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Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.
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- Oncogene, 2009, v. 28, n. 45, p. 4009, doi. 10.1038/onc.2009.250
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- Article
PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia.
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- Oncogene, 2008, v. 27, n. 44, p. 5785, doi. 10.1038/onc.2008.192
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- Article
MANOMETRIC STUDY OF THE ACTIVITY OF ALIZAPRIDE ON THE MOTOR FUNCTION OF THE HUMAN SPHINCTER OF ODDI.
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- Journal of Clinical Pharmacy & Therapeutics, 1988, v. 13, n. 4, p. 281, doi. 10.1111/j.1365-2710.1988.tb00194.x
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- Article
IgA subclasses in various secretions and in serum.
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- Immunology, 1982, v. 47, n. 2, p. 383
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- Article
Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis.
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- Nature, 1991, v. 349, n. 6310, p. 612, doi. 10.1038/349612a0
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- Article
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.
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- Cell Death & Disease, 2013, v. 4, n. 5, p. 1, doi. 10.1038/cddis.2013.137
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- Article
A study to investigate dose escalation of doxorubicin in ABVD chemotherapy for Hodgkin lymphoma incorporating biomarkers of response and toxicity.
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- British Journal of Cancer, 2013, v. 109, n. 10, p. 2560, doi. 10.1038/bjc.2013.605
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- Article
The interaction between prognostic and pharmacodynamic biomarkers.
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- British Journal of Cancer, 2013, v. 109, n. 7, p. 1782, doi. 10.1038/bjc.2013.527
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- Article
Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients.
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- British Journal of Cancer, 2013, v. 108, n. 8, p. 1704, doi. 10.1038/bjc.2013.112
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- Article
Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.
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- British Journal of Cancer, 2012, v. 107, n. 9, p. 1518, doi. 10.1038/bjc.2012.416
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- Article
Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial.
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- British Journal of Cancer, 2012, v. 106, n. 11, p. 1766, doi. 10.1038/bjc.2012.165
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- Article
A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.
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- British Journal of Cancer, 2012, v. 106, n. 3, p. 508, doi. 10.1038/bjc.2011.545
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- Article
Assessment of circulating biomarkers for potential pharmacodynamic utility in patients with lymphoma.
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- 2011
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- journal article
Fit-for-purpose biomarker method validation for application in clinical trials of anticancer drugs.
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- British Journal of Cancer, 2010, v. 103, n. 9, p. 1313, doi. 10.1038/sj.bjc.6605910
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- Article
Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs.
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- 2010
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- journal article
Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.
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- 2010
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- journal article
A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.
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- 2010
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- journal article
Biomarkers of angiogenesis and their role in the development of VEGF inhibitors.
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- 2010
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- Publication type:
- journal article
Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.
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- 2009
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- journal article
Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.
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- 2009
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- journal article
Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
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- 2009
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- journal article
Biomarkers of apoptosis.
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- 2008
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- journal article
Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer.
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- 2008
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- journal article
Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity.
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- 2006
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- journal article
Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.
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- 2006
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- journal article
Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response.
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- Cell Death & Differentiation, 2013, v. 20, n. 5, p. 765, doi. 10.1038/cdd.2013.8
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- Article
Report of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland.
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- QJM: An International Journal of Medicine, 2018, v. 111, n. 12, p. 927, doi. 10.1093/qjmed/hcy194
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- Article
A proof-of-principle gel-free proteomics strategy for the identification of predictive biomarkers for the onset of pre-eclampsia.
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- BJOG: An International Journal of Obstetrics & Gynaecology, 2009, v. 116, n. 11, p. 1473, doi. 10.1111/j.1471-0528.2009.02283.x
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- Article
Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors.
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- 2000
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- Publication type:
- journal article
Refeeding after starvation in the rat: comparative effects of lipids, proteins and carbohydrates on jejunal and ileal mucosal adaptation.
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- European Journal of Clinical Investigation, 1990, v. 20, n. 4, p. 441, doi. 10.1111/j.1365-2362.1990.tb01882.x
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- Article
Intestinal development in the suckling rat: effect of insulin on the maturation of villus and crypt cell functions.
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- European Journal of Clinical Investigation, 1988, v. 18, n. 4, p. 391, doi. 10.1111/j.1365-2362.1988.tb01029.x
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- Article
Proapoptotic Bid binds to monolysocardiolipin, a new molecular connection between mitochondrial membranes and cell death.
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- Cell Death & Differentiation, 2003, v. 10, n. 12, p. 1300, doi. 10.1038/sj.cdd.4401306
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- Article
Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface.
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- Cell Death & Differentiation, 2000, v. 7, n. 2, p. 234, doi. 10.1038/sj.cdd.4400634
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- Article
Immunohistochemical Localization of Secretory Component in the Liver of Guinea Pigs and Dogs versus Rats, Rabbits, and Mice.
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- Scandinavian Journal of Immunology, 1984, v. 19, n. 5, p. 425, doi. 10.1111/j.1365-3083.1984.tb00951.x
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- Article
AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies.
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- Investigational New Drugs, 2015, v. 33, n. 3, p. 679, doi. 10.1007/s10637-015-0235-5
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- Article
Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced <em>in vivo</em> secretion of secretory IgA.
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- Clinical & Experimental Immunology, 1990, v. 80, n. 2, p. 196
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- Publication type:
- Article
The rodent non-genotoxic hepatocarcinogen nafenopin suppresses apoptosis preferentially in non-cycling hepatocytes but also elevates CDK4, a cell cycle progression factor.
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- Carcinogenesis, 1998, v. 19, n. 10, p. 1743, doi. 10.1093/carcin/19.10.1743
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- Article
The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFβ1, DNA damage and Fas.
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- Carcinogenesis, 1998, v. 19, n. 2, p. 299, doi. 10.1093/carcin/19.2.299
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- Article
Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix.
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- 2005
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- Publication type:
- journal article
Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.
- Published in:
- British Journal of Cancer, 2005, v. 92, n. 3, p. 532, doi. 10.1038/sj.bjc.6602363
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- Publication type:
- Article
iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms.
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- Cancer Cell International, 2021, v. 21, n. 1, p. 1, doi. 10.1186/s12935-021-01918-8
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- Article
Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma.
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- Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 6, p. 921, doi. 10.1007/s00280-007-0437-4
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- Article
Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.
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- 2010
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- Publication type:
- journal article
Biomarker method validation in anticancer drug development.
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- British Journal of Pharmacology, 2008, v. 153, n. 4, p. 646, doi. 10.1038/sj.bjp.0707441
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- Article
Cancer Moonshot Connecting International Liquid Biopsy Efforts Through Academic Partnership.
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- Clinical Pharmacology & Therapeutics, 2017, v. 101, n. 5, p. 622, doi. 10.1002/cpt.657
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- Article