Works by Diao, Xingxing

Results: 23

A mass balance study of [14C] SHR6390 (dalpiciclib), a selective and potent CDK4/6 inhibitor in humans.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1116073

By:

Hua Zhang;
Shu Yan;
Yan Zhan;
Sheng Ma;
Yicong Bian;
Shaorong Li;
Junjun Tian;
Guangze Li;
Dafang Zhong;
Xingxing Diao;
Liyan Miao

Publication type:

Article

A Traceless Site‐Specific Conjugation on Native Antibodies Enables Efficient One‐Step Payload Assembly.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 36, p. 1, doi. 10.1002/anie.202204132

By:

Zeng, Yue;
Shi, Wei;
Dong, Qian;
Li, Wanzhen;
Zhang, Jianxin;
Ren, Xuelian;
Tang, Caihong;
Liu, Bo;
Song, Yuanli;
Wu, Yali;
Diao, Xingxing;
Zhou, Hu;
Huang, He;
Tang, Feng;
Huang, Wei

Publication type:

Article

25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry.

Published in:

Drug Testing & Analysis, 2017, v. 9, n. 5, p. 680, doi. 10.1002/dta.2044

By:

Wohlfarth, Ariane;
Roman, Markus;
Andersson, Mikael;
Kugelberg, Fredrik C.;
Diao, Xingxing;
Carlier, Jeremy;
Eriksson, Caroline;
Wu, Xiongyu;
Konradsson, Peter;
Josefsson, Martin;
Huestis, Marilyn A.;
Kronstrand, Robert

Publication type:

Article

Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2016, v. 30, n. 8, p. 1067, doi. 10.1002/rcm.7538

By:

Andersson, Maria;
Diao, Xingxing;
Wohlfarth, Ariane;
Scheidweiler, Karl B.;
Huestis, Marilyn A.

Publication type:

Article

First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.

Published in:

Analytical & Bioanalytical Chemistry, 2016, v. 408, n. 18, p. 4845, doi. 10.1007/s00216-016-9599-4

By:

Swortwood, Madeleine;
Ellefsen, Kayla;
Wohlfarth, Ariane;
Diao, Xingxing;
Concheiro-Guisan, Marta;
Kronstrand, Robert;
Huestis, Marilyn

Publication type:

Article

Pharmacokinetics, mass balance, and metabolism of [14C]PLB1004, a selective and irreversible EGFR-TKI in humans.

Published in:

Cancer Chemotherapy & Pharmacology, 2025, v. 95, n. 1, p. 1, doi. 10.1007/s00280-024-04744-7

By:

Liu, Donghui;
Li, Qian;
Yan, Shu;
Zhang, Xinyue;
Li, Weiqiang;
Wang, Feiyu;
Gao, Lei;
Geng, Fei;
Zhou, Haiyan;
Ye, Panpan;
Zhao, Furong;
Xue, Weizhe;
Zhang, Peilong;
Diao, Xingxing;
Zhao, Wei

Publication type:

Article

Pharmacokinetics, mass balance, and metabolism of [14C]envonalkib (TQ-B3139), a novel ALK tyrosine kinase inhibitor, in healthy Chinese subjects.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 5, p. 647, doi. 10.1007/s00280-024-04647-7

By:

Ma, Sheng;
Wang, Xin;
Yan, Shu;
Miao, Liyan;
Wan, Xiaojing;
Ding, Dawei;
Yu, Ding;
Diao, Xingxing;
Wang, Xunqiang;
Zhang, Hua

Publication type:

Article

Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 230, doi. 10.3390/ijms22010230

By:

Carlier, Jeremy;
Diao, Xingxing;
Giorgetti, Raffaele;
Busardò, Francesco P.;
Huestis, Marilyn A.

