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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
Published in:
PLoS Pathogens, 2022, v. 18, n. 2, p. 1, doi. 10.1371/journal.ppat.1010278
By:
- Small-Saunders, Jennifer L.;
- Hagenah, Laura M.;
- Wicht, Kathryn J.;
- Dhingra, Satish K.;
- Deni, Ioanna;
- Kim, Jonathan;
- Vendome, Jeremie;
- Gil-Iturbe, Eva;
- Roepe, Paul D.;
- Mehta, Monica;
- Mancia, Filippo;
- Quick, Matthias;
- Eppstein, Margaret J.;
- Fidock, David A.
Publication type:
Article
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.66277
By:
- Stokes, Barbara H.;
- Dhingra, Satish K.;
- Rubiano, Kelly;
- Mok, Sachel;
- Straimer, Judith;
- Gnädig, Nina F.;
- Deni, Ioanna;
- Schindler, Kyra A.;
- Bath, Jade R.;
- Ward, Kurt E.;
- Striepen, Josefine;
- Yeo, Tomas;
- Ross, Leila S.;
- Legrand, Eric;
- Ariey, Frédéric;
- Cunningham, Clark H.;
- Souleymane, Issa M.;
- Gansané, Adama;
- Nzoumbou-Boko, Romaric;
- Ndayikunda, Claudette
Publication type:
Article
Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter.
Published in:
Molecular Microbiology, 2015, v. 97, n. 2, p. 381, doi. 10.1111/mmi.13035
By:
- Petersen, Ines;
- Gabryszewski, Stanislaw J.;
- Johnston, Geoffrey L.;
- Dhingra, Satish K.;
- Ecker, Andrea;
- Lewis, Rebecca E.;
- Almeida, Mariana Justino;
- Straimer, Judith;
- Henrich, Philipp P.;
- Palatulan, Eugene;
- Johnson, David J.;
- Coburn‐Flynn, Olivia;
- Sanchez, Cecilia;
- Lehane, Adele M.;
- Lanzer, Michael;
- Fidock, David A.
Publication type:
Article
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
Published in:
Nature Communications, 2016, v. 7, n. 5, p. 11553, doi. 10.1038/ncomms11553
By:
- Veiga, M. Isabel;
- Dhingra, Satish K.;
- Henrich, Philipp P.;
- Straimer, Judith;
- Gnädig, Nina;
- Uhlemann, Anne-Catrin;
- Martin, Rowena E.;
- Lehane, Adele M.;
- Fidock, David A.
Publication type:
Article
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
Published in:
PLoS Pathogens, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.ppat.1005976
By:
- Gabryszewski, Stanislaw J.;
- Dhingra, Satish K.;
- Combrinck, Jill M.;
- Lewis, Ian A.;
- Callaghan, Paul S.;
- Hassett, Matthew R.;
- Siriwardana, Amila;
- Henrich, Philipp P.;
- Lee, Andrew H.;
- Gnädig, Nina F.;
- Musset, Lise;
- Llinás, Manuel;
- Egan, Timothy J.;
- Roepe, Paul D.;
- Fidock, David A.
Publication type:
Article
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05652-0
By:
- Ross, Leila S.;
- Dhingra, Satish K.;
- Mok, Sachel;
- Yeo, Tomas;
- Wicht, Kathryn J.;
- Kümpornsin, Krittikorn;
- Takala-Harrison, Shannon;
- Witkowski, Benoit;
- Fairhurst, Rick M.;
- Ariey, Frederic;
- Menard, Didier;
- Fidock, David A.
Publication type:
Article
Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine.
Published in:
Journal of Infectious Diseases, 2023, v. 227, n. 10, p. 1121, doi. 10.1093/infdis/jiac469
By:
- Ward, Kurt E;
- Christensen, Peter;
- Racklyeft, Annie;
- Dhingra, Satish K;
- Chua, Adeline C Y;
- Remmert, Caroline;
- Suwanarusk, Rossarin;
- Matheson, Jessica;
- Blackman, Michael J;
- Kaneko, Osamu;
- Kyle, Dennis E;
- Lee, Marcus C S;
- Moon, Robert W;
- Snounou, Georges;
- Rénia, Laurent;
- Fidock, David A;
- Russell, Bruce;
- Bifani, Pablo
Publication type:
Article

Found: 7

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.

Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter.

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.

Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine.