Works by Doecke, James D.

Results: 113
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    RUNX2 is an essential transcription factor required for skeletal development and cartilage formation. Haploinsufficiency of RUNX2 leads to cleidocranial displaysia (CCD) a skeletal disorder characterised by gross dysgenesis of bones particularly those derived from intramembranous bone formation. A notable feature of the RUNX2 protein is the polyglutamine and polyalanine (23Q/17A) domain coded by a repeat sequence. Since none of the known mutations causing CCD characterised to date map in the glutamine repeat region, we hypothesised that Q-repeat mutations may be related to a more subtle bone phenotype. We screened subjects derived from four normal populations for Q- repeat variants. A total of 22 subjects were identified who were heterozygous for a wild type allele and a Q-repeat variant allele: (15Q, 16Q, 18Q and 30Q). Although not every subject had data for all measures, Q-repeat variants had a significant deficit in BMD with an average decrease of 0.7SD measured over 12 BMD-related parameters (p = 0.005). Femoral neck BMD was measured in all subjects (--0.6SD, p = 0.0007). The transactivation function of RUNX2 was determined for 16Q and 30Q alleles using a reporter gene assay. 16Q and 30Q alleles displayed significantly lower transactivation function compared to wild type (23Q). Our analysis has identified novel Q-repeat mutations that occur at a collective frequency of about 0.4%. These mutations significantly alter BMD and display impaired transactivation function, introducing a new class of functionally relevant RUNX2 mutants.

    Published in:
    PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042617
    By:
    • Morrison, Nigel A.;
    • Stephens, Alexandre A.;
    • Osato, Motomi;
    • Polly, Patsie;
    • Tan, Timothy C.;
    • Yamashita, Namiko;
    • Doecke, James D.;
    • Pasco, Julie;
    • Fozzard, Nicolette;
    • Jones, Graeme;
    • Ralston, Stuart H.;
    • Sambrook, Philip N.;
    • Prince, Richard L.;
    • Nicholson, Geoff C.;
    • Laird, Elizabeth G.
    Publication type:
    Article
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    Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 2, p. 1, doi. 10.1002/alz.14577
    By:
    • Sim, Ming Ann;
    • Doecke, James D.;
    • Liew, Oi Wah;
    • Wong, Lee Lee;
    • Tan, Eugene S. J.;
    • Chan, Siew Pang;
    • Chong, Joyce R. F.;
    • Cai, Yuan;
    • Hilal, Saima;
    • Venketasubramanian, Narayanaswamy;
    • Tan, Boon Yeow;
    • Lai, Mitchell K. P;
    • Choi, Hyungwon;
    • Masters, Colin L.;
    • Richards, Arthur Mark;
    • Chen, Christopher L. H.
    Publication type:
    Article
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    Comparing plasma Aβ42/40 and pTau217 to predict Amyloid‐β status across the Alzheimer's disease continuum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.091746
    By:
    • Doecke, James D.;
    • Chenna, Ahmed;
    • Lo, Mintzu;
    • Badal, Youssouf;
    • Yee, Brandon;
    • Martone, Robert L.;
    • Petropoulos, Christos;
    • Fowler, Christopher J;
    • Laws, Simon M.;
    • Smith, Stephanie Rainey;
    • Martins, Ralph N;
    • Rowe, Christopher C.;
    • Masters, Colin L;
    • Winslow, John W
    Publication type:
    Article
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    Plasma p217+tau accurately discriminates Intermediate or Advanced Alzheimer's Disease biological PET stages.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.090530
    By:
    • Feizpour, Azadeh;
    • Dore, Vincent;
    • Krishnadas, Natasha;
    • Bourgeat, Pierrick;
    • Doecke, James D.;
    • Saad, Ziad S.;
    • Triana‐Baltzer, Gallen;
    • Laws, Simon M.;
    • Shishegar, Rosita;
    • Huang, Kun;
    • Fowler, Christopher J;
    • Ward, Larry;
    • Masters, Colin L;
    • Fripp, Jurgen;
    • Kolb, Hartmuth C.;
    • Villemagne, Victor L;
    • Rowe, Christopher C.