Publication type:

Article

Development and validation of a sensitive liquid chromatography‐tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration

Published in:

Journal of Separation Science, 2024, v. 47, n. 1, p. 1, doi. 10.1002/jssc.202300786

By:

Wang, Linwei;
Yin, Xiaoying;
Liu, Huan;
Wang, Yangyang;
Li, Zhixiong;
Zhao, Yuxuan;
Xu, Haibo;
Huang, Chenggang;
Diao, Xingxing

Publication type:

Article

A Traceless Site‐Specific Conjugation on Native Antibodies Enables Efficient One‐Step Payload Assembly.

Published in:

Angewandte Chemie, 2022, v. 134, n. 36, p. 1, doi. 10.1002/ange.202204132

By:

Zeng, Yue;
Shi, Wei;
Dong, Qian;
Li, Wanzhen;
Zhang, Jianxin;
Ren, Xuelian;
Tang, Caihong;
Liu, Bo;
Song, Yuanli;
Wu, Yali;
Diao, Xingxing;
Zhou, Hu;
Huang, He;
Tang, Feng;
Huang, Wei

Publication type:

Article

Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients.

Published in:

British Journal of Pharmacology, 2013, v. 168, n. 7, p. 1687, doi. 10.1111/bph.12047

By:

Xie, Cen;
Zhou, Jialan;
Guo, Zitao;
Diao, Xingxing;
Gao, Zhiwei;
Zhong, Dafang;
Jiang, Haoyuan;
Zhang, Lijia;
Chen, Xiaoyan

Publication type:

Article

Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC–MS/MS.

Published in:

AAPS Journal, 2025, v. 27, n. 1, p. 1, doi. 10.1208/s12248-024-01007-4

By:

Yu, Xiong;
Li, Weiqiang;
Huang, Wensi;
Xiao, Bo;
Long, Jing;
Wang, Qi;
Wang, Guifeng;
Wang, Chunhe;
Yu, Mingming;
Yu, Jinghua;
Diao, Xingxing

Publication type:

Article

Identification of New Synthetic Cannabinoid ADB-CHMINACA (MAB-CHMINACA) Metabolites in Human Hepatocytes.

Published in:

AAPS Journal, 2017, v. 19, n. 2, p. 568, doi. 10.1208/s12248-016-0037-5

By:

Carlier, Jeremy;
Diao, Xingxing;
Sempio, Cristina;
Huestis, Marilyn

Publication type:

Article

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.

Published in:

AAPS Journal, 2016, v. 18, n. 2, p. 455, doi. 10.1208/s12248-016-9867-4

By:

Diao, Xingxing;
Scheidweiler, Karl;
Wohlfarth, Ariane;
Pang, Shaokun;
Kronstrand, Robert;
Huestis, Marilyn

Publication type:

Article

Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18.

Published in:

Clinical Chemistry, 2017, v. 63, n. 11, p. 1753, doi. 10.1373/clinchem.2017.277152

By:

Xingxing Diao;
Carlier, Jeremy;
Mingshe Zhu;
Huestis, Marilyn A.

Publication type:

Article

Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry.

Published in:

Clinical Chemistry, 2017, v. 63, n. 5, p. 1008, doi. 10.1373/clinchem.2016.267575

By:

Carlier, Jeremy;
Xingxing Diao;
Scheidweiler, Karl B.;
Huestis, Marilyn A.

Publication type:

Article

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes.

Published in:

Clinical Chemistry, 2016, v. 62, n. 1, p. 157, doi. 10.1373/clinchem.2015.243535

By:

Xingxing Diao;
Wohlfarth, Ariane;
Shaokun Pang;
Scheidweiler, Karl B.;
Huestis, Marilyn A.

Publication type:

Article

Absorption, Distribution, Metabolism, and Excretion of [ 14 C]BS1801, a Selenium-Containing Drug Candidate, in Rats.

Published in:

Molecules, 2023, v. 28, n. 24, p. 8102, doi. 10.3390/molecules28248102

By:

Yang, Cheng;
Xue, Mingzhen;
He, Yifei;
Yin, Hanwei;
Yang, Chen;
Zhong, Dafang;
Zeng, Huihui;
Zheng, Yuandong;
Diao, Xingxing

Publication type:

Article

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide.

