Works by DiGiovanni, John

Results: 118

Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models.

Published in:

Journal of Skin Cancer, 2013, p. 1, doi. 10.1155/2013/684050

By:

Macias, Everardo;
Rao, Dharanija;
DiGiovanni, John

Publication type:

Article

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model.

Published in:

Nature Medicine, 2005, v. 11, n. 1, p. 43, doi. 10.1038/nm1162

By:

Sano, Shigetoshi;
Chan, Keith Syson;
Carbajal, Steve;
Clifford, John;
Peavey, Mary;
Kiguchi, Kaoru;
Itami, Satoshi;
Nickoloff, Brian J;
DiGiovanni, John

Publication type:

Article

STUDIES WITH CHLORINATED DIBENZO- p-DIOXINS, POLYBROMINATED BIPHENYLS, AND POLYCHLORINATED BIPHENYLS IN A TWO-STAGE SYSTEM OF MOUSE SKIN TUMORIGENESIS: POTENT ANTICARCINOGENIC EFFECTS*.

Published in:

Annals of the New York Academy of Sciences, 1979, v. 320, n. 1, p. 405, doi. 10.1111/j.1749-6632.1979.tb56621.x

By:

Berry, David L.;
Slaga, Thomas J.;
DiGiovanni, John;
Juchau, Mont R.

Publication type:

Article

Constitutive activation of Stat3 in mouse epidermis is linked to hair deficiency and cytoskeletal network damage.

Published in:

Experimental Dermatology, 2015, v. 24, n. 10, p. 796, doi. 10.1111/exd.12744

By:

Lee, Hyunseung;
Kim, Mihwa;
Morales, Liza D.;
Riggs, Penny K.;
DiGiovanni, John;
Kim, Dae Joon

Publication type:

Article

Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.

Published in:

Carcinogenesis, 2012, v. 33, n. 11, p. 2208, doi. 10.1093/carcin/bgs213

By:

Shen, Jianjun;
Abel, Erika L.;
Riggs, Penny K.;
Repass, John;
Hensley, Sean C.;
Schroeder, Lisa J.;
Temple, Angelina;
Chau, Alexander;
McClellan, S.Alex;
Rho, Okkyung;
Kiguchi, Kaoru;
Ward, Michael D.;
Semmes, O.John;
Person, Maria D.;
Angel, Joe M.;
DiGiovanni, John

Publication type:

Article

Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018266

By:

Swindell, William R.;
Johnston, Andrew;
Carbajal, Steve;
Gangwen Han;
Wohn, Christian;
Jun Lu;
Xianying Xing;
Nair, Rajan P.;
Voorhees, John J.;
Elder, James T.;
Xiao-Jing Wang;
Shigetoshi Sano;
Prens, Errol P.;
DiGiovanni, John;
Pittelkow, Mark R.;
Ward, Nicole L.;
Gudjonsson, Johann E.

Publication type:

Article

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation.

Published in:

PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010290

By:

Dae Joon Kim;
Tremblay, Michel L.;
DiGiovanni, John

Publication type:

Article

A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity.

Published in:

Assay & Drug Development Technologies, 2010, v. 8, n. 2, p. 200, doi. 10.1089/adt.2009.0248

By:

Adam Yasgar;
John Shultz;
Wenhui Zhou;
Hui Wang;
Fen Huang;
Nancy Murphy;
Erika L. Abel;
John DiGiovanni;
James Inglese;
Anton Simeonov

Publication type:

Article

Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin.

Published in:

Molecular Carcinogenesis, 1996, v. 17, n. 2, p. 62, doi. 10.1002/(SICI)1098-2744(199610)17:2<62::AID-MC2>3.0.CO;2-V

By:

Rho, Okkyung;
Bol, David K.;
You, Jinsong;
Beltrán, Linda;
Rupp, Tim;
DiGiovanni, John

Publication type:

Article

Elevation of transforming growth factor-α mRNA and protein expression by diverse tumor promoters in sencar mouse epidermis.