    Publication type:
    Article
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    OML‐Combine: Online Machine Learning tool for Combining datasets to increase power and facilitate multi‐centre collaboration on Alzheimer's disease studies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.085143
    By:
    • Christodoulides, Chris Dalas;
    • Canovas, Rodrigo;
    • Dore, Vincent;
    • Doecke, James D.;
    • Laws, Simon M;
    • Weiner, Michael W;
    • Rowe, Christopher C.;
    • Villemagne, Victor L;
    • Masters, Colin L.;
    • Fripp, Jurgen;
    • Maruff, Paul;
    • Shishegar, Rosita
    Publication type:
    Article
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    Data‐driven Cognitive Composites and APOE ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.090147
    By:
    • Tallapragada, Bhargav;
    • Galna, Brook;
    • Shishegar, Rosita;
    • Markovic, Shaun J.;
    • Brown, Belinda M.;
    • Dore, Vincent;
    • Laws, Simon M.;
    • O'Brien, Eleanor K.;
    • Porter, Tenielle;
    • Burnham, Samantha C.;
    • Weiner, Michael S. W.;
    • Morris, John C.;
    • Hassenstab, Jason J.;
    • Rowe, Christopher C.;
    • Jin, Liang;
    • Fripp, Jurgen;
    • Lim, Yen Ying;
    • Doecke, James D.;
    • Masters, Colin L.;
    • Maruff, Paul
    Publication type:
    Article
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    Polygenic scores for Alzheimer's disease risk and resilience predict age at onset of amyloid‐β.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.090024
    By:
    • O'Brien, Eleanor K.;
    • Porter, Tenielle;
    • Fernandez, Shane;
    • Cox, Timothy;
    • Dore, Vincent;
    • Bourgeat, Pierrick;
    • Goudey, Benjamin;
    • Doecke, James D.;
    • Masters, Colin L.;
    • Rowe, Christopher C.;
    • Villemagne, Victor L;
    • Cruchaga, Carlos;
    • Saykin, Andrew J.;
    • Laws, Simon M
    Publication type:
    Article
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    Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.085009
    By:
    • Shishegar, Rosita;
    • Cox, Timothy;
    • Markovic, Shaun J;
    • Tallapragada, Bhargav;
    • Bourgeat, Pierrick;
    • Dore, Vincent;
    • Laws, Simon M;
    • Porter, Tenielle;
    • Burnham, Samantha C.;
    • Feizpour, Azadeh;
    • Weiner, Michael S. W.;
    • Hassenstab, Jason J.;
    • Morris, John C.;
    • Rowe, Christopher C.;
    • Villemagne, Victor L;
    • Masters, Colin L.;
    • Fripp, Jurgen;
    • Lim, Yen Ying;
    • Doecke, James D.;
    • Sohrabi, Hamid R.
    Publication type:
    Article
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    Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 11, p. 7923, doi. 10.1002/alz.14270
    By:
    • Sewell, Kelsey R.;
    • Doecke, James D.;
    • Xiong, Chengjie;
    • Benzinger, Tammie;
    • Masters, Colin L.;
    • Laske, Christoph;
    • Jucker, Mathias;
    • Lopera, Francisco;
    • Gordon, Brian A.;
    • Llibre‐Guerra, Jorge;
    • Levin, Johannes;
    • Huey, Edward D.;
    • Hassenstab, Jason;
    • Schofield, Peter R.;
    • Day, Gregory S.;
    • Fox, Nick C.;
    • Chhatwal, Jasmeer;
    • Ibanez, Laura;
    • Roh, Jee Hoon;
    • Perrin, Richard
    Publication type:
    Article
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    Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 1350, doi. 10.1002/alz.13556
    By:
    • Slee, Michael G.;
    • Rainey‐Smith, Stephanie R.;
    • Villemagne, Victor L.;
    • Doecke, James D.;
    • Sohrabi, Hamid R.;
    • Taddei, Kevin;
    • Ames, David;
    • Dore, Vincent;
    • Maruff, Paul;
    • Laws, Simon M.;
    • Masters, Colin L.;
    • Rowe, Christopher C.;
    • Martins, Ralph N.;
    • Erickson, Kirk I.;
    • Brown, Belinda M.
