Works matching AU Deswarte, Kim

Results: 28

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pKa of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 28, p. 1, doi. 10.1002/anie.202506954

By:

Chen, Yong;
De Lombaerde, Emily;
Bugler‐Lamb, Aimée;
Zhong, Zifu;
Schuijs, Martijn J.;
Gomez, Claudia M. Brenis;
De Baere, Jamie;
Gontsarik, Mark;
Lauwers, Heleen;
Deswarte, Kim;
Sanders, Niek N.;
Lambrecht, Bart N.;
Guilliams, Martin;
De Geest, Bruno G.

Publication type:

Article

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pKa of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Published in:

Angewandte Chemie, 2025, v. 137, n. 28, p. 1, doi. 10.1002/ange.202506954

By:

Chen, Yong;
De Lombaerde, Emily;
Bugler‐Lamb, Aimée;
Zhong, Zifu;
Schuijs, Martijn J.;
Gomez, Claudia M. Brenis;
De Baere, Jamie;
Gontsarik, Mark;
Lauwers, Heleen;
Deswarte, Kim;
Sanders, Niek N.;
Lambrecht, Bart N.;
Guilliams, Martin;
De Geest, Bruno G.

Publication type:

Article

Ym1 protein crystals promote type 2 immunity.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.90676

By:

Heyndrickx, Ines;
Deswarte, Kim;
Verstraete, Kenneth;
Verschueren, Koen H. G.;
Smole, Ursula;
Aegerter, Helena;
Dansercoer, Ann;
Hammad, Hamida;
Savvides, Savvas N.;
Lambrecht, Bart N.

Publication type:

Article

Berichtigung: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie, 2021, v. 133, n. 31, p. 16878, doi. 10.1002/ange.202105635

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie, 2021, v. 133, n. 17, p. 9553, doi. 10.1002/ange.202015362

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems.

Published in:

Angewandte Chemie, 2019, v. 131, n. 43, p. 15535, doi. 10.1002/ange.201905687

By:

De Vrieze, Jana;
Louage, Benoit;
Deswarte, Kim;
Zhong, Zifu;
De Coen, Ruben;
Van Herck, Simon;
Nuhn, Lutz;
Kaas Frich, Camilla;
Zelikin, Alexander N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
David, Sunil A.;
De Geest, Bruno G.

Publication type:

Article

Synthetisch hergestellte, transient thermoresponsive Homopolymere mit einer oberen kritischen Lösungstemperatur für physiologisch relevante Anwendungen.

Published in:

Angewandte Chemie, 2019, v. 131, n. 23, p. 7948, doi. 10.1002/ange.201900224

By:

Zhang, Zhiyue;
Li, Hui;
Kasmi, Sabah;
Van Herck, Simon;
Deswarte, Kim;
Lambrecht, Bart N.;
Hoogenboom, Richard;
Nuhn, Lutz;
De Geest, Bruno G.

Publication type:

Article

Förster‐Resonanzenergietransfer‐basierter Nachweis intrazellulärer Ketal‐Hydrolyse in synthetisch vernetzten Nanopartikeln.

Published in:

Angewandte Chemie, 2018, v. 130, n. 33, p. 10920, doi. 10.1002/ange.201803847

By:

Nuhn, Lutz;
Van Herck, Simon;
Best, Andreas;
Deswarte, Kim;
Kokkinopoulou, Maria;
Lieberwirth, Ingo;
Koynov, Kaloian;
Lambrecht, Bart N.;
De Geest, Bruno G.

Publication type:

Article

Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid‐Polyethylene Glycol Amphiphiles.

Published in:

Advanced Therapeutics, 2021, v. 4, n. 8, p. 1, doi. 10.1002/adtp.202100079

By:

De Vrieze, Jana;
Baptista, Antonio P.;
Nuhn, Lutz;
Van Herck, Simon;
Deswarte, Kim;
Yu, Haijun;
Lambrecht, Bart N.;
De Geest, Bruno G.

Publication type:

Article

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome.

Published in:

OncoImmunology, 2017, v. 6, n. 1, p. 1, doi. 10.1080/2162402X.2016.1253655

By:

Pyfferoen, Lotte;
Brabants, Elisabeth;
Everaert, Celine;
De Cabooter, Nancy;
Heyns, Kelly;
Deswarte, Kim;
Vanheerswynghels, Manon;
De Prijck, Sofie;
Waegemans, Glenn;
Dullaers, Melissa;
Hammad, Hamida;
De Wever, Olivier;
Mestdagh, Pieter;
Vandesompele, Jo;
Lambrecht, Bart N.;
Vermaelen, Karim Y.