Published in:

Molecular Carcinogenesis, 1995, v. 12, n. 4, p. 225, doi. 10.1002/mc.2940120407

By:

Kiguchi, Kaoru;
Beltrán, Linda M.;
You, Jinsong;
Rho, Okkyung;
Digiovanni, John

Publication type:

Article

Altered expression of the epidermal growth factor receptor and transforming growth factor-α during multistage skin carcinogenesis in SENCAR mice.

Published in:

Molecular Carcinogenesis, 1994, v. 11, n. 1, p. 19, doi. 10.1002/mc.2940110105

By:

Rho, Okkyung;
Beltrán, Linda M.;
Gimenez-Conti, Irma B.;
Digiovanni, John

Publication type:

Article

Further analysis of c-Ha- ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in sencar mice.

Published in:

Molecular Carcinogenesis, 1993, v. 8, n. 4, p. 272, doi. 10.1002/mc.2940080410

By:

Digiovanni, John;
Beltrán, Linda;
Rupp, Amy;
Gill, Rosalynn D.;
Harvey, Ronald G.

Publication type:

Article

Mutagenic specificity of the (+) anti-diol epoxide of dibenz[ a,j]anthracene in the supF gene of an Escherichia coli plasmid.

Published in:

Molecular Carcinogenesis, 1993, v. 8, n. 3, p. 145, doi. 10.1002/mc.2940080305

By:

Gill, Rosalynn D.;
Digiovanni, John;
Cortez, Cecilia;
Harvey, Ronald G.;
Rodriguez, Henry;
Loechler, Edward L.

Publication type:

Article

Analysis of point mutations in murine c-Ha- ras of skin tumors initiated with dibenz[ a,j]anthracene and derivatives.

Published in:

Molecular Carcinogenesis, 1992, v. 6, n. 1, p. 53, doi. 10.1002/mc.2940060109

By:

Gill, Rosalynn D.;
Beltrán, Linda;
Nettikumara, Anusha N.;
Harvey, Ronald G.;
Kootstra, Arend;
Digiovanni, John

Publication type:

Article

Evidence for autocrine/paracrine growth stimulation by transforming growth factor-α during the process of skin tumor promotion.

Published in:

Molecular Carcinogenesis, 1991, v. 4, n. 1, p. 52, doi. 10.1002/mc.2940040109

By:

Imamoto, Akira;
Beltrán, Linda M.;
Digiovanni, John

Publication type:

Article

Partial characterization of epidermal protein kinase C in mice sensitive or resistant to phorbol ester.

Published in:

Molecular Carcinogenesis, 1990, v. 3, n. 3, p. 171, doi. 10.1002/mc.2940030311

By:

Hirabayashi, Naoki;
Warren, Barbour S.;
Wang, Xiao-Jing;
Petersen-Marht, Svend;
Beltran, Linda;
Davis, Melika M.;
Ashendel, Curtis L.;
Digiovanni, John

Publication type:

Article

Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells.

Published in:

Cancer Biology & Therapy, 2012, v. 13, n. 10, p. 908, doi. 10.4161/cbt.20843

By:

Piyanuch Wonganan;
Woon-Gye Chung;
Saijie Zhu;
Kaoru Kiguchi;
Digiovanni, John;
Zhengrong Cui

Publication type:

Article

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.

Published in:

PLoS Genetics, 2016, v. 12, n. 1, p. 1, doi. 10.1371/journal.pgen.1005777

By:

Lomada, Dakshayani;
Jain, Manju;
Bolner, Michelle;
Reeh, Kaitlin A. G.;
Kang, Rhea;
Reddy, Madhava C.;
DiGiovanni, John;
Richie, Ellen R.

Publication type:

Article

Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 192, doi. 10.1172/JCI42204

By:

Jie Tian;
Berton, Thomas R.;
Shirley, Stephanie H.;
Lambertz, Isabel;
Gimenez-Conti, Irma B.;
DiGiovanni, John;
Korach, Kenneth S.;
Conti, Claudio J.;
Fuchs-Young, Robin

Publication type:

Article

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.

Published in:

2004

By:

Chan, Keith Syson;
Sano, Shigetoshi;
Kiguchi, Kaoru;
Anders, Joanne;
Komazawa, Nobuyasu;
Takeda, Junji;
DiGiovanni, John

Publication type:

journal article

Characterization of a major aromatic DNA adduct detected in human breast tissues.