Published in:

Drug Design, Development & Therapy, 2016, v. 10, p. 2181, doi. 10.2147/DDDT.S111352

By:

Jinfang Jiang;
Xuehai Pang;
Liang Li;
Xiaojian Dai;
Xingxing Diao;
Xiaoyan Chen;
Dafang Zhong;
Yingwei Wang;
Yuanwei Chen

Publication type:

Article

Utility of quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis in the assessment of tissue distribution of [14C]Mefuparib (CVL218) in SD and LE rats.

Published in:

PLoS ONE, 2024, v. 19, n. 12, p. 1, doi. 10.1371/journal.pone.0315223

By:

Li, Xinmei;
Wang, Feiyu;
Zhang, Xinyue;
Shen, Xiaokun;
Yang, Chunhao;
Zheng, Yuandong;
Diao, Xingxing

Publication type:

Article

Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS.

Published in:

Xenobiotica, 2024, v. 54, n. 1, p. 1, doi. 10.1080/00498254.2023.2289635

By:

Yuan, Yali;
Wang, Weiqiang;
Luo, Jing;
Tang, Chongzhuang;
Zheng, Yuandong;
Yu, Jinghua;
Xu, Honghong;
Zhu, Mingshe;
Hang, Taijun;
Wang, Hao;
Diao, Xingxing

Publication type:

Article

Absorption, metabolism, and excretion of [14C]YY-20394, a highly selective PI3K-Delta inhibitor in humans.

Published in:

Xenobiotica, 2022, v. 52, n. 3, p. 254, doi. 10.1080/00498254.2022.2062581

By:

Yu, Jinghua;
Zhang, Hua;
Zhang, Yifan;
Zhan, Yan;
Ma, Sheng;
Hu, Tao;
Zhang, Ning;
Lou, Yangtong;
Bao, Hanying;
Xu, Zusheng;
Zhong, Dafang;
Miao, Liyan;
Diao, Xingxing

Publication type:

Article

Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats.

Published in:

Xenobiotica, 2022, v. 52, n. 1, p. 79, doi. 10.1080/00498254.2022.2030504

By:

Cheng, Huan;
Yu, Jinghua;
Yang, Chen;
Zhang, Ning;
Fan, Zhen;
Zhang, Xiaojuan;
Wang, Junchen;
Wang, Zhen;
Zhong, Da-fang;
He, Ji-Xiang;
Yan, Shu;
Diao, Xingxing

Publication type:

Article

Works by Diao, Xingxing

A mass balance study of [<sup>14</sup>C] SHR6390 (dalpiciclib), a selective and potent CDK4/6 inhibitor in humans.

A Traceless Site‐Specific Conjugation on Native Antibodies Enables Efficient One‐Step Payload Assembly.

25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry.

Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry.

First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.

Pharmacokinetics, mass balance, and metabolism of [<sup>14</sup>C]PLB1004, a selective and irreversible EGFR-TKI in humans.

Pharmacokinetics, mass balance, and metabolism of [<sup>14</sup>C]envonalkib (TQ-B3139), a novel ALK tyrosine kinase inhibitor, in healthy Chinese subjects.

Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations.

Development and validation of a sensitive liquid chromatography‐tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration

A Traceless Site‐Specific Conjugation on Native Antibodies Enables Efficient One‐Step Payload Assembly.

Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients.

Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC–MS/MS.

Identification of New Synthetic Cannabinoid ADB-CHMINACA (MAB-CHMINACA) Metabolites in Human Hepatocytes.

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.

Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18.

Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry.

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes.

Absorption, Distribution, Metabolism, and Excretion of [ 14 C]BS1801, a Selenium-Containing Drug Candidate, in Rats.

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide.

Utility of quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis in the assessment of tissue distribution of [<sup>14</sup>C]Mefuparib (CVL218) in SD and LE rats.

Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS.

Absorption, metabolism, and excretion of [<sup>14</sup>C]YY-20394, a highly selective PI3K-Delta inhibitor in humans.

Absorption, distribution, metabolism, and excretion of [<sup>14</sup>C]TPN729 after oral administration to rats.