    Publication type:
    Article
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    High risk of obstructive sleep apnoea is associated with higher baseline plasma glial fibrillary acidic protein and predicts decline in levels over time in cognitively unimpaired older adults.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082950
    By:
    • Pivac, Louise N;
    • Pedrini, Steve;
    • Chatterjee, Pratishtha;
    • Doecke, James D;
    • Villemagne, Victor L;
    • Dore, Vincent;
    • Brown, Belinda M;
    • Weinborn, Michael;
    • Sohrabi, Hamid R;
    • Gardener, Samantha L;
    • Asih, Prita Riana;
    • Bucks, Romola S;
    • Masters, Colin L;
    • Rowe, Christopher C;
    • Martins, Ralph N;
    • Rainey‐Smith, Stephanie R
    Publication type:
    Article
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    CSF markers YKL40, sTREM2, and a‐synuclein enhance the Alzheimer's disease A/T/N criteria to detect early changes in cognition.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082891
    By:
    • Canovas, Rodrigo;
    • Fowler, Christopher J;
    • Li, Qiao‐Xin;
    • Rainey‐Smith, Stephanie R;
    • Carboni, Margherita;
    • Suridjan, Ivonne;
    • Kollmorgen, Gwendlyn;
    • Logan, Chad;
    • Collins, Steven J;
    • Maruff, Paul;
    • Martins, Ralph N;
    • Fripp, Jurgen;
    • Zetterberg, Henrik;
    • Blennow, Kaj;
    • Masters, Colin L;
    • Doecke, James D
    Publication type:
    Article
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    Later life Body composition and Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079467
    By:
    • Canovas, Rodrigo;
    • Doecke, James D;
    • Huynh, Andrew;
    • Fowler, Christopher J;
    • Rainey‐Smith, Stephanie R;
    • Dore, Vincent;
    • Fripp, Jurgen;
    • Bourgeat, Pierrick;
    • Maruff, Paul;
    • Ames, David;
    • Rowe, Christopher C;
    • Villemagne, Victor L;
    • Ellis, Kathryn A;
    • Martins, Ralph N;
    • Masters, Colin L;
    • Yates, Paul A
    Publication type:
    Article
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    Cross‐sectional investigation of synaptic markers Neurogranin and BACE1 in CSF from the AIBL study.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078048
    By:
    • Fowler, Christopher J;
    • Stoops, Erik;
    • Vanmechelen, Eugeen;
    • Vanbrabant, Jeroen;
    • Dewit, Nele;
    • Mauroo, Kimberley;
    • Rowe, Christopher C;
    • Fripp, Jurgen;
    • Li, Qiao‐Xin;
    • Bourgeat, Pierrick;
    • Collins, Steven J;
    • Martins, Ralph N;
    • Masters, Colin L;
    • Maruff, Paul;
    • Vanderstichele, Hugo Marcel;
    • Doecke, James D
    Publication type:
    Article
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    Prognostic utility of plasma p217+tau vs amyloid and tau PET in the Alzheimer's continuum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078042
    By:
    • Feizpour, Azadeh;
    • Dore, Vincent;
    • Doecke, James D;
    • Saad, Ziad S.;
    • Triana‐Baltzer, Gallen;
    • Krishnadas, Natasha;
    • Fowler, Christopher J;
    • Ward, Larry;
    • Martins, Ralph N;
    • Masters, Colin L;
    • Villemagne, Victor L;
    • Fripp, Jurgen;
    • Kolb, Hartmuth C.;
    • Rowe, Christopher C
    Publication type:
    Article
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    Plasma pTau181 and biomarker combinations to identify Alzheimer´s disease at any stage along the AD continuum compared with both controls and non‐AD dementia.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077504
    By:
    • Doecke, James D;
    • Bellomo, Giovanni;
    • Vermunt, Lisa;
    • Alcolea, Daniel;
    • Halbgebauer, Steffen;
    • in 't Veld, Sjors G.J.G.;
    • Mattsson‐Carlgren, Niklas;
    • Veverova, Katerina;
    • Fowler, Christopher J;
    • Boonkamp, Lynn;
    • Koel‐Simmerlink, Marleen;
    • Hussainali, Zulaiga;
    • Ruiters, Daimy N.;
    • Gaetani, Lorenzo;
    • Toja, Andrea;
    • Fortea, Juan;
    • Pijnenburg, Yolande A.L.;
    • Lemstra, Afina W.;
    • van der Flier, Wiesje M.;
    • Hort, Jakub
    Publication type:
    Article
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    Plasma protein profiling reveals novel specific biomarkers reflecting the multifactorial nature of Alzheimer´s disease continuum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074777
    By:
    • Bellomo, Giovanni;
    • in 't Veld, Sjors G.J.G.;
    • Doecke, James D;
    • Quesada, Carlos;
    • Vermunt, Lisa;
    • Alcolea, Daniel;
    • Halbgebauer, Steffen;
    • Mattsson‐Carlgren, Niklas;
    • Veverova, Katerina;
    • Boonkamp, Lynn;
    • Hok‐A‐Hin, Yanaika S.;