Published in:

Environmental & Molecular Mutagenesis, 2002, v. 39, n. 2/3, p. 193, doi. 10.1002/em.10063

By:

Li, Donghui;
Wang, Mianying;
Firozi, Pervez Firoz;
Chang, Ping;
Zhang, Weiqing;
Baer-Dubowska, Wanda;
Moorthy, Bhagavatula;
Vulimiri, Suryanarayana V.;
Goth-Goldstein, Regine;
Weyand, Eric H.;
DiGiovanni, John

Publication type:

Article

Biotransformation and Bioactivation of 7,12-Dimethylbenz[a]anthracene (7,12-DMBA).

Published in:

Drug Metabolism Reviews, 1980, v. 11, n. 1, p. 61, doi. 10.3109/03602538008994022

By:

Digiovanni, John;
Juchau, Mont R.

Publication type:

Article

Inflammation appears as high Prostate Imaging–Reporting and Data System scores on prostate magnetic resonance imaging (MRI) leading to false positive MRI fusion biopsy.

Published in:

Investigative & Clinical Urology, 2019, v. 60, n. 5, p. 388, doi. 10.4111/icu.2019.60.5.388

By:

Rourke, Elizabeth;
Sunnapwar, Abhijit;
Mais, Daniel;
Kukkar, Vishal;
DiGiovanni, John;
Kaushik, Dharam;
Liss, Michael A.

Publication type:

Article

Evidence That Gsta4 Modifies Susceptibility to Skin Tumor Development in Mice and Humans.

Published in:

JNCI: Journal of the National Cancer Institute, 2010, v. 102, n. 21, p. 1663, doi. 10.1093/jnci/djq392

By:

Abel, Erika L.;
Angel, Joe M.;
Riggs, Penny K.;
Langfield, Laura;
Herng-Hsiang Lo;
Person, Maria D.;
Awasthi, Yogesh C.;
Li-E Wang;
Strom, Sara S.;
Qingyi Wei;
DiGiovanni, John

Publication type:

Article

DNA Structure-induced Genomic Instability In Vivo.

Published in:

JNCI: Journal of the National Cancer Institute, 2008, v. 100, n. 24, p. 1815, doi. 10.1093/jnci/djn385

By:

Guliang Wang;
Carbajal, Steve;
Vijg, Jan;
DiGiovanni, John;
Vasquez, Karen M.

Publication type:

Article

Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.

Published in:

1999

By:

Hursting, Stephen D.;
Slaga, Thomas J.;
Fischer, Susan M.;
DiGiovanni,, John;
Phang, James M.;
Hursting, S D;
Slaga, T J;
Fischer, S M;
DiGiovanni, J;
Phang, J M

Publication type:

journal article

Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development.

Published in:

Scientific Reports, 2017, p. 45077, doi. 10.1038/srep45077

By:

Lee, Hyunseung;
Kim, Mihwa;
Baek, Minwoo;
Morales, Liza D.;
Jang, Ik-Soon;
Slaga, Thomas J.;
DiGiovanni, John;
Kim, Dae Joon

Publication type:

Article

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

Published in:

Oncogene, 1997, v. 14, n. 14, p. 1725, doi. 10.1038/sj.onc.1201011

By:

Bol, David K;
Kiguchi, Kaoru;
Gimenez-Conti, Irma;
Rupp, Tim;
DiGiovanni, John

Publication type:

Article

Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion.

Published in:

Oncogene, 1997, v. 14, n. 12, p. 1435, doi. 10.1038/sj.onc.1200980

By:

Xian, Wenjuan;
Rosenberg, Michael P;
DiGiovanni, John

Publication type:

Article

Saturated fat intake predicts biochemical failure after prostatectomy.

Published in:

International Journal of Cancer, 2008, v. 122, n. 11, p. 2581, doi. 10.1002/ijc.23414

By:

Strom, Sara S.;
Yamamura, Yuko;
Forman, Michele R.;
Pettaway, Curtis A.;
Barrera, Stephanie L.;
DiGiovanni, John

Publication type:

Article

Alterations in Cholesterol Sulfate and its Biosynthetic Enzyme During Multistage Carcinogenesis in Mouse Skin.

