der Key, Harjeet;
Shohet, Jason M.;
Donehower, Lawrence A.;
Kumar, Rakesh

Publication type:

Article

Activation of WIP1 Phosphatase by HTLV-1 Tax Mitigates the Cellular Response to DNA Damage.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055989

By:

Dayaram, Tajhal;
Lemoine, Francene J.;
Donehower, Lawrence A.;
Marriott, Susan J.

Publication type:

Article

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice.

Published in:

PLoS ONE, 2010, v. 5, n. 6, p. 1, doi. 10.1371/journal.pone.0010995

By:

Lee, Susie;
Donehower, Lawrence A.;
Herron, Alan J.;
Moore, David D.;
Loning Fu

Publication type:

Article

Timed Somatic Deletion of p53 in Mice Reveals Age- Associated Differences in Tumor Progression.

Published in:

PLoS ONE, 2009, v. 4, n. 8, p. 1, doi. 10.1371/journal.pone.0006654

By:

Hinkal, George;
Parikh, Neha;
Donehower, Lawrence A.

Publication type:

Article

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

Published in:

Molecular Carcinogenesis, 2006, v. 45, n. 8, p. 594, doi. 10.1002/mc.20195

By:

Bonnie Nannenga;
Xiongbin Lu;
Melissa Dumble;
Marc Van Maanen;
Thuy‐Ai Nguyen;
Richard Sutton;
T. Rajendra Kumar;
Lawrence A. Donehower

Publication type:

Article

Cooperation between Ha- ras and fos or transforming growth factor α overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.

Published in:

Molecular Carcinogenesis, 2000, v. 29, n. 2, p. 67, doi. 10.1002/1098-2744(200010)29:2<67::AID-MC3>3.0.CO;2-2

By:

Wang, Xiao-Jing;
Greenhalgh, David A.;
Donehower, Lawrence A.;
Roop, Dennis R.

Publication type:

Article

Effect of Intragastric Application of N-Methylnitrosourea in p53 Knockout Mice.

Published in:

Molecular Carcinogenesis, 2000, v. 28, n. 2, p. 97, doi. 10.1002/1098-2744(200006)28:2<97::AID-MC5>3.0.CO;2-O

By:

Ohgaki, Hiroko;
Fukuda, Masakatsu;
Tohma, Yasuo;
Huang, Huatao;
Stoica, George;
Tatematsu, Masae;
Donehower, Lawrence A.

Publication type:

Article

Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53.

Published in:

Molecular Carcinogenesis, 1999, v. 24, n. 3, p. 197, doi. 10.1002/(SICI)1098-2744(199903)24:3<197::AID-MC6>3.0.CO;2-V

By:

Tyner, Stuart D.;
Choi, Jene;
Laucirica, Rodolfo;
Ford, Richard J.;
Donehower, Lawrence A.

Publication type:

Article

Effects of genetic background on tumorigenesis in p53-deficient mice.

Published in:

Molecular Carcinogenesis, 1995, v. 14, n. 1, p. 16, doi. 10.1002/mc.2940140105

By:

Donehower, Lawrence A.;
Harvey, Michele;
Vogel, Hannes;
McArthur, Mark J.;
Montgomery, Charles A.;
Park, Sang H.;
Thompson, Timothy;
Ford, Richard J.;
Bradley, Allan

Publication type:

Article

Infrequent p53 mutations in 7,12-dimethylbenz[ a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

Published in:

Molecular Carcinogenesis, 1994, v. 9, n. 3, p. 175, doi. 10.1002/mc.2940090309

By:

Jerry, D. Joseph;
Butel, Janet S.;
Donehower, Lawrence A.;
Paulson, Emily J.;
Cochran, Charles;
Wiseman, Roger W.;
Medina, Daniel

Publication type:

Article

Comprehensive molecular characterization of human colon and rectal cancer.

Published in:

Nature, 2012, v. 487, n. 7407, p. 330, doi. 10.1038/nature11252

By:

Muzny, Donna M.;
Bainbridge, Matthew N.;
Chang, Kyle;
Dinh, Huyen H.;
Drummond, Jennifer A.;
Fowler, Gerald;
Kovar, Christie L.;
Lewis, Lora R.;
Morgan, Margaret B.;
Newsham, Irene F.;
Reid, Jeffrey G.;
Santibanez, Jireh;
Shinbrot, Eve;
Trevino, Lisa R.;
Wu, Yuan-Qing;
Wang, Min;
Gunaratne, Preethi;
Donehower, Lawrence A.;
Creighton, Chad J.;
Wheeler, David A.

Publication type:

Article