    • Fowler, Christopher J;
    • Fortea, Juan;
    • Gaetani, Lorenzo;
    • Toja, Andrea;
    • Pijnenburg, Yolande A.L.;
    • Lemstra, Afina W.;
    • van der Flier, Wiesje M.;
    • Hort, Jakub;
    • Otto, Markus
    Publication type:
    Article
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    Amyloid‐β and monocytes in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074481
    By:
    • Huang, Xin;
    • Fowler, Christopher J;
    • Li, Qiao‐Xin;
    • Perez, Keyla;
    • Lim, Yen Ying;
    • Drysdale, Candace;
    • Rumble, Rebecca;
    • Villemagne, Victor L;
    • Rowe, Christopher C;
    • Martins, Ralph N;
    • Maruff, Paul;
    • Doecke, James D;
    • Lin, Yong;
    • Barnham, Kevin J;
    • Masters, Colin L;
    • Gu, Ben J
    Publication type:
    Article
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    Amyloid‐β and monocytes in Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074481
    By:
    • Huang, Xin;
    • Fowler, Christopher J;
    • Li, Qiao‐Xin;
    • Perez, Keyla;
    • Lim, Yen Ying;
    • Drysdale, Candace;
    • Rumble, Rebecca;
    • Villemagne, Victor L;
    • Rowe, Christopher C;
    • Martins, Ralph N;
    • Maruff, Paul;
    • Doecke, James D;
    • Lin, Yong;
    • Barnham, Kevin J;
    • Masters, Colin L;
    • Gu, Ben J
    Publication type:
    Article
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    Head‐to‐head comparison of plasma biomarkers across the AD continuum in an Australian population.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.065323
    By:
    • Chatterjee, Pratishtha;
    • Pedrini, Steve;
    • Doecke, James D;
    • Thota, Rohith N;
    • Villemagne, Victor L;
    • Dore, Vincent;
    • Singh, Abhay K;
    • Wang, Penghao;
    • Rainey‐Smith, Stephanie;
    • Fowler, Christopher J;
    • Taddei, Kevin;
    • Sohrabi, Hamid R;
    • Molloy, Mark P;
    • Ames, David;
    • Maruff, Paul;
    • Rowe, Christopher C.;
    • Masters, Colin L.;
    • Martins, Ralph N
    Publication type:
    Article
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    Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 5, p. 2084, doi. 10.1002/alz.12813
    By:
    • Huang, Xin;
    • Li, Yihan;
    • Fowler, Christopher;
    • Doecke, James D.;
    • Lim, Yen Ying;
    • Drysdale, Candace;
    • Zhang, Vicky;
    • Park, Keunha;
    • Trounson, Brett;
    • Pertile, Kelly;
    • Rumble, Rebecca;
    • Pickering, John W.;
    • Rissman, Robert A.;
    • Sarsoza, Floyd;
    • Abdel‐Latif, Sara;
    • Lin, Yong;
    • Doré, Vincent;
    • Villemagne, Victor;
    • Rowe, Christopher C.;
    • Fripp, Jurgen
    Publication type:
    Article
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    Plasma Aβ42/40 ratio, p‐tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross‐sectional and longitudinal study in the AIBL cohort.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 4, p. 1117, doi. 10.1002/alz.12724
    By:
    • Chatterjee, Pratishtha;
    • Pedrini, Steve;
    • Doecke, James D.;
    • Thota, Rohith;
    • Villemagne, Victor L.;
    • Doré, Vincent;
    • Singh, Abhay K.;
    • Wang, Penghao;
    • Rainey‐Smith, Stephanie;
    • Fowler, Christopher;
    • Taddei, Kevin;
    • Sohrabi, Hamid R.;
    • Molloy, Mark P.;
    • Ames, David;
    • Maruff, Paul;
    • Rowe, Christopher C.;
    • Masters, Colin L.;
    • Martins, Ralph N.
    Publication type:
    Article
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    Plasma pTau181/Aβ42 identifies cognitive change earlier than CSF pTau181/Ab42.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.064341
    By:
    • Fowler, Christopher;
    • Stoops, Erik;
    • Rainey‐Smith, Stephanie;
    • Vanmechelen, Eugeen;
    • Vanbrabant, Jeroen;
    • Dewit, Nele;
    • Mauroo, Kimberley;
    • Rowe, Christopher;
    • Fripp, Jurgen;
    • Li, Qiao‐Xin;
    • Bourgeat, Pierrick;
    • Collins, Steven;
    • Martins, Ralph N;
    • Masters, Colin L;
    • Maruff, Paul;
    • Doecke, James D
    Publication type:
    Article
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    Suboptimal sleep efficiency and duration predicts rate of accumulation of Aβ‐ Amyloid in cognitively normal older adults.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.060975
    By:
    • Pivac, Louise N;
    • Brown, Belinda M;
    • Sewell, Kelsey R;
    • Doecke, James D;
    • Villemagne, Victor L;
    • Dore, Vincent;
    • Weinborn, Michael;
    • Sohrabi, Hamid R;
    • Gardener, Samantha L;
    • Bucks, Romola S;
    • Masters, Colin L;
    • Rowe, Christopher;
    • Martins, Ralph N;
    • Rainey‐Smith, Stephanie
    Publication type:
    Article