Published in:

Journal of Investigative Dermatology, 1998, v. 111, n. 6, p. 973, doi. 10.1046/j.1523-1747.1998.00404.x

By:

Kiguchi, Kaoru;
Kagehara, Miwako;
Higo, Ryuzaburo;
Iwamori, Masao;
DiGiovanni, John

Publication type:

Article

Analysis of the Ability of 12-O-Tetradecanoylphorbol-13-Acetate to Induce Epidermal Hyperplasia, Transforming Growth Factor-α, and Skin Tumor Promotion in wa-1 Mice.

Published in:

Journal of Investigative Dermatology, 1997, v. 108, n. 5, p. 784, doi. 10.1111/1523-1747.ep12292237

By:

Kiguchi, Kaoru;
Beltrán, Linda;
Dubowski, Adam;
DiGiovanni, John

Publication type:

Article

Histologic Alterations Produced by Chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) in SENCAR Mouse Skin: Relationship to Skin Tumor Promoting Activity.

Published in:

Journal of Investigative Dermatology, 1989, v. 92, n. 1, p. 64, doi. 10.1111/1523-1747.ep13071228

By:

Kruszewski, Francis H.;
Naito, Masashi;
Naito, Yukiko;
DiGiovanni, John

Publication type:

Article

Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer.

Published in:

2025

By:

Trecarten, Shaun;
Liss, Michael A.;
Hamilton-Reeves, Jill;
DiGiovanni, John

Publication type:

Literature Review

Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.

Published in:

Oncogene, 2000, v. 19, n. 37, p. 4243, doi. 10.1038/sj.onc.1203778

By:

Kiguchi, Kaoru;
Bol, David;
Carbajal, Steve;
Beltrán, Linda;
Moats, Samantha;
Chan, Keith;
Jorcano, José;
DiGiovanni, John

Publication type:

Article

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening.

Published in:

Cancers, 2020, v. 12, n. 12, p. 3714, doi. 10.3390/cancers12123714

By:

Hackman, G. Lavender;
Collins, Meghan;
Lu, Xiyuan;
Lodi, Alessia;
DiGiovanni, John;
Tiziani, Stefano

Publication type:

Article

High levels of oxidative DNA damage in lymphocyte DNA of premenopausal breast cancer patients from Egypt.

Published in:

International Journal of Environmental Health Research, 2004, v. 14, n. 2, p. 121, doi. 10.1080/0960312042000209534

By:

Soliman, Amr S;
Vulimiri, Suryanarayana V;
Kleiner, Heather E;
Shen, Jianjun;
Eissa, Saad;
Morad, Magda;
Taha, Hala;
Lukmanji, Farzana;
LI, Donghui;
Johnston, Dennis A;
Lo, Herng-Hsang;
Lau, Serrine;
Digiovanni, John;
Bondy, Melissa L

Publication type:

Article

Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cance.

Published in:

Cell Cycle, 2014, v. 13, n. 11, p. 1, doi. 10.4161/cc.28757

By:

Suraneni, Mahipal V.;
Moore, John R.;
Dingxiao Zhang;
Badeaux, Mark;
Macaluso, Marc D.;
DiGiovanni, John;
Kusewitt, Donna;
Tang, Dean G.

Publication type:

Article

Transgenic overexpression of PKC&epsilon, in the mouse prostate induces preneoplastic lesions.

Published in:

Cell Cycle, 2011, v. 10, n. 2, p. 268, doi. 10.4161/cc.10.2.14469

By:

Benavides, Fernando;
Blando, Jorge;
Perez, Carlos J.;
Garg, Rachana;
Conti, Claudio J.;
DiGiovanni, John;
Kazanietz, Marcelo G.

Publication type:

Article

Carcinogenic Effects of MGP-7 and B[a]P on the Hamster Cheek Pouch.

Published in:

Toxicologic Pathology, 2009, v. 37, n. 6, p. 733, doi. 10.1177/0192623309344203

By:

Brandon, Jimi Lynn;
Conti, Claudio J.;
Goldstein, Lawrence S.;
Digiovanni, John;
Gimenez-Conti, Irma B.