Publication type:

Article

Corrigendum: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 31, p. 16741, doi. 10.1002/anie.202105635

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 17, p. 9467, doi. 10.1002/anie.202015362

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 43, p. 15390, doi. 10.1002/anie.201905687

By:

De Vrieze, Jana;
Louage, Benoit;
Deswarte, Kim;
Zhong, Zifu;
De Coen, Ruben;
Van Herck, Simon;
Nuhn, Lutz;
Kaas Frich, Camilla;
Zelikin, Alexander N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
David, Sunil A.;
De Geest, Bruno G.

Publication type:

Article

A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 23, p. 7866, doi. 10.1002/anie.201900224

By:

Zhang, Zhiyue;
Li, Hui;
Kasmi, Sabah;
Van Herck, Simon;
Deswarte, Kim;
Lambrecht, Bart N.;
Hoogenboom, Richard;
Nuhn, Lutz;
De Geest, Bruno G.

Publication type:

Article

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model.

Published in:

Allergy, 2021, v. 76, n. 11, p. 3546, doi. 10.1111/all.15045

By:

Cloots, Eva;
Debeuf, Nincy;
Deswarte, Kim;
Fayazpour, Farzaneh;
Vanheerswynghels, Manon;
De Wolf, Caroline;
Van De Velde, Evelien;
Hammad, Hamida;
Lambrecht, Bart N.;
Eyckerman, Sven;
Janssens, Sophie

Publication type:

Article

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.

Published in:

Angewandte Chemie, 2025, v. 137, n. 7, p. 1, doi. 10.1002/ange.202419031

By:

Zhong, Zifu;
Deventer, Marie H.;
Chen, Yong;
Vanhee, Stijn;
Lammens, Inés;
Deswarte, Kim;
Huang, Yi;
Ye, Tingting;
Wang, Haixiu;
Nuhn, Lutz;
Vandeputte, Marthe M.;
Gontsarik, Mark;
Cui, Xiaole;
Sanders, Niek N.;
Lienenklaus, Stefan;
N. Lambrecht, Bart;
Baptista, Antonio P.;
Stove, Christophe P.;
G. De Geest, Bruno

Publication type:

Article

Role of NKp46+ natural killer cells in house dust mite‐driven asthma.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 4, p. 1, doi. 10.15252/emmm.201708657

By:

Haspeslagh, Eline;
van Helden, Mary J.;
Deswarte, Kim;
De Prijck, Sofie;
van Moorleghem, Justine;
Boon, Louis;
Hammad, Hamida;
Vivier, Eric;
Lambrecht, Bart N.

Publication type:

Article

Nanoparticle‐Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.

Published in:

Advanced Materials, 2018, v. 30, n. 45, p. N.PAG, doi. 10.1002/adma.201803397

By:

Nuhn, Lutz;
De Koker, Stefaan;
Van Lint, Sandra;
Zhong, Zifu;
Catani, João Portela;
Combes, Francis;
Deswarte, Kim;
Li, Yupeng;
Lambrecht, Bart N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
David, Sunil A.;
Tavernier, Jan;
De Geest, Bruno G.

Publication type:

Article

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.

Published in:

Nature Communications, 2015, v. 6, n. 2, p. 6219, doi. 10.1038/ncomms7219

By:

Matheu, Melanie P.;
Othy, Shivashankar;
Greenberg, Milton L.;
Dong, Tobias X.;
Schuijs, Martijn;
Deswarte, Kim;
Hammad, Hamida;
Lambrecht, Bart N.;
Parker, Ian;
Cahalan, Michael D.

Publication type:

Article

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Published in:

Nature Communications, 2015, v. 6, n. 1, p. 5794, doi. 10.1038/ncomms6794

By:

Goossens, Steven;
Radaelli, Enrico;
Blanchet, Odile;
Durinck, Kaat;
Van der Meulen, Joni;
Peirs, Sofie;
Taghon, Tom;
Tremblay, Cedric S.;
Costa, Magdaline;
Ghahremani, Morvarid Farhang;
De Medts, Jelle;
Bartunkova, Sonia;
Haigh, Katharina;
Schwab, Claire;
Farla, Natalie;
Pieters, Tim;
Matthijssens, Filip;
Van Roy, Nadine;
Best, J. Adam;
Deswarte, Kim

Publication type:

Article

LXR signaling controls homeostatic dendritic cell maturation.

Published in:

Science Immunology, 2023, v. 8, n. 83, p. 1, doi. 10.1126/sciimmunol.add3955

By:

Bosteels, Victor;
Maréchal, Sandra;
De Nolf, Clint;
Rennen, Sofie;
Maelfait, Jonathan;
Tavernier, Simon J.;
Vetters, Jessica;
Van De Velde, Evelien;
Fayazpour, Farzaneh;
Deswarte, Kim;
Lamoot, Alexander;
Van Duyse, Julie;
Martens, Liesbet;
Bosteels, Cédric;
Roelandt, Ria;
Emmaneel, Annelies;
Van Gassen, Sofie;
Boon, Louis;
Van Isterdael, Gert;
Guillas, Isabelle

Publication type:

Article

Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection.

