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The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.
Published in:
EMBO Molecular Medicine, 2014, v. 6, n. 9, p. 1161, doi. 10.15252/emmm.201403944
By:
- McCloskey, Conor;
- Rada, Cara;
- Bailey, Elizabeth;
- McCavera, Samantha;
- Berg, Hugo A;
- Atia, Jolene;
- Rand, David A;
- Shmygol, Anatoly;
- Chan, Yi‐Wah;
- Quenby, Siobhan;
- Brosens, Jan J;
- Vatish, Manu;
- Zhang, Jie;
- Denton, Jerod S;
- Taggart, Michael J;
- Kettleborough, Catherine;
- Tickle, David;
- Jerman, Jeff;
- Wright, Paul;
- Dale, Timothy
Publication type:
Article
The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel.
Published in:
Physiological Reports, 2019, v. 7, n. 23, p. N.PAG, doi. 10.14814/phy2.14303
By:
- Afzal, Aqeela;
- Figueroa, Eric E.;
- Kharade, Sujay V.;
- Bittman, Kevin;
- Matlock, Brittany K.;
- Flaherty, David K.;
- Denton, Jerod S.
Publication type:
Article
Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides.
Published in:
ChemMedChem, 2021, v. 16, n. 2, p. 319, doi. 10.1002/cmdc.202000598
By:
- Aretz, Christopher D.;
- Kharade, Sujay V.;
- Chronister, Keagan;
- Trigueros, Renata Rusconi;
- Rodriguez, Erick J. Martinez;
- Piermarini, Peter M.;
- Denton, Jerod S.;
- Hopkins, Corey R.
Publication type:
Article
An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria.
Published in:
Scientific Reports, 2016, p. 36954, doi. 10.1038/srep36954
By:
- Swale, Daniel R.;
- Engers, Darren W.;
- Bollinger, Sean R.;
- Gross, Aaron;
- Inocente, Edna Alfaro;
- Days, Emily;
- Kanga, Fariba;
- Johnson, Reed M.;
- Yang, Liu;
- Bloomquist, Jeffrey R.;
- Hopkins, Corey R.;
- Piermarini, Peter M.;
- Denton, Jerod S.
Publication type:
Article
High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.
Published in:
PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0143243
By:
- Herington, Jennifer L.;
- Swale, Daniel R.;
- Brown, Naoko;
- Shelton, Elaine L.;
- Choi, Hyehun;
- Williams, Charles H.;
- Hong, Charles C.;
- Paria, Bibhash C.;
- Denton, Jerod S.;
- Reese, Jeff
Publication type:
Article
Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels.
Published in:
PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0110772
By:
- Raphemot, Rene;
- Rouhier, Matthew F.;
- Swale, Daniel R.;
- Days, Emily;
- Weaver, C. David;
- Lovell, Kimberly M.;
- Konkel, Leah C.;
- Engers, Darren W.;
- Bollinger, Sean F.;
- Hopkins, Corey;
- Piermarini, Peter M.;
- Denton, Jerod S.
Publication type:
Article
Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever Mosquito Aedes aegypti.
Published in:
PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100700
By:
- Rouhier, Matthew F.;
- Raphemot, Rene;
- Denton, Jerod S.;
- Piermarini, Peter M.
Publication type:
Article
Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064905
By:
- Raphemot, Rene;
- Rouhier, Matthew F.;
- Hopkins, Corey R.;
- Gogliotti, Rocco D.;
- Lovell, Kimberly M.;
- Hine, Rebecca M.;
- Ghosalkar, Dhairyasheel;
- Longo, Anthony;
- Beyenbach, Klaus W.;
- Denton, Jerod S.;
- Piermarini, Peter M.
Publication type:
Article
Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti.
Published in:
Insects (2075-4450), 2018, v. 9, n. 4, p. 163, doi. 10.3390/insects9040163
By:
- Rusconi Trigueros, Renata;
- Hopkins, Corey R.;
- Denton, Jerod S.;
- Piermarini, Peter M.
Publication type:
Article
Development and Validation of Fluorescence-Based and Automated Patch Clamp-Based Functional Assays for the Inward Rectifier Potassium Channel Kir4.1.
Published in:
Assay & Drug Development Technologies, 2013, v. 11, n. 9/10, p. 532, doi. 10.1089/adt.2013.544
By:
- Raphemot, Rene;
- Kadakia, Rishin J.;
- Olsen, Michelle L.;
- Banerjee, Sreedatta;
- Days, Emily;
- Smith, Stephen S.;
- Weaver, C. David;
- Denton, Jerod S.
Publication type:
Article
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.82431
By:
- Hirohide Takahashi;
- Toshiki Yamada;
- Denton, Jerod S.;
- Strange, Kevin;
- Karakas, Erkan
Publication type:
Article
Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir4.1/Kir5.1) in the cortical collecting duct.
Published in:
British Journal of Pharmacology, 2022, v. 179, n. 12, p. 2953, doi. 10.1111/bph.15779
By:
- Isaeva, Elena;
- Bohovyk, Ruslan;
- Fedoriuk, Mykhailo;
- Shalygin, Alexey;
- Klemens, Christine A.;
- Zietara, Adrian;
- Levchenko, Vladislav;
- Denton, Jerod S.;
- Staruschenko, Alexander;
- Palygin, Oleg
Publication type:
Article
Malpighian Tubules as Novel Targets for Mosquito Control.
Published in:
International Journal of Environmental Research & Public Health, 2017, v. 14, n. 2, p. 111, doi. 10.3390/ijerph14020111
By:
- Piermarini, Peter M.;
- Esquivel, Carlos J.;
- Denton, Jerod S.
Publication type:
Article
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Published in:
Nature, 2015, v. 520, n. 7545, p. 94, doi. 10.1038/nature14051
By:
- Ghamari-Langroudi, Masoud;
- Digby, Gregory J.;
- Sebag, Julien A.;
- Millhauser, Glenn L.;
- Palomino, Rafael;
- Matthews, Robert;
- Gillyard, Taneisha;
- Panaro, Brandon L.;
- Tough, Iain R.;
- Cox, Helen M.;
- Denton, Jerod S.;
- Cone, Roger D.
Publication type:
Article
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49562-w
By:
- Zhang, Yahua;
- Bock, Fabian;
- Ferdaus, Mohammed;
- Arroyo, Juan Pablo;
- L Rose, Kristie;
- Patel, Purvi;
- Denton, Jerod S.;
- Delpire, Eric;
- Weinstein, Alan M.;
- Zhang, Ming-Zhi;
- Harris, Raymond C.;
- Terker, Andrew S.
Publication type:
Article

Found: 15

The inwardly rectifying K<sup>+</sup> channel KIR7.1 controls uterine excitability throughout pregnancy.

The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel.

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides.

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria.

High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.

Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels.

Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever Mosquito <i>Aedes aegypti</i>.

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti.

Development and Validation of Fluorescence-Based and Automated Patch Clamp-Based Functional Assays for the Inward Rectifier Potassium Channel Kir4.1.

Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.

Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (K<sub>ir</sub>4.1/K<sub>ir</sub>5.1) in the cortical collecting duct.

Malpighian Tubules as Novel Targets for Mosquito Control.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.