Publication type:

Article

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 12, p. 3133, doi. 10.1038/jid.2015.314

By:

Perez, Carlos J;
Mecklenburg, Lars;
Jaubert, Jean;
Martinez-Santamaria, Lucia;
Iritani, Brian M;
Espejo, Alexsandra;
Napoli, Eleonora;
Song, Gyu;
del Río, Marcela;
DiGiovanni, John;
Giulivi, Cecilia;
Bedford, Mark T;
Dent, Sharon Y R;
Wood, Richard D;
Kusewitt, Donna F;
Guénet, Jean-Louis;
Conti, Claudio J;
Benavides, Fernando

Publication type:

Article

Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes.

Published in:

Journal of Investigative Dermatology, 2014, v. 134, n. 7, p. 1971, doi. 10.1038/jid.2014.68

By:

Macias, Everardo;
Rao, Dharanija;
Carbajal, Steve;
Kiguchi, Kaoru;
DiGiovanni, John

Publication type:

Article

Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor.

Published in:

Journal of Investigative Dermatology, 2011, v. 131, n. 1, p. 108, doi. 10.1038/jid.2010.255

By:

Miyoshi, Ken;
Takaishi, Mikiro;
Nakajima, Kimiko;
Ikeda, Mitsunori;
Kanda, Takashi;
Tarutani, Masahito;
Iiyama, Tatsuo;
Asao, Naoki;
DiGiovanni, John;
Sano, Shigetoshi

Publication type:

Article

Short-Term Biomarkers of Tumor Promotion in Mouse Skin Treated with Petroleum Middle Distillates1.

Published in:

Toxicological Sciences, 1998, v. 45, n. 2, p. 137, doi. 10.1093/toxsci/45.2.137

By:

Walborg, Earl F.;
DiGiovanni, John;
Conti, Claudio J.;
Slaga, Thomas J.;
Freeman, James J.;
Steup, David R.;
Skisak, Christopher M.

Publication type:

Article

Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium.

Published in:

NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00160-9

By:

Su, Fei;
Daquinag, Alexes C.;
Ahn, Songyeon;
Saha, Achinto;
Dai, Yulin;
Zhao, Zhongming;
DiGiovanni, John;
Kolonin, Mikhail G.

Publication type:

Article

Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth.

Published in:

NPJ Precision Oncology, 2019, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41698-019-0088-z

By:

Kshattry, Sabin;
Saha, Achinto;
Gries, Paul;
Tiziani, Stefano;
Stone, Everett;
Georgiou, George;
DiGiovanni, John

Publication type:

Article

Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth.

Published in:

NPJ Precision Oncology, 2019, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41698-019-0088-z

By:

Kshattry, Sabin;
Saha, Achinto;
Gries, Paul;
Tiziani, Stefano;
Stone, Everett;
Georgiou, George;
DiGiovanni, John

Publication type:

Article

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis.

Published in:

Nature Communications, 2015, v. 6, n. 8, p. 8137, doi. 10.1038/ncomms9137

By:

Nowinski, Sara M.;
Solmonson, Ashley;
Rundhaug, Joyce E.;
Rho, Okkyung;
Cho, Jiyoon;
Lago, Cory U.;
Riley, Christopher L.;
Lee, Sunhee;
Kohno, Shohei;
Dao, Christine K.;
Nikawa, Takeshi;
Bratton, Shawn B.;
Wright, Casey W.;
Fischer, Susan M.;
DiGiovanni, John;
Mills, Edward M.

Publication type:

Article

Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions.

Published in:

Molecular Cancer, 2006, v. 5, p. 15, doi. 10.1186/1476-4598-5-15

By:

Weihong Yin;
Cheepala, Satish;
Roberts, Jennifer N.;
Syson-Chan, Keith;
DiGiovanni, John;
Clifford, John L.

Publication type:

Article

FGFR2 in the Development and Progression of Cutaneous Squamous Cell Cancer.

Published in:

Molecular Carcinogenesis, 2025, v. 64, n. 1, p. 5, doi. 10.1002/mc.23835

By:

Kallenberger, Ethan M;
Khandelwal, Alok;
Nath, Priyatosh;
Nguyen, Shaun A.;
DiGiovanni, John;
Nathan, Cherie‐Ann

Publication type:

Article