Published in:

Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00312

By:

Neyt, Katrijn;
GeurtsvanKessel, Corine H.;
Deswarte, Kim;
Hammad, Hamida;
Lambrecht, Bart N.

Publication type:

Article

PH‐Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2‐Propionic‐3‐Methyl‐maleic Anhydrides with Cholesteryl End Groups.

Published in:

Advanced Healthcare Materials, 2024, v. 13, n. 32, p. 1, doi. 10.1002/adhm.202402875

By:

Heck, Alina G.;
Medina‐Montano, Carolina;
Zhong, Zifu;
Deswarte, Kim;
Eigen, Katharina;
Stickdorn, Judith;
Kockelmann, Johannes;
Scherger, Maximilian;
Sanders, Niek N.;
Lienenklaus, Stefan;
Lambrecht, Bart N.;
Grabbe, Stephan;
De Geest, Bruno G.;
Nuhn, Lutz

Publication type:

Article

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Published in:

Advanced Healthcare Materials, 2023, v. 12, n. 32, p. 1, doi. 10.1002/adhm.202301687

By:

Zhong, Zifu;
Chen, Yong;
Deswarte, Kim;
Lauwers, Heleen;
De Lombaerde, Emily;
Cui, Xiaole;
Van Herck, Simon;
Ye, Tingting;
Gontsarik, Mark;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
De Koker, Stefaan;
De Geest, Bruno G.

Publication type:

Article

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide.

Published in:

Advanced Healthcare Materials, 2017, v. 6, n. 13, p. n/a, doi. 10.1002/adhm.201601412

By:

Udhayakumar, Vimal K.;
De Beuckelaer, Ans;
McCaffrey, Joanne;
McCrudden, Cian M.;
Kirschman, Jonathan L.;
Vanover, Daryll;
Van Hoecke, Lien;
Roose, Kenny;
Deswarte, Kim;
De Geest, Bruno G.;
Lienenklaus, Stefan;
Santangelo, Philip J.;
Grooten, Johan;
McCarthy, Helen O.;
De Koker, Stefaan

Publication type:

Article

Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels.

Published in:

Advanced Functional Materials, 2022, v. 32, n. 35, p. 1, doi. 10.1002/adfm.202203490

By:

Czysch, Christian;
Medina‐Montano, Carolina;
Zhong, Zifu;
Fuchs, Alexander;
Stickdorn, Judith;
Winterwerber, Pia;
Schmitt, Sascha;
Deswarte, Kim;
Raabe, Marco;
Scherger, Maximilian;
Combes, Francis;
De Vrieze, Jana;
Kasmi, Sabah;
Sandners, Niek N.;
Lienenklaus, Stefan;
Koynov, Kaloian;
Räder, Hans‐Joachim;
Lambrecht, Bart N.;
David, Sunil A.;
Bros, Matthias

Publication type:

Article

FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles.

Published in:

Angewandte Chemie International Edition, 2018, v. 57, n. 33, p. 10760, doi. 10.1002/anie.201803847

By:

Nuhn, Lutz;
Van Herck, Simon;
Best, Andreas;
Deswarte, Kim;
Kokkinopoulou, Maria;
Lieberwirth, Ingo;
Koynov, Kaloian;
Lambrecht, Bart N.;
De Geest, Bruno G.

Publication type:

Article

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 7, p. 1, doi. 10.1002/anie.202419031

By:

Zhong, Zifu;
Deventer, Marie H.;
Chen, Yong;
Vanhee, Stijn;
Lammens, Inés;
Deswarte, Kim;
Huang, Yi;
Ye, Tingting;
Wang, Haixiu;
Nuhn, Lutz;
Vandeputte, Marthe M.;
Gontsarik, Mark;
Cui, Xiaole;
Sanders, Niek N.;
Lienenklaus, Stefan;
N. Lambrecht, Bart;
Baptista, Antonio P.;
Stove, Christophe P.;
G. De Geest, Bruno

Publication type:

Article

Works matching AU Deswarte, Kim

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pK<sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pK<sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Ym1 protein crystals promote type 2 immunity.

Berichtigung: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems.

Synthetisch hergestellte, transient thermoresponsive Homopolymere mit einer oberen kritischen Lösungstemperatur für physiologisch relevante Anwendungen.

Förster‐Resonanzenergietransfer‐basierter Nachweis intrazellulärer Ketal‐Hydrolyse in synthetisch vernetzten Nanopartikeln.

Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid‐Polyethylene Glycol Amphiphiles.

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome.

Corrigendum: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists.

A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.

IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model.

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.

Role of NKp46<sup>+</sup> natural killer cells in house dust mite‐driven asthma.

Nanoparticle‐Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

LXR signaling controls homeostatic dendritic cell maturation.

Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection.

PH‐Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2‐Propionic‐3‐Methyl‐maleic Anhydrides with Cholesteryl End Groups.

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide.

Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels.

FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles.

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.